LOCUS       NM_019822               1429 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adhesion regulating molecule 1 26S proteasome
            ubiquitin receptor (Adrm1), mRNA.
ACCESSION   NM_019822
VERSION     NM_019822.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1429)
  AUTHORS   Otsubo,R., Mimuro,H., Ashida,H., Hamazaki,J., Murata,S. and
            Sasakawa,C.
  TITLE     Shigella effector IpaH4.5 targets 19S regulatory particle subunit
            RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte
            activation
  JOURNAL   Cell Microbiol 21 (3), e12974 (2019)
   PUBMED   30414351
  REMARK    GeneRIF: Here, the authors show that Shigella flexneri invasion
            plasmid antigen H (IpaH) 4.5, a member of the E3 ubiquitin ligase
            effector family, targets the proteasome regulatory particle
            non-ATPase 13 (RPN13) and induces its degradation via the
            ubiquitin-proteasome system (UPS).
REFERENCE   2  (bases 1 to 1429)
  AUTHORS   Huang,Z.N., Chung,H.M., Fang,S.C. and Her,L.S.
  TITLE     Adhesion Regulating Molecule 1 Mediates HAP40
            Overexpression-Induced Mitochondrial Defects
  JOURNAL   Int J Biol Sci 13 (11), 1420-1437 (2017)
   PUBMED   29209146
  REMARK    GeneRIF: studies suggest that HAP40-mediated reduction of ADRM1
            alters the mitochondrial fission activity and results in
            mitochondrial fragmentation and mitochondrial dysfunction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1429)
  AUTHORS   Huang,Z.N. and Her,L.S.
  TITLE     The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome
            Activity
  JOURNAL   Mol Neurobiol 54 (9), 7382-7400 (2017)
   PUBMED   27815841
  REMARK    GeneRIF: ADRM1-dependent ubiquitin proteasome system (UPS) may be a
            general mechanism to guard cells from mutant Htt toxicity
REFERENCE   4  (bases 1 to 1429)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   5  (bases 1 to 1429)
  AUTHORS   Soong,R.S., Anchoori,R.K., Yang,B., Yang,A., Tseng,S.H., He,L.,
            Tsai,Y.C., Roden,R.B. and Hung,C.F.
  TITLE     RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived
            suppressor cells
  JOURNAL   Oncotarget 7 (42), 68489-68502 (2016)
   PUBMED   27655678
  REMARK    GeneRIF: Data show that either Rpn13 knock down or RA190 treatment
            reduced the capacity of myeloid-derived-suppressor cells (MDSCs) to
            suppress T cell proliferation in vitro.
REFERENCE   6  (bases 1 to 1429)
  AUTHORS   Husnjak,K., Elsasser,S., Zhang,N., Chen,X., Randles,L., Shi,Y.,
            Hofmann,K., Walters,K.J., Finley,D. and Dikic,I.
  TITLE     Proteasome subunit Rpn13 is a novel ubiquitin receptor
  JOURNAL   Nature 453 (7194), 481-488 (2008)
   PUBMED   18497817
  REMARK    GeneRIF: identification of a new ubiquitin receptor, Rpn13/ARM1, a
            known component of the proteasome
REFERENCE   7  (bases 1 to 1429)
  AUTHORS   Qiu,X.B., Ouyang,S.Y., Li,C.J., Miao,S., Wang,L. and Goldberg,A.L.
  TITLE     hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the
            deubiquitinating enzyme, UCH37
  JOURNAL   EMBO J 25 (24), 5742-5753 (2006)
   PUBMED   17139257
REFERENCE   8  (bases 1 to 1429)
  AUTHORS   Jorgensen,J.P., Lauridsen,A.M., Kristensen,P., Dissing,K.,
            Johnsen,A.H., Hendil,K.B. and Hartmann-Petersen,R.
  TITLE     Adrm1, a putative cell adhesion regulating protein, is a novel
            proteasome-associated factor
  JOURNAL   J Mol Biol 360 (5), 1043-1052 (2006)
   PUBMED   16815440
REFERENCE   9  (bases 1 to 1429)
  AUTHORS   Lamerant,N. and Kieda,C.
  TITLE     Adhesion properties of adhesion-regulating molecule 1 protein on
            endothelial cells
  JOURNAL   FEBS J 272 (8), 1833-1844 (2005)
   PUBMED   15819879
  REMARK    GeneRIF: ARM-1 is a cytosolic protein associated with the plasma
            membrane. However, no cell surface expression of the protein was
            observed. These results suggest an indirect role of ARM-1 in
            adhesion rather than a direct role as an adhesion molecule itself.
REFERENCE   10 (bases 1 to 1429)
  AUTHORS   Simins,A.B., Weighardt,H., Weidner,K.M., Weidle,U.H. and
            Holzmann,B.
  TITLE     Functional cloning of ARM-1, an adhesion-regulating molecule
            upregulated in metastatic tumor cells
  JOURNAL   Clin Exp Metastasis 17 (8), 641-648 (1999)
   PUBMED   10919708
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL663027.9.
