LOCUS       NM_178755               3479 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ATP/GTP binding protein-like 2 (Agbl2), transcript
            variant 1, mRNA.
ACCESSION   NM_178755
VERSION     NM_178755.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3479)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3479)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   3  (bases 1 to 3479)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3479)
  AUTHORS   Liu,B., Ye,B., Zhu,X., Huang,G., Yang,L., Zhu,P., Du,Y., Wu,J.,
            Meng,S., Tian,Y. and Fan,Z.
  TITLE     IL-7Ralpha glutamylation and activation of transcription factor
            Sall3 promote group 3 ILC development
  JOURNAL   Nat Commun 8 (1), 231 (2017)
   PUBMED   28794449
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3479)
  AUTHORS   Xia,P., Ye,B., Wang,S., Zhu,X., Du,Y., Xiong,Z., Tian,Y. and Fan,Z.
  TITLE     Glutamylation of the DNA sensor cGAS regulates its binding and
            synthase activity in antiviral immunity
  JOURNAL   Nat Immunol 17 (4), 369-378 (2016)
   PUBMED   26829768
  REMARK    Erratum:[Nat Immunol. 2016 Apr;17(4):469. doi:
            10.1038/ni0416-469e.. PMID: 27002845]
REFERENCE   6  (bases 1 to 3479)
  AUTHORS   Tort,O., Tanco,S., Rocha,C., Bieche,I., Seixas,C., Bosc,C.,
            Andrieux,A., Moutin,M.J., Aviles,F.X., Lorenzo,J. and Janke,C.
  TITLE     The cytosolic carboxypeptidases CCP2 and CCP3 catalyze
            posttranslational removal of acidic amino acids
  JOURNAL   Mol Biol Cell 25 (19), 3017-3027 (2014)
   PUBMED   25103237
  REMARK    GeneRIF: CCP2 and CCP3 are deglutamylases and are highly regulated
            proteins confined to ciliated tissues.
REFERENCE   7  (bases 1 to 3479)
  AUTHORS   Kalinina,E., Biswas,R., Berezniuk,I., Hermoso,A., Aviles,F.X. and
            Fricker,L.D.
  TITLE     A novel subfamily of mouse cytosolic carboxypeptidases
  JOURNAL   FASEB J 21 (3), 836-850 (2007)
   PUBMED   17244818
REFERENCE   8  (bases 1 to 3479)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (bases 1 to 3479)
  AUTHORS   Wang,T., Parris,J., Li,L. and Morgan,J.I.
  TITLE     The carboxypeptidase-like substrate-binding site in Nna1 is
            essential for the rescue of the Purkinje cell degeneration (pcd)
            phenotype
  JOURNAL   Mol Cell Neurosci 33 (2), 200-213 (2006)
   PUBMED   16952463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029744.1 and AK029932.1.
            
            On Oct 7, 2017 this sequence version replaced NM_178755.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK029744.1         2-18
            18-3479             AK029932.1         2-3463
FEATURES             Location/Qualifiers
     source          1..3479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.37 cM"
     gene            1..3479
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /note="ATP/GTP binding protein-like 2"
                     /db_xref="GeneID:271813"
                     /db_xref="MGI:MGI:2443254"
     exon            1..34
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            35..132
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            133..272
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..2761
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytosolic carboxypeptidase 2; carboxypeptidase 2,
                     cytosolic; protein deglutamylase CCP2"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase 2 isoform 1"
