LOCUS       NM_007418               3214 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adrenergic receptor, alpha 2c (Adra2c), mRNA.
ACCESSION   NM_007418 XM_910443
VERSION     NM_007418.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3214)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3214)
  AUTHORS   Gonzatti,M.B., Freire,B.M., Antunes,M.M., de Menezes,G.B.,
            Talbot,J., Peron,J.P.S., Basso,A.S. and Keller,A.C.
  TITLE     Targeting adrenergic receptors to mitigate invariant natural killer
            T cells-induced acute liver injury
  JOURNAL   iScience 26 (10), 107947 (2023)
   PUBMED   37841583
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3214)
  AUTHORS   Joca,H.C., Santos-Miranda,A., Joviano-Santos,J.V.,
            Maia-Joca,R.P.M., Brum,P.C., Williams,G.S.B. and Cruz,J.S.
  TITLE     Chronic Sympathetic Hyperactivity Triggers Electrophysiological
            Remodeling and Disrupts Excitation-Contraction Coupling in Heart
  JOURNAL   Sci Rep 10 (1), 8001 (2020)
   PUBMED   32409748
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3214)
  AUTHORS   Araujo,L.P., Maricato,J.T., Guereschi,M.G., Takenaka,M.C.,
            Nascimento,V.M., de Melo,F.M., Quintana,F.J., Brum,P.C. and
            Basso,A.S.
  TITLE     The Sympathetic Nervous System Mitigates CNS Autoimmunity via
            beta2-Adrenergic Receptor Signaling in Immune Cells
  JOURNAL   Cell Rep 28 (12), 3120-3130 (2019)
   PUBMED   31533035
REFERENCE   5  (bases 1 to 3214)
  AUTHORS   Luhrs,L., Manlapaz,C., Kedzie,K., Rao,S., Cabrera-Ghayouri,S.,
            Donello,J. and Gil,D.
  TITLE     Function of brain alpha2B-adrenergic receptor characterized with
            subtype-selective alpha2B antagonist and KO mice
  JOURNAL   Neuroscience 339, 608-621 (2016)
   PUBMED   27751959
REFERENCE   6  (bases 1 to 3214)
  AUTHORS   Link,R.E., Stevens,M.S., Kulatunga,M., Scheinin,M., Barsh,G.S. and
            Kobilka,B.K.
  TITLE     Targeted inactivation of the gene encoding the mouse alpha
            2c-adrenoceptor homolog
  JOURNAL   Mol Pharmacol 48 (1), 48-55 (1995)
   PUBMED   7623774
REFERENCE   7  (bases 1 to 3214)
  AUTHORS   Avraham,K.B., Givol,D., Avivi,A., Yayon,A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of murine fibroblast growth factor receptors refines
            regions of homology between mouse and human chromosomes
  JOURNAL   Genomics 21 (3), 656-658 (1994)
   PUBMED   7959747
REFERENCE   8  (bases 1 to 3214)
  AUTHORS   Chang,N.C., Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Chang,Y.H.,
            Chen,W.M. and Chang,A.C.
  TITLE     Assignment of two alpha 2 adrenoceptor subtype genes to murine
            chromosomes
  JOURNAL   Neurosci Lett 167 (1-2), 105-108 (1994)
   PUBMED   8177505
REFERENCE   9  (bases 1 to 3214)
  AUTHORS   Link,R., Daunt,D., Barsh,G., Chruscinski,A. and Kobilka,B.
  TITLE     Cloning of two mouse genes encoding alpha 2-adrenergic receptor
            subtypes and identification of a single amino acid in the mouse
            alpha 2-C10 homolog responsible for an interspecies variation in
            antagonist binding
  JOURNAL   Mol Pharmacol 42 (1), 16-27 (1992)
   PUBMED   1353249
REFERENCE   10 (bases 1 to 3214)
  AUTHORS   Oakey,R.J., Caron,M.G., Lefkowitz,R.J. and Seldin,M.F.
  TITLE     Genomic organization of adrenergic and serotonin receptors in the
            mouse: linkage mapping of sequence-related genes provides a method
            for examining mammalian chromosome evolution
  JOURNAL   Genomics 10 (2), 338-344 (1991)
   PUBMED   1676978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE648133.1, BE957015.1, CJ062611.1, CK622790.1, AC164118.4 and
            BE994823.1.
