LOCUS       NM_009633               4043 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adrenergic receptor, alpha 2b (Adra2b), mRNA.
ACCESSION   NM_009633
VERSION     NM_009633.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4043)
  AUTHORS   Gonzatti,M.B., Freire,B.M., Antunes,M.M., de Menezes,G.B.,
            Talbot,J., Peron,J.P.S., Basso,A.S. and Keller,A.C.
  TITLE     Targeting adrenergic receptors to mitigate invariant natural killer
            T cells-induced acute liver injury
  JOURNAL   iScience 26 (10), 107947 (2023)
   PUBMED   37841583
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4043)
  AUTHORS   Luhrs,L., Manlapaz,C., Kedzie,K., Rao,S., Cabrera-Ghayouri,S.,
            Donello,J. and Gil,D.
  TITLE     Function of brain alpha2B-adrenergic receptor characterized with
            subtype-selective alpha2B antagonist and KO mice
  JOURNAL   Neuroscience 339, 608-621 (2016)
   PUBMED   27751959
  REMARK    GeneRIF: alpha2B KO mice exhibit altered locomotor behaviors and
            compulsive burying behavior, are acutely sensitive to the
            stereotypy effects of the psychostimulant amphetamine; an identical
            tendency in alpha2C KO mice administered the
            alpha2B-receptor-selective antagonist AGN-209419 with amphetamine.
            Findings suggest a compulsive phenotype for alpha2B KO mice, and a
            broader role for the alpha2B receptor.
REFERENCE   3  (bases 1 to 4043)
  AUTHORS   Che,P., Chen,Y., Lu,R., Peng,N., Gannon,M., Wyss,J.M., Jiao,K. and
            Wang,Q.
  TITLE     Spinophilin Is Indispensable for the alpha2B Adrenergic
            Receptor-Elicited Hypertensive Response
  JOURNAL   PLoS One 10 (8), e0135030 (2015)
   PUBMED   26244553
  REMARK    GeneRIF: Data indicate that In arrestin 3 deficient mice, where the
            alpha2B adrenergic receptor has a stronger binding to spinophilin,
            the hypertensive response is enhanced.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4043)
  AUTHORS   Alldred,M.J., Lee,S.H., Petkova,E. and Ginsberg,S.D.
  TITLE     Expression profile analysis of vulnerable CA1 pyramidal neurons in
            young-Middle-Aged Ts65Dn mice
  JOURNAL   J Comp Neurol 523 (1), 61-74 (2015)
   PUBMED   25131634
REFERENCE   5  (bases 1 to 4043)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 4043)
  AUTHORS   Link,R.E., Desai,K., Hein,L., Stevens,M.E., Chruscinski,A.,
            Bernstein,D., Barsh,G.S. and Kobilka,B.K.
  TITLE     Cardiovascular regulation in mice lacking alpha2-adrenergic
            receptor subtypes b and c
  JOURNAL   Science 273 (5276), 803-805 (1996)
   PUBMED   8670422
REFERENCE   7  (bases 1 to 4043)
  AUTHORS   Chang,N.C., Jenkins,N.A., Gilbert,D.J., Copeland,N.G., Chang,Y.H.,
            Chen,W.M. and Chang,A.C.
  TITLE     Assignment of two alpha 2 adrenoceptor subtype genes to murine
            chromosomes
  JOURNAL   Neurosci Lett 167 (1-2), 105-108 (1994)
   PUBMED   8177505
REFERENCE   8  (bases 1 to 4043)
  AUTHORS   Link,R.E., Kobilka,B.K. and Barsh,G.S.
  TITLE     Linkage mapping of alpha-2 adrenergic receptor genes to mouse
            chromosomes 2 and 5
  JOURNAL   Mamm Genome 4 (11), 650-655 (1993)
   PUBMED   8281014
REFERENCE   9  (bases 1 to 4043)
  AUTHORS   Chen,W.M., Chang,A.C., Shie,B.J., Chang,Y.H. and Chang,N.C.
  TITLE     Molecular cloning and characterization of a mouse alpha 2C2
            adrenoceptor subtype gene
  JOURNAL   Biochim Biophys Acta 1171 (2), 219-223 (1992)
   PUBMED   1336396
REFERENCE   10 (bases 1 to 4043)
  AUTHORS   Chruscinski,A.J., Link,R.E., Daunt,D.A., Barsh,G.S. and
            Kobilka,B.K.
