LOCUS       NM_007422               2553 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus adenylosuccinate synthetase, non muscle (Adss), mRNA.
ACCESSION   NM_007422
VERSION     NM_007422.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Luo XM, Lam SM, Dong Y, Ma XJ, Yan C, Zhang YJ, Cao Y, Su L, Lu G,
            Yang JK, Shui G and Feng YM.
  TITLE     The purine metabolite inosine monophosphate accelerates
            myelopoiesis and acute pancreatitis progression
  JOURNAL   Commun Biol 5 (1), 1088 (2022)
   PUBMED   36224248
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Nemkov T, Sun K, Reisz JA, Song A, Yoshida T, Dunham A, Wither MJ,
            Francis RO, Roach RC, Dzieciatkowska M, Rogers SC, Doctor A,
            Kriebardis A, Antonelou M, Papassideri I, Young CT, Thomas TA,
            Hansen KC, Spitalnik SL, Xia Y, Zimring JC, Hod EA and D'Alessandro
            A.
  TITLE     Hypoxia modulates the purine salvage pathway and decreases red
            blood cell and supernatant levels of hypoxanthine during
            refrigerated storage
  JOURNAL   Haematologica 103 (2), 361-372 (2018)
   PUBMED   29079593
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Baresova V, Krijt M, Skopova V, Souckova O, Kmoch S and Zikanova M.
  TITLE     CRISPR-Cas9 induced mutations along de novo purine synthesis in
            HeLa cells result in accumulation of individual enzyme substrates
            and affect purinosome formation
  JOURNAL   Mol Genet Metab 119 (3), 270-277 (2016)
   PUBMED   27590927
REFERENCE   4  (bases 1 to 2553)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2553)
  AUTHORS   Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, Sikela JM,
            Williams RW and Miles MF.
  TITLE     Ethanol-responsive brain region expression networks: implications
            for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J
            mice
  JOURNAL   J Neurosci 25 (9), 2255-2266 (2005)
   PUBMED   15745951
REFERENCE   6  (bases 1 to 2553)
  AUTHORS   Borza T, Iancu CV, Pike E, Honzatko RB and Fromm HJ.
  TITLE     Variations in the response of mouse isozymes of adenylosuccinate
            synthetase to inhibitors of physiological relevance
  JOURNAL   J Biol Chem 278 (9), 6673-6679 (2003)
   PUBMED   12482871
REFERENCE   7  (bases 1 to 2553)
  AUTHORS   Guicherit OM, Cooper BF, Rudolph FB and Kellems RE.
  TITLE     Amplification of an adenylosuccinate synthetase gene in
            alanosine-resistant murine T-lymphoma cells. Molecular cloning of a
            cDNA encoding the 'non-muscle' isozyme
  JOURNAL   J Biol Chem 269 (6), 4488-4496 (1994)
   PUBMED   8308018
REFERENCE   8  (bases 1 to 2553)
  AUTHORS   Powell SM, Zalkin H and Dixon JE.
  TITLE     Cloning and characterization of the cDNA encoding human
            adenylosuccinate synthetase
  JOURNAL   FEBS Lett 303 (1), 4-10 (1992)
   PUBMED   1592113
REFERENCE   9  (bases 1 to 2553)
  AUTHORS   Guicherit OM, Rudolph FB, Kellems RE and Cooper BF.
  TITLE     Molecular cloning and expression of a mouse muscle cDNA encoding
            adenylosuccinate synthetase
  JOURNAL   J Biol Chem 266 (33), 22582-22587 (1991)
   PUBMED   1939273
REFERENCE   10 (bases 1 to 2553)
  AUTHORS   Swain,J.L., Hines,J.J., Sabina,R.L., Harbury,O.L. and Holmes,E.W.
  TITLE     Disruption of the purine nucleotide cycle by inhibition of
            adenylosuccinate lyase produces skeletal muscle dysfunction
  JOURNAL   J Clin Invest 74 (4), 1422-1427 (1984)
   PUBMED   6480832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028060.1.
            
            [WARNING] On Apr 24, 2023 this sequence was replaced by
            NM_007422.4.
