LOCUS       NM_010806               7401 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus afadin, adherens junction formation factor (Afdn),
            transcript variant 1, mRNA.
ACCESSION   NM_010806 XM_890447 XM_911010
VERSION     NM_010806.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7401)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 7401)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7401)
  AUTHORS   Xinyu,W., Qian,W., Yanjun,W., Jingwen,K., Keying,X., Jiazheng,J.,
            Haibing,Z., Kai,W., Xiao,X. and Lixing,Z.
  TITLE     Polarity protein AF6 functions as a modulator of necroptosis by
            regulating ubiquitination of RIPK1 in liver diseases
  JOURNAL   Cell Death Dis 14 (10), 673 (2023)
   PUBMED   37828052
  REMARK    GeneRIF: Polarity protein AF6 functions as a modulator of
            necroptosis by regulating ubiquitination of RIPK1 in liver
            diseases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7401)
  AUTHORS   Hiremath,C., Gao,L., Geshow,K., Patterson,Q., Barlow,H., Cleaver,O.
            and Marciano,D.K.
  TITLE     Rap1 regulates lumen continuity via Afadin in renal epithelia
  JOURNAL   Dev Biol 501, 20-27 (2023)
   PUBMED   37276970
  REMARK    GeneRIF: Rap1 regulates lumen continuity via Afadin in renal
            epithelia.
REFERENCE   5  (bases 1 to 7401)
  AUTHORS   Maruo,T., Mizutani,K., Miyata,M., Kuriu,T., Sakakibara,S.,
            Takahashi,H., Kida,D., Maesaka,K., Sugaya,T., Sakane,A., Sasaki,T.,
            Takai,Y. and Mandai,K.
  TITLE     s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of
            the AMPA receptor and glutamatergic synaptic response in
            hippocampal neurons
  JOURNAL   J Biol Chem 299 (4), 103040 (2023)
   PUBMED   36803960
  REMARK    GeneRIF: s-Afadin binds to MAGUIN/Cnksr2 and regulates the
            localization of the AMPA receptor and glutamatergic synaptic
            response in hippocampal neurons.
REFERENCE   6  (bases 1 to 7401)
  AUTHORS   Ikeda,W., Nakanishi,H., Miyoshi,J., Mandai,K., Ishizaki,H.,
            Tanaka,M., Togawa,A., Takahashi,K., Nishioka,H., Yoshida,H.,
            Mizoguchi,A., Nishikawa,S. and Takai,Y.
  TITLE     Afadin: A key molecule essential for structural organization of
            cell-cell junctions of polarized epithelia during embryogenesis
  JOURNAL   J Cell Biol 146 (5), 1117-1132 (1999)
   PUBMED   10477764
REFERENCE   7  (bases 1 to 7401)
  AUTHORS   Zhadanov,A.B., Provance,D.W. Jr., Speer,C.A., Coffin,J.D., Goss,D.,
            Blixt,J.A., Reichert,C.M. and Mercer,J.A.
  TITLE     Absence of the tight junctional protein AF-6 disrupts epithelial
            cell-cell junctions and cell polarity during mouse development
  JOURNAL   Curr Biol 9 (16), 880-888 (1999)
   PUBMED   10469590
REFERENCE   8  (bases 1 to 7401)
  AUTHORS   Quilliam,L.A., Castro,A.F., Rogers-Graham,K.S., Martin,C.B.,
            Der,C.J. and Bi,C.
  TITLE     M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1,
            and p120 Ras GTPase-activating protein, interacts with the putative
            Ras effector AF6
  JOURNAL   J Biol Chem 274 (34), 23850-23857 (1999)
   PUBMED   10446149
REFERENCE   9  (bases 1 to 7401)
  AUTHORS   Takahashi,K., Nakanishi,H., Miyahara,M., Mandai,K., Satoh,K.,
            Satoh,A., Nishioka,H., Aoki,J., Nomoto,A., Mizoguchi,A. and
            Takai,Y.
