LOCUS       NM_001408078            3583 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus ATP/GTP binding protein-like 5 (Agbl5), transcript
            variant 10, mRNA.
ACCESSION   NM_001408078 XM_030254378
VERSION     NM_001408078.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3583)
  AUTHORS   Aljammal,R., Saravanan,T., Guan,T., Rhodes,S., Robichaux,M.A. and
            Ramamurthy,V.
  TITLE     Excessive tubulin glutamylation leads to progressive cone-rod
            dystrophy and loss of outer segment integrity
  JOURNAL   Hum Mol Genet 33 (9), 802-817 (2024)
   PUBMED   38297980
REFERENCE   2  (bases 1 to 3583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3583)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   4  (bases 1 to 3583)
  AUTHORS   Giordano,T., Gadadhar,S., Bodakuntla,S., Straub,J., Leboucher,S.,
            Martinez,G., Chemlali,W., Bosc,C., Andrieux,A., Bieche,I.,
            Arnoult,C., Geimer,S. and Janke,C.
  TITLE     Loss of the deglutamylase CCP5 perturbs multiple steps of
            spermatogenesis and leads to male infertility
  JOURNAL   J Cell Sci 132 (3) (2019)
   PUBMED   30635446
  REMARK    GeneRIF: Loss of the deglutamylase CCP5 perturbs multiple steps of
            spermatogenesis and leads to male infertility.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3583)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3583)
  AUTHORS   Tort,O., Tanco,S., Rocha,C., Bieche,I., Seixas,C., Bosc,C.,
            Andrieux,A., Moutin,M.J., Aviles,F.X., Lorenzo,J. and Janke,C.
  TITLE     The cytosolic carboxypeptidases CCP2 and CCP3 catalyze
            posttranslational removal of acidic amino acids
  JOURNAL   Mol Biol Cell 25 (19), 3017-3027 (2014)
   PUBMED   25103237
REFERENCE   7  (bases 1 to 3583)
  AUTHORS   Berezniuk,I., Lyons,P.J., Sironi,J.J., Xiao,H., Setou,M.,
            Angeletti,R.H., Ikegami,K. and Fricker,L.D.
  TITLE     Cytosolic carboxypeptidase 5 removes alpha- and gamma-linked
            glutamates from tubulin
  JOURNAL   J Biol Chem 288 (42), 30445-30453 (2013)
   PUBMED   24022482
  REMARK    GeneRIF: CCP5 functions as a dual-functional deglutamylase cleaving
            both alpha- and gamma-linked glutamate from tubulin.
REFERENCE   8  (bases 1 to 3583)
  AUTHORS   Rogowski,K., van Dijk,J., Magiera,M.M., Bosc,C., Deloulme,J.C.,
            Bosson,A., Peris,L., Gold,N.D., Lacroix,B., Bosch Grau,M., Bec,N.,
            Larroque,C., Desagher,S., Holzer,M., Andrieux,A., Moutin,M.J. and
            Janke,C.
  TITLE     A family of protein-deglutamylating enzymes associated with
            neurodegeneration
  JOURNAL   Cell 143 (4), 564-578 (2010)
   PUBMED   21074048
REFERENCE   9  (bases 1 to 3583)
  AUTHORS   Kimura,Y., Kurabe,N., Ikegami,K., Tsutsumi,K., Konishi,Y.,
            Kaplan,O.I., Kunitomo,H., Iino,Y., Blacque,O.E. and Setou,M.
  TITLE     Identification of tubulin deglutamylase among Caenorhabditis
            elegans and mammalian cytosolic carboxypeptidases (CCPs)
  JOURNAL   J Biol Chem 285 (30), 22936-22941 (2010)
   PUBMED   20519502
REFERENCE   10 (bases 1 to 3583)
  AUTHORS   Kalinina,E., Biswas,R., Berezniuk,I., Hermoso,A., Aviles,F.X. and
            Fricker,L.D.
  TITLE     A novel subfamily of mouse cytosolic carboxypeptidases
  JOURNAL   FASEB J 21 (3), 836-850 (2007)
   PUBMED   17244818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109606.11.
