LOCUS       NM_001290814            9485 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus AF4/FMR2 family, member 3 (Aff3), mRNA.
ACCESSION   NM_001290814 XM_006495740 XM_036162335
VERSION     NM_001290814.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9485)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9485)
  AUTHORS   Tsukumo,S.I., Subramani,P.G., Seija,N., Tabata,M., Maekawa,Y.,
            Mori,Y., Ishifune,C., Itoh,Y., Ota,M., Fujio,K., Di Noia,J.M. and
            Yasutomo,K.
  TITLE     AFF3, a susceptibility factor for autoimmune diseases, is a
            molecular facilitator of immunoglobulin class switch recombination
  JOURNAL   Sci Adv 8 (34), eabq0008 (2022)
   PUBMED   36001653
REFERENCE   3  (bases 1 to 9485)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9485)
  AUTHORS   Knupp,D., Cooper,D.A., Saito,Y., Darnell,R.B. and Miura,P.
  TITLE     NOVA2 regulates neural circRNA biogenesis
  JOURNAL   Nucleic Acids Res 49 (12), 6849-6862 (2021)
   PUBMED   34157123
REFERENCE   5  (bases 1 to 9485)
  AUTHORS   Voisin,N., Schnur,R.E., Douzgou,S., Hiatt,S.M., Rustad,C.F.,
            Brown,N.J., Earl,D.L., Keren,B., Levchenko,O., Geuer,S.,
            Verheyen,S., Johnson,D., Zarate,Y.A., Hancarova,M., Amor,D.J.,
            Bebin,E.M., Blatterer,J., Brusco,A., Cappuccio,G., Charrow,J.,
            Chatron,N., Cooper,G.M., Courtin,T., Dadali,E., Delafontaine,J.,
            Del Giudice,E., Doco,M., Douglas,G., Eisenkolbl,A., Funari,T.,
            Giannuzzi,G., Gruber-Sedlmayr,U., Guex,N., Heron,D., Holla,O.L.,
            Hurst,A.C.E., Juusola,J., Kronn,D., Lavrov,A., Lee,C., Lorrain,S.,
            Merckoll,E., Mikhaleva,A., Norman,J., Pradervand,S., Prchalova,D.,
            Rhodes,L., Sanders,V.R., Sedlacek,Z., Seebacher,H.A., Sellars,E.A.,
            Sirchia,F., Takenouchi,T., Tanaka,A.J., Taska-Tench,H., Tonne,E.,
            Tveten,K., Vitiello,G., Vlckova,M., Uehara,T., Nava,C., Yalcin,B.,
            Kosaki,K., Donnai,D., Mundlos,S., Brunetti-Pierri,N., Chung,W.K.
            and Reymond,A.
  TITLE     Variants in the degron of AFF3 are associated with intellectual
            disability, mesomelic dysplasia, horseshoe kidney, and epileptic
            encephalopathy
  JOURNAL   Am J Hum Genet 108 (5), 857-873 (2021)
   PUBMED   33961779
REFERENCE   6  (bases 1 to 9485)
  AUTHORS   Britanova,O., Lukyanov,S., Gruss,P. and Tarabykin,V.
  TITLE     The mouse Laf4 gene: exon/intron organization, cDNA sequence,
            alternative splicing, and expression during central nervous system
            development
  JOURNAL   Genomics 80 (1), 31-37 (2002)
   PUBMED   12079280
  REMARK    GeneRIF: Alternatively spliced forms encode several forms of
            putative protein with potentially different transactivation
            functions.
REFERENCE   7  (bases 1 to 9485)
  AUTHORS   Gu,Y., McIlwain,K.L., Weeber,E.J., Yamagata,T., Xu,B.,
            Antalffy,B.A., Reyes,C., Yuva-Paylor,L., Armstrong,D., Zoghbi,H.,
            Sweatt,J.D., Paylor,R. and Nelson,D.L.
