LOCUS       NM_001177797            3915 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus actin filament associated protein 1-like 2 (Afap1l2),
            transcript variant 2, mRNA.
ACCESSION   NM_001177797
VERSION     NM_001177797.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3915)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3915)
  AUTHORS   Sugihara,J., Wong,A., Shimizu,H., Zhao,J., Cho,H.R., Wang,Y.,
            Refetoff,S., Arvan,P. and Liu,M.
  TITLE     Thyroidal Transcriptomic Profiles of Pathoadaptive Responses to
            Congenital Hypothyroidism in XB130 Knockout Mice
  JOURNAL   Cells 11 (6), 975 (2022)
   PUBMED   35326426
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3915)
  AUTHORS   Cho,H.R., Wang,Y., Bai,X., Xiang,Y.Y., Lu,C., Post,A., Al Habeeb,A.
            and Liu,M.
  TITLE     XB130 deficiency enhances carcinogen-induced skin tumorigenesis
  JOURNAL   Carcinogenesis 40 (11), 1363-1375 (2019)
   PUBMED   30820526
  REMARK    GeneRIF: XB130 acts as a tumor suppressor in carcinogen-induced
            skin tumorigenesis that may be mediated through inhibiting
            inflammation.
REFERENCE   4  (bases 1 to 3915)
  AUTHORS   Tanga,N., Kuboyama,K., Kishimoto,A., Kiyonari,H., Shiraishi,A.,
            Suzuki,R., Watanabe,T., Fujikawa,A. and Noda,M.
  TITLE     The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT
            pathway for oligodendrocyte differentiation: Targeted inactivation
            of PTPRZ activity in mice
  JOURNAL   Glia 67 (5), 967-984 (2019)
   PUBMED   30667096
REFERENCE   5  (bases 1 to 3915)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3915)
  AUTHORS   Toba,H., Tomankova,T., Wang,Y., Bai,X., Cho,H.R., Guan,Z.,
            Adeyi,O.A., Tian,F., Keshavjee,S. and Liu,M.
  TITLE     XB130 deficiency enhances lipopolysaccharide-induced septic
            response and acute lung injury
  JOURNAL   Oncotarget 7 (18), 25420-25431 (2016)
   PUBMED   27029000
  REMARK    GeneRIF: we showed that XB130 might play protective roles in
            lipopolysaccharide-induced systemic septic response and acute lung
            injury
REFERENCE   7  (bases 1 to 3915)
  AUTHORS   Zhao,J., Wang,Y., Wakeham,A., Hao,Z., Toba,H., Bai,X.,
            Keshavjee,S., Mak,T.W. and Liu,M.
  TITLE     XB130 deficiency affects tracheal epithelial differentiation during
            airway repair
  JOURNAL   PLoS One 9 (10), e108952 (2014)
   PUBMED   25272040
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3915)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 3915)
  AUTHORS   Bouma,G.J., Hudson,Q.J., Washburn,L.L. and Eicher,E.M.
  TITLE     New candidate genes identified for controlling mouse gonadal sex
            determination and the early stages of granulosa and Sertoli cell
            differentiation
  JOURNAL   Biol Reprod 82 (2), 380-389 (2010)
   PUBMED   19864314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB849668.1, AC161518.3, AK220430.1 and BB064561.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in
            an isoform (2) that is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220430.1, SRR17253014.5144951.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                BB849668.1         2-70
            70-377              AC161518.3         52450-52757
            378-3909            AK220430.1         1-3532
            3910-3915           BB064561.1         242-247
FEATURES             Location/Qualifiers
     source          1..3915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 52.04 cM"
     gene            1..3915
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /note="actin filament associated protein 1-like 2"
                     /db_xref="GeneID:226250"
                     /db_xref="MGI:MGI:2147658"
     exon            1..425
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..2887
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /note="isoform 2 is encoded by transcript variant 2;
