LOCUS       NM_001289656            5261 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ATP/GTP binding protein-like 3 (Agbl3), transcript
            variant 1, mRNA.
ACCESSION   NM_001289656
VERSION     NM_001289656.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5261)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   2  (bases 1 to 5261)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5261)
  AUTHORS   Liu,B., Ye,B., Zhu,X., Huang,G., Yang,L., Zhu,P., Du,Y., Wu,J.,
            Meng,S., Tian,Y. and Fan,Z.
  TITLE     IL-7Ralpha glutamylation and activation of transcription factor
            Sall3 promote group 3 ILC development
  JOURNAL   Nat Commun 8 (1), 231 (2017)
   PUBMED   28794449
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5261)
  AUTHORS   Xia,P., Ye,B., Wang,S., Zhu,X., Du,Y., Xiong,Z., Tian,Y. and Fan,Z.
  TITLE     Glutamylation of the DNA sensor cGAS regulates its binding and
            synthase activity in antiviral immunity
  JOURNAL   Nat Immunol 17 (4), 369-378 (2016)
   PUBMED   26829768
  REMARK    Erratum:[Nat Immunol. 2016 Apr;17(4):469. doi:
            10.1038/ni0416-469e.. PMID: 27002845]
REFERENCE   5  (bases 1 to 5261)
  AUTHORS   Tort,O., Tanco,S., Rocha,C., Bieche,I., Seixas,C., Bosc,C.,
            Andrieux,A., Moutin,M.J., Aviles,F.X., Lorenzo,J. and Janke,C.
  TITLE     The cytosolic carboxypeptidases CCP2 and CCP3 catalyze
            posttranslational removal of acidic amino acids
  JOURNAL   Mol Biol Cell 25 (19), 3017-3027 (2014)
   PUBMED   25103237
  REMARK    GeneRIF: CCP2 and CCP3 are deglutamylases and are highly regulated
            proteins confined to ciliated tissues.
REFERENCE   6  (bases 1 to 5261)
  AUTHORS   Kalinina,E., Biswas,R., Berezniuk,I., Hermoso,A., Aviles,F.X. and
            Fricker,L.D.
  TITLE     A novel subfamily of mouse cytosolic carboxypeptidases
  JOURNAL   FASEB J 21 (3), 836-850 (2007)
   PUBMED   17244818
REFERENCE   7  (bases 1 to 5261)
  AUTHORS   Wang,T., Parris,J., Li,L. and Morgan,J.I.
  TITLE     The carboxypeptidase-like substrate-binding site in Nna1 is
            essential for the rescue of the Purkinje cell degeneration (pcd)
            phenotype
  JOURNAL   Mol Cell Neurosci 33 (2), 200-213 (2006)
   PUBMED   16952463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029793.1, AK029798.1 and AC153869.7.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3734              AK029793.1         2-3735
            3735-4183           AK029798.1         3293-3741
            4184-4184           AC153869.7         113258-113258
            4185-5261           AK029798.1         3743-4819
FEATURES             Location/Qualifiers
     source          1..5261
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.13 cM"
     gene            1..5261
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /note="ATP/GTP binding protein-like 3"
                     /db_xref="GeneID:76223"
                     /db_xref="MGI:MGI:1923473"
     exon            1..628
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            629..747
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             685..3705
