LOCUS       NM_009637               2738 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus AE binding protein 2 (Aebp2), transcript variant 3,
            mRNA.
ACCESSION   NM_009637
VERSION     NM_009637.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Ragazzini,R., Perez-Palacios,R., Baymaz,I.H., Diop,S., Ancelin,K.,
            Zielinski,D., Michaud,A., Givelet,M., Borsos,M., Aflaki,S.,
            Legoix,P., Jansen,P.W.T.C., Servant,N., Torres-Padilla,M.E.,
            Bourc'his,D., Fouchet,P., Vermeulen,M. and Margueron,R.
  TITLE     EZHIP constrains Polycomb Repressive Complex 2 activity in germ
            cells
  JOURNAL   Nat Commun 10 (1), 3858 (2019)
   PUBMED   31451685
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Grijzenhout,A., Godwin,J., Koseki,H., Gdula,M.R., Szumska,D.,
            McGouran,J.F., Bhattacharya,S., Kessler,B.M., Brockdorff,N. and
            Cooper,S.
  TITLE     Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a
            Trithorax phenotype in embryonic development and in ESCs
  JOURNAL   Development 143 (15), 2716-2723 (2016)
   PUBMED   27317809
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Davidovich,C., Wang,X., Cifuentes-Rojas,C., Goodrich,K.J.,
            Gooding,A.R., Lee,J.T. and Cech,T.R.
  TITLE     Toward a consensus on the binding specificity and promiscuity of
            PRC2 for RNA
  JOURNAL   Mol Cell 57 (3), 552-558 (2015)
   PUBMED   25601759
REFERENCE   6  (bases 1 to 2738)
  AUTHORS   Li,G., Margueron,R., Ku,M., Chambon,P., Bernstein,B.E. and
            Reinberg,D.
  TITLE     Jarid2 and PRC2, partners in regulating gene expression
  JOURNAL   Genes Dev 24 (4), 368-380 (2010)
   PUBMED   20123894
REFERENCE   7  (bases 1 to 2738)
  AUTHORS   Shen,X., Kim,W., Fujiwara,Y., Simon,M.D., Liu,Y., Mysliwiec,M.R.,
            Yuan,G.C., Lee,Y. and Orkin,S.H.
  TITLE     Jumonji modulates polycomb activity and self-renewal versus
            differentiation of stem cells
  JOURNAL   Cell 139 (7), 1303-1314 (2009)
   PUBMED   20064376
REFERENCE   8  (bases 1 to 2738)
  AUTHORS   Peng,J.C., Valouev,A., Swigut,T., Zhang,J., Zhao,Y., Sidow,A. and
            Wysocka,J.
  TITLE     Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and
            target gene occupancy in pluripotent cells
  JOURNAL   Cell 139 (7), 1290-1302 (2009)
   PUBMED   20064375
REFERENCE   9  (bases 1 to 2738)
  AUTHORS   Kim,H., Kang,K. and Kim,J.
  TITLE     AEBP2 as a potential targeting protein for Polycomb Repression
            Complex PRC2
  JOURNAL   Nucleic Acids Res 37 (9), 2940-2950 (2009)
   PUBMED   19293275
  REMARK    GeneRIF: A large fraction of AEBP2's target loci also map closely
            to the known target loci of the Polycomb Repression Complex PRC2.
REFERENCE   10 (bases 1 to 2738)
  AUTHORS   He,G.P., Kim,S. and Ro,H.S.
  TITLE     Cloning and characterization of a novel zinc finger transcriptional
            repressor. A direct role of the zinc finger motif in repression
  JOURNAL   J Biol Chem 274 (21), 14678-14684 (1999)
   PUBMED   10329662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133098.7 and AEKQ02102408.1.
            
            On Feb 15, 2022 this sequence version replaced NM_009637.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF090326.1, AB221647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-819               AC133098.7         30239-31057
            820-969             AC133098.7         40402-40551
            970-1027            AEKQ02102408.1     5569-5626           c
            1028-1135           AC133098.7         44373-44480
            1136-1322           AC133098.7         48885-49071
            1323-1447           AC133098.7         50661-50785
            1448-1515           AC133098.7         53523-53590
            1516-1629           AC133098.7         54685-54798
            1630-1656           AC133098.7         57469-57495
            1657-2738           AC133098.7         84104-85185
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 70.71 cM"
     gene            1..2738
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /note="AE binding protein 2"
                     /db_xref="GeneID:11569"
                     /db_xref="MGI:MGI:1338038"
     exon            1..819
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1684
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /note="isoform 3 is encoded by transcript variant 3; zinc
                     finger protein AEBP2; adipocyte enhancer-binding protein
                     2"
                     /codon_start=1
                     /product="zinc finger protein AEBP2 isoform 3"
                     /protein_id="NP_033767.2"
                     /db_xref="CCDS:CCDS39689.2"
                     /db_xref="GeneID:11569"
                     /db_xref="MGI:MGI:1338038"
                     /translation="MAAALADMADLEELSRLSPLSPGSPGPAARGRAEPPEEEEEEDD
