LOCUS       NM_009636               4072 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus AE binding protein 1 (Aebp1), transcript variant 2,
            mRNA.
ACCESSION   NM_009636
VERSION     NM_009636.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4072)
  AUTHORS   Jin,R., Li,C., Yang,Y. and Xie,J.
  TITLE     AEBP1 restores osteoblastic differentiation under dexamethasone
            treatment by activating PI3K/AKT signalling
  JOURNAL   Clin Exp Pharmacol Physiol 51 (11), e13923 (2024)
   PUBMED   39358837
  REMARK    GeneRIF: AEBP1 restores osteoblastic differentiation under
            dexamethasone treatment by activating PI3K/AKT signalling.
REFERENCE   2  (bases 1 to 4072)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4072)
  AUTHORS   Li,J., Ruan,Y., Zheng,C., Pan,Y., Lin,B., Chen,Q. and Zheng,Z.
  TITLE     AEBP1 Contributes to Breast Cancer Progression by Facilitating Cell
            Proliferation, Migration, Invasion, and Blocking Apoptosis
  JOURNAL   Discov Med 35 (174), 45-56 (2023)
   PUBMED   37024441
  REMARK    GeneRIF: AEBP1 Contributes to Breast Cancer Progression by
            Facilitating Cell Proliferation, Migration, Invasion, and Blocking
            Apoptosis.
REFERENCE   4  (bases 1 to 4072)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4072)
  AUTHORS   Wang,D., Rabhi,N., Yet,S.F., Farmer,S.R. and Layne,M.D.
  TITLE     Aortic carboxypeptidase-like protein regulates vascular adventitial
            progenitor and fibroblast differentiation through myocardin related
            transcription factor A
  JOURNAL   Sci Rep 11 (1), 3948 (2021)
   PUBMED   33597582
  REMARK    GeneRIF: Aortic carboxypeptidase-like protein regulates vascular
            adventitial progenitor and fibroblast differentiation through
            myocardin related transcription factor A.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4072)
  AUTHORS   Layne,M.D., Yet,S.F., Maemura,K., Hsieh,C.M., Bernfield,M.,
            Perrella,M.A. and Lee,M.E.
  TITLE     Impaired abdominal wall development and deficient wound healing in
            mice lacking aortic carboxypeptidase-like protein
  JOURNAL   Mol Cell Biol 21 (15), 5256-5261 (2001)
   PUBMED   11438679
REFERENCE   7  (bases 1 to 4072)
  AUTHORS   Cooper,P., Mueck,B., Yousefi,S., Potter,S. and Jarai,G.
  TITLE     cDNA-RDA of genes expressed in fetal and adult lungs identifies
            factors important in development and function
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 278 (2), L284-L293 (2000)
   PUBMED   10666112
REFERENCE   8  (bases 1 to 4072)
  AUTHORS   Layne,M.D., Endege,W.O., Jain,M.K., Yet,S.F., Hsieh,C.M.,
            Chin,M.T., Perrella,M.A., Blanar,M.A., Haber,E. and Lee,M.E.
  TITLE     Aortic carboxypeptidase-like protein, a novel protein with
            discoidin and carboxypeptidase-like domains, is up-regulated during
            vascular smooth muscle cell differentiation
  JOURNAL   J Biol Chem 273 (25), 15654-15660 (1998)
   PUBMED   9624159
REFERENCE   9  (bases 1 to 4072)
  AUTHORS   Ohno,I., Hashimoto,J., Shimizu,K., Takaoka,K., Ochi,T.,
            Matsubara,K. and Okubo,K.
  TITLE     A cDNA cloning of human AEBP1 from primary cultured osteoblasts and
            its expression in a differentiating osteoblastic cell line
  JOURNAL   Biochem Biophys Res Commun 228 (2), 411-414 (1996)
   PUBMED   8920928
REFERENCE   10 (bases 1 to 4072)
  AUTHORS   He,G.P., Muise,A., Li,A.W. and Ro,H.S.
  TITLE     A eukaryotic transcriptional repressor with carboxypeptidase
            activity
  JOURNAL   Nature 378 (6552), 92-96 (1995)
   PUBMED   7477299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY309657.1, BC082577.1, AA162039.1 and AI322823.1.
