LOCUS       NM_001145875            2519 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus androgen dependent TFPI regulating protein (Adtrp),
            transcript variant 2, mRNA.
ACCESSION   NM_001145875
VERSION     NM_001145875.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Li,P., Song,R., Du,Y., Liu,H. and Li,X.
  TITLE     Adtrp regulates thermogenic activity of adipose tissue via
            mediating the secretion of S100b
  JOURNAL   Cell Mol Life Sci 79 (8), 407 (2022)
   PUBMED   35804197
  REMARK    GeneRIF: Adtrp regulates thermogenic activity of adipose tissue via
            mediating the secretion of S100b.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Defour,M., van Weeghel,M., Hermans,J. and Kersten,S.
  TITLE     Hepatic ADTRP overexpression does not influence lipid and glucose
            metabolism
  JOURNAL   Am J Physiol Cell Physiol 321 (4), C585-C595 (2021)
   PUBMED   34288722
  REMARK    GeneRIF: Hepatic ADTRP overexpression does not influence lipid and
            glucose metabolism.
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   Erikci Ertunc,M., Kok,B.P., Parsons,W.H., Wang,J.G., Tan,D.,
            Donaldson,C.J., Pinto,A.F.M., Vaughan,J.M., Ngo,N., Lum,K.M.,
            Henry,C.L., Coppola,A.R., Niphakis,M.J., Cravatt,B.F., Saez,E. and
            Saghatelian,A.
  TITLE     AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of
            hydroxy fatty acids (FAHFAs) in mice
  JOURNAL   J Biol Chem 295 (18), 5891-5905 (2020)
   PUBMED   32152231
  REMARK    GeneRIF: AIG1 and ADTRP are endogenous hydrolases of fatty acid
            esters of hydroxy fatty acids (FAHFAs) in mice.
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Patel,M.M., Behar,A.R., Silasi,R., Regmi,G., Sansam,C.L.,
            Keshari,R.S., Lupu,F. and Lupu,C.
  TITLE     Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor
            Regulating Protein) in Vascular Development and Function
  JOURNAL   J Am Heart Assoc 7 (22), e010690 (2018)
   PUBMED   30571485
  REMARK    GeneRIF: role in vascular development and function
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135327.1, BY719442.1 and AC165263.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a shorter N-terminus when it is compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079178.1, SRR13861905.133471.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               AK135327.1         2-603
            603-619             BY719442.1         600-616
            620-1016            AK135327.1         621-1017
            1017-2519           AC165263.2         113126-114628
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 20.61 cM"
     gene            1..2519
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /note="androgen dependent TFPI regulating protein"
                     /db_xref="GeneID:109254"
                     /db_xref="MGI:MGI:1924596"
     exon            1..126
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            127..369
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..909
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     androgen-dependent TPF1-regulating protein; FAHFA
                     hydrolase ADTRP; fatty acid esters of hydroxy fatty acids
                     hydrolase ADTRP"
                     /codon_start=1
                     /product="androgen-dependent TFPI-regulating protein
                     isoform 2"
                     /protein_id="NP_001139347.1"
                     /db_xref="CCDS:CCDS49250.1"
                     /db_xref="GeneID:109254"
                     /db_xref="MGI:MGI:1924596"
                     /translation="MTKTTTCVYHFLVLNWYIFLNYHIPQIGRNEEKLREFHDGGRSK
                     YLTLLNLLLQAIFFGVACLDDVLKRVIGRKDIKFVTSFRDLLFTTMAFPISTFVFLVF
                     WTLFHYDRSLVYPKGLDDFFPAWVNHAMHTSIFPFSLFETILRPHNYPSKKLGLTLLG
                     AFNFAYIIRILWRYVQTGNWVYPVFDSLSPLGIIIFFSAAYILVAGIYLFGEKINHWK
                     WGAIAKPQMKKN"
     exon            370..504