  TITLE     Impaired conditioned fear and enhanced long-term potentiation in
            Fmr2 knock-out mice
  JOURNAL   J Neurosci 22 (7), 2753-2763 (2002)
   PUBMED   11923441
REFERENCE   8  (bases 1 to 9485)
  AUTHORS   Bassett,D.E. Jr., Boguski,M.S., Spencer,F., Reeves,R., Kim,S.,
            Weaver,T. and Hieter,P.
  TITLE     Genome cross-referencing and XREFdb: implications for the
            identification and analysis of genes mutated in human disease
  JOURNAL   Nat Genet 15 (4), 339-344 (1997)
   PUBMED   9090377
REFERENCE   9  (bases 1 to 9485)
  AUTHORS   Liao,X., Ma,C., Trask,B., Massa,H., Gilbert,D.J., Staudt,L.M.,
            Jenkins,N.A. and Copeland,N.G.
  TITLE     LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12
  JOURNAL   Mamm Genome 7 (6), 467-468 (1996)
   PUBMED   8662235
REFERENCE   10 (bases 1 to 9485)
  AUTHORS   Ma,C. and Staudt,L.M.
  TITLE     LAF-4 encodes a lymphoid nuclear protein with transactivation
            potential that is homologous to AF-4, the gene fused to MLL in
            t(4;11) leukemias
  JOURNAL   Blood 87 (2), 734-745 (1996)
   PUBMED   8555498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132381.4, AC117789.17 and AC138386.7.
            
            On or before Nov 9, 2022 this sequence version replaced
            XM_036162335.1, NM_001290814.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.1504473.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC132381.4         49192-49289
            99-254              AC132381.4         86903-87058
            255-375             AC132381.4         177201-177321
            376-688             AC132381.4         178424-178736
            689-1074            AC132381.4         178856-179241
            1075-1122           AC117789.17        169678-169725       c
            1123-1203           AC117789.17        104903-104983       c
            1204-1240           AC117789.17        93054-93090         c
            1241-1292           AC117789.17        83294-83345         c
            1293-1344           AC117789.17        32892-32943         c
            1345-1385           AC138386.7         2684-2724
            1386-1578           AC138386.7         36910-37102
            1579-2673           AC138386.7         44718-45812
            2674-2798           AC138386.7         47335-47459
            2799-3000           AC138386.7         50274-50475
            3001-3128           AC138386.7         51427-51554
            3129-3192           AC138386.7         61736-61799
            3193-3329           AC138386.7         64058-64194
            3330-3401           AC138386.7         68358-68429
            3402-3495           AC138386.7         69947-70040
            3496-3545           AC138386.7         73701-73750
            3546-3769           AC138386.7         73882-74105
            3770-9485           AC138386.7         75795-81510
FEATURES             Location/Qualifiers
     source          1..9485
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 16.58 cM"
     gene            1..9485
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /note="AF4/FMR2 family, member 3"
                     /db_xref="GeneID:16764"
                     /db_xref="MGI:MGI:106927"