                     /protein_id="NP_848870.2"
                     /db_xref="CCDS:CCDS38177.2"
                     /db_xref="GeneID:271813"
                     /db_xref="MGI:MGI:2443254"
                     /translation="MNVLLEMAFLSQTLPDPYEDFIHHHLQYYGYFKAQKSSLPNSGT
                     HQRVWRNSPRYMLNGSFGERDDFISDSLEKEMLLWPTCLSSTGHAHIDAVNRDSLLLS
                     SPLLRTRQLIFDELDEASPRLREPRELFSCFSSRGPLQAPRWPIECEVIKENIHHIEW
                     VPHQPEYFYQPTGSEKVPEIVGEEQGTVVYQLDSVPAEGTYFTSSRIGGKRGTIKELA
                     VTLQGPDDNTLLFESRFESGNLQKAVRVGIYEYELTLRTDLYTDKHTQWFYFRVQNTR
                     KDATYRFTIVNLLKPKSLYAVGMKPLMYSQLDATIYNIGWRREGREIKYYKNNVDDGQ
                     QPLYCLTWTTQFPHDQDTCFFAHFYPYTYTDLQCYLLSVANNPIQSQFCKLRALCRSL
                     AGNTVYLLTITNPSRTPQEAAAKKAVVLSARVHPGESNSSWIMNGFLDFILSNSPDAQ
                     LLRDIFVFKVIPMLNPDGVIVGNYRCSLAGRDLNRHYKTVLKDSFPCIWYTKNMIKRL
                     LEEREVLLYCDFHGHSRKNNIFLYGCHSNNRKHWLHERVFPLMLSKNAPDKFSFDSCN
                     FKVQKCKEGTGRVVMWRMGIINSYTMESTFGGSTLGSKRDTHFTIEDLKSLGYHVCDT
                     LLDFCDPDQTKYTQCLQELKELLQQEINKKLNNFGQDMDLEGNWSDIPLSDIESSTSG
                     SDSSLSDGPPIRLLNIVADEPNQKTVLKNPKKKRLQTRKQRNEQYQKSYLMRELKLTE
                     NAPGRARFVSTLQKQPTFLKSPESPSPSVRRSENPRLNETQLSGREKGTSLDPPLTSP
                     KNKERIQSKKPGFTASCSPKRSTNSSLGPAPDVKPNWSKTRYSATRKDHATMAVYPSL
                     HIYTYP"
     exon            273..407
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..461
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..647
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..755
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..909
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1692
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1849
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1976
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2077
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2208
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2278
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2401
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2509
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2587
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..3479
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3454..3459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /note="hexamer: ATTAAA"
     polyA_site      3477
                     /gene="Agbl2"
                     /gene_synonym="4930524K04; A430081C19Rik; CCP2"
                     /note="major polyA site"
ORIGIN      
        1 aggctcccag ggtcctcgca gaaaactcca gcaggcagat attgcagctg ggtacggtgc
       61 tactaactcg cctacatcat actatgcggc agtaacatgt tcccggcgtt ggaaacagaa
      121 ctaaagccgg agcgtgtttg gtgcttttgg ttaagaagtc agtgtcatct gaatgaatgt
      181 cctgcttgag atggcttttc tttcacagac tcttcctgat ccctatgagg actttattca
      241 ccatcacctc cagtattatg gatatttcaa agctcagaaa agcagcctgc caaactcagg
      301 cactcatcag cgcgtttgga ggaacagccc tcggtacatg ttgaatggct cttttggaga
      361 aagagatgat ttcatctcgg acagtttgga aaaagagatg cttctgtggc ctacctgttt
      421 atcttcaact gggcatgctc acatagacgc tgtaaacaga gactcacttc tgctgagctc
      481 gccgctcctg aggaccaggc agctgatttt tgatgagcta gatgaagcaa gcccacggct
      541 tcgagaaccc cgagaactct tctcatgttt ctctagcaga gggccgctgc aggctccaag
      601 atggccaatc gaatgtgagg tcatcaagga aaacattcat cacattgagt gggttccaca
      661 tcaaccagaa tatttctacc aacctacagg aagcgagaag gtgccagaga ttgtgggaga