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            505..606
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            607..722
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..874
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            875..2519
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1060..1065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /note="hexamer: AATAAA"
     regulatory      1069..1074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1078
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /note="major polyA site"
     polyA_site      1112
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /note="major polyA site"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2418
                     /gene="Adtrp"
                     /gene_synonym="9530008L14Rik"
ORIGIN      
        1 atctttcaga cagagcgtgt cttagtaagg tggcgatctg ggccaggaaa tttttctggc
       61 cactagaaat ctggcttgat ctcaagctcc ctgcgttttc cttggtagaa gacccaggta
      121 gctaagcttt ccagcctgaa cagagggcag ctgggacacc caggactcag agtgaacgca
      181 gagcgggtgc cactgtcgct ccgatccagg gaagccatga cgaaaacaac cacttgcgtg
      241 taccacttcc ttgttctgaa ctggtacatt ttcctcaatt atcacatccc acagattgga
      301 aggaatgagg agaagctaag ggaattccat gacggtgggc gatccaagta cttgacactc
      361 cttaatctgc tcttgcaggc cattttcttt ggggtcgcct gcctggatga tgtgctgaaa
      421 agagtcatcg gaaggaaaga catcaagttt gtcacatcct tcagagatct gctctttacc
      481 acaatggctt ttcctatatc cacatttgtg ttcttggtat tctggactct ctttcactac
      541 gaccggagcc tcgtttaccc caagggcttg gatgacttct tcccagcatg ggttaaccac
      601 gcaatgcata cctccatatt tcccttttca ctgtttgaaa ccatcctcag accacacaac
      661 tatccatcga agaagctagg actcaccttg ctgggtgctt ttaattttgc ctacatcatc
      721 aggatcctgt ggcgctacgt tcagactgga aactgggtgt accccgtgtt tgactccctc
      781 agcccactgg gtattatcat cttcttctca gccgcttaca tcctagtcgc cggcatctac
      841 ctgtttggcg agaagatcaa tcactggaaa tggggtgcca tagcaaagcc acagatgaag
      901 aagaattgat gacgtactat tttccaagag ccatggaaga agaaacttaa gaaccggtca
      961 tctttctatt atcctcatta ttattattat tatttctttt tggatcaggg gtggacttgc
     1021 ttggggagat agaaaggacg gagaatgttg catagtttta ataaaggata taaagggagc
     1081 ttctcttggg atctcctggt tttctaaaag gctgacatct cctgttactt ttgattgacc
     1141 tccacatttt gtttctgacc aaaaaggctc aacaagcttg tctaaacttg ttgctggacc
     1201 atttagagaa tgggtgtggg gacaagaaca tgggggcata aactctcttt accttctagg
     1261 ggtatgggga agacacagat gacatgctcc aaacgtcaaa atcatgacca agctggagta
     1321 gtggtgcaca cagggcattc cctgcattct ggaggctaaa tcaggaagat cgtgaattca
     1381 gggttgccct ggactgcaga gtaagaccct gtcattagaa gaccaaaaat aataatttaa
     1441 aagtagttgt tgctgggtgg gtaggggatt ggggggaggg tatgggggac ttttgggata
     1501 gcatttgaaa tgtaaatgaa gaaaatacct aattaaaaaa aagtttaaga aacactaaaa
     1561 aaaaaaaaaa gaaaaagtag ttgtcgaaat gaagacagtg ccggcttctt ctagatctcc
     1621 caataccaaa tactgggcca tttttcaata atccccactt ctctttaaaa aaaaaagtac
     1681 gtatttttaa taagctaatt gttttcagtg atttctgacc tatttttccc ttgatttaga
     1741 agtgtacaga aatataacct agcggcagct aactttataa taacaactaa taaaaaaaat
     1801 ggcagcaaac tcgctggggc agtgagaata atttataaca agtggtggga agtctacccc
     1861 tcttcagagc aaacatttgg ggtgggagtt accaattaat gtggaacgta aggggctgtc
     1921 aaatggctct tccatttgga tactggtttg aagggaggca cagatgagtt attgggaagt
     1981 cagtgtgtat accatatgca agcaggactt tagctgggac aaaggctaac tgagggagcc
     2041 aagggtgctt ctatacaagc tcctcaactg atcaggtgac tcacaagagc tcatgagccc
     2101 tttcctttct ctgggggctt ttaagtccag ctttgtcact gctgtatatt tgttttacac
     2161 agaacagggt cttgtaaaaa taattcatgt gttttaacca tatttgcctc ccaagaccat
     2221 cacctcccca cccttgccca actcctgctc ctcctaccag cttcccttct gatttcatct
     2281 tcccccacct ctcagacaca tacacacaga cagacatgca gacacacaca catggaacat
     2341 gtacatgcat gggtccatgt atctgtaata taatctaaga tctacatatg agaaaaaaat
     2401 aaacatttgt atttctaagt ttggcttatt tcccttaatt tgatggtctc tgcgtacctc
     2461 cattgtccag caaaggatgt aatttcattc tttatgagta aataaaaccg catttctat
//
