LOCUS       NM_013462               2795 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus adrenergic receptor, beta 3 (Adrb3), mRNA.
ACCESSION   NM_013462
VERSION     NM_013462.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2795)
  AUTHORS   Branquinho,J., Neves,R.L., Martin,R.P., Arata,J.G.,
            Bittencourt,C.A., Araujo,R.C., Icimoto,M.Y. and Pesquero,J.B.
  TITLE     Kinin B1 receptor deficiency promotes enhanced adipose tissue
            thermogenic response to beta3-adrenergic stimulation
  JOURNAL   Inflamm Res 73 (9), 1565-1579 (2024)
   PUBMED   39017739
  REMARK    GeneRIF: Kinin B1 receptor deficiency promotes enhanced adipose
            tissue thermogenic response to beta3-adrenergic stimulation.
REFERENCE   2  (bases 1 to 2795)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2795)
  AUTHORS   Milano,S., Saponara,I., Gerbino,A., Lapi,D., Lela,L., Carmosino,M.,
            Dal Monte,M., Bagnoli,P., Svelto,M. and Procino,G.
  TITLE     beta3-Adrenoceptor as a new player in the sympathetic regulation of
            the renal acid-base homeostasis
  JOURNAL   Front Physiol 15, 1304375 (2024)
   PUBMED   38455846
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2795)
  AUTHORS   Grockowiak,E., Korn,C., Rak,J., Lysenko,V., Hallou,A.,
            Panvini,F.M., Williams,M., Fielding,C., Fang,Z.,
            Khatib-Massalha,E., Garcia-Garcia,A., Li,J., Khorshed,R.A.,
            Gonzalez-Anton,S., Baxter,E.J., Kusumbe,A., Wilkins,B.S., Green,A.,
            Simons,B.D., Harrison,C.N., Green,A.R., Lo Celso,C.,
            Theocharides,A.P.A. and Mendez-Ferrer,S.
  TITLE     Different niches for stem cells carrying the same oncogenic driver
            affect pathogenesis and therapy response in myeloproliferative
            neoplasms
  JOURNAL   Nat Cancer 4 (8), 1193-1209 (2023)
   PUBMED   37550517
REFERENCE   5  (bases 1 to 2795)
  AUTHORS   Ravache,T.T., Batistuzzo,A., Nunes,G.G., Gomez,T.G.B., Lorena,F.B.,
            Do Nascimento,B.P.P., Bernardi,M.M., Lima,E.R.R., Martins,D.O.,
            Campos,A.C.P., Pagano,R.L. and Ribeiro,M.O.
  TITLE     Multisensory Stimulation Reverses Memory Impairment in Adrbeta3KO
            Male Mice
  JOURNAL   Int J Mol Sci 24 (13), 10522 (2023)
   PUBMED   37445699
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2795)
  AUTHORS   Susulic,V.S., Frederich,R.C., Lawitts,J., Tozzo,E., Kahn,B.B.,
            Harper,M.E., Himms-Hagen,J., Flier,J.S. and Lowell,B.B.
  TITLE     Targeted disruption of the beta 3-adrenergic receptor gene
  JOURNAL   J Biol Chem 270 (49), 29483-29492 (1995)
   PUBMED   7493988
REFERENCE   7  (bases 1 to 2795)
  AUTHORS   Granneman,J.G. and Lahners,K.N.
  TITLE     Regulation of mouse beta 3-adrenergic receptor gene expression and
            mRNA splice variants in adipocytes
  JOURNAL   Am J Physiol 268 (4 Pt 1), C1040-C1044 (1995)
   PUBMED   7733225
REFERENCE   8  (bases 1 to 2795)
  AUTHORS   Granneman,J.G., Lahners,K.N. and Rao,D.D.
  TITLE     Rodent and human beta 3-adrenergic receptor genes contain an intron
            within the protein-coding block
  JOURNAL   Mol Pharmacol 42 (6), 964-970 (1992)
   PUBMED   1336117
REFERENCE   9  (bases 1 to 2795)
  AUTHORS   Capeless,C.G., Whitney,G. and Azen,E.A.