  TITLE     Cloning and expression of the mouse homolog of the human alpha 2-C2
            adrenergic receptor
  JOURNAL   Biochem Biophys Res Commun 186 (3), 1280-1287 (1992)
   PUBMED   1354956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731836.10.
            
            On Feb 13, 2019 this sequence version replaced NM_009633.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC066862.1, AF332050.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4043              AL731836.10        11223-15265
FEATURES             Location/Qualifiers
     source          1..4043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.95 cM"
     gene            1..4043
                     /gene="Adra2b"
                     /gene_synonym="a2b-AR; Adra-2b; alpha2-C2; alpha2B; [a]2B"
                     /note="adrenergic receptor, alpha 2b"
                     /db_xref="GeneID:11552"
                     /db_xref="MGI:MGI:87935"
     exon            1..4043
                     /gene="Adra2b"
                     /gene_synonym="a2b-AR; Adra-2b; alpha2-C2; alpha2B; [a]2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4018..4023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adra2b"
                     /gene_synonym="a2b-AR; Adra-2b; alpha2-C2; alpha2B; [a]2B"
                     /note="hexamer: AATAAA"
     polyA_site      4043
                     /gene="Adra2b"
                     /gene_synonym="a2b-AR; Adra-2b; alpha2-C2; alpha2B; [a]2B"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcctca cgcccctgcg cggagggctg actgcaggcg cggctccggg agagagcgcc
       61 tttaccgaga gcagggtgcg cttccccagt cggttctgtg agtcctgcag ctgtgccgca
      121 cgacggcgcg actttcctct ggtcccggga cggcagtgag acaacttgga aaacttctct
      181 ggggcggact gcagggacgc cgggcaccag tggcagagaa cgtaagagag cgatagatgg
      241 tcctgggtgt ccccggacct ccggccaggc tacggtgctc cagagccatc tgcaccgcct
      301 ggggggacgg cccccaacag tagcggagct agggtggcgc tttctcctgc gtactgtgag
      361 tttggccagc atctttctct ctggacatgt ccggccccgc catggtccac caggagccct
      421 actcggtgca ggccaccgcc gccatcgcgt cggccatcac ctttctcatc ctcttcacca
      481 ttttcggcaa tgcgctggta attctggctg tgttgaccag ccgctctctc cgtgcaccac
      541 aaaacctctt cctggtgtca ctggcagcag ccgacatcct agtggctact cttatcatcc
      601 ctttctctct ggccaacgag ctgctgggct attggtactt ctggcgtgcg tggtgcgagg
      661 tctacctggc gctagacgtg ctcttctgta cctcctccat cgtgcacctg tgtgccatca
      721 gtctggacag atactgggca gtgagccgag cattggagta caactccaag cgcactccac
      781 gccgcatcaa atgcatcatc ctcaccgtgt ggctcattgc agccgtcatt tctctaccgc
      841 ccctcatcta caagggcgac cagcgcccag agccccacgg gctcccccag tgtgagctca
      901 accaagaagc ctggtacatc ttggcttcca gcatcggatc tttttttgct ccctgcctca
      961 tcatgattct cgtctacctg cgaatctatg taattgccaa acgcagccac tgcagaggtc
     1021 tcggagctaa gaggggctct ggggagggtg agtccaagaa gccccatccg gccgccgggg
     1081 gagttccagc ctcggctaaa gtgcccaccc tggtctctcc tctatcttct gtcggagagg
     1141 ctaatggaca ccccaagcct ccaagggaga aggaggaggg ggagacccct gaagatcccg
     1201 aagccagggc tttgccaccc aattggtctg ccctgcccag atcagtccag gaccagaaga
     1261 aggggactag tggggcaact gcagagaagg gagctgaaga ggatgaagag gaggtggaag
     1321 aatgtgaacc ccaaacactg ccagcttctc ctgcctcagt attcaaccca cccttgcagc
     1381 agcctcagac ttcccgggtg ctggccacgc tacgtggcca ggtgcttctg agcaagaatg