            
            On Sep 5, 2007 this sequence version replaced NM_007418.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the
            reference strain was available for the full length of the gene. The
            extent of this transcript and the encoded protein are supported by
            data from other mouse strain, and by human and rat orthologs.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               BE648133.1         279-634
            357-519             BE957015.1         1-163               c
            520-677             CJ062611.1         42-199
            678-1215            CK622790.1         19-556
            1216-2865           AC164118.4         89590-91239
            2866-3085           BE994823.1         130-349             c
            3086-3087           AC164118.4         91460-91461
            3088-3214           BE994823.1         1-127               c
FEATURES             Location/Qualifiers
     source          1..3214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 18.09 cM"
     gene            1..3214
                     /gene="Adra2c"
                     /gene_synonym="Adra-2c; alpha2-C4; alpha2C; [a]2C"
                     /note="adrenergic receptor, alpha 2c"
                     /db_xref="GeneID:11553"
                     /db_xref="MGI:MGI:87936"
     exon            1..3198
                     /gene="Adra2c"
                     /gene_synonym="Adra-2c; alpha2-C4; alpha2C; [a]2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             1321..2697
                     /gene="Adra2c"
                     /gene_synonym="Adra-2c; alpha2-C4; alpha2C; [a]2C"
                     /note="alpha-2CAR; alpha-2C adrenoceptor; alpha-2C
                     adrenoreceptor; alpha-2 adrenergic receptor subtype C4;
                     subtype alpha2-C4"
                     /codon_start=1
                     /product="alpha-2C adrenergic receptor"
                     /protein_id="NP_031444.2"
                     /db_xref="CCDS:CCDS19226.1"
                     /db_xref="GeneID:11553"
                     /db_xref="MGI:MGI:87936"
                     /translation="MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWVPPPG
                     QYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVAT
                     LVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYN
                     LKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGS
                     FFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAP
                     PRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRS
                     PGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWF
                     PFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFR
                     RRRRGFRQ"
     regulatory      3179..3184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adra2c"
                     /gene_synonym="Adra-2c; alpha2-C4; alpha2C; [a]2C"
                     /note="hexamer: AATAAA"
     polyA_site      3198
                     /gene="Adra2c"
                     /gene_synonym="Adra-2c; alpha2-C4; alpha2C; [a]2C"
                     /note="major polyA site"
ORIGIN      
        1 tgtgaaaagc gggatcacac agcattaaga ttcaacttca acaattgcca acatgggtat
       61 agagcttggg agcttgatct gggcctcgac tgacaccgtg gttatgattc acgatcccgc
      121 agcgctgaga ggtactcaga ggagggaact gaggctgact gaggaggtgg ctctgcaggg
      181 gagcagggac cctaagctcc aaaggaatga tgcgcaccag cagtgtctct gccatgctgc
      241 tacaagcgca ctctccaatc aggccgcgga ccccgagcca gccccttacg agccggtgtg
      301 cgcgcccgcg cgcgctccgt cgcctgtaac cgagtgaggt ggagactacg atcttagaaa
