LOCUS       NM_027827               2332 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus arylformamidase (Afmid), transcript variant 3, mRNA.
ACCESSION   NM_027827
VERSION     NM_027827.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2332)
  AUTHORS   Lourenco,C., Kelly,D., Cantillon,J., Cauchi,M., Yon,M.A.,
            Bentley,L., Cox,R.D. and Turner,C.
  TITLE     Monitoring type 2 diabetes from volatile faecal metabolome in
            Cushing's syndrome and single Afmid mouse models via a longitudinal
            study
  JOURNAL   Sci Rep 9 (1), 18779 (2019)
   PUBMED   31827172
  REMARK    GeneRIF: Monitoring type 2 diabetes from volatile faecal metabolome
            in Cushing's syndrome and single Afmid mouse models via a
            longitudinal study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2332)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 2332)
  AUTHORS   Hugill,A.J., Stewart,M.E., Yon,M.A., Probert,F., Cox,I.J.,
            Hough,T.A., Scudamore,C.L., Bentley,L., Wall,G., Wells,S.E. and
            Cox,R.D.
  TITLE     Loss of arylformamidase with reduced thymidine kinase expression
            leads to impaired glucose tolerance
  JOURNAL   Biol Open 4 (11), 1367-1375 (2015)
   PUBMED   26432886
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2332)
  AUTHORS   Probert,F., Rice,P., Scudamore,C.L., Wells,S., Williams,R.,
            Hough,T.A. and Cox,I.J.
  TITLE     (1)H NMR metabolic profiling of plasma reveals additional
            phenotypes in knockout mouse models
  JOURNAL   J Proteome Res 14 (5), 2036-2045 (2015)
   PUBMED   25849460
REFERENCE   6  (bases 1 to 2332)
  AUTHORS   Schuettengruber,B., Doetzlhofer,A., Kroboth,K., Wintersberger,E.
            and Seiser,C.
  TITLE     Alternate activation of two divergently transcribed mouse genes
            from a bidirectional promoter is linked to changes in histone
            modification
  JOURNAL   J Biol Chem 278 (3), 1784-1793 (2003)
   PUBMED   12411446
  REMARK    GeneRIF: activation from a bidirectional promoter is linked to
            changes in histone modification
REFERENCE   7  (bases 1 to 2332)
  AUTHORS   Pabarcus,M.K. and Casida,J.E.
  TITLE     Kynurenine formamidase: determination of primary structure and
            modeling-based prediction of tertiary structure and catalytic triad
  JOURNAL   Biochim Biophys Acta 1596 (2), 201-211 (2002)
   PUBMED   12007602
REFERENCE   8  (bases 1 to 2332)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2332)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 2332)
  AUTHORS   Dobrovolsky,V.N., Casciano,D.A. and Heflich,R.H.
  TITLE     Tk+/- mouse model for detecting in vivo mutation in an endogenous,
            autosomal gene
  JOURNAL   Mutat Res 423 (1-2), 125-136 (1999)
   PUBMED   10029690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY780917.1, AY099479.1 and AL591433.6.