     exon            1..98
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            99..254
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..3891
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /note="lymphoid nuclear protein related to AF4; protein
                     LAF-4; lymphoid nuclear protein 4"
                     /codon_start=1
                     /product="AF4/FMR2 family member 3"
                     /protein_id="NP_001277743.1"
                     /db_xref="CCDS:CCDS69884.1"
                     /db_xref="GeneID:16764"
                     /db_xref="MGI:MGI:106927"
                     /translation="MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRSQETQQDSG
                     SFNSGYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQ
                     TPVNKIDEHFGAESRAQPQPSTVCSTASSTPAAVPVQQGKRGAMGWQKAGHPPSDGQQ
                     RAAQQGSLRTLLGDGVGRQQTRAKQVCNMETGLQTQERPPAMAAKHGGSGHCVQNFPP
                     SLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSTETAVHCTAYRGVPANKPESAR
                     AKAKLAKFSIPKQAEESRSGENNSCVEEIIREMTWLPPLSAIQAPAKVEPSKFPFPNK
                     DSQLVSSGHSNPKKADAEPGSPDNGASNTSTLEDDLKLSSDDEEGEQQAAQRTALRAL
                     ADSSVVQQTNCRGSAPSSKGGGSSSSSGGSSSSSDSESTSGSDSETESSSSSSESEGS
                     KPPHCSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGPERNQYYTPPVKDEGQ
                     DCGKLPEICQASLRDKELKTTCKEEQRPRTANKAPGSKSVKQKSPPAAVAVTAAALPP
                     AVPSAPTESAPAPTRRSAGKKPTRRTERTSAGDGANCHRPEEPVAPDTLGASVVGPLE
                     PPKTRPCGNNRTGHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDL
                     ESEQEEYVLSKAPTTTGSEQRLKEAASSNNNSNSNSSTSRASVGSINARTTSDIAKEL
                     EEQFYTLVPFGRNELLSPLKDSDEVRSLWVKIDLTLLSRIPEHLSQEPGVLSAPSAKD
                     TDSAPASHALDAPAEKTLPKSKRKRKCDNEDDYREIKKVQGRKESASRLAASTNNTLS
                     GNHCNVNVNSLAIPINKNEKMLRSPTSPLSDTCKHKYASEDLTSSSRPHGNGLLTSAS
                     SNKEPKAESQLQTIAGDLTKASHNSSENGTLHSKSRPQTEPWSPGSNGHRDCKRQKLI
                     FDDMPRSADYFMREAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKS
                     PYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVK
                     YSKALIDYFKNSSKAAQAPSPWGSSGKSTGSPSPMSPNPSPASSVGSQGSLSSSSGLS
                     PSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTL
                     HSSMEHLVQYSQQGLHWLRSSVHLS"
     exon            255..375
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            376..688
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            689..1074
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1122
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1203
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1240
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1292
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1344
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1385
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1578
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..2673
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2798
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..3000
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3128
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3192