  TITLE     Chromosome mapping of Soa, a gene influencing gustatory sensitivity
            to sucrose octaacetate in mice
  JOURNAL   Behav Genet 22 (6), 655-663 (1992)
   PUBMED   1290451
REFERENCE   10 (bases 1 to 2795)
  AUTHORS   Nahmias,C., Blin,N., Elalouf,J.M., Mattei,M.G., Strosberg,A.D. and
            Emorine,L.J.
  TITLE     Molecular characterization of the mouse beta 3-adrenergic receptor:
            relationship with the atypical receptor of adipocytes
  JOURNAL   EMBO J 10 (12), 3721-3727 (1991)
   PUBMED   1718744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102544.14.
            
            [WARNING] On Feb 5, 2025 this sequence was replaced by NM_013462.4.
            
            On Mar 21, 2007 this sequence version replaced NM_013462.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AC102544.14        35444-35923         c
            481-1974            AC102544.14        33592-35085         c
            1975-2042           AC102544.14        33061-33128         c
            2043-2795           AC102544.14        32111-32863         c
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 15.94 cM"
     gene            1..2795
                     /gene="Adrb3"
                     /gene_synonym="Adrb-3; beta 3-AR"
                     /note="adrenergic receptor, beta 3"
                     /db_xref="GeneID:11556"
                     /db_xref="MGI:MGI:87939"
     exon            1..480
                     /gene="Adrb3"
                     /gene_synonym="Adrb-3; beta 3-AR"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1974
                     /gene="Adrb3"
                     /gene_synonym="Adrb-3; beta 3-AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             812..2014
                     /gene="Adrb3"
                     /gene_synonym="Adrb-3; beta 3-AR"
                     /note="beta-3 adrenoreceptor; beta-3 adrenoceptor; Beta-3
                     AR"
                     /codon_start=1
                     /product="beta-3 adrenergic receptor"
                     /protein_id="NP_038490.2"
                     /db_xref="CCDS:CCDS22213.1"
                     /db_xref="GeneID:11556"
                     /db_xref="MGI:MGI:87939"
                     /translation="MAPWPHRNGSLALWSDAPTLDPSAANTSGLPGVPWAAALAGALL
                     ALATVGGNLLVIIAIARTPRLQTITNVFVTSLAAADLVVGLLVMPPGATLALTGHWPL
                     GETGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWI
                     VSAAVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVML
                     FVYARVFVVAKRQRHLLRRELGRFSPEESPPSPSRSPSPATGGTPAAPDGVPPCGRRP
                     ARLLPLREHRALRTLGLIMGIFSLCWLPFFLANVLRALAGPSLVPSGVFIALNWLGYA
                     NSAFNPVIYCRSPDFRDAFRRLLCSYGGRGPEEPRAVTFPASPVEARQSPPLNRFDGY
                     EGARPFPT"
     exon            1975..2042
                     /gene="Adrb3"
                     /gene_synonym="Adrb-3; beta 3-AR"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2795
                     /gene="Adrb3"
                     /gene_synonym="Adrb-3; beta 3-AR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2776..2781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adrb3"
                     /gene_synonym="Adrb-3; beta 3-AR"
                     /note="hexamer: AATAAA"
     polyA_site      2795
                     /gene="Adrb3"
                     /gene_synonym="Adrb-3; beta 3-AR"
                     /note="major polyA site"
ORIGIN      