      361 gagcaggctt ctagaactca ccgctcaggc cagcccgcgc tcagccgggc cccgcaggct
      421 gcagttggcc ctggaggggg cgccctcgcc gagtgcgcgc cctgcgccgc cgcctagggc
      481 tcctccccgg cgccgccggc aggttcgccc aggcggccgc gggctccggc tcccggcccg
      541 ctccccccgg gcccgcggct cgggcctgcg gggcgccccg ccccgccccg ctgcgccctc
      601 cccgctgcgc tactggactc aagttggaag ccgagcccgg gcgacagcac ttgcgccaag
      661 cgctccgcgg cggcggagac gctgcaccgg cgagcgggga gggcgaggcg gcgcccgcac
      721 ggccgaacgc ggaccttggg gggcgcccgc actcgggagc agcaggagga ccgcgggtgt
      781 cggcgcccag ccccgcaaag taaagttgca gggacccgga agaacggcaa cctgcgcccc
      841 ggctcgctta gccccagcca gcccgttggg aagcagagtg tccgggccgc cgcctgcagc
      901 ctgcagccca gtcgggcacc cggaccgtgg agccgcttgc gtgcaccagc ttggacaccg
      961 catctccgtg ggctggcggc cgggacgctc ccactgaacc caggccgagg gcggggccgc
     1021 tcgaggaccc gggacctacc cccattcccc cccaccgccg cgtcgccgcg ctctctgggc
     1081 acctccagct ctgcacttac gcgcgcggca gctgcgggga gcccggcagc cacgctctcc
     1141 ggcgcgccgc ccgcccgccg ggccaccacg gccgagagcc ggctgcgggg cttcgtggcc
     1201 cccagccggc gcgccggagg agcaggcggc gatgcggacg ccgaccctgg ctgtggggcg
     1261 cccgagctgc cgaggctgcg cccgggctcc tggcaggacc gcgtagctct cgggaggacc
     1321 atggcgtccc cagcgctggc cgcggcgctg gcggcggcgg cggctgaggg ccccaacggg
     1381 agcgacgcgg gcgaatgggg tagcggcggg ggtgccaacg cctcggggac cgactgggtg
     1441 ccaccgccgg gccagtactc cgcaggtgct gtggcggggt tggcagctgt ggtgggtttc
     1501 ctcatcgttt tcaccgtggt aggcaatgtg ctcgtggtga tcgctgtgtt gaccagccga
     1561 gcactgcgcg ccccgcagaa cctcttcctg gtgtctctgg cctcagctga catcctggtg
     1621 gccacactgg tcatgccctt ttctctggcc aatgagctca tggcctactg gtacttcggg
     1681 caagtgtggt gtggtgtata cctggcactg gacgtgctct tctgcacctc gtccatcgtg
     1741 cacctgtgtg ccattagtct ggaccgctac tggtcggtga cgcaagcggt agagtacaac
     1801 ctgaagcgca cgccgcgccg tgtcaaggcc accatcgtgg ccgtgtggct catctccgct
     1861 gtcatctcct tcccgcctct cgtctcgttc taccgccggc ccgacggcgc cgcctatccg
     1921 cagtgcggcc tcaacgatga gacctggtac atcttgtcct cctgcatagg ctccttcttc
     1981 gcgccctgcc tcatcatggg cctggtctat gcgcgcatct accgcgtggc caagctgcgc
     2041 acgcgtacgc tcagcgagaa acgcggcccc gccggccccg acggcgcgtc cccgaccaca
     2101 gagaatgggc tgggcaaggc agcgggggag aacgggcatt gcgcgccccc gcgcactgaa
     2161 gtggagccgg atgagagcag tgcggccgag aggcggaggc gccggggcgc gctgcgcaga
     2221 ggaggacggc ggcgagaggg tgctgagggg gacacgggca gtgcggacgg accgggaccg
     2281 ggactggcag ccgagcaggg tgctcggacg gcgtctcggt ccccaggccc cggagggcgc
     2341 ctgtcgcggg ccagctcgcg ctccgtcgag ttcttcctgt cgcgtcggcg ccgggcgcgc
     2401 agcagtgtgt gccgccgcaa ggtggcccag gcacgcgaga agcgcttcac cttcgtgttg
     2461 gcggtggtca tgggcgtgtt cgtactgtgc tggttcccct tcttcttcag ctacagcctg
     2521 tatggcatct gccgtgaggc ctgccagttg ccagaaccgc tctttaagtt tttcttctgg
     2581 atcggctact gcaacagttc gctcaacccg gtcatctaca ctgtcttcaa tcaggacttc
     2641 aggcgctctt tcaagcatat cctctttcga aggaggagaa ggggcttcag gcaatgaccc
     2701 tctggcctcc tggacctgga cccactgacg tcctggacag ctctgaactc gggtagacag
     2761 agagaccaac agtgtggtct ctccagagtc ccagggtgga cttcagggca cagtgtggga
     2821 tgtggcagac aggagctggg cgagagacaa ctgggccttg gggagtgggg aggagaaagg
     2881 gagacctttg ccttcccatc tcagcgaggg gctgtagcta ggttgtggat ccagttcctg
     2941 agaaggcttc tgtggagtgt ggctgtgaac ttagggcttt agagctcaga caactaaacc
     3001 acaccaagaa aggagcacac cacccccttc tcggtcttcc ctgtgagcaa gggctgactt
     3061 cctatgacct gaaaaaggca tctgtctggg ggaggagaga tagcacaggc aatctctggt
     3121 tactgagatt gtttgccaaa tacaatgaca gccaaaacaa ccaaaccatt tttttttaaa
     3181 taaacctttg taatctaaaa aaaaaaaaaa aaaa
//