            
            On Jun 9, 2022 this sequence version replaced XM_030254378.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.7438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: translation inferred from conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC109606.11        112978-113342
            366-626             AC109606.11        113938-114198
            627-798             AC109606.11        114417-114588
            799-885             AC109606.11        114692-114778
            886-1049            AC109606.11        114878-115041
            1050-1227           AC109606.11        115631-115808
            1228-1406           AC109606.11        116256-116434
            1407-1863           AC109606.11        116823-117279
            1864-2033           AC109606.11        117719-117888
            2034-2169           AC109606.11        118193-118328
            2170-2372           AC109606.11        118815-119017
            2373-2587           AC109606.11        119584-119798
            2588-2743           AC109606.11        126871-127026
            2744-2856           AC109606.11        128521-128633
            2857-2903           AC109606.11        128927-128973
            2904-3034           AC109606.11        129449-129579
            3035-3583           AC109606.11        129934-130482
FEATURES             Location/Qualifiers
     source          1..3583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.9 cM"
     gene            1..3583
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /note="ATP/GTP binding protein-like 5"
                     /db_xref="GeneID:231093"
                     /db_xref="MGI:MGI:2441745"
     exon            1..365
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            366..626
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..2952
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /EC_number="3.4.17.24"
                     /note="isoform 3 is encoded by transcript variant 10;
                     cytosolic carboxypeptidase-like protein 5;
                     carboxypeptidase 5, cytosolic; protein deglutamylase CCP5"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase-like protein 5
                     isoform 3"
                     /protein_id="NP_001395007.1"
                     /db_xref="GeneID:231093"
                     /db_xref="MGI:MGI:2441745"
                     /translation="MELRCGGLLFSSRFDSGNLAHVEKVETVSSDGEGVGGVATAPAS
                     GSAASPDYEFNVWTRPDCAETEYENGNRSWFYFSVRGGTPGKLIKINIMNMNKQSKLY
                     SQGMAPFVRTLPSRPRWERIRERPTFELGSKLSPCFSKPEEAGSHVESVRGRELVKMT
                     ETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQDLLSQLDQRFSENYSTHSSPLDSI
                     YYHRELLCYSLDGLRVDLLTITSCHGLRDDREPRLEQLFPDLGTPRPFRFTGKRIFFL
                     SSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTD
                     SRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNAKSPTNQQPTLHLPPEAPLS
                     DLEKANNLHNEAHLGQSPDGENPATWPETEPAEEKTDPVWLMPQPIPELEEPAPDTIP
                     PKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNF
                     SEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGR
                     ASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLR
                     HVRNSRGLTSAGNMGASKKRGARTPPKSNNSLPVSCSENALSRVRSFSTGTSTGGSSS
                     SQQNSPQMKNSPSFPFHGSRTAGLPGLGSSTQKVSHRVLGPVREPRCSDRRRRQQPLN
                     HRSTTSSLAPSPTLASSGPTSSRNMGSCLLPNSLSLSGSSCSFSSSGDKPEAVMVIGK
                     SLLGAGARIPCIRTRLQTCQRRVSARRGPGFPRLGPGWAGAHRRLAEG"
     exon            627..798
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            799..885
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1049
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1227
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1406
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1863
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2033
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2169
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2372
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2587
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2743
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2856
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2903
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3034
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3583
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3563..3568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /note="hexamer: AATAAA"
     polyA_site      3583
                     /gene="Agbl5"