                     EEAEAEAVAALLLNGGAGGGAGGGEAETMSEPSPESASQAGGDEDEDEEDDEDEGSSS
                     GGAEEESSAESLVGSSSGGCSGDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGGPGG
                     PGSSGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSI
                     SSTLMDIDSTISSGRSTPAMMNGQGSTTASSKHIAYNCCWDQCQACFNSSPDLADHIR
                     SIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFAS
                     QGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFD
                     AQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEESGKIKLLLHWMPEDIL
                     PDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRFDILNFPR"
     exon            820..1027
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1135
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1322
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1447
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1515
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1629
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1656
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..2738
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2326..2331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2346
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
     regulatory      2712..2717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2738
                     /gene="Aebp2"
                     /gene_synonym="B230313N05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgtccccgc gcgggctccg tagcgcgtgt gcagcctgac gcagccccgc gggccctcct
       61 cccgctctgc ggcggccgcg cggagtttgg ggcgtgcggg cgcggagcgg ggggtggcgg
      121 gggcgaggag gcggcggcga gaggaggcgg aggagcagca ggcgccgcca tggccgccgc
      181 gctcgccgac atggccgacc tggaggagct ctcccgcctc agcccgctgt cccccggcag
      241 ccccgggccc gcggcgcgcg gccgggccga gccgccggag gaagaggagg aggaggatga
      301 cgaggaggcg gaggcagagg cggtggccgc gctgctgttg aacgggggag cgggcggcgg
      361 cgcggggggc ggcgaggcgg agaccatgtc ggagccgagc cccgagagcg ccagccaggc
      421 gggcggggac gaggacgagg acgaggagga cgacgaggac gagggcagca gcagcggcgg
      481 cgcggaggag gagagcagcg ccgagagcct ggtgggcagc agcagcggcg gctgcagcgg
      541 cgacgagacg cgctcgctga gcccgggcgc ggcgagcagc agcagcggcg atggggacgg
      601 gaaggagggc ctggaggagc ccaagggacc gcggggcggc ccgggcggcc cgggcagcag
      661 cggtggcggt agcagcagca gtagcgtggt gtcgagcggc ggcgacgagg gctacggcac
      721 cgggggaggc gggagcagcg cgacctccgg gggccggcgg ggcagcctgg agatgtcgtc
      781 cgacggggag ccgctgagcc gcatggactc ggaggacagc ataagcagta cgctaatgga
      841 catagacagc acaatttcca gtggacgctc aaccccggcc atgatgaatg gacaggggag
      901 cacgactgct tcaagcaaac acattgccta taactgttgc tgggaccagt gccaggcatg
      961 cttcaactcc agcccagacc tggcagacca cattcgctcc atacatgtcg atggtcagcg
     1021 tggaggggtg ttcgtttgct tgtggaaagg ttgcaaggtg tataacaccc cgtcaaccag
     1081 tcagagttgg ctacagcggc acatgctgac acacagtgga gacaagcctt tcaagtgtgt
     1141 agttggtggc tgcaatgcca gctttgcttc tcagggaggg ctagctcgcc atgtacccac
     1201 acacttcagt cagcagaact cctcaaaagt ttctagccag ccaaaggcca aagaagaatc
     1261 tccttctaaa gctggaatga acaagcggag gaaactaaag aacaaaagac ggcgctcatt
     1321 accgcggcca cacgatttct tcgatgcaca aacactggat gccataagac atcgagccat
     1381 ctgctttaac ctctctgctc acatagaaag tctagggaag ggacacagtg ttgttttcca
     1441 cagtactgta atagcgaaga gaaaggagga atctggaaag ataaagcttt tgcttcattg
     1501 gatgccggaa gacattctgc cagatgtatg ggtgaatgag agtgaacgac atcagttaaa
     1561 aacgaaagta gttcatttat caaagctacc caaagatact gccttgctgt tggacccaaa
     1621 catttacaga acaatgccgc agaagaggtt gaagagattt gacatcctca atttcccaag
     1681 gtgatgagtg cttcttcatc tggaacctca cagccatgag aacggaaagg ggacgactta
     1741 ttttaaccgg ttacagcgta aacacacatc tccacaggtg tctcctggct gctattgccc
     1801 taaggtcttg ggttacctca cctgttccat cgtgtggttt cctagtaacc cagaaattta
     1861 tctaagtgag actctcagga tagacttaat ttcactgcaa ctgcaggctt tgtgtgtgtt
     1921 atgtgccctg tgtgttatgt gctctgtggc atactctctg ccctccttgt aggtggaagt
     1981 ggaggagaca aacaggtgtg gagaagtccc ttcgggttgg ccacagtagt atagtatagt
     2041 agtagtatag catgcctgac ccctgctgaa gtgaggggag actgaattca cgtgtaaccc
     2101 aggctataca atgagacctt tcctcaacgg acagacagac aaagccccgt tgactaggag
     2161 agccagtcta aggcatggct ttaaccggtt tcgcagcaag aatgatatgg aggcatctgg
     2221 aagattgaca cccccccccc ccgcctcccg acagaggaac agaaaaggct aagagggagc
     2281 tataatctgt gagaggctgc tgccaaggaa aatatctgaa acccaaataa aaagaaaaat
     2341 cccaaaccga gagatgggtt gcacaccaaa gggtcgagca gcagtggacc ggaaacttcc
     2401 ttccacacca aattcctgtg atccttgcgc tgttcatctt ggggtggaag gagcagcgag
     2461 ccaaatgctt ggaggagttg ggttgaaatt taactggcga acacagaaag gcttctctct
     2521 cagaaaaagt tacagaacaa aataatgatt gtgtagtagt agatcttgtg cttagagacc
     2581 ataggccccc tggccaaatg catttctagc agccttgcgt gtaaggagag agaatggcca
     2641 gcctggacta catggtaaga tttttatcag aaaaaaaaaa agaagtagaa aatgggaatc
     2701 taagcaatga aattaaattg ttccaacgga aaagctga
//
