LOCUS       NM_007425               1387 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus advanced glycosylation end product-specific receptor
            (Ager), transcript variant 1, mRNA.
ACCESSION   NM_007425
VERSION     NM_007425.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1387)
  AUTHORS   Du,M., Li,J., Yu,S., Chen,X., She,Y., Lu,Y. and Shu,H.
  TITLE     RAGE mediates hippocampal pericyte responses and neurovascular unit
            lesions after TBI
  JOURNAL   Exp Neurol 380, 114912 (2024)
   PUBMED   39097075
  REMARK    GeneRIF: RAGE mediates hippocampal pericyte responses and
            neurovascular unit lesions after TBI.
REFERENCE   2  (bases 1 to 1387)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1387)
  AUTHORS   Liu,K., Meng,X., Liu,Z., Tang,M., Lv,Z., Huang,X., Jin,H., Han,X.,
            Liu,X., Pu,W., Zhu,H. and Zhou,B.
  TITLE     Tracing the origin of alveolar stem cells in lung repair and
            regeneration
  JOURNAL   Cell 187 (10), 2428-2445 (2024)
   PUBMED   38579712
REFERENCE   4  (bases 1 to 1387)
  AUTHORS   Ge,X., Han,H., Desert,R., Das,S., Song,Z., Komakula,S.S.B.,
            Chen,W., Athavale,D., Lantvit,D. and Nieto,N.
  TITLE     A Protein Complex of Liver Origin Activates a Pro-inflammatory
            Program That Drives Hepatic and Intestinal Injury in
            Alcohol-Associated Liver Disease
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (3), 101362 (2024)
   PUBMED   38788899
REFERENCE   5  (bases 1 to 1387)
  AUTHORS   Kalea,A.Z., Reiniger,N., Yang,H., Arriero,M., Schmidt,A.M. and
            Hudson,B.I.
  TITLE     Alternative splicing of the murine receptor for advanced glycation
            end-products (RAGE) gene
  JOURNAL   FASEB J 23 (6), 1766-1774 (2009)
   PUBMED   19164451
  REMARK    GeneRIF: Results suggest that the murine receptor for advanced
            glycation end-products (RAGE) gene undergoes extensive splicing
            with distinct splice isoforms being uniquely distributed in
            different tissues.
REFERENCE   6  (bases 1 to 1387)
  AUTHORS   Harashima,A., Yamamoto,Y., Cheng,C., Tsuneyama,K., Myint,K.M.,
            Takeuchi,A., Yoshimura,K., Li,H., Watanabe,T., Takasawa,S.,
            Okamoto,H., Yonekura,H. and Yamamoto,H.
  TITLE     Identification of mouse orthologue of endogenous secretory receptor
            for advanced glycation end-products: structure, function and
            expression
  JOURNAL   Biochem J 396 (1), 109-115 (2006)
   PUBMED   16503878
  REMARK    GeneRIF: The murine equivalent of esRAGE was isolated from brain
            polysomal poly(A)+ (polyadenylated) RNA by RT (reverse
            transcription)-PCR cloning. Its expression is increased in kidneys
            of diabetic mice.
REFERENCE   7  (bases 1 to 1387)
  AUTHORS   Herr,C., Smyth,N., Ullrich,S., Yun,F., Sasse,P., Hescheler,J.,
            Fleischmann,B., Lasek,K., Brixius,K., Schwinger,R.H., Fassler,R.,
            Schroder,R. and Noegel,A.A.
  TITLE     Loss of annexin A7 leads to alterations in frequency-induced
            shortening of isolated murine cardiomyocytes
  JOURNAL   Mol Cell Biol 21 (13), 4119-4128 (2001)
   PUBMED   11390641
REFERENCE   8  (bases 1 to 1387)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (bases 1 to 1387)
  AUTHORS   Hofmann,M.A., Drury,S., Fu,C., Qu,W., Taguchi,A., Lu,Y., Avila,C.,
            Kambham,N., Bierhaus,A., Nawroth,P., Neurath,M.F., Slattery,T.,
            Beach,D., McClary,J., Nagashima,M., Morser,J., Stern,D. and
            Schmidt,A.M.
  TITLE     RAGE mediates a novel proinflammatory axis: a central cell surface
            receptor for S100/calgranulin polypeptides
  JOURNAL   Cell 97 (7), 889-901 (1999)
   PUBMED   10399917
REFERENCE   10 (bases 1 to 1387)
  AUTHORS   Renard,C., Chappey,O., Wautier,M.P., Nagashima,M., Lundh,E.,
            Morser,J., Zhao,L., Schmidt,A.M., Scherrmann,J.M. and Wautier,J.L.
  TITLE     Recombinant advanced glycation end product receptor
            pharmacokinetics in normal and diabetic rats
  JOURNAL   Mol Pharmacol 52 (1), 54-62 (1997)
   PUBMED   9224812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009767.6 and BC061182.1.