  TITLE     Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited
            to cadherin-based adherens junctions through interaction with
            Afadin, a PDZ domain-containing protein
  JOURNAL   J Cell Biol 145 (3), 539-549 (1999)
   PUBMED   10225955
REFERENCE   10 (bases 1 to 7401)
  AUTHORS   Hock,B., Bohme,B., Karn,T., Yamamoto,T., Kaibuchi,K., Holtrich,U.,
            Holland,S., Pawson,T., Rubsamen-Waigmann,H. and Strebhardt,K.
  TITLE     PDZ-domain-mediated interaction of the Eph-related receptor
            tyrosine kinase EphB3 and the ras-binding protein AF6 depends on
            the kinase activity of the receptor
  JOURNAL   Proc Natl Acad Sci U S A 95 (17), 9779-9784 (1998)
   PUBMED   9707552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ165098.1, AF172447.1, CF538789.1, CK637291.1, CN537179.1,
            CN538841.1, BU611478.1, CO433521.1, CN529812.1, BI991173.1,
            BQ929757.1, CB181965.1 and CO042367.1.
            
            On or before Jul 25, 2007 this sequence version replaced
            XM_911010.3, XM_890447.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               CJ165098.1         5-431
            428-1093            AF172447.1         427-1092
            1094-1458           CF538789.1         80-444
            1459-2135           CK637291.1         111-787
            2136-2807           CN537179.1         6-677
            2808-3471           CN538841.1         29-692
            3472-4112           BU611478.1         74-714
            4113-4724           CO433521.1         59-670
            4725-5331           CN529812.1         97-703
            5332-5761           BI991173.1         171-600
            5762-6154           BQ929757.1         212-604
            6155-6740           CB181965.1         180-765
            6741-7401           CO042367.1         1-661               c
FEATURES             Location/Qualifiers
     source          1..7401
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.95 cM"
     gene            1..7401
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /note="afadin, adherens junction formation factor"
                     /db_xref="GeneID:17356"
                     /db_xref="MGI:MGI:1314653"
     exon            1..238
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            239..434
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            435..547
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            548..711
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            712..872
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1030
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1142
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1310
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1355
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1450
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1713
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1783
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1902
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1964
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2170
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2316
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2411
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2677
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2821
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..3020