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytosolic carboxypeptidase 3; protein deglutamylase CCP3"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase 3 isoform 1"
                     /protein_id="NP_001276585.1"
                     /db_xref="CCDS:CCDS80515.1"
                     /db_xref="GeneID:76223"
                     /db_xref="MGI:MGI:1923473"
                     /translation="MSEDSEEEDYSDRSISDDDDLDEDSFMKFVSDDIHPCTLLAADS
                     IGDPFFPRTTQILLEYQLGRWVPRLRGPRDLYGVSSSGPLSPTRWPYHCEVIDEKVQH
                     IEWTPFVPEPVYVPTGLEIEPVYPNSKEDTVVYLAEDDHLCKAYKEPCFVYSRVGGNR
                     TSLKQPVDNCDNTLVFEARFESGNLQKVVKVADHEYELTVRPDLFTNKHTQWYYFQVT
                     NTQAEIVYRFTIVNFTKPASLYNRGMKPLFYSEKEAKTHNIGWQRIGDQIKYYKNNLG
                     QDGRHFFSLTWTFQFPHSQDTCYFAHCYPYTYSNLQEYLSGINSDPVRSKFCKIRVLC
                     HTLARNMVYVLTITTPLKTSDSKRKAVILTARVHPGETNSSWIMKGFLDYILGDSSDA
                     RLLRDTFIFKVVPMLNPDGVIVGNYRCSLAGRDLNRNYTSLLKESFPSVWYTRNMINR
                     LMEKREVILYCDLHGHSRKQNIFMYGCDGSSRSKTKGLYLQQRIFPLMLSKNCPNIFS
                     FSACKFNVQKSKEGTGRVVMWKMGIRNSFTLEATFCGSTLGNKRGTHFGTKDLESMGY
                     HFCDSLLDYCDPDRSKYYQCLKELEEMEKHLSSERVSDNTDTSLVEISLDVESSSRGS
                     DSSESNDTQTYLLKVTSQARNKKKYLKTKRERNAILANCQNNMQEVYGKEHLLQRHDE
                     SNSDGNDPRIDAPDVYVAHCFRRPLPNQGVVKIPGQRFYPGKTWSSSQRMIKSLNKDH
                     RTCILETCKNPIQEVQSRGINIHESCFKMAKCPMNKRPSHWIEKTRIPTESHHQLKSK
                     AKRCSSFQSKRTGTNWTDDEKRIYRDKRIAQTQEILKYLLPIVESSQNRKSTQMNNLI
                     NPIANLQQHQLIPTACINRRRYSIPWTPTRNLPFKAQRNLMTDTSEWLQSVPLGSFES
                     LLPLCNLQKKTKHFELWGKKAKDVQLATSQWEAVPLSSNMDASIIRGNSVLQPKEFTM
                     RSSKQRIPYLTKTSKKPSESDGLLTFQLKIHRNS"
     exon            748..808
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..994
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1102
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1117
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1256
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..2033
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2202
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2329
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2430
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2543
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2610
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2691
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2749
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2821
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2867
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3052
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3281
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..5261
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4996..5001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /note="hexamer: TATAAA"
     polyA_site      5017
                     /gene="Agbl3"
                     /gene_synonym="2900053G10Rik; 4930431N21Rik;
                     6530406M24Rik; CCP3"
                     /note="major polyA site"
ORIGIN      
        1 ctgctctctc agcgaccgct gaatttcgat ggcatttgct ctgaccctgt cgtcgcccgg
       61 tgcctggggg acatcctaaa gtattctccc ggcaggggtg ggacgaccgg cggacttgaa
