LOCUS       NM_139153               3207 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus ArfGAP with GTPase domain, ankyrin repeat and PH
            domain 3 (Agap3), transcript variant 1, mRNA.
ACCESSION   NM_139153 XM_906432
VERSION     NM_139153.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Hojgaard,K., Szollosi,B., Henningsen,K., Minami,N., Nakanishi,N.,
            Kaadt,E., Tamura,M., Morris,R.G.M., Takeuchi,T. and Elfving,B.
  TITLE     Novelty-induced memory consolidation is accompanied by increased
            Agap3 transcription: a cross-species study
  JOURNAL   Mol Brain 16 (1), 69 (2023)
   PUBMED   37749596
  REMARK    GeneRIF: Novelty-induced memory consolidation is accompanied by
            increased Agap3 transcription: a cross-species study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3207)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3207)
  AUTHORS   Nagashima,S., Ito,N., Kobayashi,R., Shiiba,I., Shimura,H.,
            Fukuda,T., Hagihara,H., Miyakawa,T., Inatome,R. and Yanagi,S.
  TITLE     Forebrain-specific deficiency of the GTPase CRAG/Centaurin-gamma3
            leads to immature dentate gyri and hyperactivity in mice
  JOURNAL   J Biol Chem 296, 100620 (2021)
   PUBMED   33811862
  REMARK    GeneRIF: Forebrain-specific deficiency of the GTPase
            CRAG/Centaurin-gamma3 leads to immature dentate gyri and
            hyperactivity in mice.
REFERENCE   4  (bases 1 to 3207)
  AUTHORS   Nagashima,S., Takeda,K., Shiiba,I., Higashi,M., Fukuda,T.,
            Tokuyama,T., Matsushita,N., Nagano,S., Araki,T., Kaneko,M.,
            Shioi,G., Inatome,R. and Yanagi,S.
  TITLE     Critical role of CRAG, a splicing variant of
            centaurin-gamma3/AGAP3, in ELK1-dependent SRF activation at PML
            bodies
  JOURNAL   Sci Rep 9 (1), 20107 (2019)
   PUBMED   31882856
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3207)
  AUTHORS   Nagashima,S., Fukuda,T., Kubota,Y., Sugiura,A., Nakao,M.,
            Inatome,R. and Yanagi,S.
  TITLE     CRMP5-associated GTPase (CRAG) protein protects neuronal cells
            against cytotoxicity of expanded polyglutamine protein partially
            via c-Fos-dependent activator protein-1 activation
  JOURNAL   J Biol Chem 286 (39), 33879-33889 (2011)
   PUBMED   21832068
  REMARK    GeneRIF: CRAG enhances the cell survival signal against the
            accumulation of unfolded proteins, including polyQ, through not
            only proteasome activation, but also the activation of
            c-Fos-dependent AP-1.
REFERENCE   6  (bases 1 to 3207)
  AUTHORS   Qin,Q., Inatome,R., Hotta,A., Kojima,M., Yamamura,H., Hirai,H.,
            Yoshizawa,T., Tanaka,H., Fukami,K. and Yanagi,S.
  TITLE     A novel GTPase, CRAG, mediates promyelocytic leukemia
            protein-associated nuclear body formation and degradation of
            expanded polyglutamine protein
  JOURNAL   J Cell Biol 172 (4), 497-504 (2006)
   PUBMED   16461359
  REMARK    GeneRIF: We propose that CRAG is a modulator of promyelocytic
            leukemia protein function and dynamics in reactive oxygen species
            signaling and is protectively involved in the pathogenesis of
            polyglutamine diseases.
REFERENCE   7  (bases 1 to 3207)
  AUTHORS   Meurer,S., Pioch,S., Wagner,K., Muller-Esterl,W. and Gross,S.
  TITLE     AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl
            cyclase
  JOURNAL   J Biol Chem 279 (47), 49346-49354 (2004)
   PUBMED   15381706
REFERENCE   8  (bases 1 to 3207)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120353.9, CJ052480.1, CJ053222.1, AK079516.1, BM943884.1,
            BM943676.1 and AV241066.1.