                     AFAP1-like protein 2"
                     /codon_start=1
                     /product="actin filament-associated protein 1-like 2
                     isoform 2"
                     /protein_id="NP_001171268.1"
                     /db_xref="CCDS:CCDS50476.1"
                     /db_xref="GeneID:226250"
                     /db_xref="MGI:MGI:2147658"
                     /translation="MERYKALEQLLTELDDFLKVLDQENLSSAAVLKKSGLSELLRLY
                     TKSSSSDEEYIYMNKVSVNGEQNSASPDKVPEEQGPLTNGEPSQHSSAPQKSLPDLPP
                     PKMIPERKQPTVPKIESPEGYYEEAEPFDRSINEDGEAVSSSYESYDEDENSKGKAAP
                     YQWPSPEASIELMRDARICAFLWRKKWLGQWAKQLCVIRDTRLLCYKSSKDHSPQLDV
                     NLRGSSVVHKEKQVRKKGHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEG
                     ASEGNQYTPDAQRLNCQKPDIAEKYLSAAEYGITINGHPEIPETKDVKKKCSAGLKLS
                     NLMNLGRKKSTSLEPPERSLETSSYLNVLVNSQWKSRWCFVRDSHLHFYQDRNRSKVA
                     QQPLSLVGCDVLPDPSPDHLYSFRILHNGEELAKLEAKSSEEMGHWLGLLLSESGSKT
                     DPEELTYDYVDAERVSCIVSAAKTSLLLMQRKFSEPNTYIDGLPSRDCQDDLYDDVEV
                     SELIAVVEPAEEAAPAVDANSGSEPDRVYLDLTPVKSFLHSSSEAQAQASLPAVPHQD
                     DVAETLTVDPKPGTTPEEPHTESPGDPEVQQRQPEVQESSEPIEPTPRITMVKLQAEQ
                     QRISFPANCPDTMASAPIAASPPVKEKLRVTSAEIKLGKNRTEAEVKRYTEEKERLER
                     SKEEIRGHLAQLRREKRELKETLLRCTDKGVLAKLEQTLKKIDEECRMEESRRVDLEL
                     SIMEVKDNLKKAEAGPVTLGTTVDTTHLDNMSPRPQPKAATPNPPPDSTPVNSASVLK
                     NRPLSVMVTGKGTVLQKAKEWEKKGAS"
     exon            426..554
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            555..629
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            630..724
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            725..815
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1021
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1201
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1291
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1376
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1481
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1693
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1839
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1951
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2200
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2381
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2537
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2731
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2860
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..3915
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3893..3898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /note="hexamer: AATAAA"
     polyA_site      3910
                     /gene="Afap1l2"
                     /gene_synonym="mKIAA1914"
                     /note="major polyA site"
ORIGIN      
        1 agtctcaaca ctggagaaaa cagatcttgg tggagaccta cgggagctcg ctgttcccgg
       61 agtcttcccc gggctttgag gacgtcccag gctctttctt tcgcgccgcc gccctcgggc
      121 caacttggag gaagtgatct gcgttcggga cggggagccc agtgcggggt gcgtgaggac
      181 cagagcgctg attgtcctga ccggctgtgg agatccctgg cggggtccag ggcggctcgg
      241 gtggagtcag gatcggaggg ctaggggcgc ggcggccact ccgggaggtc gggcggcgag
      301 cgtgacttca ctgggagggg ccagcgctca gcgggggcgc ggagcccagc gcggagtcca
      361 gcgcggagaa ctcagcgcgg agccgatagc agcgcacacc gtgcccggga tggagcgcta
      421 caaagccctg gagcagctgc tgacagagct ggacgacttc cttaaggtcc tcgaccagga
      481 gaacctgagc agtgcagccg tgctgaagaa gagcggcctg tcagagctcc tgcggcttta
      541 caccaagagc agcagttctg atgaggagta tatttacatg aacaaagtgt cagtcaacgg
      601 ggaacaaaac tcagcatctc cagacaaagt tcccgaggag cagggtccac tgaccaatgg
      661 ggagcccagc cagcattcct cagcccctca gaagagcctt ccagacctcc ctccgcccaa
      721 gatgattcca gagaggaaac agcccaccgt tccaaagatc gagtcccctg agggctacta
