LOCUS       NM_007417               3724 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus adrenergic receptor, alpha 2a (Adra2a), mRNA.
ACCESSION   NM_007417 XM_974141
VERSION     NM_007417.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3724)
  AUTHORS   Qi,L., Iskols,M., Shi,D., Reddy,P., Walker,C., Lezgiyeva,K.,
            Voisin,T., Pawlak,M., Kuchroo,V.K., Chiu,I.M., Ginty,D.D. and
            Sharma,N.
  TITLE     A mouse DRG genetic toolkit reveals morphological and physiological
            diversity of somatosensory neuron subtypes
  JOURNAL   Cell 187 (6), 1508-1526 (2024)
   PUBMED   38442711
REFERENCE   2  (bases 1 to 3724)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3724)
  AUTHORS   Ten Hove,A.S., Mallesh,S., Zafeiropoulou,K., de Kleer,J.W.M., van
            Hamersveld,P.H.P., Welting,O., Hakvoort,T.B.M., Wehner,S.,
            Seppen,J. and de Jonge,W.J.
  TITLE     Sympathetic activity regulates epithelial proliferation and wound
            healing via adrenergic receptor alpha2A
  JOURNAL   Sci Rep 13 (1), 17990 (2023)
   PUBMED   37863979
  REMARK    GeneRIF: Sympathetic activity regulates epithelial proliferation
            and wound healing via adrenergic receptor alpha2A.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3724)
  AUTHORS   Gonzatti,M.B., Freire,B.M., Antunes,M.M., de Menezes,G.B.,
            Talbot,J., Peron,J.P.S., Basso,A.S. and Keller,A.C.
  TITLE     Targeting adrenergic receptors to mitigate invariant natural killer
            T cells-induced acute liver injury
  JOURNAL   iScience 26 (10), 107947 (2023)
   PUBMED   37841583
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3724)
  AUTHORS   Janumpalli,S., Butler,L.S., MacMillan,L.B., Limbird,L.E. and
            McNamara,J.O.
  TITLE     A point mutation (D79N) of the alpha2A adrenergic receptor
            abolishes the antiepileptogenic action of endogenous norepinephrine
  JOURNAL   J Neurosci 18 (6), 2004-2008 (1998)
   PUBMED   9482787
REFERENCE   6  (bases 1 to 3724)
  AUTHORS   Wang,R., Macmillan,L.B., Fremeau,R.T. Jr., Magnuson,M.A.,
            Lindner,J. and Limbird,L.E.
  TITLE     Expression of alpha 2-adrenergic receptor subtypes in the mouse
            brain: evaluation of spatial and temporal information imparted by 3
            kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in
            transgenic animals
  JOURNAL   Neuroscience 74 (1), 199-218 (1996)
   PUBMED   8843087
REFERENCE   7  (bases 1 to 3724)
  AUTHORS   Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   8  (bases 1 to 3724)
  AUTHORS   Link,R., Daunt,D., Barsh,G., Chruscinski,A. and Kobilka,B.
  TITLE     Cloning of two mouse genes encoding alpha 2-adrenergic receptor
            subtypes and identification of a single amino acid in the mouse
            alpha 2-C10 homolog responsible for an interspecies variation in
            antagonist binding
  JOURNAL   Mol Pharmacol 42 (1), 16-27 (1992)
   PUBMED   1353249
REFERENCE   9  (bases 1 to 3724)
  AUTHORS   Johnson,K.R., Cook,S.A., Bustin,M. and Davisson,M.T.
  TITLE     Genetic mapping of the murine gene and 14 related sequences
            encoding chromosomal protein HMG-14
  JOURNAL   Mamm Genome 3 (11), 625-632 (1992)
   PUBMED   1360278
REFERENCE   10 (bases 1 to 3724)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA10 homologous loci in cattle
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 123-126 (1991)
   PUBMED   1655359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113491.18.
            
            On Mar 8, 2019 this sequence version replaced NM_007417.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: The 5'-most in-frame translation initiation codon is
            selected for this CCDS based on good conservation across mammalian
            species. A possible downstream start codon would result in a
            protein that is 15 aa shorter at the N-terminus. The downstream
            start codon is assumed in the literature, including in
            PMIDs:1353249, 8843087 and 9482787, but there is no experimental
            evidence indicating which start codon is preferentially used in
            vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK141573.1, BC138531.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3724              AC113491.18        144211-147934       c
FEATURES             Location/Qualifiers
     source          1..3724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 49.04 cM"
     gene            1..3724
                     /gene="Adra2a"
                     /gene_synonym="Adra-2; Adra-2a; alpha(2A)AR; alpha2-C10;
                     alpha2A; alpha2A-AR"
                     /note="adrenergic receptor, alpha 2a"
                     /db_xref="GeneID:11551"
                     /db_xref="MGI:MGI:87934"
     exon            1..3724
                     /gene="Adra2a"
