LOCUS       NM_001271424            1455 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus advanced glycosylation end product-specific receptor
            (Ager), transcript variant 4, mRNA.
ACCESSION   NM_001271424
VERSION     NM_001271424.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1455)
  AUTHORS   Du,M., Li,J., Yu,S., Chen,X., She,Y., Lu,Y. and Shu,H.
  TITLE     RAGE mediates hippocampal pericyte responses and neurovascular unit
            lesions after TBI
  JOURNAL   Exp Neurol 380, 114912 (2024)
   PUBMED   39097075
  REMARK    GeneRIF: RAGE mediates hippocampal pericyte responses and
            neurovascular unit lesions after TBI.
REFERENCE   2  (bases 1 to 1455)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1455)
  AUTHORS   Liu,K., Meng,X., Liu,Z., Tang,M., Lv,Z., Huang,X., Jin,H., Han,X.,
            Liu,X., Pu,W., Zhu,H. and Zhou,B.
  TITLE     Tracing the origin of alveolar stem cells in lung repair and
            regeneration
  JOURNAL   Cell 187 (10), 2428-2445 (2024)
   PUBMED   38579712
REFERENCE   4  (bases 1 to 1455)
  AUTHORS   Ge,X., Han,H., Desert,R., Das,S., Song,Z., Komakula,S.S.B.,
            Chen,W., Athavale,D., Lantvit,D. and Nieto,N.
  TITLE     A Protein Complex of Liver Origin Activates a Pro-inflammatory
            Program That Drives Hepatic and Intestinal Injury in
            Alcohol-Associated Liver Disease
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (3), 101362 (2024)
   PUBMED   38788899
REFERENCE   5  (bases 1 to 1455)
  AUTHORS   Kalea,A.Z., Reiniger,N., Yang,H., Arriero,M., Schmidt,A.M. and
            Hudson,B.I.
  TITLE     Alternative splicing of the murine receptor for advanced glycation
            end-products (RAGE) gene
  JOURNAL   FASEB J 23 (6), 1766-1774 (2009)
   PUBMED   19164451
  REMARK    GeneRIF: Results suggest that the murine receptor for advanced
            glycation end-products (RAGE) gene undergoes extensive splicing
            with distinct splice isoforms being uniquely distributed in
            different tissues.
REFERENCE   6  (bases 1 to 1455)
  AUTHORS   Harashima,A., Yamamoto,Y., Cheng,C., Tsuneyama,K., Myint,K.M.,
            Takeuchi,A., Yoshimura,K., Li,H., Watanabe,T., Takasawa,S.,
            Okamoto,H., Yonekura,H. and Yamamoto,H.
  TITLE     Identification of mouse orthologue of endogenous secretory receptor
            for advanced glycation end-products: structure, function and
            expression
  JOURNAL   Biochem J 396 (1), 109-115 (2006)
   PUBMED   16503878
  REMARK    GeneRIF: The murine equivalent of esRAGE was isolated from brain
            polysomal poly(A)+ (polyadenylated) RNA by RT (reverse
            transcription)-PCR cloning. Its expression is increased in kidneys
            of diabetic mice.
REFERENCE   7  (bases 1 to 1455)
  AUTHORS   Herr,C., Smyth,N., Ullrich,S., Yun,F., Sasse,P., Hescheler,J.,
            Fleischmann,B., Lasek,K., Brixius,K., Schwinger,R.H., Fassler,R.,
            Schroder,R. and Noegel,A.A.
  TITLE     Loss of annexin A7 leads to alterations in frequency-induced
            shortening of isolated murine cardiomyocytes
  JOURNAL   Mol Cell Biol 21 (13), 4119-4128 (2001)
   PUBMED   11390641
REFERENCE   8  (bases 1 to 1455)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (bases 1 to 1455)
  AUTHORS   Hofmann,M.A., Drury,S., Fu,C., Qu,W., Taguchi,A., Lu,Y., Avila,C.,
            Kambham,N., Bierhaus,A., Nawroth,P., Neurath,M.F., Slattery,T.,
            Beach,D., McClary,J., Nagashima,M., Morser,J., Stern,D. and
            Schmidt,A.M.
  TITLE     RAGE mediates a novel proinflammatory axis: a central cell surface
            receptor for S100/calgranulin polypeptides
  JOURNAL   Cell 97 (7), 889-901 (1999)
   PUBMED   10399917
REFERENCE   10 (bases 1 to 1455)
  AUTHORS   Renard,C., Chappey,O., Wautier,M.P., Nagashima,M., Lundh,E.,
            Morser,J., Zhao,L., Schmidt,A.M., Scherrmann,J.M. and Wautier,J.L.
  TITLE     Recombinant advanced glycation end product receptor
            pharmacokinetics in normal and diabetic rats
  JOURNAL   Mol Pharmacol 52 (1), 54-62 (1997)
   PUBMED   9224812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009767.6.