      121 gaggcccagg gaacgaggcg ggcggcggac gcgccgctta ggcagcgggg agcgggggaa
      181 atgcggccct cggcgcggga cggcgcgggg cccgcgtgag tgaggaggct ccgcgcgggt
      241 cccgccccga gagaaggcct ggcgcggccg cacgcccccc gctcgccgct tcgggcgcgg
      301 accggcgtcc gcgggcttcc ggcgcctagc gcctgcacgc ctcgtccgcg cacgtaagga
      361 gctgccgccg ggcgtcccgg cgggttgtcg taatttcgag ccgtcatccg gggctgaagc
      421 ttcggtctcc gccccgagat gtcacctaga aaccgctctc tcgactgcag ttggcgttta
      481 tgatgaagct tcgcgaggcc ttccgcgccg tccgcgcccc cgaacgcgct cgtctgtaga
      541 cgtcaaccgg gggctgagaa ggtgtttgtc ggcggtggtc aaaaggctcg cttttagaga
      601 gaaccaaaca ccagtagttg tgaaattgac attttacagc ctactcacat aattaaagac
      661 attccgagga agacactaga agagatgtca gaagattcag aggaggaaga ctactcagat
      721 agaagcatca gtgatgacga tgacttggat gaggattcct tcatgaaatt tgtaagtgat
      781 gatattcatc cgtgcacact actggcagct gattctattg gtgacccatt cttccctcgg
      841 actacacaaa ttttattgga gtatcagcta ggaagatggg taccacgcct tcgcggacca
      901 cgagatttat atggtgtctc ttcttctggt ccactgagcc caacacggtg gccataccac
      961 tgtgaggtca ttgatgaaaa agtccagcat attgaatgga ctccctttgt ccctgagcca
     1021 gtgtatgtcc cgacaggcct ggaaatagag cctgtttacc caaactccaa ggaagatact
     1081 gtggtttatt tagctgaaga tgatcacctt tgtaaagctt acaaagagcc ctgttttgtg
     1141 tattcccgag ttgggggtaa ccgaacatcc ttgaaacaac ctgtggataa ctgtgacaac
     1201 acgctggtgt ttgaagcaag gtttgagagt ggtaatctac agaaggtagt caaagttgca
     1261 gatcatgaat acgagttgac tgtgcgccca gacctcttca caaataagca cactcagtgg
     1321 tactatttcc aggtcactaa tacccaagca gaaatagtct acagattcac tattgtcaac
     1381 tttaccaagc ctgctagtct ttacaatcgg ggtatgaagc cattgttcta ttctgaaaaa
     1441 gaggccaaaa cccataacat tggctggcag agaataggag atcaaatcaa gtattataaa
     1501 aataaccttg ggcaagatgg gcgccatttt ttttctctta cgtggacatt tcagtttcca
     1561 cacagccagg atacgtgcta ctttgctcac tgctatccat acacttactc caaccttcaa
     1621 gaatacctgt ctggcatcaa cagtgaccca gtaagatcaa agttttgtaa aatacgtgtc
     1681 ttgtgtcaca cacttgccag gaatatggtg tatgtcttga caataactac tcccttgaag
     1741 actagtgact caaagcgcaa ggctgtgatt ttgactgcaa gggtccatcc aggagagacc
     1801 aacagctctt ggatcatgaa aggcttcctg gattatattt taggagactc aagtgatgca
     1861 cgcttgcttc gggacacttt catcttcaag gtggtaccca tgctgaatcc agatggcgtg
     1921 attgtgggaa attatcgatg ttccttagct ggacgggatt taaaccgtaa ttacacatcg
     1981 ctcctgaagg agtctttccc ttctgtttgg tatacaagga acatgatcaa taggttaatg
     2041 gagaaacgag aggttatttt atattgtgat cttcatggcc atagtaggaa acagaatatt
     2101 ttcatgtatg gttgtgatgg tagcagcaga tctaaaacaa aaggattata cttacagcaa
     2161 cggatctttc cactcatgct gagcaaaaat tgcccaaata tattttcctt ctcagcttgc
     2221 aagtttaacg ttcagaaaag caaagagggg acaggaaggg ttgtaatgtg gaagatgggc
     2281 atcaggaaca gcttcacgct ggaggccacc ttctgcggat ctactctggg caataaacga
     2341 ggcactcatt tcggcacaaa agatttagag tcgatgggat atcatttttg tgattctctg
     2401 ttggactact gtgatcctga caggagcaaa tattatcagt gcttgaaaga attagaagaa
     2461 atggagaaac atttgagctc cgaaagagtc tctgataaca cagatacttc tctagtagaa
     2521 atttctttgg atgtagagtc tagtagtcga ggctctgaca gctcagagtc caatgacact
     2581 cagacttacc ttctcaaggt gacctctcag gcaagaaaca agaaaaagta tctgaaaaca
     2641 aagagggaaa gaaatgccat cctagcaaac tgccagaata acatgcaaga ggtttatggc
