LOCUS       NM_007419               3034 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus adrenergic receptor, beta 1 (Adrb1), mRNA.
ACCESSION   NM_007419
VERSION     NM_007419.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3034)
  AUTHORS   Evans,A.K., Park,H.H., Woods,C.E., Lam,R.K., Rijsketic,D.R., Xu,C.,
            Chu,E.K., Ciari,P., Blumenfeld,S., Vidano,L.M., Saw,N.L.,
            Heifets,B.D. and Shamloo,M.
  TITLE     Impact of noradrenergic inhibition on neuroinflammation and
            pathophysiology in mouse models of Alzheimer's disease
  JOURNAL   J Neuroinflammation 21 (1), 322 (2024)
   PUBMED   39696597
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3034)
  AUTHORS   Xu,B., Bahriz,S., Salemme,V.R., Wang,Y., Zhu,C., Zhao,M. and
            Xiang,Y.K.
  TITLE     Differential Downregulation of beta1-Adrenergic Receptor Signaling
            in the Heart
  JOURNAL   J Am Heart Assoc 13 (12), e033733 (2024)
   PUBMED   38860414
  REMARK    GeneRIF: Differential Downregulation of beta1-Adrenergic Receptor
            Signaling in the Heart.
REFERENCE   3  (bases 1 to 3034)
  AUTHORS   Liu,T., Wang,H., Kutsovsky,D.Y., Iskols,M., Chen,H., Ohn,C.Y.J.,
            Patel,N., Yang,J. and Simon,D.J.
  TITLE     An axon-T cell feedback loop enhances inflammation and axon
            degeneration
  JOURNAL   Cell Rep 43 (2), 113721 (2024)
   PUBMED   38310514
REFERENCE   4  (bases 1 to 3034)
  AUTHORS   Jaschke,N.P., Breining,D., Hofmann,M., Pahlig,S., Baschant,U.,
            Oertel,R., Traikov,S., Grinenko,T., Saettini,F., Biondi,A.,
            Stylianou,M., Bringmann,H., Zhang,C., Yoshida,T.M., Weidner,H.,
            Poller,W.C., Swirski,F.K., Gobel,A., Hofbauer,L.C., Rauner,M.,
            Scheiermann,C., Wang,A. and Rachner,T.D.
  TITLE     Small-molecule CBP/p300 histone acetyltransferase inhibition
            mobilizes leukocytes from the bone marrow via the endocrine stress
            response
  JOURNAL   Immunity 57 (2), 364-378 (2024)
   PUBMED   38301651
REFERENCE   5  (bases 1 to 3034)
  AUTHORS   Lin,T.Y., Ramsamooj,S., Perrier,T., Liberatore,K., Lantier,L.,
            Vasan,N., Karukurichi,K., Hwang,S.K., Kesicki,E.A.,
            Kastenhuber,E.R., Wiederhold,T., Yaron,T.M., Huntsman,E.M., Zhu,M.,
            Ma,Y., Paddock,M.N., Zhang,G., Hopkins,B.D., McGuinness,O.,
            Schwartz,R.E., Ersoy,B.A., Cantley,L.C., Johnson,J.L. and
            Goncalves,M.D.
  TITLE     Epinephrine inhibits PI3Kalpha via the Hippo kinases
  JOURNAL   Cell Rep 42 (12), 113535 (2023)
   PUBMED   38060450
REFERENCE   6  (bases 1 to 3034)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   7  (bases 1 to 3034)
  AUTHORS   Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   8  (bases 1 to 3034)
  AUTHORS   Bos,N.A., Meeuwsen,C.G., De Glopper-Van der Veer,E., van den
            Akker,T.W., Radl,J., Zwaagstra,K.A. and Benner,R.
  TITLE     Isolation and molecular characterization of the B cells producing
            the paraprotein in a case of benign monoclonal gammapathy in C57BL
            mice
  JOURNAL   Eur J Immunol 21 (8), 1893-1898 (1991)
   PUBMED   1868874
REFERENCE   9  (bases 1 to 3034)
  AUTHORS   Oakey,R.J., Caron,M.G., Lefkowitz,R.J. and Seldin,M.F.