            
            On Mar 4, 2015 this sequence version replaced NM_009636.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. The
            resulting protein (isoform 2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128980.1, BC082577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                BY309657.1         1-72
            73-3913             BC082577.1         1-3841
            3914-4049           AA162039.1         273-408
            4050-4072           AI322823.1         409-431
FEATURES             Location/Qualifiers
     source          1..4072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.88 cM"
     gene            1..4072
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /note="AE binding protein 1"
                     /db_xref="GeneID:11568"
                     /db_xref="MGI:MGI:1197012"
     exon            1..533
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..3673
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; adipocyte enhancer-binding protein 1; aortic
                     carboxypeptidase-like protein"
                     /codon_start=1
                     /product="adipocyte enhancer-binding protein 1 isoform 2
                     precursor"
                     /protein_id="NP_033766.2"
                     /db_xref="CCDS:CCDS24406.1"
                     /db_xref="GeneID:11568"
                     /db_xref="MGI:MGI:1197012"
                     /translation="MAPVRTASLLCGLLALLTLCPEGNPQTVLTDDEIEEFLEGFLSE
                     LETQSPPREDDVEVQPLPEPTQRPRKSKAGGKQRADVEVPPEKNKDKEKKGKKDKGPK
                     ATKPLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKR
                     PSAGKKFSTVAPLETLDRLLPSPSNPSAQELPQKRDTPFPNAWQGQGEETQVEAKQPR
                     PEPEEETEMPTLDYNDQIEKEDYEDFEYIRRQKQPRPTPSRRRLWPERPEEKTEEPEE
                     RKEVEPPLKPLLPPDYGDSYVIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEEMKKPKK
                     EGSSPKEDTEDKWTVEKNKDHKGPRKGEELEEEWAPVEKIKCPPIGMESHRIEDNQIR
                     ASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRRTTRFTGVIT
                     QGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFYGNVDKDTPVLSELPEPVVA
                     RFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDMRQLMK
                     AVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRE
                     LLLLLMQYLCQEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLW
                     TEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIS
                     WMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAEALAAARGEDDDGVSEAQETP
                     DHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLH
                     TNCLELSVYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANA
                     TISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNFI
                     LARSNWKRIREILAMNGNRPILRVDPSRPMTPQQRRMQQRRLQYRLRMREQMRLRRLN
                     STAGPATSPTPALMPPPSPTPAITLRPWEVLPTTTAGWEESETETYTEVVTEFETEYG
                     TDLEVEEIEEEEEEEEEEMDTGLTFPLTTVETYTVNFGDF"
     exon            534..872
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            873..944
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1016
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1127
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1196
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1274
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1355
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1409
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1519
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1659
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1744
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1889
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1975
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2099
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2296
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2476
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2828
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2968
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3068
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..4072
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3890..3895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /note="hexamer: AATAAA"
     polyA_site      3912
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /note="major polyA site"
     regulatory      3997..4002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
                     /note="hexamer: AACAAG"
     polyA_site      4020
                     /gene="Aebp1"
                     /gene_synonym="ACLP"
ORIGIN      
        1 ggaaacccga agcccccgcc ccggccaggc cgtcgcaagc gctctggagg gcggtccgcg
       61 tgagagccag ccacgcgggg caggagcgcc cagttgctgc cggagctggg cccgccagaa
      121 cctctcctgg agccccttgc tctccttgaa tctccctttc ccaccgcttt ctggataccc