                     /gene_synonym="9430057O19Rik; CCP5"
                     /note="major polyA site"
ORIGIN      
        1 gaatgccacc ccgccccccg gcctgccgcg gccggcccgc cgaccccgcc tttggttgac
       61 tccctctgct cctgtggcct cacctctgac ccctaggacc cgccttcctg tccgccagtg
      121 tacctgtctc gacccctccc acgcttccaa accccaccct gccctggaca agccaggcag
      181 cgcgagggtc ctcgcgaatc gaggagctgc ctgctgcttc caagcgggac tctactggcc
      241 cagccttcct aggggtgctt aggacgcccg ttacccacac cttcgagggt agcttttgca
      301 cgggctcgtg tctacagggc gggaggatgg aaacagaccc taattggaac tgaggttcag
      361 ggcagctctc agggcctgtg tggggcaaga ggatgctttc ccagccccac catggagctg
      421 cgctgtgggg gattgctgtt cagttctcgc tttgattcag ggaacctagc ccatgtggaa
      481 aaggtggaga ctgtgtctag tgatggggaa ggcgtaggag gggtggcaac agcccccgct
      541 agtgggtctg ctgcttcccc tgactacgag ttcaacgtgt ggacccggcc tgactgtgct
      601 gaaacggaat atgaaaatgg caacaggtca tggttctact tcagtgtccg gggagggact
      661 ccaggaaagc ttatcaagat caacattatg aacatgaaca agcaaagcaa actgtattcc
      721 cagggcatgg ccccctttgt gcgcacactg ccttcccggc cacgctggga acgcattaga
      781 gagcggccca cctttgagct ggggtccaag ctgagcccct gcttcagcaa gcctgaagaa
      841 gctggttctc atgtggagag tgtcagaggg agggagttgg taaagatgac agagacacag
      901 tttgtgctat cctttgttca ccgtttcgta gagggccggg gagccaccac cttcttcgcc
      961 ttctgctacc ccttctccta cagtgactgc caggatctgc tgagccagct agaccagcgc
     1021 ttttcagaga attactctac ccatagcagt cctctggata gtatttatta ccaccgagag
     1081 cttctctgct attctctgga tggacttcgt gtagatctac taacaatcac ttcctgccat
     1141 gggcttcgag atgatcggga gccccgacta gagcagctat ttcctgatct cggcactccc
     1201 cgaccattcc gtttcacagg caaaaggata ttcttcttaa gcagtagggt acaccctgga
     1261 gagactccat ctagctttgt gttcaatggc tttctggact tcatccttcg acctgatgat
     1321 ccccgggcac aaactctccg tcgactcttt gtttttaagt tgattcccat gttaaaccct
     1381 gatggtgtgg tccggggcca ctaccgcacg gactcccgtg gagtgaatct gaaccgtcag
     1441 tacttgaagc ctgatgccgt cctgcacccg gccatctatg gcgccaaagc tgtgctgctt
     1501 tatcatcacg tgcactcgag gctcaacgcc aagagtccca cgaaccagca acccactctc
     1561 catctccctc cggaagcccc tctctctgac ctcgagaaag ccaataatct ccacaatgaa
     1621 gctcacctcg ggcagtcacc tgatggggaa aaccctgcga cttggcctga gacagagcca
     1681 gcagaagaga agactgaccc tgtgtggctt atgccacagc caattcctga actcgaggag
     1741 ccagcccctg acaccatccc cccaaaagag agtggtgttg cttactatgt agacttgcac
     1801 ggacatgctt ccaaaagggg ctgcttcatg tatggcaaca gctttagtga cgagagcacc
     1861 caggtggaaa acatgctata tccaaagctc atctccttga attcagccca ctttgacttc
     1921 cagggctgca atttctcaga gaagaacatg tatgcccgag accgtagaga tggccagtcc
     1981 aaagagggaa gcggccgtgt cgcaatctac aaagcctcag ggataatcca cagctacaca
     2041 cttgaatgca actacaacac tggacgctca gtcaacagca tccctgctgc ctgccatgac
     2101 aacgggcgcg ccagcccccc tccccctccg gctttcccct ccagatacac tgtggaacta
     2161 ttcgagcagg tggggcgagc tatggccatc gcagctctgg acatggcaga gtgtaatccg
     2221 tggccccgaa ttgtgctgtc ggaacacagc agcctcacca acctgcgagc ctggatgctg
     2281 aggcacgtgc gcaacagcag agggctgacc agtgctggga acatgggcgc gagcaagaag
     2341 cgaggggctc gaacccctcc caaaagcaac aacagcttgc ctgtttcctg ctctgaaaat
     2401 gctctgagcc gggttcgcag ttttagcacc ggcacgagta ctggtggcag cagcagcagc
     2461 caacaaaact ctccacagat gaagaactct cccagcttcc cttttcatgg cagtcggact
     2521 gcggggctac caggcctggg ctctagcacc caaaaggtca gccatcgggt gctgggccct
     2581 gtcagagagc cccgatgctc agacagaagg cggcgacagc agccactgaa ccatcgctct
     2641 accacaagca gcctggcccc atccccaact ctggctagtt ctggcccaac ctcctcacga
     2701 aacatgggct cctgcctcct acccaattca ctcagcttat cagggagcag ctgctcattc
     2761 tcgtcttcag gggacaagcc agaggctgtc atggtgattg ggaaaagcct actaggggct
     2821 ggtgctcgga tcccttgcat taggactcga ttgcagacct gccagaggag agtttccgcc
     2881 aggaggggtc ccggattccc caggctaggc ccaggttggg ccggagctca ccgccgactc
     2941 gcagagggat gagaggttca agccccacat cccccatccc ccagaccaga gagagcagtg
     3001 agctggagcc gggaccccac tctgctacac cagggctgcc tcaggccggc cccccacggc
     3061 ctcgctctgc ccccgccttt tctcctattt cctgtactct atctgactcc ccatcccgga
     3121 tttgttacag cagggggctc ttgaaccaat gtgaggtttg ttttgtccct aaatcaccac
     3181 cactcactat ttctcccagg gtctgataat gcctttacct ccatgtccag gatgtagccc
     3241 taaggtgagg gaacacagtg aaatgatacg ttagtcccgt cttccagctg ctggtaccat
     3301 gtgacaacca tagctccttg gaatgtcggc cacactgtcc aaggccttgc agaacatcac
     3361 cttaagacag aacaaaacag ggacctgctc cctcccactc ccccacagca caagattttg
     3421 ggaccacaaa aaaatatata tctatatata tatatctata tttttgtatt ggggggaggg
     3481 agtagaaaag aaagcagccc ctatactggg ccctattcag tggcagcttc ttgctccata
     3541 gggttaagga agactttgag gaaataaaag ttgtttggaa aaa
//