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3124
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3211
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3277
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3351
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3470
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3665
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3757
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3943
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4939
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5074
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            5075..5357
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            5358..5442
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
     exon            5443..7383
                     /gene="Afdn"
                     /gene_synonym="5033403D15Rik; Af-6; AF6; Afadin; Gm314;
                     I-afadin; Mllt4; S-afadin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgaggcg ggctgaagcg gcgcgggccg gacgcgggcc gagcccggcg gaggacgcgc
       61 ggcggcggcg gcggcggtga ggcggcctgc ggtgttccgg cccggctggc cctggggagg
      121 agcggccgcg atcatgtcgg cgggcggccg cgacgaagag cggcggaagc tggccgacat
      181 cattcaccac tggaacgcca accggctgga cctgttcgag atcagccagc cgaccgagga
      241 tttggagttt catggagtca tgagatttta ttttcaagat aaagctgctg gaaactttgc
      301 aacaaaatgt attcgagtct ctagcacagc caccactcaa gatgtgattg aaacactggc
      361 agagaagttc cgccctgaca tgcgcatgct ctcctctccc aagtactccc tctatgaagt
      421 gcatgtcagt ggagaaagaa gattggacat tgatgagaaa cctctagttg tacagttgaa
      481 ttggaacaaa gatgatcgag agggtcgatt cgtccttaag aacgagaatg acgccattcc
      541 tgccaagaag gctcagagta atggacctga aaagcaggag aaagaaggtg ttattcagaa
      601 cttcaaaaga actctctcaa agaaagaaaa gaaggaaaaa aagaagaaag agaaggaggc
      661 attgagacaa gcctctgata aggaagaaag gccttctcaa ggggatgaca gtgagaactc
      721 acgactggct gctgaagttt acaaagacat gcctgagacc agctttacta ggaccatttc
      781 taaccctgaa gttgtcatga aacggcggcg gcagcaaaaa ctggagaaga gaatgcaaga
      841 gtttcggagc tcagatgggc ggcctgactc aggtggaaca ctgaggatat atgcagatag
      901 tttaaaacca aatattccat acaagacaat cctgctgtct actaccgata ccgcagactt
      961 tgctgtagcc gaatctttgg agaagtatgg tctggaaaaa gagaatccca aggactactg
     1021 tattgcccgg gttatgcttc ctcctggagc ccagcattct gatgagagag gtgctaagga
     1081 aataattctt gacgatgatg aatgtccttt acaaatcttc agggaatggc caagtgacaa
     1141 agggatttta gtctttcagt tgaagaggag accaccggac tacatcccaa agaaaatgaa
     1201 gaaacatgtt gaagggaagt cgttgaaggg gaaagacaga gctgacgggt ctggctacgg
     1261 ctccgctctt cctcccgaga agctgcccta cttagtagag ctaagcccag ggagaaggaa
     1321 tcactttgcc tactacagct atcacactta cgaagatggc tctgactcca gagacaagcc
     1381 aaagttatac cgccttcaat taagtgtgac tgaagttggg acagagaaat ttgatgacaa
     1441 ttctatccag ctgtttggcc ccggaattca gccccatcac tgtgatctca ccaacatgga
     1501 tggagtggtc actgtgacac ccagaagtat ggatgcagag acctacgtgg atggtcagcg
     1561 catctcagag accacaatgc tgcagagtgg catgagactg cagtttggca cctcgcatgt
     1621 gtttaagttt gtggacccca tccaggacca cgttctttcc aagagatctg tggatggagg
     1681 cctgatggtc aagggcccaa gacataaacc tggagctgtt caggagacaa cctttgaatt
     1741 gggaggagat gtccacagtg ggacagcatt gccggcaagc aggagcacta ctagactgga
     1801 cagtgacagg gtgtcctctg cctctagcac agctgagcga gggatggtga agccgatgat
     1861 ccgactggac caggagcagg aatatcgacg acgagaaaac aggactcagg atgctactgg