     2701 aaagaacatt tactccaaag acacgatgaa tcaaattctg atgggaatga tccaaggata
     2761 gatgcaccag atgtttatgt ggctcactgt ttcagaagac cgttgcctaa ccaaggcgtg
     2821 gtgaaaattc ctggacaaag gttttatccc ggaaaaacat ggtccagctc ccagcgtatg
     2881 attaagagtc ttaacaaaga ccataggaca tgtattttag aaacttgtaa gaatccaatc
     2941 caggaagttc agtccagagg aatcaatata catgaaagtt gtttcaaaat ggcgaaatgt
     3001 cctatgaaca aaagaccttc acattggatt gagaagacaa gaataccaac agagtcacat
     3061 caccagttga aaagcaaagc aaaaagatgc tcgtctttcc aaagcaagag gactgggacg
     3121 aattggacag atgatgagaa acgaatttac agggataaaa gaatagctca aactcaggaa
     3181 atattaaagt atttactccc tatcgtggag tcctctcaaa acaggaaatc tactcaaatg
     3241 aacaatctaa tcaacccgat agccaacttg caacagcatc aacttattcc aactgcttgc
     3301 ataaatagaa gaagatacag cataccttgg acaccaacca gaaatctccc ttttaaagcc
     3361 caaaggaatc ttatgacaga cacctccgaa tggctccagt ctgtgcccct tgggtcattt
     3421 gaaagtttgt tacctctctg caatcttcag aagaagacaa aacattttga actctggggc
     3481 aaaaaggcta aggatgtgca gcttgccacc agccaatggg aggctgtgcc cttgagttct
     3541 aacatggatg caagtatcat caggggtaac agtgttctgc agcctaaaga attcaccatg
     3601 aggagctcta agcagagaat tccttaccta accaaaacca gcaagaaacc cagtgagagt
     3661 gatggcctgc tcaccttcca gctgaagatt cacaggaaca gttaactggg ctgaaagtgc
     3721 ctccaagaac tcgtaaaaaa aacaaaacaa aaaacaaaaa caacagcagc tccctcccaa
     3781 ccttccccct cccccttcac atgcataggt ggctactata ctactgagtt ttacaaatcc
     3841 caacttcctt agaggagaca tctttcagag gttttaaaat tccagagaaa atatagaaac
     3901 gtttaaaaca caaatattta atttgtatcc acatgggaaa gagctcaaaa cttttgattc
     3961 cttctaaaag tatgtatgca tataaagccc caaaatgcag acttgaagaa aggaaagaca
     4021 tgcactagtg atgattttac ttattagtca ctttgatgag ccagcagcca ccatcatttc
     4081 ctgtatttct tttatatatt tggtgtaata gaaagcgcag gagaaaaaaa aagatttctc
     4141 cccctaaaag atcatcatat aattgttcct ttgaacacac tcgatagctg ggcatgatgg
     4201 catatactag caatcccaga aggatcaggg actcaagact agcttaggca acacttaaaa
     4261 acaagataat aaatcctatt acctgactag gaatacatag tacaacacta atttgtgtac
     4321 ctctgggtga taaaatagca catattaaaa gacaccactt gcatagacca caaaaggtag
     4381 aaccaaatga catggaaata tattatggtt ccaaagtcat ttatcactta taattcaatg
     4441 ttgtaaacga ttagaagtcc tgattcttcc agagccagtg aaggcacacc ttcagccatt
     4501 tcttcaagca gatacttcag gaacaaaccc tgcacatttg tcttaggtgg tgagcactca
     4561 gtcccagggt gcaagctaca atcccatctg cataggagcc tgactcagga agatcacaag
     4621 ctcaatgctt gcctggacta taatgtgagt tcaaaagcag tctcagcaag ctaatgaagt
     4681 tttgtcacta accaaaaggc taaacaaaga ggagggaaat tgagttcaat gacagagaac
     4741 tacaagccta gtgttgggga agccctaggt cccacttcag tatcatgcaa ataagactac
     4801 agaagctcaa ggaatgagtg agtgtaggcg cccagcttct cagctcttca ggattctcac
     4861 taggaattct caccctggta actgacacca gggtaaagta aaagctttac ccttattctc
     4921 atcaatcaag gaaagcctaa acctggtgga aatctaaatt gttaaattga cacttgttat
     4981 ataaaacttc aaatgtataa aagtttgaga ctacaaactc tagagttgac tatgtgagta
     5041 taagcaaagt aacaatctgg ctcctcagaa gactgaggag tgcagagata ttctcttaat
     5101 tatttttctg ttttccttgc cctcaaaatt actcccccat atcaattttt cataatattt
     5161 gtattatttg ggaattttac atcatgaacc ccgagctcac acccttccaa gtactcccag
     5221 gtttgcccat gcacccttgt ggcctcccac caccaccacc c
//