  TITLE     Genomic organization of adrenergic and serotonin receptors in the
            mouse: linkage mapping of sequence-related genes provides a method
            for examining mammalian chromosome evolution
  JOURNAL   Genomics 10 (2), 338-344 (1991)
   PUBMED   1676978
REFERENCE   10 (bases 1 to 3034)
  AUTHORS   Yang-Feng,T.L., Xue,F.Y., Zhong,W.W., Cotecchia,S., Frielle,T.,
            Caron,M.G., Lefkowitz,R.J. and Francke,U.
  TITLE     Chromosomal organization of adrenergic receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1516-1520 (1990)
   PUBMED   2154750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158549.8.
            
            On Jun 25, 2019 this sequence version replaced NM_007419.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7652917.419217.1, BC140970.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3034              AC158549.8         59499-62532
FEATURES             Location/Qualifiers
     source          1..3034
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.96 cM"
     gene            1..3034
                     /gene="Adrb1"
                     /gene_synonym="Adrb-1; beta-AR"
                     /note="adrenergic receptor, beta 1"
                     /db_xref="GeneID:11554"
                     /db_xref="MGI:MGI:87937"
     exon            1..3034
                     /gene="Adrb1"
                     /gene_synonym="Adrb-1; beta-AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1656
                     /gene="Adrb1"
                     /gene_synonym="Adrb-1; beta-AR"
                     /note="beta-1 adrenoceptor; beta-1 adrenoreceptor; beta
                     1-AR; cardiac beta adrenergic receptor"
                     /codon_start=1
                     /product="beta-1 adrenergic receptor"
                     /protein_id="NP_031445.2"
                     /db_xref="CCDS:CCDS29919.1"
                     /db_xref="GeneID:11554"
                     /db_xref="MGI:MGI:87937"
                     /translation="MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLP
                     PASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLAS
                     ADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI
                     TSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDF
                     VTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPE
                     PSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANV
                     VKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRA
                     AHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGTTPPARLLEPWTGCNGGTTTVDSDS
                     SLDEPGRQGFSSESKV"
     regulatory      3011..3016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adrb1"
                     /gene_synonym="Adrb-1; beta-AR"
                     /note="hexamer: AATAAA"
     polyA_site      3034
                     /gene="Adrb1"
                     /gene_synonym="Adrb-1; beta-AR"
                     /note="major polyA site"
ORIGIN      
        1 agaaacatgc tgaggtcccg gcggctcttc cagcagcgac agcggctcca gcagcagcgg
       61 cggcggcggc ggcggagaca gcgctcggct acggaggaga aggcgcccgg cgtccatgcc
      121 tccggccccg agccgcggct gccctgacct ggccgcgacc tccccgcgcg ggccccgcag
      181 ccccggctcc tggggtgctc cccaggcgcg gcccagcccc gccacacccc ccgcccccgg
      241 cctccgcagc tcggcatggg cgcgggggcg ctcgccctgg gcgcctccga accctgcaac