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3329
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3401
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3495
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3545
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3769
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..9485
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5995..6000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /note="hexamer: AATATA"
     polyA_site      6014
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /note="major polyA site"
     regulatory      6544..6549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /note="hexamer: AATAGA"
     polyA_site      6562
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
     regulatory      9461..9466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
                     /note="hexamer: TATAAA"
     polyA_site      9484
                     /gene="Aff3"
                     /gene_synonym="3222402O04Rik; A730046J16; LAF-4; Laf4"
ORIGIN      
        1 agaacgcttg ccagcgagga gggatccgta cacagaagag agaagccgaa caatttattt
       61 ggaacaggaa aaaaataaaa ccaagagtgt gttgagagcg cgcgggcggc ccgaggctcg
      121 gcagcggcgg cggcggacac ggcggcggcg gacacagcgg cggcggcgga cacggcggcg
      181 gcggcgctga cacctcccac catggacagc ttcgacttag ccctgctcca ggaatgggac
      241 ctcgagtcgc tgtgtgtcta tgaaccggac aggaatgcgt tacggaggaa agagcgagaa
      301 agaagaagtc aagaaacaca gcaggacagt ggcagcttta actccggtta ctcgctcttc
      361 agcgaaccct acaagacgaa caagggggat gaactctcca accggatcca gaatacatta
      421 ggaaattatg atgagatgaa agacttttta actgatagat ccaaccagag tcatcttgtt
      481 ggcgtcccca agccaggtgt ccctcagact cccgtgaaca agatagatga gcattttggg
      541 gcagagtcga gagcccagcc ccagccctca accgtctgca gcactgcgtc ctctacacct
      601 gcagctgtcc ctgtgcagca gggcaagaga ggtgccatgg gctggcagaa ggctgggcac
      661 ccaccgtccg atggccaaca gagagcagcg caacagggct ctctcaggac cttgcttgga
      721 gatggtgttg gcagacagca gacaagggcc aagcaagtgt gcaatatgga gacggggctt
      781 cagacccagg agaggccacc tgcaatggca gccaagcacg gcggcagtgg acactgtgtt
      841 cagaactttc ccccatccct ggcttcaaaa cccagcctgg tgcagcagaa accaactgcc
      901 tacgtgcggc caatggatgg ccaggaccaa gctcctgacg aatctcctaa gctgaagtca
      961 tccacagaaa ctgctgtgca ctgcacagcc tacagagggg tcccggccaa caaaccagag
     1021 tcagcccgag ccaaggccaa gcttgccaag ttcagcatcc ccaagcaggc agaggagagt
     1081 agatctggag aaaacaacag ctgtgtggaa gaaataattc gggagatgac ctggcttcct
     1141 ccactttctg ctattcaagc tcctgccaaa gtggaaccaa gcaagttccc attcccaaat
     1201 aaggactcgc aacttgtatc ctctggacac agtaatccaa agaaagctga tgcggagcca
     1261 gggagtccag acaatggcgc atcgaacact tcaactctgg aagacgacct taagctaagc
     1321 agtgatgacg aagagggtga gcagcaggca gcccagagaa cagctctccg cgctctagct
     1381 gacagctccg tggttcagca gaccaactgt agaggttcgg cgccatccag caagggcggc
     1441 ggcagcagca gcagcagcgg cggcagcagc tcctccagcg actcagagag cacttccggc
     1501 tccgactccg agacggagag cagctccagc tccagcgaga gcgagggcag caagcctccg
     1561 cactgctcca gccccgaggc cgaacctgcg tcctctaaca agtggcagct ggataaatgg
     1621 ctaaacaaag ttaatcctca caagccgcca attctgatcc aaaatgaaag ccacggcccg
     1681 gaaaggaatc aatactacac gccgccggtg aaagatgaag ggcaagactg cgggaaactt
