LOCUS       NM_007421               1806 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus adenylosuccinate synthase 1 (Adss1), mRNA.
ACCESSION   NM_007421
VERSION     NM_007421.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Zhao,K., Huang,X., Zhao,W., Lu,B. and Yang,Z.
  TITLE     LONP1-mediated mitochondrial quality control safeguards metabolic
            shifts in heart development
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35237793
REFERENCE   2  (bases 1 to 1806)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1806)
  AUTHORS   Nemkov,T., Sun,K., Reisz,J.A., Song,A., Yoshida,T., Dunham,A.,
            Wither,M.J., Francis,R.O., Roach,R.C., Dzieciatkowska,M.,
            Rogers,S.C., Doctor,A., Kriebardis,A., Antonelou,M.,
            Papassideri,I., Young,C.T., Thomas,T.A., Hansen,K.C.,
            Spitalnik,S.L., Xia,Y., Zimring,J.C., Hod,E.A. and D'Alessandro,A.
  TITLE     Hypoxia modulates the purine salvage pathway and decreases red
            blood cell and supernatant levels of hypoxanthine during
            refrigerated storage
  JOURNAL   Haematologica 103 (2), 361-372 (2018)
   PUBMED   29079593
REFERENCE   4  (bases 1 to 1806)
  AUTHORS   Wu,J., Bond,C., Chen,P., Chen,M., Li,Y., Shohet,R.V. and Wright,G.
  TITLE     HIF-1alpha in the heart: remodeling nucleotide metabolism
  JOURNAL   J Mol Cell Cardiol 82, 194-200 (2015)
   PUBMED   25681585
REFERENCE   5  (bases 1 to 1806)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   6  (bases 1 to 1806)
  AUTHORS   Iancu,C.V., Borza,T., Choe,J.Y., Fromm,H.J. and Honzatko,R.B.
  TITLE     Recombinant mouse muscle adenylosuccinate synthetase:
            overexpression, kinetics, and crystal structure
  JOURNAL   J Biol Chem 276 (45), 42146-42152 (2001)
   PUBMED   11560929
REFERENCE   7  (bases 1 to 1806)
  AUTHORS   Lewis,A.L., Xia,Y., Datta,S.K., McMillin,J. and Kellems,R.E.
  TITLE     Combinatorial interactions regulate cardiac expression of the
            murine adenylosuccinate synthetase 1 gene
  JOURNAL   J Biol Chem 274 (20), 14188-14197 (1999)
   PUBMED   10318837
REFERENCE   8  (bases 1 to 1806)
  AUTHORS   Lewis,A.L., Guicherit,O.M., Datta,S.K., Hanten,G.R. and
            Kellems,R.E.
  TITLE     Structure and expression of the murine muscle adenylosuccinate
            synthetase gene
  JOURNAL   J Biol Chem 271 (37), 22647-22656 (1996)
   PUBMED   8798436
REFERENCE   9  (bases 1 to 1806)
  AUTHORS   Guicherit,O.M., Cooper,B.F., Rudolph,F.B. and Kellems,R.E.
  TITLE     Amplification of an adenylosuccinate synthetase gene in
            alanosine-resistant murine T-lymphoma cells. Molecular cloning of a
            cDNA encoding the 'non-muscle' isozyme
  JOURNAL   J Biol Chem 269 (6), 4488-4496 (1994)
   PUBMED   8308018
REFERENCE   10 (bases 1 to 1806)
  AUTHORS   Guicherit,O.M., Rudolph,F.B., Kellems,R.E. and Cooper,B.F.
  TITLE     Molecular cloning and expression of a mouse muscle cDNA encoding
            adenylosuccinate synthetase
  JOURNAL   J Biol Chem 266 (33), 22582-22587 (1991)
   PUBMED   1939273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146907.1 and BY629115.1.