            
            On Nov 17, 2006 this sequence version replaced NM_019822.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008974.1, AF225959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL663027.9         42506-42606
            102-315             AL663027.9         42952-43165
            316-432             AL663027.9         43774-43890
            433-556             AL663027.9         44828-44951
            557-643             AL663027.9         45227-45313
            644-725             AL663027.9         45783-45864
            726-958             AL663027.9         46078-46310
            959-1116            AL663027.9         46516-46673
            1117-1219           AL663027.9         46772-46874
            1220-1429           AL663027.9         46992-47201
FEATURES             Location/Qualifiers
     source          1..1429
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.69 cM"
     gene            1..1429
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /note="adhesion regulating molecule 1 26S proteasome
                     ubiquitin receptor"
                     /db_xref="GeneID:56436"
                     /db_xref="MGI:MGI:1929289"
     exon            1..101
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
     exon            102..315
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1326
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /note="rpn13 homolog; 110 kDa cell membrane glycoprotein;
                     glycoprotein 110; adhesion-regulating molecule 1"
                     /codon_start=1
                     /product="proteasomal ubiquitin receptor ADRM1"
                     /protein_id="NP_062796.2"
                     /db_xref="CCDS:CCDS17171.1"
                     /db_xref="GeneID:56436"
                     /db_xref="MGI:MGI:1929289"
                     /translation="MTTSGALFPSLVPGSRGSSTKYLVEFRAGKMSLKGTTVTPDKRK
                     GLVYIQQTDDSLIHFCWKDRTSGTVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGS
                     KRLFFWMQEPKTDQDEEHCRKVNECLNNPPMPGSLGASGSSGHELSALGGEGGLQSLL
                     GNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPASSSSSSSRSQSAAVTP
                     SSSTSSARATPAPSAPAAASATSPSPAPSSGNGTSTAASPTQPIQLSDLQSILATMNV
                     PAGPGGSQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSP
                     QFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKSDPKEG
                     DTKDKKDEEEDMSLD"
     exon            316..432
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
     exon            433..556
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
     exon            557..643
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
     exon            644..725
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
     exon            726..958
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1116
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1219
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1429
                     /gene="Adrm1"
                     /gene_synonym="1110063P18Rik; 2510006J17Rik; ARM-1; Arm1;
                     Gp110; Rpn13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggggcggg ccaagcacgg gcttccggcg aggcccggca ggcgccgagg aggaagagcg
       61 agcccggacg gtgcccctag gccgagtgtg agcaccgcca ggatgacgac ttcaggcgct
      121 ctgttcccaa gcctggtgcc cggctctcgg gggtcttcta ccaaatattt ggtggagttc
      181 cgggcaggaa aaatgtcatt aaaaggaact acggtcaccc cagataaacg gaaaggtctc
      241 gtgtacatcc agcagacgga cgactccctt attcacttct gttggaaaga caggacctct
      301 gggaccgtgg aggatgactt gattatcttt cctgatgact gtgagttcaa gcgggtacct
      361 cagtgcccca gtgggagggt ctacgtgctc aagtttaagg cagggtccaa gcggctcttc
      421 ttctggatgc aggagcccaa gactgaccaa gatgaggagc actgccggaa agtcaacgag
      481 tgtctgaaca acccccccat gcctgggtca ctgggagcaa gtgggagtag tggccatgag
      541 ctttcagcac tgggcggtga gggtggcctg cagagcctgt tggggaacat gagtcacagc
      601 cagcttatgc agctcatcgg accagccggc ctgggaggac tgggtggact tggggccctc
      661 actgggccag gcctggccag cttgctgggg agcagtggac ctccagccag cagctcttca
      721 tccagctccc ggagccagtc ggcagccgtc accccatcct cctccacctc ttccgctcgc
      781 gccaccccag ccccttctgc cccagcagct gcctcggcaa ccagcccaag ccccgcaccc
      841 agctcaggta atggaaccag cacagcagcc agcccgaccc agcccatcca gctgagcgac
      901 ctccagagca ttctggccac tatgaacgtg ccggcagggc caggaggcag ccagcaagtg
      961 gatctggcga gtgtgctgac cccagagatc atggctccca tccttgccaa tgcagacgtt
     1021 caggagcgcc tgctgcccta cctgccctct ggggagtctc tgccccagac tgcagatgag
     1081 atccagaaca cattaacctc gccccagttc cagcaggccc tgggtatgtt cagtgcggcc
     1141 ttggcctcag gacagcttgg ccctctcatg tgccagttcg gccttcctgc agaggctgtt
     1201 gaggccgcca acaaaggtga tgtggaagca tttgccaaag ccatgcagaa caatgccaaa
     1261 tcggacccaa aggagggcga cacaaaagac aagaaagacg aagaagaaga tatgagtcta
     1321 gactaaatta ttcagtgtcc gtccccaagt tggaattggt agctgtgtga ttccgtagtg
     1381 gtgattgtga tttgcccacc tcactaataa agtccttcct tgtacctgt
//
