LOCUS       NM_007420               2269 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus adrenergic receptor, beta 2 (Adrb2), mRNA.
ACCESSION   NM_007420
VERSION     NM_007420.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Kobayashi,H., Iida,T., Ochiai,Y., Malagola,E., Zhi,X., White,R.A.,
            Qian,J., Wu,F., Waterbury,Q.T., Tu,R., Zheng,B., LaBella,J.S.,
            Zamechek,L.B., Ogura,A., Woods,S.L., Worthley,D.L., Enomoto,A. and
            Wang,T.C.
  TITLE     Neuro-Mesenchymal Interaction Mediated by a beta2-Adrenergic Nerve
            Growth Factor Feedforward Loop Promotes Colorectal Cancer
            Progression
  JOURNAL   Cancer Discov 15 (1), 202-226 (2025)
   PUBMED   39137067
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Evans,A.K., Park,H.H., Woods,C.E., Lam,R.K., Rijsketic,D.R., Xu,C.,
            Chu,E.K., Ciari,P., Blumenfeld,S., Vidano,L.M., Saw,N.L.,
            Heifets,B.D. and Shamloo,M.
  TITLE     Impact of noradrenergic inhibition on neuroinflammation and
            pathophysiology in mouse models of Alzheimer's disease
  JOURNAL   J Neuroinflammation 21 (1), 322 (2024)
   PUBMED   39696597
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Nagao,K., Yoshikawa,S., Urakami,H., Fujita,Y., Komura,A.,
            Nakashima,M., Oh-Hora,M., Fujimura,A., Hiyama,T.Y., Naruse,K.,
            Morizane,S., Tominaga,M., Takamori,K. and Miyake,S.
  TITLE     Ligand-independent function of beta2-adrenergic receptor affects
            IgE-mediated Ca2+ influx in mast cells
  JOURNAL   Biochem Biophys Res Commun 733, 150595 (2024)
   PUBMED   39191189
  REMARK    GeneRIF: Ligand-independent function of beta2-adrenergic receptor
            affects IgE-mediated Ca[2+] influx in mast cells.
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Saha,P.P., Gogonea,V., Sweet,W., Mohan,M.L., Singh,K.D.,
            Anderson,J.T., Mallela,D., Witherow,C., Kar,N., Stenson,K.,
            Harford,T., Fischbach,M.A., Brown,J.M., Karnik,S.S., Moravec,C.S.,
            DiDonato,J.A., Naga Prasad,S.V. and Hazen,S.L.
  TITLE     Gut microbe-generated phenylacetylglutamine is an endogenous
            allosteric modulator of beta2-adrenergic receptors
  JOURNAL   Nat Commun 15 (1), 6696 (2024)
   PUBMED   39107277
  REMARK    GeneRIF: Gut microbe-generated phenylacetylglutamine is an
            endogenous allosteric modulator of beta2-adrenergic receptors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Jiang,R., Lu,Z., Wang,C., Xiao,J., Liu,Q., Xu,X., Shi,J., Shen,J.,
            Zhu,X., Gong,P., Zhuang,Q.X., Shi,K. and Shi,W.
  TITLE     Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives
            neuroinflammation in aged patients with traumatic brain injury
  JOURNAL   Sci Adv 10 (29), eadp5239 (2024)
   PUBMED   39028822
  REMARK    GeneRIF: Beta2 adrenergic receptor-mediated abnormal myelopoiesis
            drives neuroinflammation in aged patients with traumatic brain
            injury.
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Parola,A.L. and Kobilka,B.K.
  TITLE     The peptide product of a 5' leader cistron in the beta 2 adrenergic
            receptor mRNA inhibits receptor synthesis
  JOURNAL   J Biol Chem 269 (6), 4497-4505 (1994)
   PUBMED   8308019
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Byrd,L., Grossmann,M., Potter,M. and Shen-Ong,G.L.
  TITLE     Chronic multifocal osteomyelitis, a new recessive mutation on
            chromosome 18 of the mouse
  JOURNAL   Genomics 11 (4), 794-798 (1991)
   PUBMED   1686018
REFERENCE   9  (bases 1 to 2269)
  AUTHORS   Oakey,R.J., Caron,M.G., Lefkowitz,R.J. and Seldin,M.F.
