LOCUS       NM_007423               2086 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus alpha fetoprotein (Afp), mRNA.
ACCESSION   NM_007423
VERSION     NM_007423.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2086)
  AUTHORS   Koike,S., Keino-Masu,K., Tanimoto,Y., Takahashi,S. and Masu,M.
  TITLE     The autotaxin-LPA axis promotes membrane trafficking and secretion
            in yolk sac visceral endoderm cells
  JOURNAL   Biol Open 12 (11) (2023)
   PUBMED   37795611
REFERENCE   2  (bases 1 to 2086)
  AUTHORS   Schule,K.M., Weckerle,J., Probst,S., Wehmeyer,A.E., Zissel,L.,
            Schroder,C.M., Tekman,M., Kim,G.J., Schlagl,I.M., Sagar and
            Arnold,S.J.
  TITLE     Eomes restricts Brachyury functions at the onset of mouse
            gastrulation
  JOURNAL   Dev Cell 58 (18), 1627-1642 (2023)
   PUBMED   37633271
REFERENCE   3  (bases 1 to 2086)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2086)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2086)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   6  (bases 1 to 2086)
  AUTHORS   Ferrer,N., Portugal,J. and Franco,R.
  TITLE     Interaction of trans-acting factors with the proximal promoter of
            the mouse alpha-fetoprotein gene
  JOURNAL   Int J Biochem 24 (12), 1985-1989 (1992)
   PUBMED   1282109
REFERENCE   7  (bases 1 to 2086)
  AUTHORS   Emerson,J.A., Vacher,J., Cirillo,L.A., Tilghman,S.M. and Tyner,A.L.
  TITLE     The zonal expression of alpha-fetoprotein transgenes in the livers
            of adult mice
  JOURNAL   Dev Dyn 195 (1), 55-66 (1992)
   PUBMED   1284040
REFERENCE   8  (bases 1 to 2086)
  AUTHORS   Altherr,M.R., Wasmuth,J.J., Seldin,M.F., Nadeau,J.H., Baehr,W. and
            Pittler,S.J.
  TITLE     Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase
            beta-subunit gene in mouse and human: tight linkage to the
            Huntington disease region (4p16.3)
  JOURNAL   Genomics 12 (4), 750-754 (1992)
   PUBMED   1315306
REFERENCE   9  (bases 1 to 2086)
  AUTHORS   Tilghman,S.M., Kioussis,D., Gorin,M.B., Ruiz,J.P. and Ingram,R.S.
  TITLE     The presence of intervening sequences in the alpha-fetoprotein gene
            of the mouse
  JOURNAL   J Biol Chem 254 (15), 7393-7399 (1979)
   PUBMED   88451
REFERENCE   10 (bases 1 to 2086)
  AUTHORS   Olsson,M., Lindahl,G. and Ruoslahti,E.
  TITLE     Genetic control of alpha-fetoprotein synthesis in the mouse
  JOURNAL   J Exp Med 145 (4), 819-827 (1977)
   PUBMED   67170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY773400.1, BC066206.1 and AV105248.2.
            
            On Dec 19, 2007 this sequence version replaced NM_007423.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075972.1, AK076197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY773400.1         8-44
            38-2033             BC066206.1         1-1996
            2034-2086           AV105248.2         952-1004
FEATURES             Location/Qualifiers
     source          1..2086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.77 cM"
     gene            1..2086
                     /gene="Afp"
                     /note="alpha fetoprotein"
                     /db_xref="GeneID:11576"
                     /db_xref="MGI:MGI:87951"
     exon            1..152
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1885
                     /gene="Afp"
                     /note="alpha-fetoglobulin; alpha-1-fetoprotein;
                     alpha-foetoprotein"
                     /codon_start=1
                     /product="alpha-fetoprotein precursor"
                     /protein_id="NP_031449.3"
                     /db_xref="CCDS:CCDS19413.1"
                     /db_xref="GeneID:11576"
                     /db_xref="MGI:MGI:87951"
                     /translation="MKWITPASLILLLHFAASKALHENEFGIASTLDSSQCVTEKNVL
                     SIATITFTQFVPEATEEEVNKMTSDVLAAMKKNSGDGCLESQLSVFLDEICHETELSN
                     KYGLSGCCSQSGVERHQCLLARKKTAPASVPPFQFPEPAESCKAHEENRAVFMNRFIY
                     EVSRRNPFMYAPAILSLAAQYDKVVLACCKADNKEECFQTKRASIAKELREGSMLNEH
                     VCSVIRKFGSRNLQATTIIKLSQKLTEANFTEIQKLALDVAHIHEECCQGNSLECLQD
                     GEKVMTYICSQQNILSSKIAECCKLPMIQLGFCIIHAENGVKPEGLSLNPSQFLGDRN