        1 aattgtaatt ttactattat tctgactcgt gatgtaaata tctgatatgc aggatatcta
       61 tctgatatgt gaacacggtg gggactgcaa gccacgggtt gagaaccact gtgctagaca
      121 gcctcaaatg catcctttct ctctctgtct ctctctgtct ctgtctctct ctctctcttt
      181 ctgtgctgga cctcaagcat gttaagtatg cactctacca ccgagataca cccctccctc
      241 tccaaaactc catcctctca ttttaatgtg tctatcactt cagaatttga agggactttt
      301 ctagaaattt tctaggagaa aggtgtgtgg actgggcagt gcaggaggaa gatggaaacc
      361 agaagccctc agcatcccaa gctacacgat gccatgtcaa actagagtga ctcctgaaac
      421 aagcgggtgt ctccagtaac tgaaaagaag aagaactgaa acagcagaca gggacagagg
      481 ggttgcctca ggttctgcca ggaaggagct gctgagctcc aggaaaccgg tgctgaggga
      541 gtgtcaagac aggacgcccc tctccaccct ccaattccca ccagaggcct ctcttgtgac
      601 tattggacgc tgttccttta aaagcagcca ctcctcccgg caactagggt gtacatgggg
      661 ggtgagatgg agggaagctg acagacttac cccagcaatt agggaagatg gcccaggctg
      721 gaagagtcgc tcccaagccc tactgtcccc ttccctaagc cagcgggtct ggggaggagg
      781 gggaaccttc ccaccccagg cgccacacga gatggctccg tggcctcaca gaaacggctc
      841 tctggctttg tggtcggacg cccctaccct ggaccccagt gcagccaaca ccagtgggtt
      901 gccaggagta ccatgggcag cggcattggc tggggcattg ctggcgctgg ccacggtggg
      961 aggcaacctg ctggtaatca tagccatcgc ccgcacgccg agactacaga ccataaccaa
     1021 cgtgttcgtg acttcactgg ccgcagctga cttggtagtg ggactcctcg taatgccacc
     1081 aggggccaca ttggcgctga ctggccattg gcccttgggc gaaactggtt gcgaactgtg
     1141 gacgtcagtg gacgtgctct gtgtaactgc tagcatcgag accttgtgcg ccctggctgt
     1201 ggaccgctac ctagctgtca ccaacccttt gcgttacggc acgctggtta ccaagcgccg
     1261 cgcccgcgcg gcagttgtcc tggtgtggat cgtgtccgct gccgtgtcct ttgcgcccat
     1321 catgagccag tggtggcgtg taggggcaga tgccgaggca caggaatgcc actccaatcc
     1381 gcgctgctgt tcctttgcct ccaacatgcc ctatgcgctg ctctcctcct ccgtctcctt
     1441 ctaccttccc ctccttgtga tgctcttcgt ctatgctcga gtgttcgttg tggctaagcg
     1501 ccaacggcat ttgctgcgcc gggaactggg ccgcttctcg cccgaggagt ctccgccgtc
     1561 tccgtcgcgc tctccgtccc ctgccacagg cgggacaccc gcggcaccgg atggagtgcc
     1621 cccctgcggc cggcggcctg cgcgcctcct gccactccgg gaacaccgcg ccctgcgcac
     1681 cttaggtctc attatgggca tcttctctct gtgctggctg cccttcttcc tggccaacgt
     1741 gctgcgcgca ctcgcggggc cctctctagt tcccagcgga gttttcatcg ccctgaactg
     1801 gctgggctat gccaactccg ccttcaaccc ggtcatctac tgccgcagcc cggactttcg
     1861 cgacgccttc cgtcgtcttc tgtgtagcta cggtggccgt ggaccggagg agccacgcgc
     1921 agtcaccttc ccagccagcc ctgttgaagc caggcagagt ccaccgctca acaggtttga
     1981 tggctatgaa ggtgcgcgtc cgtttcccac gtgaagggcc gtgaagatcc agcaaggaag
     2041 cttgcttgat ccccatcttc ttgactggtt gccccaagaa atattgtttc cgtttttgca
     2101 ggacttctgg ggattttttt tttcctccag aaagacaagc aacggctatg gatgcaacat
     2161 ttttataatg cctttgattt ctactcagag tgagtcccct ggaacctcaa ctctccaacg
     2221 ctccagaacc gatgactaga ccacgaggtg taagggaaat cttaccaaat gggtttcacc
     2281 gtcctctctc tctttccgag agaagttgtc taagacccac cttgaacttc actactacct
     2341 cagcagctgg gacggcaggc cacctgtgct tgacggccct gggaggagcc ctatggcctt
     2401 ggaggcctgc cagtccctgc ctatgtttgt gctgtatgct tagggaaaag agagcacccc
     2461 tccctccctt tcttcctact gctttcctaa ccctgatgat cgacatgttc ctccacaaat
     2521 cactctgtct ccaggctctg tgtctctggt tagtttgaga gcaggaatcc aggaaaaaaa
     2581 aaaagtttga ggtttcatcc ctgtctcctc actatggctc tctaagcacc atcttggacc
     2641 atctctcaca ataggcacaa aacagctcta atctacctca cagttaggac ttcaaggttt
     2701 gggggggaaa ttccagggtt cataggaaga agtcaaacta ttggaatggg tcctttttcc
     2761 acttaaaatc aaattaataa atattattga atgtg
//
