LOCUS       NM_026531               4956 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus apoptosis enhancing nuclease (Aen), transcript variant
            1, mRNA.
ACCESSION   NM_026531
VERSION     NM_026531.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4956)
  AUTHORS   Bizen,N., Bepari,A.K., Zhou,L., Abe,M., Sakimura,K., Ono,K. and
            Takebayashi,H.
  TITLE     Ddx20, an Olig2 binding factor, governs the survival of neural and
            oligodendrocyte progenitor cells via proper Mdm2 splicing and p53
            suppression
  JOURNAL   Cell Death Differ 29 (5), 1028-1041 (2022)
   PUBMED   34974536
REFERENCE   2  (bases 1 to 4956)
  AUTHORS   Tiu,G.C., Kerr,C.H., Forester,C.M., Krishnarao,P.S.,
            Rosenblatt,H.D., Raj,N., Lantz,T.C., Zhulyn,O., Bowen,M.E.,
            Shokat,L., Attardi,L.D., Ruggero,D. and Barna,M.
  TITLE     A p53-dependent translational program directs tissue-selective
            phenotypes in a model of ribosomopathies
  JOURNAL   Dev Cell 56 (14), 2089-2102 (2021)
   PUBMED   34242585
REFERENCE   3  (bases 1 to 4956)
  AUTHORS   Ulmke,P.A., Xie,Y., Sokpor,G., Pham,L., Shomroni,O., Berulava,T.,
            Rosenbusch,J., Basu,U., Fischer,A., Nguyen,H.P., Staiger,J.F. and
            Tuoc,T.
  TITLE     Post-transcriptional regulation by the exosome complex is required
            for cell survival and forebrain development via repression of P53
            signaling
  JOURNAL   Development 148 (3) (2021)
   PUBMED   33462115
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4956)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031972.1 and AC138376.11.
            
            On Feb 10, 2018 this sequence version replaced NM_026531.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 both encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031972.1, AK167658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AK031972.1         2-63
            63-63               AC138376.11        131223-131223       c
            64-589              AK031972.1         65-590
            590-590             AC138376.11        124481-124481       c
            591-2580            AK031972.1         592-2581
            2581-4956           AC138376.11        116003-118378       c
FEATURES             Location/Qualifiers
     source          1..4956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 44.83 cM"
     gene            1..4956
                     /gene="Aen"
                     /gene_synonym="2700083B06Rik; Isg20l1"
                     /note="apoptosis enhancing nuclease"
                     /db_xref="GeneID:68048"
                     /db_xref="MGI:MGI:1915298"
     exon            1..88
                     /gene="Aen"
                     /gene_synonym="2700083B06Rik; Isg20l1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..689
                     /gene="Aen"
                     /gene_synonym="2700083B06Rik; Isg20l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1163
                     /gene="Aen"
                     /gene_synonym="2700083B06Rik; Isg20l1"
                     /EC_number="3.1.-.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interferon stimulated exonuclease gene 20-like 1;
                     interferon-stimulated 20 kDa exonuclease-like 1"
                     /codon_start=1
                     /product="apoptosis-enhancing nuclease isoform 1"
                     /protein_id="NP_080807.3"
                     /db_xref="CCDS:CCDS39988.2"
                     /db_xref="GeneID:68048"