            
            Transcript Variant: This variant (4) contains multiple differences
            in the coding region, compared to variant 1, and initiates
            translation at an alternate start codon. The encodes isoform (d) is
            shorter and has a distinct N-terminus, compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GU164727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               CT009767.6         155277-155674
            399-491             CT009767.6         155907-155999
            492-556             CT009767.6         156157-156221
            557-644             CT009767.6         156324-156411
            645-824             CT009767.6         156503-156682
            825-955             CT009767.6         156773-156903
            956-1097            CT009767.6         157423-157564
            1098-1224           CT009767.6         157922-158048
            1225-1455           CT009767.6         158134-158364
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.18 cM"
     gene            1..1455
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="advanced glycosylation end product-specific
                     receptor"
                     /db_xref="GeneID:11596"
                     /db_xref="MGI:MGI:893592"
     exon            1..398
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1321
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="isoform d is encoded by transcript variant 4;
                     advanced glycation end-products receptor; receptor for
                     advanced glycosylation end products"
                     /codon_start=1
                     /product="advanced glycosylation end product-specific
                     receptor isoform d"
                     /protein_id="NP_001258353.1"
                     /db_xref="GeneID:11596"
                     /db_xref="MGI:MGI:893592"
                     /translation="METATGIVDEGTFRCRATNRRGKEVKSNYRVRVYQIPGKPEIVD
                     PASELTASVPNKVGTCVSEGSYPAGTLSWHLDGKLLIPDGKETLVKEETRRHPETGLF
                     TLRSELTVIPTQGGTHPTFSCSFSLGLPRRRPLNTAPIQLRVREPGPPEGIQLLVEPE
                     GGIVAPGGTVTLTCAISAQPPPQVHWIKDGAPLPLAPSPVLLLPEVGHEDEGTYSCVA
                     THPSHGPQESPPVSIRVTGSVGESGLGTLALALGILGGLGVVALLVGAILWRKRQPRR
                     EERKAPESQEDEEERAELNQSEEAEMPENGAGGP"
     exon            399..491
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            492..556
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            557..644
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            645..824
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            825..955
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1097
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1224
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1455
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1434..1439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="hexamer: AGTAAA"
     polyA_site      1453
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="major polyA site"
ORIGIN      
        1 gggaagaggg gcagacagaa cctggagcct gggaaggaag caccatgcca gcggggacag
       61 cagctagagc ctgggtgctg gttcttgctc tatggggtga gacactccca gccccaactc
      121 tccccctcag cagccctgct cccaccccac ccccagtacc tccctgcccc ctagaaatcc
      181 ccctgaacct gggcaccact ttccaaagac cctcacccac cctgtcctac acacgcacac
      241 cccagcccca cctctcccct tccaccctcc cacaatgatg ctatcaccca ggagctgtag
      301 ctggtggtca gaacatcaca gcccggattg gagagccact tgtgctaagc tgtaaggggg
      361 cccctaagaa gccgccccag cagctagaat ggaaactgcc actggaattg tcgatgaggg
      421 gactttccgg tgtcgggcaa ctaacaggcg agggaaggag gtcaagtcca actaccgagt
      481 ccgagtctac cagattcctg ggaagccaga aattgtggat cctgcctctg aactcacagc
      541 cagtgtccct aataaggtgg ggacatgtgt gtctgaggga agctaccctg cagggaccct
      601 tagctggcac ttagatggga aacttctgat tcccgatggc aaagaaacac tcgtgaagga
      661 agagaccagg agacaccctg agacgggact ctttacactg cggtcagagc tgacagtgat
      721 ccccacccaa ggaggaaccc atcctacctt ctcctgcagt ttcagcctgg gccttccccg
      781 gcgcagaccc ctgaacacag cccccatcca actccgagtc agggagcctg ggcctccaga
      841 gggcattcag ctgttggttg agcctgaagg tggaatagtc gctcctggtg ggactgtgac
      901 cttgacctgt gccatctctg cccagccccc tcctcaggtc cactggataa aggatggtgc
      961 acccttgccc ctggctccca gccctgtgct gctcctccct gaggtggggc acgaggatga
     1021 gggcacctat agctgcgtgg ccacccaccc tagccacgga cctcaggaaa gccctcctgt
     1081 cagcatcagg gtcacaggct ctgtgggtga gtctgggctg ggtacgctag ccctggcctt
     1141 ggggatcctg ggaggcctgg gagtagtagc cctgctcgtc ggggctatcc tgtggcgaaa
     1201 acgacaaccc aggcgtgagg agaggaaggc cccggaaagc caggaggatg aggaggaacg
     1261 tgcagagctg aatcagtcag aggaagcgga gatgccagag aatggtgccg ggggaccgta
     1321 agagcaccca gatcgagcct gtgtgatggc cctagagcag ctcccccaca ttccatccca
     1381 attcctcctt gaggcacttc cttctccaac cagagcccac atgatccatg ctgagtaaac
     1441 atttgacacg gtgtg
//
