LOCUS       NM_030231               1900 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ATP/GTP binding protein-like 4 (Agbl4), transcript
            variant 1, mRNA.
ACCESSION   NM_030231 XM_980062
VERSION     NM_030231.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Bodakuntla,S., Schnitzler,A., Villablanca,C., Gonzalez-Billault,C.,
            Bieche,I., Janke,C. and Magiera,M.M.
  TITLE     Tubulin polyglutamylation is a general traffic-control mechanism in
            hippocampal neurons
  JOURNAL   J Cell Sci 133 (3) (2020)
   PUBMED   31932508
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Magiera,M.M., Bodakuntla,S., Ziak,J., Lacomme,S., Marques Sousa,P.,
            Leboucher,S., Hausrat,T.J., Bosc,C., Andrieux,A., Kneussel,M.,
            Landry,M., Calas,A., Balastik,M. and Janke,C.
  TITLE     Excessive tubulin polyglutamylation causes neurodegeneration and
            perturbs neuronal transport
  JOURNAL   EMBO J 37 (23) (2018)
   PUBMED   30420556
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Ye,B., Li,C., Yang,Z., Wang,Y., Hao,J., Wang,L., Li,Y., Du,Y.,
            Hao,L., Liu,B., Wang,S., Xia,P., Huang,G., Sun,L., Tian,Y. and
            Fan,Z.
  TITLE     Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by
            modulating Mad2 polyglutamylation
  JOURNAL   J Exp Med 211 (12), 2439-2454 (2014)
   PUBMED   25332286
  REMARK    GeneRIF: study shows that Mad2 is a novel substrate for CCP6 in
            megakaryocytes; Mad2 polyglutamylation plays a crucial role in the
            regulation of megakaryopoiesis
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Tort,O., Tanco,S., Rocha,C., Bieche,I., Seixas,C., Bosc,C.,
            Andrieux,A., Moutin,M.J., Aviles,F.X., Lorenzo,J. and Janke,C.
  TITLE     The cytosolic carboxypeptidases CCP2 and CCP3 catalyze
            posttranslational removal of acidic amino acids
  JOURNAL   Mol Biol Cell 25 (19), 3017-3027 (2014)
   PUBMED   25103237
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Rogowski,K., van Dijk,J., Magiera,M.M., Bosc,C., Deloulme,J.C.,
            Bosson,A., Peris,L., Gold,N.D., Lacroix,B., Bosch Grau,M., Bec,N.,
            Larroque,C., Desagher,S., Holzer,M., Andrieux,A., Moutin,M.J. and
            Janke,C.
  TITLE     A family of protein-deglutamylating enzymes associated with
            neurodegeneration
  JOURNAL   Cell 143 (4), 564-578 (2010)
   PUBMED   21074048
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Kalinina,E., Biswas,R., Berezniuk,I., Hermoso,A., Aviles,F.X. and
            Fricker,L.D.
  TITLE     A novel subfamily of mouse cytosolic carboxypeptidases
  JOURNAL   FASEB J 21 (3), 836-850 (2007)
   PUBMED   17244818
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Ding,S., Wu,X., Li,G., Han,M., Zhuang,Y. and Xu,T.
  TITLE     Efficient transposition of the piggyBac (PB) transposon in
            mammalian cells and mice
  JOURNAL   Cell 122 (3), 473-483 (2005)
   PUBMED   16096065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15, AL669940.14, AL669959.22, AL662829.8, AL627183.16,
            AL627347.10, AL669965.13 and AL671895.9.
            
            On Sep 26, 2013 this sequence version replaced NM_030231.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ867040.1, SRR5189685.173001.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL627425.15        201896-202103
            209-331             AL669940.14        57696-57818
            332-456             AL669959.22        31295-31419
            457-551             AL662829.8         64691-64785
            552-768             AL627183.16        47880-48096
            769-808             AL627347.10        36061-36100
            809-898             AL669965.13        89166-89255
            899-1013            AL669965.13        109765-109879
            1014-1125           AL669965.13        129200-129311
            1126-1278           AL669965.13        177542-177694
            1279-1441           AL669965.13        179702-179864
            1442-1538           AL671895.9         39712-39808
            1539-1900           AL671895.9         40544-40905
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.43 cM"
     gene            1..1900
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /note="ATP/GTP binding protein-like 4"
                     /db_xref="GeneID:78933"
                     /db_xref="MGI:MGI:1918244"
     exon            1..208
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1797