     1741 cctgagatct gccaagccag cctgagggac aaggagctca agaccacctg caaggaggag
     1801 cagaggccga ggaccgcaaa caaggcccct ggcagcaaaa gtgtaaagca gaagtcccca
     1861 cccgctgctg tggctgtgac cgcagctgcc ctcccgcccg cggtgcccag cgcacccacg
     1921 gagagcgcgc ctgcgcccac ccgcaggtca gcaggcaaga agcccacccg gcgcaccgag
     1981 aggacctcag ccggggacgg tgccaactgc caccggcctg aggagccagt ggccccagac
     2041 acgctggggg cgagcgtggt gggaccccta gagcccccca aaaccagacc ctgcggtaac
     2101 aacaggacag gccaccgcaa ggagctgcgc tcctccgtga cctgtgagaa gcggcgcacg
     2161 agggggctga gcagaatcgt ccccaaatcc aaggagttta ttgaaacaga atcttcgtct
     2221 tcctcttcct cctcggactc agacctggag tcagagcaag aggagtacgt cctgtccaag
     2281 gctccgacca ccactgggag cgagcagcgg ctgaaggagg ccgccagcag caacaacaac
     2341 agcaacagca acagcagcac ctcccgggct tctgtgggct ccatcaacgc caggaccacc
     2401 agtgacattg ccaaggagct agaggaacag ttctacacgc tggtcccctt tggcaggaat
     2461 gaactactat ctccgctaaa ggacagcgat gaggtcaggt ctctctgggt caaaattgac
     2521 ctgaccctcc tgtccaggat cccagaacac ctgtcccagg agcctggggt tttgagtgct
     2581 ccttcggcca aggacactga tagtgcccca gccagtcatg cattagacgc tcctgctgaa
     2641 aagactttgc caaaatccaa gaggaaacgc aagtgcgaca acgaagatga ctacagggag
     2701 ataaagaagg tccagggaag gaaggagagt gcctcacgcc tcgccgcctc cactaataac
     2761 accttgtccg gcaatcactg caatgtgaac gtcaacagct tggcaatacc aataaacaaa
     2821 aatgaaaaga tgctccggtc gcccacttcg ccactctcag acacatgtaa acacaaatac
     2881 gccagcgagg acctgacttc ttccagccga cctcacggca acgggttgtt gacttcagcg
     2941 tcttccaaca aagagccaaa ggctgagagt cagctgcaga cgattgctgg ggacctcacg
     3001 aaggcatctc acaacagttc tgaaaatggc accctccata gcaagtcacg gccccagacg
     3061 gagccatggt ctccaggttc caatggccac agggactgca agagacagaa actgatcttc
     3121 gatgacatgc ctcgaagtgc agattatttt atgcgagaag ccaagcggat gaaacataaa
     3181 gcagacgcca tggtggagaa gttcgggaag gccctgaact atgccgaagc tgccttgtcc
     3241 ttcatcgagt gcggaaacgc aatggaacaa gggccaatgg aatccaagtc tccctacacc
     3301 atgtactcgg agacagtgga gctcatcagg tatgctatga gactaaaaac ccactcaggc
     3361 cccaatgcca caccagagga caaacagtta gctgcgcttt gttaccgatg cctggctctc
     3421 ctatactggc ggatgtttcg actcaaaaga gaccatgctg taaaatattc aaaagcactt
     3481 atcgactatt tcaagaattc atcgaaagct gcccaagccc catccccatg ggggtccagt
     3541 ggcaagagca ctggaagccc atcccccatg tctcccaacc cttctcccgc cagctccgtg
     3601 gggtctcagg gcagcctctc cagctccagc ggcctgtccc catcgaccat cgtcagcatc
     3661 ccccagcgca ttcaccagat ggcggccaat cacgtcagca tcaccaacag catcctccac
     3721 agctatgact actgggagat ggctgataac ctggccaagg aaaacagaga gttcttcaat
     3781 gacctggatt tgctcatggg acctgtcacc ctgcacagca gcatggaaca cctggtccag
     3841 tactcccagc aaggcctgca ttggcttcgg agcagcgtac acctgtccta gggaccaagc
     3901 ctttgagcca gactgtgttt tcttctcttc agtggctcaa tgtttccgga cactgtgcta
     3961 ctgacattcc cagcccaaac cacagtgaac atctcagagt ctaacaacga tgtttctctg
     4021 gggtgtgtgt gtttagatgt gggttcgtac aaagctgcct gtgtatgtgt gtaagatcaa
     4081 cagctcatca aaatgtattc cctttgtcta gtttctatga tcccaggcta gacagtgatt
     4141 agaggttcct cattggagaa aacccatgca gtacacacgt gctcacacac tcagacacat
     4201 cctccccgcc agtgctaagc cattgccttc ttggaaagtc ccaccgagat cacatgcatt
     4261 gctgcacctg gtgcactcct gcacctggag agcgtaactg ccggacgagt tgaacctttc