  TITLE     Genomic organization of adrenergic and serotonin receptors in the
            mouse: linkage mapping of sequence-related genes provides a method
            for examining mammalian chromosome evolution
  JOURNAL   Genomics 10 (2), 338-344 (1991)
   PUBMED   1676978
REFERENCE   10 (bases 1 to 2269)
  AUTHORS   Yang-Feng,T.L., Xue,F.Y., Zhong,W.W., Cotecchia,S., Frielle,T.,
            Caron,M.G., Lefkowitz,R.J. and Francke,U.
  TITLE     Chromosomal organization of adrenergic receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1516-1520 (1990)
   PUBMED   2154750
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124430.3, BC032883.1 and
            BB844430.1.
            
            On Apr 17, 2013 this sequence version replaced NM_007420.2.
            
            Summary: This intronless gene belongs to the G-protein-coupled
            receptor superfamily, which includes transmembrane proteins that
            play a role in signal transduction across biological membranes
            resulting in a variety of physiological responses. The encoded
            protein is a beta-2 adrenergic receptor which is activated by
            catecholamine ligands such as adrenaline and epinephrine. The
            protein participates in the classical signaling pathway involving G
            protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine
            monophosphate) and protein kinase A (PKA). In humans, this gene is
            implicated in susceptibility to nocturnal asthma, obesity and type
            2 diabetes. [provided by RefSeq, Apr 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC032883.1, AK080276.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 8308019
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC124430.3         121477-121498
            23-2166             BC032883.1         1-2144
            2167-2269           BB844430.1         196-298
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 35.1 cM"
     gene            1..2269
                     /gene="Adrb2"
                     /gene_synonym="Adrb-2; Badm; Gpcr7"
                     /note="adrenergic receptor, beta 2"
                     /db_xref="GeneID:11555"
                     /db_xref="MGI:MGI:87938"
     exon            1..2269
                     /gene="Adrb2"
                     /gene_synonym="Adrb-2; Badm; Gpcr7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      120..179
                     /regulatory_class="uORF"
                     /gene="Adrb2"
                     /gene_synonym="Adrb-2; Badm; Gpcr7"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:8308019]"
                     /note="this uORF is predicted to encode a 19 aa peptide
                     (PMID:8308019)"
     CDS             230..1486
                     /gene="Adrb2"
                     /gene_synonym="Adrb-2; Badm; Gpcr7"
                     /note="beta-2 adrenoceptor; beta-2 adrenoreceptor; beta
                     2-AR"
                     /codon_start=1
                     /product="beta-2 adrenergic receptor"
                     /protein_id="NP_031446.2"
                     /db_xref="CCDS:CCDS29289.1"
                     /db_xref="GeneID:11555"
                     /db_xref="MGI:MGI:87938"
                     /translation="MGPHGNDSDFLLAPNGSRAPDHDVTQERDEAWVVGMAILMSVIV
                     LAIVFGNVLVITAIAKFERLQTVTNYFIISLACADLVMGLAVVPFGASHILMKMWNFG
                     NFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIV
                     SGLTSFLPIQMHWYRATHKKAIDCYTEETCCDFFTNQAYAIASSIVSFYVPLVVMVFV