            
            On Jan 31, 2007 this sequence version replaced NM_139153.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF459091.1, SRR1660821.144958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AC120353.9         85507-85864         c
            359-591             CJ052480.1         110-342
            592-676             CJ053222.1         343-427
            677-2298            AK079516.1         16-1637
            2299-2556           BM943884.1         364-621
            2557-3176           BM943676.1         69-688
            3177-3207           AV241066.1         222-252
FEATURES             Location/Qualifiers
     source          1..3207
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.81 cM"
     gene            1..3207
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /note="ArfGAP with GTPase domain, ankyrin repeat and PH
                     domain 3"
                     /db_xref="GeneID:213990"
                     /db_xref="MGI:MGI:2183446"
     exon            1..358
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2763
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /note="isoform a is encoded by transcript variant 1;
                     centaurin, gamma 3; spidin; arf-GAP with GTPase, ANK
                     repeat and PH domain-containing protein 3; CRAM-associated
                     GTPase; MR1-interacting protein"
                     /codon_start=1
                     /product="arf-GAP with GTPase, ANK repeat and PH
                     domain-containing protein 3 isoform a"
                     /protein_id="NP_631892.2"
                     /db_xref="CCDS:CCDS19122.1"
                     /db_xref="GeneID:213990"
                     /db_xref="MGI:MGI:2183446"
                     /translation="MNFQAGGGQSPQQQQSLAAPGTGGGGGGGAGGGGQFGGAGPGAG
                     GGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIR
                     EHVISIEDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGG
                     RFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLC
                     SFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERV
                     FQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGSSAFSDY
                     SSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECR
                     VDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGK
                     EIDLLRTTVKVPGKRLPRATPTTAPGTSPRANGLAMERSNTQLGGATGAPHSASSTSL
                     HSERPHSSAWAGSRPGPEGLHQRSCSVSSTDQWSEAAALPASMQHPASGPAESLSSSP
                     KLEPPPSPHSNRKKHRGKKSTGTPRPDGPSSAAEEAEESFEFVVVSLTGQTWHFEAST
                     AEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNTALAVQAVRTVRGNSLCIDCEAP
                     NPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSV
                     WEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLR
                     LLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLT
                     PLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSIL"
     exon            359..417
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..505
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..591
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..733
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..868
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..996
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1155
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1248
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1353
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1522
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1693
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1831
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1986
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2077
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2300
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2556
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..3207
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3176..3181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      3199
                     /gene="Agap3"