      301 ctgtcgtccg ccgcgccgct gcccgacggt gcggccaccg cggcgcggct gctggtgctc
      361 gcgtcgcctc ccgcctcgct gctgcctcca gccagcgagg gctcagcgcc gctgtcgcag
      421 cagtggaccg cgggtatggg cctactgctg gcgctcatcg ttctgctcat cgtggtgggt
      481 aacgtgctgg tgatcgtggc catcgccaag accccgcggc tgcagacgct caccaacctc
      541 ttcatcatgt ccctggccag cgctgatctg gtcatgggat tgctggtggt gcctttcggg
      601 gccaccatcg tggtgtgggg ccgctgggag tacggctcct tcttctgcga gctctggact
      661 tcggtagatg tgctgtgtgt gacggccagc attgagaccc tgtgtgtcat cgccctggac
      721 cgctacctcg ccatcacgtc gccctttcgc taccagagtt tgctgacgcg cgcgcgagcg
      781 cgggccctcg tgtgcacagt gtgggccatc tcggcgttgg tgtccttcct gcccatcctc
      841 atgcactggt ggcgggccga gagcgacgaa gcgcgccgct gctacaacga ccccaagtgc
      901 tgcgatttcg tcaccaacag ggcctacgcc atcgcctcgt ccgtcgtctc cttctacgtg
      961 cccctgtgca tcatggcctt cgtgtacctg cgggtgttcc gcgaggccca aaaacaggta
     1021 aagaagatcg acagctgcga gcgccgcttc ctcggcggcc cagcccggcc gccctcgcct
     1081 gagccctcgc cgtcacctgg gccaccgcgc cccgcagact cgctggccaa cgggcgctcc
     1141 agcaagcggc ggccgtcgcg cctcgtggct ctgcgcgagc agaaggcgct caagacactg
     1201 ggcatcatca tgggtgtgtt cacgctctgc tggctgccct tcttcctggc caacgtggtg
     1261 aaggctttcc accgcgacct ggtgccggat cgcctcttcg tcttcttcaa ctggctgggc
     1321 tacgccaact cggccttcaa ccccatcatc tactgccgca gccccgactt ccgcaaggct
     1381 ttccagcgcc tgctctgctg cgcgcgccgg gccgcctgca gacgccgcgc agcccacggg
     1441 gaccggccgc gcgcctccgg ctgcctggcg agagctgggc cgccgccgtc ccccggagct
     1501 ccctcggacg acgacgacga cgacgccggg accaccccac cggcgcgcct gctggagccc
     1561 tggaccggct gcaacggcgg gacaaccact gtggacagcg attcgagcct ggacgagccg
     1621 gggcgccagg gcttctcctc ggagtccaag gtgtagagag ccaggctctc tgggcgcacg
     1681 gacgccgctc cccatagtcc cgggctggac acgggctctg catccctaga ggaagagagc
     1741 ccgcctgggc gcccctgagc cgctccccag gggagagagg agatctctgt ttactcaaga
     1801 ccgaaagcag gtgaatgcaa agcccacaga tctatcgaat catccgagac gtacagaaaa
     1861 gccccggacc gagcgtttgc gcaaaaagga aagtttagga ggagttggga gagtgtggct
     1921 tagtatggct tactggcttg tcttgagttc ctttctctct gaggttcggc ctttcgtgtg
     1981 tttaatgcac cttcaggcat tccccccccc ccccgcccct aggtgggttt tgacactttc
     2041 tgcaaggacc cgagtggaaa ctaggcgggg aggggagggg gcaggatgga gtctatcacc
     2101 tggctttccg gttccacacc taggaaccta agtattcagc tcaggtttgg tgtgggggcg
     2161 gggccggtga taattagcca ggaagtgttt ccctttgctt tctaaagaaa ttgcatacta
     2221 attccggagt actggtgtct cctgttctta aagcaaaggg aaaagaagga tgcgaaacag
     2281 acaaatctgg tttcgagaaa ctatgtgtgg agcacggttc accttgcttt ctcctagagg
     2341 gcaaaccttg tgccctgcgc gcctcggtgg tcctgctgtg ggtcctctac ctcactctgt
     2401 gcatattgca cagcaagata gaaagacttg tttatattaa acagcttatt tatgtatcaa
     2461 tactagttgg aaggaccagg cgctgagtct ctctctgtga catgtgactc tgtcaactaa
     2521 agataggaca gaacaaaaag gaaacagttg agattattgc acatgtggct aaaaacaaag
     2581 acggcaaaaa aaaaaaaaaa aggcagtggt tggaaggcca ttttgcacag tgttaggcat
     2641 tgtaaaattc atagaagttg ttaacttgca caaaaaaaat taaatatttt tactgggatg
     2701 gggaggtggg cagatcttta aaaagctaaa ataaaattca aactcagttt ctcttgtcta
     2761 ttatgttatt gagttgatgg tttattggga agttactttt tatactctta tcatggtact
     2821 gtaactgtat ccatattata aatattattc tcttacgtat ttttattatt attttttaat
     2881 gtccaagtgc ccccgtgaat ctgctggtaa aatttagcac tcgtgtgtat attctatctc
     2941 ttcttgtgtg tgtgaccaag tatttatact ctggtgcaac taactaccgt gtgggaattg
     3001 gtccatgtgc aataaagaca gcagtgcagc tcaa
//