            
            On Oct 31, 2007 this sequence version replaced NM_007421.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146907.1, AK149634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1775              AK146907.1         4-1778
            1776-1806           BY629115.1         360-390
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.2 cM"
     gene            1..1806
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /note="adenylosuccinate synthase 1"
                     /db_xref="GeneID:11565"
                     /db_xref="MGI:MGI:87947"
     exon            1..264
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1446
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /EC_number="6.3.4.4"
                     /note="M-type adenylosuccinate synthetase;
                     adenylosuccinate synthetase, basic isozyme; adSS 1;
                     AMPSase 1; IMP--aspartate ligase 1; adenylosuccinate
                     synthetase, muscle isozyme; adenylosuccinate synthetase 1,
                     muscle; adenylosuccinate synthetase like 1"
                     /codon_start=1
                     /product="adenylosuccinate synthetase isozyme 1"
                     /protein_id="NP_031447.1"
                     /db_xref="CCDS:CCDS26192.1"
                     /db_xref="GeneID:11565"
                     /db_xref="MGI:MGI:87947"
                     /translation="MSGTRASNDRPPGTGGVKRGRLQQEAAATGSRVTVVLGAQWGDE
                     GKGKVVDLLATDADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGV
                     VIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNI
                     GTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEIDVEGQL
                     KRLKGFAERIRPMVRDGVYFMYEALHGPPKKVLVEGANAALLDIDFGTYPFVTSSNCT
                     VGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGHEWGVTTG
                     RKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVGISYKLNGKRIPYFPAN
                     QEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQSYVRFVENHMGVAVKWVGVGKSR
                     ESMIQLF"
     exon            265..367
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..430
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..481
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..548
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..656
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..738
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..865
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1020
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1145
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1243
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1393
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1791
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1752..1757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /note="putative"
     polyA_site      1775
                     /gene="Adss1"
                     /gene_synonym="Adss; Adssl1"
                     /note="putative"
ORIGIN      
        1 atttaatgga gcgagagctc tggcggcggc gggctctcgc ttggcccaga gcagcagagg
       61 agctaagcca gcatgtccgg gacccgagcc tccaacgacc ggccccccgg cacaggcgga
      121 gtcaagaggg ggcggctgca gcaggaggcg gcggcgacag gctcccgcgt gaccgtggtg
      181 ctgggcgcgc agtgggggga cgagggcaaa ggcaaggtgg tggacctgct ggccacggac
      241 gccgacatcg tcagtcgctg ccaggggggc aacaatgcgg ggcacacagt agtggtggac
      301 ggcaaggagt atgactttca cctgctcccc agcggcatca tcaacaccaa ggccgtgtca
      361 ttcattggca atggcgtggt catccacttg ccgggcttgt ttgaagaggc agagaagaac
      421 gagaagaaag ggctgaagga ctgggagaag cgtctcatca tctctgaccg ggctcacctt
      481 gtgttcgact tccaccaggc agtggacggg ctgcaggaag tacaacgtca agcacaagag
      541 gggaagaata tcggcaccac caagaaggga atcggaccaa cttactcctc caaagctgcc
      601 cggacaggcc tccgcatctg tgaccttctc tcggattttg acgagttttc tgccagattc
      661 aagaacctgg cccaccagca ccagtccatg ttccccaccc tggaaataga tgtggaaggt
      721 caactcaaaa ggctcaaggg ctttgctgag cgcatcagac ccatggttcg agatggtgtc
      781 tacttcatgt atgaagccct gcatggtccc cccaaaaagg tcctggtgga aggtgccaac
      841 gcggccctgc tcgacatcga tttcgggacc tacccctttg tgacttcttc caactgcact
      901 gtgggtggtg tgtgcaccgg cctgggcatc ccgccccaga acataggcga tgtgtatggt
      961 gtggtaaagg cctacaccac ccgtgtgggc attggggcct tccccacgga gcagatcaat
     1021 gaaattggag atctgctgca gaaccgtggc catgagtggg gggtgaccac aggcaggaag
     1081 aggcgctgcg gctggctgga cctgatgatc ctccgatacg ctcacatggt caatggcttc
     1141 actgcgctgg cattgaccaa gctggacata ctggatgtcc tgagcgagat taaagttggc
     1201 atctcctaca agctcaacgg aaagaggatt ccctacttcc ctgctaacca ggagatcctg
     1261 cagaaggtgg aggtcgagta tgaaacactg cctggatgga aagcagacac cacaggcgcc
     1321 aggaagtggg aggacctgcc tccgcaggcc caaagctacg tgcgcttcgt ggagaatcac
     1381 atgggtgttg cagtcaaatg ggtcggcgtt gggaagtcca gagagtccat gatccagctt
     1441 ttttagatgc caagtggaag ccggcaggcc acaccacagt gtgccaccgt gagtgacagc
     1501 cgcagccgag accctcggca gtgccaccaa caccttcaac gaaacagtct gaagctattt
     1561 tccatacttt tatttttcta tgtatgtttt cagcttgaaa ttgttgagcc ctacaacaat
     1621 tttacatgtg tgaaatcaac actgtgtaca tttaaaaaaa aatctgcttt taaaatgagc
     1681 ctaagtgctc ataacagagg ccttcactga ctgattgtca catggtatgt gttcagttgg
     1741 agccatgtca taataaacat agccaggggt cactgagcca ccgagaggtc aaaaaaaaaa
     1801 aaaaaa
//