                     FAQFSSEEKIMFMASFLHEYSRTHPNLPVSVILRIAKTYQEILEKCSQSGNLPGCQDN
                     LEEELQKHIEESQALSKQSCALYQTLGDYKLQNLFLIGYTRKAPQLTSAELIDLTGKM
                     VSIASTCCQLSEEKWSGCGEGMADIFIGHLCIRNEASPVNSGISHCCNSSYSNRRLCI
                     TSFLRDETYAPPPFSEDKFIFHKDLCQAQGKALQTMKQELLINLVKQKPELTEEQLAA
                     VTADFSGLLEKCCKAQDQEVCFTEEGPKLISKTRDALGV"
     exon            153..204
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            205..325
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            326..537
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            538..670
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            671..768
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            769..898
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1113
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1246
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1344
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1483
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1707
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1840
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1895
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2086
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Afp"
                     /note="hexamer: AATAAA"
     polyA_site      2033
                     /gene="Afp"
                     /note="major polyA site"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Afp"
                     /note="hexamer: ATTAAA"
     polyA_site      2081
                     /gene="Afp"
ORIGIN      
        1 ggacttcagc aggactgctc gaaacatccc acttccagca ctgcctgcgg tgaaggaacc
       61 agcagccatg aagtggatca cacccgcttc cctcatcctc ctgctacatt tcgctgcgtc
      121 caaagcattg cacgaaaatg agtttgggat agcttccacg ttagattcct cccagtgcgt
      181 gacggagaag aatgtgctta gcatagctac catcaccttt acccagtttg ttccggaagc
      241 caccgaggag gaagtgaaca aaatgactag cgatgtgttg gctgcaatga agaaaaactc
      301 tggcgatggg tgtttagaaa gccagctatc tgtgtttctg gatgaaattt gtcatgagac
      361 ggaactctct aacaagtatg gactctcagg ctgctgcagc caaagtggag tggaaagaca
      421 tcagtgtctg ctggcacgca agaagactgc tccggcctct gtcccaccct tccagtttcc
      481 agaacctgcc gagagttgca aagcacatga agaaaacagg gcagtgttca tgaacaggtt
      541 catctatgaa gtgtcaagga ggaacccctt catgtatgcc ccagccattc tgtccttggc
      601 tgctcagtac gacaaggtcg ttctggcatg ctgcaaagct gacaacaagg aggagtgctt
      661 ccagacaaag agagcatcca ttgcaaagga attaagagaa ggaagcatgt taaatgagca
      721 tgtatgttca gtgataagaa aatttggatc ccgaaacctc caggcaacaa ccattattaa
      781 gctaagtcaa aagttaactg aagcaaattt tactgagatt cagaagctgg ccctggatgt
      841 ggctcacatc cacgaggagt gttgccaagg aaactcgctg gagtgtctgc aggatgggga
      901 aaaagtcatg acatatatat gttctcaaca aaatattctg tcaagcaaaa tagcagagtg
      961 ctgcaaatta cccatgatcc aactaggctt ctgcataatt cacgcagaga atggcgtcaa
     1021 acctgaaggc ttatctctaa atccaagcca gtttttggga gacagaaatt ttgcccaatt
     1081 ttcttcagag gaaaaaatca tgttcatggc aagctttctt catgaatact caagaactca
     1141 ccccaacctt cctgtctcag tcattctaag aattgctaaa acgtaccagg aaatattgga
     1201 gaagtgttcc cagtctggaa atctacctgg atgtcaggac aatctggaag aagaattgca
     1261 gaaacacatc gaggagagcc aggcactgtc caagcaaagc tgcgctctct accagacctt
     1321 aggagactac aaattacaaa atctgttcct tattggttac acgaggaaag cccctcagct
     1381 gacctcagca gagctgatcg acctcaccgg gaagatggtg agcattgcct ccacgtgctg
     1441 ccagctcagc gaggagaaat ggtccggctg tggtgaggga atggccgaca ttttcattgg
     1501 acatttgtgt ataaggaatg aagcaagccc tgtgaactct ggtatcagcc actgctgcaa
     1561 ctcttcgtat tccaacagga ggctatgcat caccagtttt ctgagggatg aaacctatgc
     1621 ccctccccca ttctctgagg ataaattcat cttccacaag gatctgtgcc aagctcaggg
     1681 caaagcccta cagaccatga aacaagagct tctcattaac ctggtgaagc aaaagcctga
     1741 actgacagag gagcagctgg cggctgtcac tgcagatttc tcgggccttt tggagaagtg
     1801 ctgcaaagcc caggaccagg aagtctgttt cacagaagag ggtccaaagt tgatttccaa
     1861 aactcgtgat gctttgggcg tttaaacatc tccagaagga agagtggaca aaaaaatgtg
     1921 ttgactcttt ggtgtgagcc ttttggctta actgtaactg ctagtacttt aaccacatgg
     1981 tgaagatgtc catgtgagat ttctatacct taggaataaa aacttttcaa ctatttctct
     2041 tctcctagtc tgcttttttt ttattaaaaa atactttttt ccattt
//