     1921 gcctgaactg atactgcctg ccagcattga attcagggaa agctctgaag actctttttt
     1981 atctgccatt ataaactata ccaatagttc tacagttcat tttaagttgt cacctacata
     2041 tgtgttatac atggcatgcc ggtatgtatt gtccagccag cacaggcccg acatcagtcc
     2101 tacagagcgt acacataagg ccattgctgt tgtcaacaag atggtgagca tgatggaagg
     2161 ggtcatccag aaacagaaga acattgcagg agcacttgct ttttggatgg caaatgcatc
     2221 tgagcttctc aacttcatca agcaggaccg agaccttagt cggatcacgc tggatgccca
     2281 ggatgtccta gcacacttgg ttcagatggc atttaagtac ttggttcatt gccttcagtc
     2341 agaacttaat aactacatgc cagcctttct ggatgatcct gaggagaaca gtctgcaaag
     2401 accaaaaata gatgatgtgc tgcacacact cacaggagcc atgtccttgc tgcggcgctg
     2461 cagagtcaat gctgccttga ccatccagct cttctctcag cttttccact tcatcaatat
     2521 gtggctgttc aacagactgg tgactgaccc agattcaggc ctgtgctccc actactgggg
     2581 tgccattatc cgccagcagc tggggcatat tgaagcgtgg gcagagaagc aggggctaga
     2641 gctggcagct gactgtcact tgagcagaat tgtacaggct acaacattgc ttacgatgga
     2701 taagtatgta cctgatgaca ttccaaatat aaacagcaca tgctttaagt taaattctct
     2761 gcagcttcaa gccttgttac aaaattacca ctgtgcaccc gatgagcctt ttattcctac
     2821 ggatctcata gaaaatgttg tggctgttgc tgagaacaca gctgatgagc tcgcccgcag
     2881 tgatggcaga gacgtgcagc tggaggaaga cccagaccta cagctgcctt ttcttctgcc
     2941 agaagatggc tattcctgtg atgttgtcag aaacattcca aatggtttac aagaattttt
     3001 agaccctctg tgccagagag gattttgtag attggttcct cacacacgtt caccaggtac
     3061 ctggacaata tattttgaag gagcagatta tgaaagtcac cttatgcgtg agaacgcaga
     3121 actggcccag cctctgagga aggagcctga gataatcact gtgactctga agaagcagaa
     3181 tggaatgggc ctcagcatcg ttgcagccaa gggtgctggc caggataaac tgggaatcta
     3241 cgttaagtcg gttgtcaaag gaggtgctgc agatgtggat ggacgattag ctgctggtga
     3301 ccaactcctc agtgtggatg gacgaagtct ggttggactt tctcaggaaa gggcagcaga
     3361 actcatgaca agaaccagtt ccgtggttac actggaagtt gcaaagcaag gtgccatcta
     3421 tcacggcctg gccaccctcc ttaaccagcc gtcccccatg atgcaaagaa tttcagatcg
     3481 tcgtggctca ggtaaaccca gaccaaagag tgaaggtttt gagctctata ataattcagc
     3541 tcaaaatggc tccccagaga gtcctcagat gccttggaca gagtacagtg agccaaagaa
     3601 actgcctggg gatgacaggc tgatgaaaaa cagagcggac caccgttcca gccccaatgt
     3661 ggcaaatcag cctcctagcc ctggagggaa gggtccatat acatctggaa cagcagctaa
     3721 gataacatct gtctccactg gaaacctctg cactgaggag cagtcccctc cacccagacc
     3781 tgaagcctat cctatcccta ctcagacata caccagagag tattttacct ttccagcttc
     3841 aaagtcgcag gatcggatgg ctcctcctca gagccagtgg ccaaattatg aggaaaaacc
     3901 acatgtgcac acagaaagta atcattccag tattgcaatc cagcgtgtta cccgttccca
     3961 ggaagagctt cgggaagaaa aggtttacca acttgagcgg catcgagtag aggcaggcat
     4021 ggatcgcaag tgtgacagtg atatgtggat caatcagagc tcctcagtgg aatccagcac
     4081 atccagccag gaacacctga accattcttc caagtcagtt acccctgctt ccactctgac
     4141 caagagtggt cctggccgtt ggaaaacacc agcagcggtg ctgcccaccc ctgtggctgt
     4201 ctctcagccc attcgaacag acctccctcc accaccacct ccaccgccgg tccactacac
     4261 cagtgagttt gatggtattc caatggattt gcccctccca cctcctcctg ccaaccaggc
     4321 aggaccccag tctgctcagg tggctgctgc agagtggaaa aagagagagg agcaccagag
     4381 gtggtatgag aaagagaagg cccgcctgga ggaagaacga gagagaaagc gcagggagca
     4441 ggagcggaag ttggggcaga tgcgctctca gaccctgaac cctgcttcct tctcaccttt
     4501 ggccacacag gccaagccag aaaagccttc cacactgcag aggccccaag aaacagtcat
     4561 tcgggagctt cagccccagc agcagccccg cacgatcgag cgcaaggatc tgcagtatat
     4621 aaccatcagt aaagaggagc tgtcctctgg tgatagtctg tctccagacc cctggaaacg