     1441 tgggtgtggc cagtgggcag tggtggcgcc gtcggacaca gctgagccga gagaagaggt
     1501 tcacctttgt gctggcggtg gtcattggtg tttttgtggt ctgttggttt cctttcttct
     1561 tcagctacag cctgggggcc atctgcccac agcactgcaa ggtaccccat ggcctcttcc
     1621 agttcttctt ctggattggc tactgcaaca gctctttgaa tcctgtcatc tacaccatct
     1681 tcaaccagga cttccgccgt gcctttcgaa ggatcctttg ccggcagtgg acccagactg
     1741 gctggtgagc ctgcctgctc cgggccagtg ccaggcaggg ttagtgccag gaccacccgg
     1801 tggtagtctg ccacctccgc agtctatgtg accatttccc tggggcccat ttgcagacct
     1861 catcctcaga cacccctgaa ggggaaagga caaatgtgct gttcccaggg gctcatttga
     1921 aaccttccct tgctgactgt actgtgggat acctcttccc tgctctctct tcaggaaggg
     1981 tagcttggac cttctcgaac gtggccaagg ctgattagaa tacctccctc ccagccacct
     2041 gtaagccaac aggcaggctt ccctttcctg gagaccccct gtgccttggc aggccacttg
     2101 tggtggtttt ctttctttct catcatattc ttctcttctc ttttattgtt catttcattt
     2161 cttttttttt tttttttttt tttttgagac agggtctcat gtagcccaga ccagtctcag
     2221 acttgctatg cagcctgagg ctgatcttaa gattctgctt acctctccag catgagaagt
     2281 aacaatgctc accaccatac ctggtttacc tgatgctggg gaatgaagtc ggggcttcaa
     2341 gcatgctagg gaaacatcca accaaccgag ttatatcccc agccttgatc ttcctcatgc
     2401 ctttcaaaga gccggaagcc catcttctac atttcccagg aggacctgat gctgagaaag
     2461 aggacaaaag gaagaggatt cagccgtgct gagcacctgt ggttctcctt ggctgttgcg
     2521 gtggctggtt atggtctagt gctggttgct gggttttttg tttgttttgt tttgttttgt
     2581 ttttaagctt tgtagcgtct ttaaggctag aagcatgggt tgttttctca ctcagcatcc
     2641 ctctgggagg caagtgggca cgtggatgcc tcagtggaat ggtctggaat cctggcctcg
     2701 acctcactaa ggtcctgatc actggcattc aacctcgcag agagcagggt gacaattgcc
     2761 tgccgcctac ttgcagcagg gagatgaaag gctttgcaga gagctttgag ctccatgggg
     2821 gaaatgcgct agagagccag caaatgtgat tatctggtga tataaaaatc cctttcctgt
     2881 gtgtttacca ctgtgagcct tcctgtagac ttttgttctg tgcttggggt gtgtgaattc
     2941 ctaccccaaa ctggaagtgg gttgaggtgc acggagtcac tctttcaaat tccggaattt
     3001 ctttgagaat gctttcttgt gcctgaaaag gtttgagtta ttatgctgtt gtcagcttct
     3061 ccatctgtta cctgtaacag agttttcagt ggcttggccc caaccccatt aggggataag
     3121 ctctttgtca ttgagcaggc aaatcgtttt cctaagctaa aaatacttac atcaaggaag
     3181 cagtctgaga tgagatcctc aggtggggtg ctggggctag aacaggcagc caaggccctg
     3241 tggactcctg ggatagccac cctctgtggg gtcccagaca actctctgaa ccccatgtaa
     3301 cacctttgga gacagaagga gaccccagct cagaaggatg tctcattagc tgttacgaac
     3361 cctcatggcg atacagctgt gcactagggt gtctctacct cctggttgtc tccccgactt
     3421 agaaattgct ccccagagtg actggggatg catctgggcc ttccccacaa gcagcctgac
     3481 ttcagctttg ggcaatagac ctcttagcct cagggaaggg gtagattgag ccatgcaggc
     3541 tacaagctac acaggctatt agcccagggt gggtttatca gattttgaag gtgctaaggg
     3601 agttttctcg ggtaaagaca aagatgggtc ctaaattgaa ttcctcttgg agaggatgaa
     3661 tagcttggtc cttggttggt tgctgtttcg aggctaggac attgatttgg ggtgtggctg
     3721 aggggttggt ttggtttttt gtttttgttt tttgtttgtt tgtttgtttt tgagacaggg
     3781 tttctctgtg tgaccctggt tactctggaa ctcactcttt agaccaggct gcccttgaac
     3841 tcacaaagat ttgcctgcct ctgcttcccg agtgctggga tcaaaggcgt acactaccac
     3901 tgcctggcag cagggcagat ttgtaaccat ctgctggctg atcttgtgta tgcttcatgg
     3961 gacccaagcc ccctgttgtg acatataggt gtttctaaga ctctgagcta ttttatcaat
     4021 aaaggctatt ttttaataag caa
//