            
            On Sep 26, 2012 this sequence version replaced NM_007425.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061182.1, EU520325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CT009767.6         155277-155288
            13-1382             BC061182.1         1-1370
            1383-1387           CT009767.6         158360-158364
FEATURES             Location/Qualifiers
     source          1..1387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.18 cM"
     gene            1..1387
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="advanced glycosylation end product-specific
                     receptor"
                     /db_xref="GeneID:11596"
                     /db_xref="MGI:MGI:893592"
     exon            1..96
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1253
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; advanced glycation end-products receptor;
                     receptor for advanced glycosylation end products"
                     /codon_start=1
                     /product="advanced glycosylation end product-specific
                     receptor isoform a precursor"
                     /protein_id="NP_031451.2"
                     /db_xref="CCDS:CCDS28649.1"
                     /db_xref="GeneID:11596"
                     /db_xref="MGI:MGI:893592"
                     /translation="MPAGTAARAWVLVLALWGAVAGGQNITARIGEPLVLSCKGAPKK
                     PPQQLEWKLNTGRTEAWKVLSPQGGPWDSVARILPNGSLLLPATGIVDEGTFRCRATN
                     RRGKEVKSNYRVRVYQIPGKPEIVDPASELTASVPNKVGTCVSEGSYPAGTLSWHLDG
                     KLLIPDGKETLVKEETRRHPETGLFTLRSELTVIPTQGGTHPTFSCSFSLGLPRRRPL
                     NTAPIQLRVREPGPPEGIQLLVEPEGGIVAPGGTVTLTCAISAQPPPQVHWIKDGAPL
                     PLAPSPVLLLPEVGHEDEGTYSCVATHPSHGPQESPPVSIRVTETGDEGPAEGSVGES
                     GLGTLALALGILGGLGVVALLVGAILWRKRQPRREERKAPESQEDEEERAELNQSEEA
                     EMPENGAGGP"
     exon            97..203
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            204..396
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            397..461
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            462..549
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            550..729
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            730..860
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1002
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1029
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1156
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1387
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1366..1371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="hexamer: AGTAAA"
     polyA_site      1385
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="major polyA site"
ORIGIN      
        1 gggaagaggg gcagacagaa cctggagcct gggaaggaag caccatgcca gcggggacag
       61 cagctagagc ctgggtgctg gttcttgctc tatggggagc tgtagctggt ggtcagaaca
      121 tcacagcccg gattggagag ccacttgtgc taagctgtaa gggggcccct aagaagccgc
      181 cccagcagct agaatggaaa ctgaacacag gaagaactga agcttggaag gtcctctctc
      241 cccagggagg cccctgggac agcgtggctc gaatcctccc caatggttcc ctcctccttc
      301 cagccactgg aattgtcgat gaggggactt tccggtgtcg ggcaactaac aggcgaggga
      361 aggaggtcaa gtccaactac cgagtccgag tctaccagat tcctgggaag ccagaaattg
      421 tggatcctgc ctctgaactc acagccagtg tccctaataa ggtggggaca tgtgtgtctg
      481 agggaagcta ccctgcaggg acccttagct ggcacttaga tgggaaactt ctgattcccg
      541 atggcaaaga aacactcgtg aaggaagaga ccaggagaca ccctgagacg ggactcttta
      601 cactgcggtc agagctgaca gtgatcccca cccaaggagg aacccatcct accttctcct
      661 gcagtttcag cctgggcctt ccccggcgca gacccctgaa cacagccccc atccaactcc
      721 gagtcaggga gcctgggcct ccagagggca ttcagctgtt ggttgagcct gaaggtggaa
      781 tagtcgctcc tggtgggact gtgaccttga cctgtgccat ctctgcccag ccccctcctc
      841 aggtccactg gataaaggat ggtgcaccct tgcccctggc tcccagccct gtgctgctcc
      901 tccctgaggt ggggcacgag gatgagggca cctatagctg cgtggccacc caccctagcc
      961 acggacctca ggaaagccct cctgtcagca tcagggtcac agaaaccggc gatgaggggc
     1021 cagctgaagg ctctgtgggt gagtctgggc tgggtacgct agccctggcc ttggggatcc
     1081 tgggaggcct gggagtagta gccctgctcg tcggggctat cctgtggcga aaacgacaac
     1141 ccaggcgtga ggagaggaag gccccggaaa gccaggagga tgaggaggaa cgtgcagagc
     1201 tgaatcagtc agaggaagcg gagatgccag agaatggtgc cgggggaccg taagagcacc
     1261 cagatcgagc ctgtgtgatg gccctagagc agctccccca cattccatcc caattcctcc
     1321 ttgaggcact tccttctcca accagagccc acatgatcca tgctgagtaa acatttgaca
     1381 cggtgtg
//