                     /db_xref="MGI:MGI:1915298"
                     /translation="MVAGEVPESTQCPSLTSLNTKDVVRRRHKRRSRQHQRFMARKAL
                     LQEQELLSTAPGPGLCLLPSPSQMPAVTEASDSRRQRPKARSGSNGLCSKKSVPREAP
                     RPGPIKCVAIDCEMVGTGPQGRVSELARCSVVSYSGDVLYDKYIRPEMPIVDYRTRWS
                     GITRQHMHKAIPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPN
                     LLSQPSSLIRTRVSLKDLALNLLHKKIQVGHQGHSSVEDAMTAMELYQLVEVQWEQQV
                     ASSAQAPAEDRGPDSSTDVEQYMDDQYWPEDLTQSTGAETNGGPDRQEGEEGQGARSA
                     PP"
     exon            690..890
                     /gene="Aen"
                     /gene_synonym="2700083B06Rik; Isg20l1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..4956
                     /gene="Aen"
                     /gene_synonym="2700083B06Rik; Isg20l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgaagcc gggcttgtcc gggcaaggag cttccgcacc cggcaagggt tccacgtgaa
       61 acctgggaaa gcgcggccgg gttttcagca cactgcccca ttggcagaca gcctccagag
      121 ctgttcttac cccaacctgt gagctggctg acatggtggc aggggaagtc cccgagtcta
      181 ctcagtgtcc atctctcacc agcctgaata ccaaggatgt ggttcggaga agacacaaga
      241 ggagaagccg gcagcaccag cgattcatgg cccgcaaggc cttgcttcag gagcaggagc
      301 tgttgagcac ggcaccaggg ccaggtctct gccttctgcc ttcaccatca cagatgccag
      361 cggtcacaga ggcttcggac agcaggaggc aacgtcccaa ggccaggtcc ggcagcaatg
      421 gcctgtgcag caaaaagtct gtccccagag aagctccaag acctgggccc atcaagtgtg
      481 tggccattga ctgtgagatg gtgggtacgg gcccccaagg acgggtgagc gagctagccc
      541 gctgctctgt ggtgagctac agtggtgacg ttctctatga caaatacatc cggcctgaaa
      601 tgcccattgt ggactatcgc acccgctgga gtggcatcac ccgccagcac atgcacaagg
      661 ctatcccctt tcaggtggcc cagaaggaga tccttaagct gttgaagggc aaggtggtgg
      721 tggggcacgc actgcacaat gacttccagg ccctgaagta cgtccaccct cggagccaga
      781 cccgggatac cacttatgtc ccaaacctgc tcagccagcc cagctccctt atccgaactc
      841 gggtctctct taaggacctg gccttgaacc tgctgcacaa gaagatccag gtcggtcacc
      901 agggccactc atctgtggaa gatgccatga cagccatgga gttgtaccag ctggtggagg
      961 tgcagtggga gcagcaagtg gccagctctg cccaggcccc tgctgaggac agggggcccg
     1021 acagcagcac tgacgtggag cagtacatgg acgaccagta ctggcccgag gacctgaccc
     1081 agagcaccgg ggccgagaca aatggaggcc cagatagaca ggagggagag gaagggcagg
     1141 gagccaggag tgctcctccc tagtcacggg gtaggattgg agttctaagg cagtgtttct
     1201 caaaacctga gggtcaggac tcctttatgg gtttaaagct tttcacaggg gtcgcctaag
     1261 accatcggaa gacacagctg tgtacgttat gattcataac tagcaaaatt agagttatga
     1321 agtagcaaca gaaataattt tattttttgg ggggggtctc cacagcatga ggaactgtaa
     1381 taaagggttg cagcattagg aaggtggaaa gccactggtc tggggtaact taagggcact
     1441 ggtaggcaaa ggctcaggtc acaccaccct ctgacagtct catcattcct gacacttaac
     1501 atggagacac tagacaagcc tgtggctttc ccagtgtaaa gtgggaagag tggcagagcc
     1561 tacctcatgg ggtgtgtctt agcactctga gtgtatccta gtgataaaca ggatggggct
     1621 ctgttcaggc ctggtttctg agcagctatt gctcaggtag gtctcttggc ttttccatcg
     1681 gatgaggtgg ggcccagggc aagggtattg caggggagtt cagaggtctt gctgccagct
     1741 tctatctcca catcagcctc ctgacactgc atttggaaac gtgacaacag taatccaggt
     1801 cagaaatgaa gggatgctac tgagaccaca cttcccactg tccactgatt acagaaagcg
     1861 ttagttagtc acggattgtt tgatttctgg ctcctccctg ccagggaaag ggggctggcc
     1921 aaatcatcac cactacttct ggcctggcac cagggtgagc tcttgtttcc ttaaaaagca
     1981 gccacttgcg ccagccttga tactgggcag tagcattggt gggttgaagg gtgaaagaac
     2041 tgtaagctgg gagaggctta ctgggagaag tcagcttgct catagtacca gaccatcggc
     2101 ataggaataa agtgcatctg gaaaagtgag tgaactggtc ctttctggat gctcaagctg