     4681 agatgccagg gagaagctgg agaagcaaca gcaaatgcac attgtggaca tgctaagcaa
     4741 ggagatccac gagctgcaaa acaaggtgga ccgtactgcg gaggagagtg accgcctgcg
     4801 gaagcttatg ctggagtggc agttccagaa gagactacag gagtccaaac agaaggatga
     4861 ggatgatgac gaagaggaag atgatgatgt ggacaccatg ctgatcatgc agcgtctgga
     4921 ggccgagcgg agagccagga tgcaggatga ggagcgcagg cgccagcaac agttggaaga
     4981 gatgcggaaa cgagaagcag aagatcgagt aagacaagag gaagatggac gccatcagga
     5041 ggaggagcga gtaaagagag atgctgaaga aaagaggcga caggaggaag ggtattacag
     5101 ccgcctagaa gctgagaggc gccgacagca cgaagaggca gcacgcaggc tgctggagcc
     5161 tgaagagccc gggctgagcc gacctccact tccacgggac tatgagcccc cgtccttgtc
     5221 ctcagcaccc tgtgcccctc ctcccccacc tcagcgaaac gcatcctacc tcaaaacaca
     5281 ggtcctctcc ccagactcgc tgttcactgc caagtttgtt gcgtatgatg aggaggagga
     5341 ggactacggc ccagcaggac caaactctta ctcgggatct gcaggcacag ctgtgggagc
     5401 ctatgatgcc cctcgggaag cgagagagaa actgactagg agccaagacg cagacttacc
     5461 tggcagttct ggagcccctg aaaatctgac atttaaagag cgtcagcgcc ttttttcaca
     5521 agggcaggat gtgtctgaca aagtgaaagc ttctcgtaaa ttaacagagc tcgagaatga
     5581 actgaacaca aagtgagaag agagaggtct gcccttggcg ggagctttgt gggggcgagc
     5641 ctgaagagga aggaacagtg ctacttctaa gtgatgttta ttttctgtac ctgaaatggt
     5701 tgcaatttag agatgttcca attccaagaa acttcgtttt actttaccaa gaaaaatcct
     5761 gtctagttct ttgtgatctg actcacatga agttacctgt ttctgttagc ttttggggag
     5821 actcttggac tcatagggca gaatgaaggg ctgtaaagat gagggggtat ttcttctacc
     5881 ctatcttctt tcattgtcat tccaagggca gtaggccaag aaattatctt tctggttttt
     5941 ttcctctaaa ctccatttgg ttagcagaca gtgacagctg agcaggtctg agcactactg
     6001 tgtcatagtg gaccctgact gcaggagtca ggcctctcag cccagggcag atgctgcctt
     6061 tatcttctat catttgtatg acgtggctgg atggagtttc ttttgtaagg tgcacaacac
     6121 attcttgaca aatgtgagtc tcctgatcaa tttaaatgtt tgagattgaa tatctaatta
     6181 ataattcaat tttgaaaatt ctcaaaaaaa tttgaggatt taagcctagg gattttattt
     6241 ttataaatac caaatcatca ttagactaat cactggtgga aattaaatat ggcagttatg
     6301 ttaggtttcc taatatttca aaggttccaa aggatctaga gctctctagt tacatagcat
     6361 tcatatagga atgagcagag acatctgaga agagtgggag ctcatgggtg acagtaaaac
     6421 ttaggtgtct cagaacttaa catttagtaa agtgatgtag atccaatgtc aggaaaggaa
     6481 ggactgtgtt actgtgcctc ctctgactca tgtgcttttc agcataatag acttatttaa
     6541 tattaattcc taaactttgc actgtcaatc ctctgctgag ttgtgggagg cagacctcag
     6601 tttgcttgtt ttttgtgaaa gctaacttta tgatttcaag cacactttct acatgagaaa
     6661 cccctaatgt gtgtccatat gatctttctg tacattctat tctcttacaa atctgtgcat
     6721 caggaaaata tgcatacttt caaatagaac agaggtattt gcaacctgaa aaaccacttt
     6781 taataagagc tgtatgataa attgttgaaa tgcaagtgta aatatttttt atgttaatcc
     6841 agtttcctat tagaaagtgt gtctttgcta tttcctctgt aagagaatag aatggccttg
     6901 agagtttatg aaggatttgc acactcgtct tgcctaggaa gtgcaatctc cttgtgactg
     6961 gagcacactg gcagccttca ggtgtcataa tcatacatcc cagagaagag cagtcacctg
     7021 ctgtcactag tgcatgggaa gacagatgca cagaagagcc aggtagcacc tgaaaacgct
     7081 gcacgtgtgt ttgtgaaacc tgtagtgaag tagacttggc cgtccctgga cagtgaggtc
     7141 agatgtgaat acatattgta agagcacgtt gaatagtgtg cattactgtg gggaaacacc
     7201 gaaactgctg ttgtttttca tttctactgt attttagttg cagcctattt ttaataaact
     7261 ttgtatctat ttaagtgtat ttgctattgt tttcaaagtg ctgacaaagt ttatatttgt
     7321 aatgccagca ttcctcttcc ccatttccag ctgtcactcc ttcattaaac tgctgagtca
     7381 ttcaaaaaaa aaaaaaaaaa a
//