     4321 tcttattatt ggttcctttc agtattatat acaattcccc gattactttt ggttgttgta
     4381 tattaatgag caattgatga gacaagccag ttactttttg tgccagaagt tcactagagt
     4441 gcatgtttcc aaacgccttt cccctcccct actaccctcc ccgacccctc attatctacc
     4501 aaacacataa gccagtggga tcccacaagc gtcccttgcc ttgtccccac atatggcacc
     4561 aggattcggt aaaagctcag caaccccact agcaacggtg gctgttccag ttcggaatga
     4621 aagtcttcac cgggtggcaa tgagtcctgc aggcatagat agtccctctt tctgccactg
     4681 tgactctgtg gctgtggcca gccaacccat ttcaagtctc ttctttctac agtagctttc
     4741 ttgcaaccgt cctcagccaa acgacgacag tgtccagagt gtgccgtccc tagatctggc
     4801 agttgctttg cagactcaga cacactcact gttgtcaccg gcctgattct tgctcgtcac
     4861 acaccatgtg cgactccagg ccttgagtga cattttgact tgggggacat ttttttttca
     4921 agctttcatt aacaagctgc ttacaatgca gggaaagtta tccctgcgat gatcaaaact
     4981 cggtttggag tagcaacaac cagagtatct tgcttttaat cttcgcattt ggtgtgtttt
     5041 tgtcttgacc atgggtcttg tctggtttgt tttggttttg gttttggttt atttgttttt
     5101 ttttaattga gtttgtttta gtttttcagc atctcattta cggtttttgt cagaagtttg
     5161 ttttctcatg tttttttcat ccccaaactt agtcttctta ttaaatatgt gtagatctga
     5221 aatattagta taaagtcctg taaacaaggt acatcttaca acactttaag aacaaaccat
     5281 tgtccttgag ttacttgaca gaactagagc agatcagcca gagggagatc agcaaggcca
     5341 tctgcagacc cctccattgt tcaaggtggc tgaggtgtca caaagtgtgt ctcctttgtc
     5401 tccctgtgag cctgactaca tacacataca catcaccgtc tgtcagcttt gtcagtaggt
     5461 ggcaaataag aatgctctca ttccccagct ccaggagtgg atgcaaaact aggcaaacag
     5521 ttgagcacgg tttggtgatt tgcaccaaag tggattgtag aatttgcatc tatctggctt
     5581 tcgccctcaa acacttgaaa attttagcag tccattgact tcaattgttt gggaccagaa
     5641 ctgtttttat aagacgttag aatatttgtg aatacataat gaggtatctt gggggagagg
     5701 attcaagtct aaacataaat ctcatttatg ttttatagag accctgtaca caggaaaata
     5761 atgtctgcaa tattgattgt aagccatccc aagaggtcag gcatgggatt taccactggt
     5821 atcatagcac tgtacaagag gttttagatt ctggagcaga ttagctttga gattcttgaa
     5881 gtgagaaggt tttacctctg tttccatctt tgtatttatc tatacaccat gctccttgca
     5941 tccctttctc tgactgttgg caggtctgtg atcccatcct gtgtttaaag tctgaatata
     6001 cgaaattgaa tcaccttgtg tgcagcactg cgactttgtt ctagttaccc ttggtgaatt
     6061 ctggcaaaga gttccaactc ttgtgtagag ccgtatcctc aagggtctct gggcaacctt
     6121 ggggagtgtc tctgctcctg cctcgcttta aagttacaag ctcggttgtg acactcacgc
     6181 aatccacatg cctgggaaac cgattaaatt gcaaaggtga cttctggctg attgtaccag
     6241 cacaggtttg accaacacac tgatgaccaa acaaaacttg tagagactgg tctggggtgg
     6301 agctgggggg ctagggggtg tggcacatag gggggtagcg tcacatagtc agagcatgca
     6361 gatcctagtc aagtttcttg ccccatccat ggagcagtga caggcccagt gtagataatt
     6421 ttattaagaa actgtctcgc atctgatggg gctcaatgtt ggtcagtctg gtaaggggcc
     6481 atcttccact tgatgccgtg caagtccatc cacaacatgt tccttgtctg aagttggatt
     6541 gcaaatagaa acatctttct tatgtgtttt ctaaagatct atttatttat tttatgtatg
     6601 agcacactgt agctgtacag atggttgtga gccttcatgt gcttgttgga aattgaattt
     6661 aggacctctg cttgctccgg tctgcctcac tccctccaga agatcattac aagtagttgt
     6721 gaaccaccat gtggttgctg ggatgtgaac tcaggatctt cgtaagagca gtcagtgctc
     6781 ttacctgctg agccatcttg ccagcccctt tcttatgttt tctgactata aaaatcctac
     6841 atgttcatta tagggattca aataatgctg aaatgtagaa gatgcaagcc tgtggttgcc