     2161 ggctgaaggt gtgtgaggcc agggaaggcc cagggctctg agccttgctg gatgctcgtc
     2221 ttgagatgca tttcaagatg gtacacgtta gctctacagc agtttctgac ttcagttgga
     2281 gttggctatt acacagcaca ctgtttgatt tggtctctcc ccaaagctag gctttcacat
     2341 tagaaagtgt ttggtttttt gccattgaaa cataatctca tggtagagtc cagcttctgt
     2401 aactccttat ggaactcagg cgatcctcct gccttagccc acccagggtt ggcattgtga
     2461 gcatatactg tctttcctgt aagactgccc tttaggacta agtcctttgt gtataatgtt
     2521 agtcacacgt tcggtcactt cctctcttgc tattgtgaat aagatagccg tatatatggt
     2581 atgcagatat gttaccctgt tttcaagtcc tttacccagg aggggaattg ttgggcaggg
     2641 agtgtggcgt catctggaaa aggagcctga caggatccga gggtaaagct gctgttccct
     2701 aactaaaagg ctagacctat atttgcatag cagcttgatt cacagataat gtagaaagca
     2761 gacttaatga ttccaagagg gttttaaccc attttagccc tgtttttcaa catccagaat
     2821 gaaagagata atcaacttta ttacagtatt tttctttgac acaaaagcag taaaagccca
     2881 gcaagcatct aggtccgcat tgctttctga ggttcagcaa ccccacccgg tgtcccttta
     2941 catttcctcc ttcaagctgt cagcctttgt ggtcagaggt gtcagacact ggggcatgat
     3001 gcagtgtttg tgccaggtag catagtaagc agggagctta tcgcacccct ctgtgcctca
     3061 gccttacaat atggcctgtt ctgcgctccc ccaagggaga gtcctgctgt cttacccttc
     3121 tttcattcta ccgcgccatc ttaatccctt ccatgtgtgc tcctcctgta tatggcagag
     3181 gggatcgagc cagttcttaa cagtttgctc ctcatggggc tttccagatc ttgctgttca
     3241 ccctgtaagt cacgtacgca gagaaacgac tgttttgtac ttaggactga acgcttgccc
     3301 ttaactgcca aggcctcaga ctctgggtct gggcacattg tttctctgga ttgtgtgttc
     3361 tcagatggta agtgcatgag agttctggaa ccatctttgt tggtgcaaac aagggcacaa
     3421 aggagattct ttgtaggagt aggcagttat catgctgtat ggtcccaccg tggtacagag
     3481 tttttccaaa gaatgcgttg gtttagagac tgccattgcc attgtacaca ttcacatcct
     3541 ctgccagact gcgacaggcg tccccaaagg cagaagcgta aggaaactcc aacacagtga
     3601 gcatcatcaa ggatgagagc aggatgctgg agaactgacc cgaaatgtcc atggatgcca
     3661 ggactttgtc aagcagcagc ggtcaccaca ccgtctacac caaggaaccg tcactttccc
     3721 acagtaaccg agtttccatt ctcatcaaca gttcacaagg atttcagttt tagaggaagg
     3781 gtcacaccat ttgacctagg ttgacttgga atttgtggtg attctcctgc cttggcctcc
     3841 ctttaagacc gaccgttgag cttgtagggc aggttgcctc tagggagaag tgcctctgat
     3901 gcggttaatt gtttaaggct gttttgtatt ctataacaaa acacctgagg gacgtgcttg
     3961 atgaagactt agataaagca cagccatggc aattggaaag caaggtgctg gtctgcaggg
     4021 ctttgctgag ggcccctata gtggatgatg tgaaaacaaa catatgtgca aaagacgaca
     4081 tggcaaggca ggaggcttgg acagtgaacc actcttaagc catttgcaca gtgataaata
     4141 gggattagaa aaagccatcc agtagctgcc tcctgtgagc tacaggcatg atgggtgagc
     4201 agctgatggg atgtgtcctt ggaaggctga caagtttgcc cagagtgact cttgctgtca
     4261 cttgatcact gcctgtggac ctggcttgct gtttgatgct gtcaggggaa gctggaaacg
     4321 aaccccacta cctggggtca gggcttcccc cttcaggact gttaataccc agtacctgga
     4381 tccagcaaaa agcactgtat tcttggacaa acgttcagca taattcaggc agggttctgg
     4441 gagctgaggc ccagctctga ggaaccacaa gagggcaaat ggaaggcgca ctatgactgc
     4501 ttgtggtata acagaaaagg atagggctgg agactgcttt taaggagagg acaggaggtg
     4561 cgcttacaca gagaggcctg gagggggagt tgccaagcag atgatgcagg tgtagtctcc
     4621 tggcctttgg acaaaatcgc ctctatctgg atcagctgtg cctgtttaca gttctgctca
     4681 ttgactattg atagcccctc ccagggggag tctgagattt cagctgctgc ctcagccatt
     4741 tgtatgcagt tctgccctgc ctgcgtggga tctgggctca gacaatggta atgtatataa
     4801 gcaagggaag cttgctgcca agctaagcta cagggatgcc accaccatcc acactagatg
     4861 aagacttacc agtgtgtgtt tgatgtcctt ccgggcttct ataagtagcc tctcacgcag
     4921 gctccataag taagcccaat aaattcattg gtcccc
//