            
            On Apr 5, 2007 this sequence version replaced NM_007422.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028060.1, AK170279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2553              AK028060.1         1-2553
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..2553
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /note="adenylosuccinate synthetase, non muscle"
                     /db_xref="GeneID:11566"
                     /db_xref="MGI:MGI:87948"
     exon            1..298
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1486
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /EC_number="6.3.4.4"
                     /note="adenylosuccinate synthetase 2, non muscle; L-type
                     adenylosuccinate synthetase; adenylosuccinate synthetase,
                     liver isozyme; adSS 2; AMPSase 2; IMP--aspartate ligase 2;
                     adenylosuccinate synthetase, acidic isozyme;
                     adenylosuccinate synthetase, non-muscle isozyme"
                     /codon_start=1
                     /product="adenylosuccinate synthetase isozyme 2"
                     /protein_id="NP_031448.2"
                     /db_xref="CCDS:CCDS15555.1"
                     /db_xref="GeneID:11566"
                     /db_xref="MGI:MGI:87948"
                     /translation="MSISESSPAATSLPNGDCGRPRARSGGNRVTVVLGAQWGDEGKG
                     KVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIH
                     LPGLFEEAEKNVQKGKGLDGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLG
                     TTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQ
                     QLKGYMERIKPMVKDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTV
                     GGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGR
                     KRRCGWLDLVSLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGETIPHFPANQ
                     EVLNKVEVQYKTLPGWNTDISNARTFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRE
                     SMIQLF"
     exon            299..401
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            402..470
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            471..521
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            522..588
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            589..696
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            697..778
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            779..905
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1060
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1185
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1283
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1433
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..2553
                     /gene="Adss"
                     /gene_synonym="Adss2; AS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccggcctc tggctccttc ttcctccgca tgtggctggt ggcggcgcag cagttgggtt
       61 cacgttccgt tctcctgccc cgtctcctta aggctcttct gccctgccgg gagccatgtc
      121 gatctccgag agcagcccgg cggccacctc cctgcccaac ggcgactgtg gccgccccag
      181 ggcgcggtcc ggagggaacc gggtgactgt ggtgctggga gcgcagtggg gcgacgaggg
      241 caaagggaag gtggtggatc tactggcgca ggacgccgac atcgtgtgcc gctgccaggg
      301 agggaataac gctggccaca cagttgtcgt agattctgtg gaatatgact ttcatctttt
      361 acctagtgga ataattaacc caaatgttac tgcctttatc ggaaatggag tggtaattca
      421 tcttcctgga ttgtttgaag aagcggagaa aaatgttcag aagggaaaag gtctagatgg
      481 ctgggagaaa aggcttatca tatcggacag agctcatatt gtgtttgact ttcatcaagc
      541 agctgatggt atccaggaac agcagagaca agagcaagca ggaaaaaatt tgggtaccac
      601 gaaaaagggg attggccctg tgtattcctc taaagctgct cggagtggac ttcggatgtg
      661 tgatcttgtt tctgactttg atggcttctc tgagaggttc aaagttctag ctaaccagta
      721 taaatctata tacccgactt tggaaataga cattgaaggt gaattacagc aactcaaggg
      781 ttatatggaa aggattaaac cgatggtgaa agatggagtt tatttcctat atgaggccct
      841 ccatggacca cccaagaaaa tcttggtaga aggtgcaaac gcagcattgt tagatattga
      901 ttttggaact tacccttttg taacctcttc aaactgtact gttggaggtg tttgtacagg
      961 tttgggcatg ccccctcaaa atgttggaga agtatatgga gttgtgaaag cttacaccac
     1021 tagagttggt attggtgcct ttcccacaga gcaagacaat gaaattggag aattattaca
     1081 aacacggggt agagaatttg gagtaactac tggaaggaaa agaagatgcg gctggttgga
     1141 ccttgtttca ctcaaatatg ctcatatgat caatggattt actgcgttgg cccttaccaa
     1201 gttggatatt ttggatatgt ttacggaaat caaagttgga gttgcttaca aattagatgg
     1261 ggaaaccata cctcatttcc cagcaaacca agaagtctta aataaagtgg aagttcagta
     1321 taagactctc ccaggatgga acacagacat atctaatgca aggacattta aggagctacc
     1381 tgtcaacgca caaaactatg ttcggtttat tgaagatgag cttcaaatac cagttaaatg
     1441 gattggtgta ggtaaatcca gagagtccat gattcagctc ttctaaggat tgccagcaac
     1501 gcatgagaca ctccttaaga ggaagggaaa aagacttaaa catttctttg tgatctgcaa
     1561 attcaagaat aaagacattg aaatgagttt tcagctggcg ttggtttgca gtttctgatg
     1621 gatggctgtc atggccggcc ttgtgctctc atccagcttc ccggctggca tggctgccac
     1681 atctgttgct ctgcttctca tggtgccgca cagtccttgc catggttaga actgtataat
     1741 ccccagttga catctagaac ttccagtgta gcttttcttc attatggccg ttgtgtttga
     1801 ggttgtaccc cgattagatg gtgagaacag ttaatgcaat tttgcacaaa tatttttaca
     1861 ttctgatcat tcacttctgt cattgtgatc tttgctgtta gaaaaagaaa tgatggaaag
     1921 ataagggttc tgtcaacatt tgtaaagcta agaattctgt ttaaattgtg aactgctttt
     1981 ttttttcctc tgctgaaacc attgcaaaat tgagctttgg tagggtaggg ggagtatgtt
     2041 catgagactt ttaatttgta taaaacacag aacttagttc tctctgcaat ttatttaata
     2101 cagtcaacat taaattgagt gttcaaaaag aagagatgtt tccctacaat aacaacctta
     2161 atgtgagaaa ataattatta aaaaaaaatc tgttgtgata tttgatggat atttttcttt
     2221 gttttcagat atgatctcaa atgtttgtct tttctttttc ttttttaagc atactgttgt
     2281 ttctaagaac agtgggtttg cttacatttc gcctgccagt atacctacaa aatgacccac
     2341 aagtaacccg catgagtcca agttgtcagc catattttga tcatgccctc atccctcctt
     2401 tcttgaaaaa gcaaagaggg atcacctggc ccttggcttt acattgtgct gagattagcc
     2461 ttccctggac cattaaatgt ttaaattagg catcacctga aattatttta taataccacc
     2521 aacagctgat taaaagcaac caaatatttc cag
//