     6901 tcactcccga gatgaccgtg gctcagtgat gctgtgtctt tccagagagt tttacatgca
     6961 agcataacat ctgtcaccac gtgtttccat tggaagacat actctgacct cagctgtccc
     7021 accaaagtcc agctggtctc ctctcccatg acctgagtag atgcccgcct ctgtcgcaat
     7081 gttagaatga cctttgaaag ggaacagctt agctattcct gagcaagctt tagcattagt
     7141 tgttactctg caggtctcag tctctggtgc agatgtgccc ggagagagat cgcttaaaac
     7201 tggcttttgg agacattcaa atggaaactt ggtcccactc tctgagagga tgcactggaa
     7261 gaatacagtt gtcagtttgt gtgctagatt gaacacctga aatgcaatgc catgagactt
     7321 tctgcactaa aatgtatccc agtatgtgca acaatggtgt gtgtgtgtgt tgtgctgtgg
     7381 agcggtgatg tgtacatctc tgacacccat acagaataga cacagttcat acaaatgcat
     7441 acatttaaaa atatatatgt atcagacagc taacacagaa ctgtagtaca cctgacagat
     7501 aggactagtg cctaatactg agtctaagtc actgcacact cggatcacct tggaagtaca
     7561 gtcattatta tacaatcaac gcagtggtat tatttatgaa tcacatcttt gaaactgtgc
     7621 agtaacagta acatatgcat atattttttt aaataacatt tttcacagtt ttccagcgtt
     7681 actcttgaaa tctgtatcgc caaaaaaaaa aaaaggaaga aagaaaaatg aaaggttttt
     7741 ttaatgatgt agacactctt cagaactagt aattggcata tgatttcctg tttatagata
     7801 ttcaagagac tttagcagtc accagcctta atgcatgtac aggatattat tgtgacttaa
     7861 tttatctgca gtttttaatc catataaaat tggagtttat aaacagacct ggattaaata
     7921 tgtctgcctc tctgaggctg caaacgatac attaaatgat ttatgttgta tgtgagagaa
     7981 accgagttgt acattttaaa aaaaagaaag tttaccagtt tcagttaata ttttacgagg
     8041 aaactttaga acttaaatat tttcaaagca gtattctcat tcccagcttg gaatctcctt
     8101 agaagcaacc ttgttttata aatgttctct tccttccttc cttccttcct tccttccttc
     8161 cttccttcct tgcttctttt ttttctcttt tcctttcttt ctcttttttt ttaatcttag
     8221 gtattgagct tagggcctgg catgtgctat gcaagctgtc cacccctgag ctgtacctcc
     8281 agccctcacc ccttcactga tgctccaatg cagattccat ggttaccatt gttacatcta
     8341 atatttttca atagaactgt agtttcctac ttctgttttc cataccaaaa tacccaaata
     8401 ggtccatatt tctcttctgt ctctgttccc cccccccctc tctctctctc tctctcacac
     8461 acacacacac acacacacac acacaggttc tcctccccct ccttctcccc catatcccaa
     8521 agactgctca tgaggaaagg gcccagtcga tgaggacatg gatggatgcc ttcgagtagt
     8581 agcccggaga tgctgctcta atcgacacat ggcacttgtc tttagtggca cacgtcagtt
     8641 ccatgactac ttgtgccaga cttttccaac tttatctagt ggcattgtgt tttcaatcct
     8701 aagtcaagaa aataagagaa ttctgaatca aagagctgaa gtattaaagc agtggccagg
     8761 acctgttcgg acaaaggtct gtcgatctta ctttgatctt atctccctcc ctcttccttc
     8821 tcctcctccc caagctgaag acgcaggaac aacagaaaca gtatgacctc ttggcctgat
     8881 ccagtccgta tccccaagtt caggcatctt ttccccacca catcatctga cagagtccac
     8941 attgtcaaga gaaaaaacac aggaaaggtt ggacatttca gttcagtcct caacagctga
     9001 gcagcaggaa aggacctctt ggtccccaga ggtagcgagg ataagggact tgtccttact
     9061 agctccgggg gccactgaga gtgatactct ttcagtggtg gactaagaaa tccagcaacc
     9121 ttcccaacca gaagtgcctt tccgttggat aacttaggtg acaccattgg catctcttct
     9181 tatcagaacc ctgttgtaaa atgtatcatc ccatttgcaa tcaagcctag accactggag
     9241 tcttgaaaga caagttcaac tgcggggaga ggctgaccac ataaactgcc ttttcaactg
     9301 tttggaggca ttggaggcag aattttgttt tcctgttccc agaaggacac ctctgtcaaa
     9361 cagcacagag atgtttccgt gtgagggcat tgttctcctg gtccacatca tcgtgtgtgc
     9421 catcagaagg gttaacttgt ttgcctggca tgaggcatgt tataaaactc tattctcaaa
     9481 ctaat
//