      781 tgaagaggct gagccatttg acagatccat caatgaggat ggagaggctg tgagcagctc
      841 ctacgagtcc tacgatgagg acgagaacag caaaggcaag gctgccccct accagtggcc
      901 ctcgcccgag gccagcattg agctgatgcg tgatgcccgc atctgtgcct tcctgtggcg
      961 caagaagtgg ctaggccagt gggccaagca gctctgtgtg atcagggaca ccaggctctt
     1021 gtgctacaaa tcgtccaaag accacagtcc tcagctggac gtgaacctgc ggggcagcag
     1081 cgtcgtgcac aaggagaagc aagtgcggaa gaaaggacac aagctcaaga tcacaccgat
     1141 gaacgctgac gttatcgtgc tgggcctgca gagcaaggac caagctgagc agtggcttcg
     1201 ggtcatccag gaggtgagtg gcctgccttc tgaaggagcc tcagagggaa accagtacac
     1261 accagatgcc cagcgcctca actgtcagaa accagacata gctgagaagt acctgtcagc
     1321 agcggagtac gggatcacca tcaacggcca ccctgagatc ccagagacca aagatgtcaa
     1381 gaagaaatgc tctgctggcc tcaagctgag caaccttatg aacctgggca ggaagaaatc
     1441 tacctcgctg gagcccccgg agagatccct tgagacatcc agctacctga atgtgctggt
     1501 gaacagtcaa tggaagtcac gctggtgctt cgttagagac agccacctgc acttctacca
     1561 ggaccggaac cggagcaagg tggcccagca gcccctcagc ctggtgggct gtgacgtgct
     1621 tccagatcct agccccgacc acctgtattc cttccgtatt ctccacaacg gcgaggagct
     1681 agccaagctt gaggccaagt cttcagagga gatgggccac tggctaggcc tcctgctctc
     1741 agagtcgggc tccaagactg acccggaaga gctcacctac gactatgtgg atgctgaaag
     1801 ggtttcctgt attgtgagtg cggccaaaac ctctctctta ctgatgcaga gaaagttctc
     1861 agagcccaac acatacatcg atggcctgcc cagccgggat tgccaggacg atctgtatga
     1921 tgatgtggag gtatcagagc tgatagccgt ggtggagcct gccgaggaag ccgcccctgc
     1981 tgtcgatgct aacagtggta gtgagccaga cagagtctac ctggatctca caccggtcaa
     2041 gtccttcctg cacagtagca gtgaggctca ggcgcaggcc tctctcccag cagtgccaca
     2101 tcaggacgat gtagctgaga ccctcacagt agacccaaag ccaggcacca ccccagagga
     2161 gccccacaca gagtctccag gagacccaga ggtgcagcag aggcaaccag aggttcaaga
     2221 gtcttcagag cctatcgagc ccaccccgcg aatcaccatg gttaagctac aggccgagca
     2281 gcagagaatc tccttcccag ccaactgccc agacaccatg gcttctgccc ccatcgctgc
     2341 cagcccacct gtgaaggaga agctgagagt gaccagtgca gagatcaaac ttgggaagaa
     2401 tcggacagag gcggaagtaa agcggtacac ggaggagaag gagaggctgg agaggagcaa
     2461 ggaggagatc cgagggcacc tggctcagct ccgcagagag aagcgggagc tcaaagagac
     2521 cctgttgaga tgcacagata agggggtcct ggccaagctg gagcagacac tgaagaaaat
     2581 agacgaggaa tgccggatgg aggagagcag gcgtgtggac cttgagctca gcatcatgga
     2641 ggtgaaggac aacctgaaga aggcagaggc tgggcccgtg accctgggca ccactgtgga
     2701 taccacgcac ctggacaaca tgagccctcg tccacagccc aaagctgcca cccccaaccc
     2761 cccaccagac tccacgccag tcaactctgc atctgtgctc aagaacaggc ctctttccgt
     2821 catggtcaca ggcaaaggca ctgtcctgca gaaagccaag gaatgggaga agaaaggagc
     2881 cagttaggag acaagaattg cctaaagact cttatgtgac tgtggacctt ggtgacaatc
     2941 ctgctctgga caagtcttca ataaaacagc aactctgagg aaaggtgagt ctgtttacaa
     3001 gacaaagcaa gggatgaggc gctcgctgca aacggagctt cggttaagag aaggccctgt
     3061 ctcctcctca agccaaaggg atcccagcag cagcatcgtg gtggcatctt tggagtcgaa
     3121 atctactggc tgtcaatgag acaatgtacc ttcccttttc tttttaaaga tttcatccat
     3181 cactcaactg ttttaccaag atttttcagg tgtgaaaaaa tgaccacatt gcttctggtt
     3241 atgagaaaaa tctaaattcc tgaccccctt atctttcatc ctgtatttgg caatgttgag
     3301 gtttaaatca tgcattgtct tcatgtttgc ccaaattggg tgggctccat gtggtctctg
     3361 atggtcttaa agaacattag aaccctgtaa tcagtagaag agggacatat tgggaaccaa
     3421 gccaaggcac tgaccccctt ggggtcacta aggacttccc cccagtccag gaaaacttta
     3481 aacaatgctg tattatatag ggggaaaatt cctgtgttta cagactgtcc tgtggccagg
     3541 ccacttttaa gagttggtca attacctctt cattaccatt gtaaagatgt tttaaatttc
     3601 tggtcccctt gcaaggaaaa cagccgtgaa ttagcctgtc tagtctgtca gactggcagc
     3661 cagtgctgtc tttatgtgct gtctctctgg gacagcacta gcacaagttg atacatttca
     3721 tctgttacct gccccatttc tgagcatttg gaactagtta cctaacactg gtttctgaag
     3781 gctaaatgtt tttacgcata tattattgtc tttctaatcc cagggcattt atttcctgta
     3841 tcataaacac ttggtgacct ttatcaagtg gtgagttaga attttttttt taaataaaat
     3901 gttcattgta ttttg
//
