LOCUS       NP_001390348             820 aa            linear   ROD 12-JUN-2024
DEFINITION  actin filament-associated protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_001390348 XP_006504161
VERSION     NP_001390348.1
DBSOURCE    REFSEQ: accession NM_001403419.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 820)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 820)
  AUTHORS   Cunnick,J.M., Kim,S., Hadsell,J., Collins,S., Cerra,C., Reiser,P.,
            Flynn,D.C. and Cho,Y.
  TITLE     Actin filament-associated protein 1 is required for cSrc activity
            and secretory activation in the lactating mammary gland
  JOURNAL   Oncogene 34 (20), 2640-2649 (2015)
   PUBMED   25043309
  REMARK    GeneRIF: These data define, for the first time, the requirement of
            AFAP1 for the spatial and temporal regulation of cSrc activity in
            the normal breast, specifically for milk production.
REFERENCE   3  (residues 1 to 820)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   4  (residues 1 to 820)
  AUTHORS   Elsen,G.E., Hodge,R.D., Bedogni,F., Daza,R.A., Nelson,B.R.,
            Shiba,N., Reiner,S.L. and Hevner,R.F.
  TITLE     The protomap is propagated to cortical plate neurons through an
            Eomes-dependent intermediate map
  JOURNAL   Proc Natl Acad Sci U S A 110 (10), 4081-4086 (2013)
   PUBMED   23431145
REFERENCE   5  (residues 1 to 820)
  AUTHORS   Xu,X., Harder,J., Flynn,D.C. and Lanier,L.M.
  TITLE     AFAP120 regulates actin organization during neuronal
            differentiation
  JOURNAL   Differentiation 77 (1), 38-47 (2009)
   PUBMED   19281763
  REMARK    GeneRIF: These results indicate that AFAP120 plays a role in
            organizing dynamic actin structures during neuronal differentiation
            and suggest that AFAP120 may help regulate the transition from
            motile precursor to morphologically differentiated neurons.
REFERENCE   6  (residues 1 to 820)
  AUTHORS   Walker,V.G., Ammer,A., Cao,Z., Clump,A.C., Jiang,B.H., Kelley,L.C.,
            Weed,S.A., Zot,H. and Flynn,D.C.
  TITLE     PI3K activation is required for PMA-directed activation of cSrc by
            AFAP-110
  JOURNAL   Am J Physiol Cell Physiol 293 (1), C119-C132 (2007)
   PUBMED   17360811
  REMARK    GeneRIF: Actin filament associated protein-110 (AFAP) colocalizes
            with cSrc to promote cSrc activation and cell migration.
REFERENCE   7  (residues 1 to 820)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   8  (residues 1 to 820)
  AUTHORS   Gatesman,A., Walker,V.G., Baisden,J.M., Weed,S.A. and Flynn,D.C.
  TITLE     Protein kinase Calpha activates c-Src and induces podosome
            formation via AFAP-110
  JOURNAL   Mol Cell Biol 24 (17), 7578-7597 (2004)
   PUBMED   15314167
  REMARK    GeneRIF: Data suggest that one major function of AFAP-110 is to
            relay signals from protein kinase C alpha that direct the
            activation of c-Src and the formation of podosomes.
REFERENCE   9  (residues 1 to 820)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (residues 1 to 820)
  AUTHORS   Clump,D.A., Clem,R., Qian,Y., Guappone-Koay,A., Berrebi,A.S. and
            Flynn,D.C.
  TITLE     Protein expression levels of the Src activating protein AFAP are
            developmentally regulated in brain
  JOURNAL   J Neurobiol 54 (3), 473-485 (2003)
   PUBMED   12532398
  REMARK    GeneRIF: In E16 mouse embryos, AFAP expression levels concentrated
            in the olfactory bulb, cortex, forebrain, cerebellum, and various
            peripheral sensory structures.In P3 mouse pups, overall expression
            was reduced. (AFAP-110)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141898.3 and AC127275.4.
            
            On Mar 30, 2022 this sequence version replaced XP_006504161.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.690174.1,
                                           SRR7652917.87963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 19.02 cM"
     Protein         1..820
                     /product="actin filament-associated protein 1 isoform 1"
                     /note="AFAP-110; 110 kDa actin filament-associated
                     protein"
                     /calculated_mol_wt=89933
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q8N556; propagated from
                     UniProtKB/Swiss-Prot (Q80YS6.1)"
     Region          56..90
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80YS6.1)"
     Region          70..73
                     /region_name="SH3-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80YS6.1)"
     Region          93..96
                     /region_name="SH2-binding 1. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80YS6.1)"
     Region          118..139
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80YS6.1)"
     Region          142..248
                     /region_name="PH1_AFAP"
                     /note="Actin filament associated protein family Pleckstrin
                     homology (PH) domain, repeat 1; cd13306"
                     /db_xref="CDD:270116"
     Region          252..318
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80YS6.1)"
     Site            283
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80YS6.1)"
     Site            284
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80YS6.1)"
     Region          348..448
                     /region_name="PH2_AFAP"
                     /note="Actin filament associated protein family Pleckstrin
                     homology (PH) domain, repeat 2; cd13307"
                     /db_xref="CDD:270117"
     Region          452..457
                     /region_name="SH2-binding 2. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80YS6.1)"
     Region          <641..>738
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..820
                     /gene="Afap1"
                     /gene_synonym="2600003E23Rik; 9630044L16Rik; Afap;
                     mKIAA3018"
                     /coded_by="NM_001403419.1:175..2637"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:70292"
                     /db_xref="MGI:MGI:1917542"
ORIGIN      
        1 meelivelrl flelldheyl tstvrekkav ltnillrlqs skgfevkdha qkaeannlpa
       61 ppqmplpeip qpwlppdsgp pplptsslpe gyyeeavpls pgkapeyits nydsdamsss
      121 yesydeeeed gkgkktrhqw pseeasmdlv kdakicafll rkkrfgqwtk llcvikdtkl
      181 lcyksskdqq pqmelplqgc sityiprdsk kkkhelkitq qgtdplvlav qskeqaeqwl
      241 kvikeaysgc sgpvdpecsp ppstsapvnk aelekklsse rpssdgeggv engvttcngk
      301 eqakrkkpsk seakgtvskv tgkkitkiig lgkkkpstde qtssaeedvp tcgylnvlsn
      361 srwrerwcrv kdsklilhkd radlkthlvs iplrgcevip gldskhpltf rllrngqeva
      421 vleasssedm grwigillae tgsstdpgal hydyidvems anviqtakqt fcfmnrravs
      481 tspylgslsn gyahpsgtal hyddvpcvng swdmdggfpg cvsrgpveev lydnaglydn
      541 lpsptifars spadrrasrp ptdrlssnhy ksptscsppc spsvtntssv graslglhsq
      601 lknkkppass ngvpvkgkap ssqqkkveta ggvkrtasna eqykygknrv eadakrlqsk
      661 eeellkrkea lrnrlaqlrk erkdlraaie vnagrktqaa ledklkrlee eckqreaerv
      721 sleleltevk eslkkalagg vtlglaiepr sgtsspqspv frhrtlensp isscdtsdae
      781 gplpvnsaav lkksqpssgs spcrghvlqk akewelkngt
//