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /EC_number="3.4.17.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytosolic carboxypeptidase 6; protein deglutamylase CCP6"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase 6 isoform 1"
                     /protein_id="NP_084507.1"
                     /db_xref="CCDS:CCDS51264.1"
                     /db_xref="GeneID:78933"
                     /db_xref="MGI:MGI:1918244"
                     /translation="MAERSQTAPEAGNDTGNEDAIGGNVNKYIVLPNGYSGQPKKGHL
                     TFDACFESGNLGRVEQVSDFEYDLFIRPDTCNPRFRVWFNFTVENVKELQRVIFNIVN
                     FSKTKSLYRDGMAPMVKSTSRPKWQRLPPKNVYYYRCPDHRKNYVMSFAFCFDREDDI
                     YQFAYCYPYTYTRFQHYLDSLQKKNMDYFFREQLGQSVQQRQLDLLTITSPENLREGS
                     EKKVIFITGRVHPGETPSSFVCQGIIDFLVSQHPIARVLREHLVFKIAPMLNPDGVYL
                     GNYRCSLMGFDLNRHWLDPSPWAHPTLHGVKQLIIKMYNDPKTSLEFYIDIHAHSTMM
                     NGFMYGNIFEDEERFQRQSIFPKLLCQNAEDFSYTSTSFNRDAVKAGTGRRFLGGLLD
                     HSSYCYTLEVSFYSYIIGGTTAAVPYTEEAYMKLGRNVARTFLDYYRLNSLVEKIAVP
                     MPRLRSKEERRLGWEHPSCLRAEQPLEVLGIPMCSGKALNEHLGNDIQWHLDCGSSTL
                     PLGLISCSPSSSASWNDMAMSNSILLPDHSFH"
     exon            209..331
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            332..456
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            457..551
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            552..768
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            769..808
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            809..898
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1013
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1125
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1278
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1441
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1538
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1900
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1891
                     /gene="Agbl4"
                     /gene_synonym="4930578N11Rik; 4931433A01Rik"
                     /note="major polyA site"
ORIGIN      
        1 tcttctgccc cgccccctgc tcccagccgg ccgctcaggg gccgccggtt tccctggcaa
       61 ccgccgcgca gcgtcttcct gagggagcct tttctgtcag cccgcggatc ccaccgctcg
      121 ctccccactg cccggtggtt tttgcgtggg ctcattgact gacggacaac aaaaatggcg
      181 gagcggagcc agacagcgcc agaggcaggc aatgatacag gaaatgagga tgccattgga
      241 gggaatgtga acaaatacat agtgcttcca aatggatact ctggacagcc caagaaagga
      301 catcttacct ttgatgcttg ctttgaaagt ggtaacctcg gccgggttga gcaagtctct
      361 gattttgagt atgatctgtt cattaggccg gacacctgta atccacgctt ccgagtctgg
      421 ttcaacttta ctgttgaaaa tgtgaaagaa ttgcagaggg taattttcaa cattgttaac
      481 ttcagtaaaa ccaagagtct ttaccgagat gggatggcac caatggtgaa atctaccagc
      541 agaccaaaat ggcaaagact accaccaaaa aacgtttatt actatcgctg cccagaccac
      601 aggaagaact atgtgatgtc ctttgcattc tgttttgacc gagaagatga tatctaccag
      661 tttgcttact gctaccctta tacatatact cgcttccagc attacctcga cagcttacaa
      721 aagaaaaaca tggattattt cttccgggaa cagcttggac agagtgtgca acagcggcag
      781 cttgacctcc tgacgataac cagcccggag aatctccgtg aagggtcaga aaagaaggtg
      841 atattcatca cagggcgagt ccacccaggg gaaacgccat cttcatttgt gtgccaagga
      901 atcatcgact tccttgtaag tcagcatcca attgcccgtg tcctacgaga acatttagtc
      961 ttcaagattg ctccaatgct caaccctgat ggagtttacc tgggcaacta caggtgttcc
     1021 ctgatggggt ttgacctgaa tcgtcactgg ctggatccct ctccatgggc ccatcccacc
     1081 ctgcatggag tgaaacagct tattatcaag atgtacaatg acccaaaaac aagcctggag
     1141 ttctatattg acatccacgc tcactccacc atgatgaatg gcttcatgta cggcaatatc
     1201 tttgaggatg aggaacggtt ccaaaggcag tccatttttc caaaactcct ttgccagaat
     1261 gccgaggact tctcctatac tagcacatcc ttcaacaggg atgctgtgaa agcaggaact
     1321 ggccggcgct tcctgggcgg gcttctggac cactcatcat actgctatac cctagaggtt
     1381 tccttctaca gctacatcat tgggggtact acagctgcag tgccctacac tgaagaagcc
     1441 tatatgaaac tgggacggaa cgtggcaaga acatttctag attattaccg gctgaactcc
     1501 ctggttgaga agatagcagt ccccatgcca agacttcgat ccaaggagga aagaagactg
     1561 ggatgggagc atccatcttg tctgagggct gaacaaccac tggaagtgct gggaattccc
     1621 atgtgttctg gtaaagcact caatgagcat cttggcaatg acatccagtg gcatctggat
     1681 tgtggtagca gtaccctacc tctgggcctc atctcctgtt cccctagtag ctcagcctcc
     1741 tggaatgaca tggcaatgtc caactctata ctcctgccag accattcttt tcactgatgt
     1801 tcacgatgtg ctttgatgcc tcaggagctt agcaccatga accttcctcc atcccccact
     1861 actactacta ataaaatgta aatcaccatt acttagtgta
//