            
            On Dec 17, 2009 this sequence version replaced NM_027827.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043309.1, AY099479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY780917.1         1-5
            6-916               AY099479.1         1-911
            917-2332            AL591433.6         14836-16251
FEATURES             Location/Qualifiers
     source          1..2332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 82.96 cM"
     gene            1..2332
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /note="arylformamidase"
                     /db_xref="GeneID:71562"
                     /db_xref="MGI:MGI:2448704"
     exon            1..88
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            89..179
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            180..284
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            285..333
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            334..419
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            420..492
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            493..590
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            591..669
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            670..811
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            812..916
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            917..2332
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /note="hexamer: AACAAG"
     polyA_site      1453
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /note="major polyA site"
     regulatory      2307..2312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /note="hexamer: ATTAAA"
     polyA_site      2332
                     /gene="Afmid"
                     /gene_synonym="9030621K19Rik; Ammd; FKF; formylase; Kf;
                     KFA"
                     /note="major polyA site"
ORIGIN      
        1 tggagctcga ccatcccctc cggatctggc catggcgttt ccttcccttt ctgcgggcca
       61 gaatccctgg aggaacttgt cttcggagga gctggagaag caatactcac ccagcagatg
      121 ggtcatccac acgaaaccag aggaagttgt tgggaacttc gtgcagatag gaagccaggc
      181 cacccagaag gcccgggcca ccaggaggaa ccagctggat gtcccctatg gagatggcga
      241 aggggagaaa ctggacatct actttcccga tgaggattcc aaggctttcc ctctgttcct
      301 gttcttgcat ggaggatact ggcagagtgg aagtaaagat gactcggcct tcatggtaaa
      361 cccactgact gcacagggaa tcgtggtggt gatagtggct tatgacattg cacccaaagg
      421 cacactggac cagatggtgg accaggtgac ccgcagtgtc gtgtttctac agaggcgcta
      481 tccaagcaat gagggaatct acctctgcgg acactctgcg ggagctcacc tggctgctat
      541 ggtgctcctg gcccgctgga ccaagcatgg cgtcacaccc aacctccaag gctttctcct
      601 ggtgagtggg atctacgacc tggagcccct catagccacc tcccagaatg accctctgcg
      661 catgaccctg gaagatgctc agagaaacag tccacagcga cacttggatg tggttccagc
      721 acagcctgtg gctccagcct gccctgtgct ggtgcttgtg ggtcagcatg actccccaga
      781 gttccaccgg cagtccaagg agttctacga gacacttctc cgcgtgggat ggaaggcctc
      841 tttccagcag ctgcgtggtg tggatcactt tgacatcata gagaatctga cccgggagga
      901 tgacgtgctc acccagatca ttttgaaaac agtcttccag aagctgtgag gacacccagt
      961 ccccattctg tatgcacctc agagagcctt cagaaaagag gctccatctc acactgcctt
     1021 gcctgtccac cctgtacagt ctccctgctg tgaacacaat ctcctctcct gccattcttc
     1081 accccaccca gatggaggcc cagggaaagc ctgcagattg ttactggaaa atgcacacag
     1141 ccaccacctg gccaagtctg ccccaccctc caccccaccc ctgcctgctg acagggagtt
     1201 gccattaact tctggctggc tttctgtgcc aattagcagt atcagtgtgg actggctggg
     1261 gctgaggctg tagctgagtg ctggagttct gcctatctcc tactgcaaga gaaggtgggg
     1321 tggggaaaag aaatgaagac agacagacag accaaccaaa cactggggga cgtagctcgc
     1381 tggtagaaag cctgaccacc atgcatacga tcctgggttt caacaaggaa acctgatact
     1441 aacaaggaaa aaagaaagaa aagagaagag acagagacag gcccagtgta tacctgaatc
     1501 ccaacactga agcaagagaa ttgcttgtga tttcaagacc atcctggaca acatagctag
     1561 accctgtctc aaaaagaaaa gggactggag agatggcttg gcagatcaga gtgcctggca
     1621 ctgagcctga caacctgtgt ttggtccttg gggatccata tggaaggaaa caaccaactc
     1681 ccccaaattg tcttttggct gccatgtgtg tgtatcttag catacacacc acacatacat
     1741 gatgatggtg ataaaaagag tccatgttgt gcctgctgta tgaactaaca aggatttact
     1801 tagaactgca ccagcccaga gaggccaccc gcacaaagac ctgtgtgtag caggctctac
     1861 cagacctgat aactattcct gcagcacacc actgggcctt ctgaaacagc tggtgtgggc
     1921 tgtagccata cttcttgcct actttattgg gttctcatag ctaccactct tccccacccc
     1981 aatcccttcc aaccccccaa cactagggag ttgagaaggt tggagggaag gggggcatag
     2041 atctctttag atgccctgct gattaggggc atcgagatct ttgggacaag aacagccagc
     2101 aagtcatcaa atagcaaagg agccacaggg gacgcagcag ccacctcctc ttggggctct
     2161 ggcattttta accctcttaa gaacccccag aattccaaat gtcaactatc ttcctctggc
     2221 agcctcacgc ccctgcctgc cagggcagga gacaaatcgt agttgcatgt ggacaatctt
     2281 aagcagcccc atttcccaca cctggcatta aagcaaaagc ttagtcacat aa
//