      181 ttgacgccca cgttcctcgc gccctttccc gcccctacgc ggggcgctgc ccctgccacc
      241 caagtccctg ctcaagcccg cccggctccc gcgcgtgccc agagccatgg ctccagtgcg
      301 caccgcatcc ctgctctgcg gcctcctggc actgctgacg ctgtgccctg aggggaaccc
      361 acagacggtg ctgacggacg acgagatcga ggagttcctc gaaggcttcc tttcggagtt
      421 ggagacccag tccccgcccc gggaagacga cgtggaagtc cagccgcttc ccgaacccac
      481 ccagcgtccc cgcaaatcca aggcaggggg caagcagcgg gcagatgtag aagtccctcc
      541 agaaaaaaac aaagacaaag agaagaaagg aaagaaggac aaaggcccca aagccacaaa
      601 acccctggag ggctctacca ggcccaccaa gaaaccaaag gagaagccac ccaaggccac
      661 caagaagccc aaggagaaac cacccaaggc caccaagaag cccaaggaga agccacccaa
      721 ggccaccaag aagcctaagg agaagccacc caaggccact aagaggccct cggcaggaaa
      781 gaagttctca actgtggccc ccttggaaac gctggatcgg ttactcccct caccctccaa
      841 ccccagcgcc caggagctac cgcagaagag agacacaccc ttcccaaatg cctggcaagg
      901 tcaaggagaa gagacccagg tggaggccaa gcagccccgg ccagagccag aggaggagac
      961 tgagatgccc acactggact acaatgacca gatagagaag gaggattacg aggattttga
     1021 gtacatccgt cgccagaagc agcccaggcc aacacccagc aggaggaggc tctggccaga
     1081 gcgccctgag gagaagactg aagagccaga ggaaaggaag gaagtcgagc cacctctgaa
     1141 gcccctgctg cctccggact atggggatag ctacgtgatc cccaactatg atgacttgga
     1201 ctattatttc ccccaccctc caccgcagaa gcctgatgtt ggacaagagg tggatgagga
     1261 aaaggaagag atgaagaagc ccaaaaagga gggtagtagc cccaaggagg acacagagga
     1321 caagtggacc gtggagaaaa acaaggacca caaagggccc cggaagggtg aggagctgga
     1381 ggaggagtgg gcgccagtgg agaaaatcaa gtgcccacct attgggatgg agtcacaccg
     1441 cattgaggac aaccagatcc gtgcctcctc catgctgcgc cacggcctcg gagcccagcg
     1501 gggccggctc aacatgcagg ctggtgccaa tgaagatgac tactatgacg gggcatggtg
     1561 tgctgaggac gagtcgcaga cccagtggat cgaggtggac acccgaagga caactcggtt
     1621 cacgggcgtc atcactcagg gccgtgactc cagcatccat gacgacttcg tgactacctt
     1681 ctttgtgggc ttcagcaatg acagccagac ctgggtgatg tacaccaatg gctacgagga
     1741 aatgaccttc tatggaaatg tggacaagga cacacctgtg ctgagcgagc tccctgagcc
     1801 agttgtggcc cgtttcatcc gcatctatcc actcacctgg aacggtagcc tgtgcatgcg
     1861 cctggaggtg ctaggctgcc ccgtgacccc tgtctacagc tactacgcac agaatgaggt
     1921 ggtaactact gacagcctgg acttccggca ccacagctac aaggacatgc gccagctgat
     1981 gaaggctgtc aatgaggagt gccccacaat cactcgcaca tacagcctgg gcaagagttc
     2041 acgagggctc aagatctacg caatggaaat ctcagacaac cctggggatc atgaactggg
     2101 ggagcccgag ttccgctaca cagccgggat ccacggcaat gaggtgctag gccgagagct
     2161 cctgctcctg ctcatgcaat acctatgcca ggagtaccgc gatgggaacc cgagagtgcg
     2221 caacctggtg caggacacac gcatccacct ggtgccctcg ctgaaccctg atggctatga
     2281 ggtggcagcg cagatgggct cagagtttgg gaactgggca ctggggctgt ggactgagga
     2341 gggctttgac atcttcgagg acttcccaga tctcaactct gtgctctggg cagctgagga
     2401 gaagaaatgg gtcccctaca gggtcccaaa caataacttg ccaatccctg aacgttacct
     2461 gtccccagat gccacggtct ccacagaagt ccgggccatt atttcctgga tggagaagaa
     2521 cccctttgtg ctgggtgcaa atctgaacgg tggtgagcgg cttgtgtctt atccctatga
     2581 catggcccgg acacctagcc aggagcagct gttggccgag gcactggcag ctgcccgcgg
     2641 agaagatgat gacggggtgt ctgaggccca ggagactcca gatcacgcta ttttccgctg
     2701 gctggccatc tcatttgcct ccgcccatct caccatgacg gagccctacc ggggagggtg
     2761 ccaggcccag gactacacca gcggcatggg cattgtcaac ggggccaagt ggaatcctcg
     2821 ctctgggact ttcaatgact ttagctacct gcacacaaac tgtctggagc tctccgtata
     2881 cctgggctgt gacaagttcc cccacgagag tgagctaccc cgagaatggg agaacaacaa
     2941 agaagcgctg ctcaccttca tggagcaggt gcaccgtggc attaagggtg tggtgacaga
     3001 tgagcaaggc atccccattg ccaatgccac catctctgtg agtggcatca accatggtgt
     3061 gaagacagca agtggaggtg actactggcg cattctgaac ccgggtgagt accgtgtgac
     3121 agctcacgca gagggctaca cctcaagtgc caagatctgc aatgtggact acgatattgg
     3181 ggccactcag tgcaacttca tcctggctcg atccaactgg aagcgcattc gggagatctt
     3241 ggctatgaac gggaaccgtc ccattctccg agttgacccc tcacgaccca tgacccccca
     3301 gcagcggcgc atgcagcagc gccgtctaca gtaccggctc cgcatgaggg aacagatgcg
     3361 actgcgtcgc ctcaattcta ccgcaggccc tgccacaagc cccactcctg cccttatgcc
     3421 tcccccttcc cctacaccag ccattacctt gaggccctgg gaagttctac ccactaccac
     3481 tgcaggctgg gaggagtcag agactgagac ctatacagaa gtagtgacag agtttgagac
     3541 agagtatggg actgacctag aggtggaaga gatagaggag gaggaggagg aggaggagga
     3601 agagatggac acaggcctta catttccact cacaacagtg gagacctaca cagtgaactt
     3661 tggggacttc tgagactggg atctcaaagc cctgcccaat tcaaactaag gcagcacctc
     3721 ccaagcctgt gccagcagac acatagccat cagatgtccc tgggtggacc ccactccccc
     3781 agtgtgggac atcaaagcta ccgggactct gcatagactc tggtctaccc gccccagctc
     3841 tacctgccag cctttgggga ggggcaggca aggaagccaa cgtcacatca ataaaacaag
     3901 ctcatgacac caccttcccc tgttctgact ggctggacaa gaggctggct tgctggatgc
     3961 tctccctacc tgtcccatcc tacacatgcc caagtgaaca aggttcagac ctgtgaaaaa
     4021 ttcatgtttt atttacaggg cttgcattgc aagggtgatg tcctgagccc gc
//