                     /gene_synonym="AGAP-3; Centg3; cnt-g3; Crag; Crag.;
                     MRIP-1"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcttcg gggcccgcgc ctccggagcc atgaacttcc aggcaggcgg gggccagagt
       61 cctcagcagc agcagagcct ggcggctccg gggaccggcg gcggcggcgg cggcggcgcg
      121 gggggcggcg ggcagttcgg cggcgcgggg cccggagccg ggggtggcgg cccctcgcag
      181 cagctggctg gcggcccccc ccagcagttc gcgctctcca actcggccgc tatccgagcc
      241 gagatccaac gcttcgagtc ggtacacccc aacatctacg ccatctacga cctgatcgag
      301 cgaatcgagg atttggcgct gcagaaccag atccgggagc acgtcatctc catcgaggac
      361 tcatttgtga acagccagga gtggaccctg agccgctctg tgccagagct taaagtgggc
      421 atagtgggca acctgtctag tgggaaatca gccttggttc accgatatct gacagggact
      481 tatgtccagg aagagtcccc tgaagggggt cgatttaaaa aggagattgt agtggatggc
      541 cagagttacc tgctgctgat ccgggatgaa ggaggccccc ctgaactcca gtttgctgcc
      601 tgggtggatg cggtggtgtt tgtgttcagc ctggaggatg aaatcagctt ccagacggtg
      661 tacaactact tcctacgcct ctgcagcttt cgaaatgcca gcgaggtgcc catggtgctg
      721 gtgggcacac aggatgccat cagtgccgcc aatccccggg tcattgatga cagcagggcc
      781 cgcaaactgt ccacagacct gaagcgctgt acctactatg aaacatgcgc aacctatggg
      841 ctcaatgtgg aacgagtctt ccaggacgtg gcccagaagg tggtagcctt gaggaagaag
      901 cagcagctgg cgatcgggcc ctgcaagtcc ctgcccaact cacccagcca ctcggccgtg
      961 tcagctgcct ccatcccagc tgtgcacatc aatcaggcca ccaacggagg cagcagcgcc
     1021 ttcagcgact actcgtcctc agtcccctcc acccctagca tcagccagcg ggagctgcgc
     1081 atcgagacca tcgctgcctc ctccaccccc acgcccatcc gcaagcagtc caagcggcgt
     1141 tctaacatct tcacgtctcg aaaaggtgct gacctggaca gggagaagaa agctgcggag
     1201 tgcagagtgg acagcatcgg gagtggccgg gccatcccca tcaagcaggg gatcctgctg
     1261 aaaagaagcg gcaaatcctt gaacaaggag tggaagaaga agtatgtgac gctgtgtgac
     1321 aacgggttgc ttacttacca ccctagcctg cacgattaca tgcaaaacat ccacggcaaa
     1381 gagatcgacc tcctacggac tacggtgaaa gtgccaggga agcgtctgcc ccgagccaca
     1441 cccactacag ccccaggcac cagtccccgt gccaacgggt tggcaatgga gcggagtaac
     1501 acacagctgg gtggggccac aggtgccccc cactcggcca gcagcacatc cctgcattct
     1561 gagcgccctc acagctcagc ctgggctggc tcacgccccg gccccgaggg gctgcaccag
     1621 cgctcctgtt cggtttccag cactgaccag tggagtgagg cagctgccct gcctgccagc
     1681 atgcagcacc ctgccagtgg cccagctgag tcactcagtt ccagccccaa gctggagcct
     1741 cccccatctc cccactccaa ccggaagaag caccgcggga aaaagagcac cgggaccccc
     1801 cgaccagacg gccccagcag tgctgctgaa gaggcagagg agtcctttga gtttgtagtg
     1861 gtgtccctca ctggtcagac ctggcatttt gaggcctcaa cagcagaaga gcgggaacta
     1921 tgggtgcaga gcgtgcaggc ccaaatcctc gccagcctac aaggatgtcg cagcgccaag
     1981 gacaagactc ggctggggaa ccagaacaca gccctggcgg tgcaggctgt ccgcacggtc
     2041 cgcggcaaca gcctctgtat tgactgtgaa gcccccaatc cagactgggc cagcctgaat
     2101 ctgggtgccc tgatgtgtat cgagtgctca gggatccacc gacacctggg agctcacctg
     2161 tcccgagtcc gctccttgga ccttgacgac tggccacctg aactgctggc cgtcatgact
     2221 gcaatgggca acgccttggc taacagtgtc tgggaggggg ctctggatgg ttactctaag
     2281 ccaggccccg aagcctgcag agaggagaaa gagcgctgga tccgagccaa gtatgagcag
     2341 aagctcttct tggccccgct gccaagctca gatgtgccgc tgggacagca gttactccgg
     2401 gctgtggtgg aggatgacct gcggctgctg gtgatgctgc tggcccacgg gtccaaggag
     2461 gaggtgaacg agacatacgg ggacggtgac gggaggacag ccctgcacct gtccagtgcc
     2521 atggccaatg tggtgttcac acagctgctc atctggtacg gggtggacgt gaggagccgt
     2581 gatgcccgag gactgacccc actggcctat gcccgtcgtg ccggcagcca ggagtgtgca
     2641 gacatcttga tccagcatgg gtgtcccggg gaaggctgtg gcttagcacc cactcccaac
     2701 agagagcctg ccaatggcac caacccctcc gcagaactgc accgcagccc tagtatccta
     2761 tgaagctcag gaagagggca gagggaccag aaggactcca cggcctgcag gaaacagacg
     2821 gagaagcagg ggtgtgcaga gaagaggggg tgccacgggt tcaggggtaa agaggtttgg
     2881 ggttgagctg cagcagagca agctgtgctc agccctcggc cctatggtgc cattaaagga
     2941 tagaaccctt tggaggtgcc tgtgaggaga ggggggcagg acctctccct cctccagaac
     3001 cctgcctcct catgacagct cccaccagcc ttccctgcgg tgggtgggga aggacaggac
     3061 acaggatggg ggtgccagct gaaagacaaa gggccactct gggagcccca tgtaaaattt
     3121 gtacattgga atatttatgt tggtgtatat acgtggtgtg tgtgtatgat gagccaataa
     3181 agcaggctgt atgtgtggcc tcctttc
//