                     YSRVFQVAKRQLQKIDKSEGRFHAQNLSQVEQDGRSGHGLRRSSKFCLKEHKALKTLG
                     IIMGTFTLCWLPFFIVNIVHVIRDNLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRI
                     AFQELLCLRRSSSKTYGNGYSSNSNGRTDYTGEPNTCQLGQEREQELLCEDPPGMEGF
                     VNCQGTVPSLSVDSQGRNCSTNDSPL"
     regulatory      2147..2152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adrb2"
                     /gene_synonym="Adrb-2; Badm; Gpcr7"
                     /note="hexamer: AATAAA"
     polyA_site      2166
                     /gene="Adrb2"
                     /gene_synonym="Adrb-2; Badm; Gpcr7"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcactgc aaggctgctt ctcaggcatt caggctgcgg ctgcaggcac cgcgagcccg
       61 gagcacccac gagctgagtg tgcaggacgc accccagcac agccacctac ggccgctgaa
      121 tgaagcttcc aggagtccgc ccccggccgg ctgcgccccg tcggaggtgc acccgctgag
      181 agcgcctggg caccgaaagc cggtgcgctc acctgctaac ctgccagcca tggggccaca
      241 cgggaacgac agcgacttct tgctggcacc caacggaagc cgagcgccag accacgacgt
      301 cactcaggaa cgggacgaag cgtgggttgt gggcatggcc atcctcatgt cggttatcgt
      361 cctggccatc gtgtttggca acgtgctggt catcacagcc attgccaagt tcgagcgact
      421 acaaaccgtc accaactact tcataatctc cttggcgtgt gctgatctag tcatgggcct
      481 agcggtggtg ccgtttgggg ccagtcacat ccttatgaaa atgtggaatt ttggcaactt
      541 ctggtgcgag ttctggactt ccattgatgt gttgtgcgtc acagccagca tcgagaccct
      601 gtgcgtgatt gcagtggatc gctatgttgc tatcacatcg cccttcaagt accagagcct
      661 gctgaccaag aataaggccc gagtggtcat cctgatggta tggattgtat ctggccttac
      721 ctcctttttg cctatccaga tgcactggta ccgtgccacc cacaagaaag ctatcgattg
      781 ttacaccgag gagacttgct gtgacttctt cacgaaccag gcctacgcca tcgcgtcctc
      841 gattgtgtct ttctacgtgc ccctggtggt gatggtcttt gtctattccc gggtcttcca
      901 ggtggccaaa aggcagctgc agaagataga caaatctgaa ggaagattcc acgcccaaaa
      961 cctcagccag gtggagcagg atgggcggag cggccacgga ctccgaaggt cctccaagtt
     1021 ctgcttgaaa gagcacaaag ccctcaagac tttaggcatc atcatgggca cattcaccct
     1081 ctgctggctg cccttcttca ttgtcaatat cgtgcacgtt atcagggaca acctcatccc
     1141 taaggaagtt tacatcctcc ttaactggtt gggctacgtc aactctgcct tcaatcctct
     1201 tatctactgt cggagtccag atttcaggat tgcctttcaa gagcttctgt gccttcgcag
     1261 gtcttcttcg aaaacctatg ggaacggcta ctctagcaat agcaacggca gaacggacta
     1321 cacaggggag ccaaacactt gtcagctggg gcaggagaga gaacaggaac tgctgtgtga
     1381 ggatccccca ggcatggaag gctttgtgaa ctgtcaaggt actgtgccta gccttagcgt
     1441 tgactcccaa ggaaggaact gtagtacaaa tgactcgcca ctgtaataca ggctttctac
     1501 tctctaagac ccctccttga caggacacta accagactat ttaacttgag tgtaataact
     1561 ttagaataaa attgtataga gatttgcaga aggggaggca catccttctg ccttttttta
     1621 aattttattt tattttttaa gctgcaaaca agagagagaa actgtatttg agtgcttatt
     1681 gttttcttgt atagttcagt tcctctttgt atggaactta aaggtttctg tctgaagagt
     1741 gttggttctg gaggactgag tctgtctgtc tgtctgtctg gatgatgttt tcatgtatct
     1801 acctcactgg tcaagtatta agaatgatat atattgctgc tggaaatcca tatctaaagg
     1861 agagagtttt cttcctgtac ccttggactt gaaatatcct gtgtcttgga cctttctgct
     1921 gtgacaatgg gccctttctc tctcactcca cttatttact caaatggagt gttgcaggca
     1981 gggatttgag ggacaacatc agttgttttg tttttgtttt tgtttttgtt tttttgtttg
     2041 tttggttcgt ttttggtttg ttgttgtttt ttggggtttt gtttttgttt ttgttttttt
     2101 gggttttttt tttttttttg ctgagaaaag tctaaagttt acagtaaata aattgtttaa
     2161 ccatgacttc attgcacccg tttcttcaaa acctcttgac tctggagtgt ccttgtctct
     2221 cccactggaa accacaggta aactatgtgt cgtgaccgat gagtggctt
//