      721 ggagcaaggt acagttgtgt accagctaga ttcagtgcct gcagaaggca cctatttcac
      781 tagttccaga ataggaggca aacgagggac catcaaggaa cttgctgtca cactgcaagg
      841 gccggacgac aatactctat tgtttgagtc aaggtttgag agcgggaatc tgcagaaagc
      901 cgtcagagta ggtatctatg agtacgagct caccttgcgg actgacctct acacggacaa
      961 acacactcag tggttttact tcagagttca gaacaccaga aaagacgcta cctatcgctt
     1021 caccatcgtc aacttgctga aacccaagag cctttacgca gtaggcatga agcctctcat
     1081 gtactctcag ctggatgcca ccatctacaa catcggctgg aggagagagg gccgtgaaat
     1141 caagtactac aagaacaatg tggacgacgg ccagcagccc ttatactgcc tcacctggac
     1201 cactcagttt cctcacgacc aggacacttg cttcttcgca cacttttacc catacactta
     1261 tactgacttg caatgctatc tcttgtcagt agcaaacaac cccatccagt ctcagttctg
     1321 caagctccga gccctatgca ggagcctagc agggaacact gtctacctgc tgaccatcac
     1381 caacccatcc aggacccctc aagaggcagc cgcaaagaaa gctgtggtct tgagcgcccg
     1441 agtccaccct ggagagagta acagctcctg gatcatgaac ggctttttgg acttcatcct
     1501 tagcaactct cccgatgccc agctcctcag ggatatcttt gtcttcaagg tgattcccat
     1561 gttaaaccca gatggcgtga tagtggggaa ctatcggtgt tcgctggctg gaagggactt
     1621 gaacaggcat tataaaaccg ttcttaagga ctccttccct tgcatttggt acaccaagaa
     1681 catgatcaaa aggcttctgg aagaaagaga ggttctcttg tactgtgatt tccatgggca
     1741 tagccgcaag aacaacatct tcctgtatgg ctgtcacagc aacaaccgca agcactggct
     1801 ccatgagcgt gtctttcctt taatgttgag caagaatgca ccagacaagt tctctttcga
     1861 cagctgtaac tttaaggtcc aaaaatgcaa agaaggaacg ggaagagtgg tgatgtggcg
     1921 gatgggcatc atcaacagct acaccatgga gtctaccttt ggcgggtcta ccctgggtag
     1981 taaaagagac actcacttta ccattgagga cctgaagtcc ctagggtatc atgtctgtga
     2041 cactcttctg gatttctgtg atcctgacca aaccaagtac acacagtgtc tacaagagct
     2101 taaggagctc ctacaacagg aaatcaacaa aaagttgaat aactttggac aagatatgga
     2161 tttagaagga aactggagtg acattccttt gtctgacatt gaatccagca cgagtggctc
     2221 ggacagctcc ctctccgatg gccctcccat tcgtctactg aacatcgttg cagatgagcc
     2281 aaatcagaag acggtgttaa agaatccaaa aaagaagaga cttcagacta gaaaacagcg
     2341 gaatgagcag taccagaaga gctacttgat gcgggagtta aagttaacag aaaacgcccc
     2401 aggaagggcg agatttgtct ctactctgca aaagcagcct acttttttga aaagtccaga
     2461 gagtcctagc ccttcagtaa ggagaagtga aaacccaagg ctcaatgaga cacagttaag
     2521 tggaagagag aagggcacct ccctggatcc accactgacc agccctaaga ataaagaaag
     2581 aattcagagt aagaagccag gctttacagc atcatgctct ccaaagagaa gcacaaactc
     2641 cagcctaggg ccagctccag atgtgaagcc aaactggtct aagactagat actctgccac
     2701 aaggaaggac catgccacca tggccgtgta cccatccttg catatataca catacccata
     2761 agtgtgctct tgctgcgaca cacagctgct tcctccaaag gttttgggta gttttgttgg
     2821 tttgttttgt atgcaatgct ggggaccaaa cctctagggc actgagcata ctaggcaagt
     2881 gctttaccat tgagctgtgt ctccagccct cctgaaaagt ttatgggtta tacacatctt
     2941 ataaggggga aatctgtgaa taaaatggaa actctattta tggtatactg tgttgtacac
     3001 tcaccacaca ctgaccttct ctggtcttcc gctgtgcact gtccttagat gcatgccttg
     3061 ttacctcgtg aatttgttag ggattttttt tttccttaga tgagattata ttttgatgta
     3121 tagaaaagcc tttattgaac gctgaagcct gtacacataa aaagacagaa cagtgtatat
     3181 acttcatttt aaccaataga tgttctcttt aaagttagat gcaaatcagt tttaaaagat
     3241 cgagctgttt taagtgtgtt ttgggaatgt gccatatgaa aaagtcttgt atcgaagttt
     3301 tcaaatggtg actgaccagt cagactgtgg ttatattagg tttgcttaaa gtaaggtatt
     3361 cctacatagg aaaaaaataa ttacatgtat tacttagaat ttaatgttgc ttatattatg
     3421 ttcaacaagg ttgtgtaagt ttttaactca gtgattaaaa ttctttctct cttgttact
//