                     /gene_synonym="Adra-2; Adra-2a; alpha(2A)AR; alpha2-C10;
                     alpha2A; alpha2A-AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             957..2354
                     /gene="Adra2a"
                     /gene_synonym="Adra-2; Adra-2a; alpha(2A)AR; alpha2-C10;
                     alpha2A; alpha2A-AR"
                     /note="alpha-2AAR; alpha-2A adrenoceptor; alpha-2A
                     adrenoreceptor; subtype alpha2-C10; alpha2A-adrenergic
                     receptor"
                     /codon_start=1
                     /product="alpha-2A adrenergic receptor"
                     /protein_id="NP_031443.4"
                     /db_xref="CCDS:CCDS29905.1"
                     /db_xref="GeneID:11551"
                     /db_xref="MGI:MGI:87934"
                     /translation="MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYS
                     LQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVI
                     PFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKR
                     TPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIG
                     SFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGP
                     TGAEAEPLPTQLNGAPGEPAPAGPRDGDALDLEESSSSEHAERPPGPRRPDRGPRAKG
                     KTRASQVKPGDSLPRRGPGAAGPGASGSGHGEERGGGAKASRWRGRQNREKRFTFVLA
                     VVIGVFVVCWFPFFFTYTLIAVGCPVPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRR
                     AFKKILCRGDRKRIV"
     regulatory      3704..3709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adra2a"
                     /gene_synonym="Adra-2; Adra-2a; alpha(2A)AR; alpha2-C10;
                     alpha2A; alpha2A-AR"
                     /note="hexamer: AATAAA"
     polyA_site      3724
                     /gene="Adra2a"
                     /gene_synonym="Adra-2; Adra-2a; alpha(2A)AR; alpha2-C10;
                     alpha2A; alpha2A-AR"
                     /note="major polyA site"
ORIGIN      
        1 agcagcctcg gctcccgctt ccgtgcagac gcccagcagc cggcgcacac cgcccagcca
       61 cccagcgcct ccagctccaa gtcctgcggt cctgcgaaaa ctcacgcggc cctccgaccc
      121 ccgccgggtc tgtggcgctc agcgcccacc cagatcgcgg ctagcagcca cccttggctc
      181 cgccgcggct cctggagagc cggtcgctca cctagcttgg ccctgaggac cgaggtggtg
      241 gtggtggggg tgcggcttca tgcggccccc acacccttca ccccaccgcc gccgcccccg
      301 agctctgtgt acagagtccc agccccagca gagcgcacaa ctttggaagt cccgtggggc
      361 tcctagagga ggcagagtcc gcgccttcgc cggaggtccg gcccagccct cgccaccccg
      421 cctggagggt agcgacggag ttggaaatct cttcgagggt ataagaagac agacctagga
      481 ctccgagccc acaccaacac ccctccgctg cctcttgggg taagacttca tgctttcgct
      541 cagcttaaga atcaaggtat agatgactag ctaaatgcat ttgtataaat ttctgacatc
      601 tttccaaatc atcaggccac cgataatttc ttttctcttt tcttgaagaa taaaatctct
      661 aaccaccagc tggccctact cgatcctgcc gcttagaaat aaaacttggc tgtgtttgag
      721 gagctgggag agagaaagca cccacccgga gcgtcggaag gacgaaccgg tgccagttcg
      781 cgggctccag tccatggacc actagcggtc cccagcttgg gcccgagctc cctgcggccc
      841 tcttccttat gtgaggcgcg gcgggacgaa ccccgcaccg gaggaagagg aggacccacg
      901 gacgcggggc cggaaggcag ctggcagcag gcccacgaga accagcaccc gcgttcatgt
      961 tccgccagga gcagccgctg gccgagggca gctttgcgcc catgggctca ctgcagccgg
     1021 atgccggcaa cagcagctgg aacgggaccg aagcgcccgg aggcggcacc cgagccaccc
     1081 cttactccct gcaggtgaca ctgacgctgg tttgcctggc tggcctgctc atgctgttca
     1141 cagtatttgg caacgtgctg gttattatcg cggtgttcac cagtcgcgcg ctcaaagctc
     1201 cccaaaacct cttcctggtg tccctggcct cagcggacat cctggtggcc acgctggtca
     1261 ttcccttttc tttggccaac gaggttatgg gttactggta ctttggtaag gtgtggtgtg
     1321 agatctattt ggctctcgac gtgctctttt gcacgtcgtc catagtgcac ctgtgcgcca
     1381 tcagccttga ccgctactgg tccatcacgc aggccatcga gtacaacctg aagcgcacgc
     1441 cgcgtcgcat caaggccatc attgtcaccg tgtgggtcat ctcggctgtc atctccttcc
     1501 cgccactcat ctccatagag aagaagggcg ctggcggcgg gcagcagccg gccgagccaa
     1561 gctgcaagat caacgaccag aagtggtatg tcatctcctc gtccatcggt tccttcttcg
     1621 cgccttgcct catcatgatc ctggtctacg tgcgtattta ccagatcgcc aagcgtcgca
     1681 cccgcgtgcc tcccagccgc cggggtccgg acgcctgttc cgcgccgccg gggggcgccg
     1741 atcgcaggcc caacgggctg ggcccggagc gcggcgcggg tcccacgggc gctgaggcgg
     1801 agccgctgcc cacccagctt aacggtgccc cgggggagcc cgcgcccgcc gggccccgcg
     1861 atggggatgc gctggaccta gaggagagtt cgtcgtccga gcacgccgag cggcccccgg
     1921 ggccccgcag acccgaccgc ggcccccgag ccaagggcaa gacccgggcg agtcaggtga
     1981 agccggggga cagtctgccg cggcgcgggc ccggggccgc ggggccgggg gcttcggggt
     2041 ccgggcacgg agaggagcgc ggcgggggcg ccaaagcgtc gcgctggcgc gggaggcaaa
     2101 accgggagaa acgcttcacg ttcgtgctgg cggtggtgat cggcgtgttc gtggtgtgtt
     2161 ggtttccgtt ctttttcacc tacacgctca tagcggtcgg ctgcccggtg cccagccagc
     2221 tcttcaactt cttcttctgg ttcggctact gcaacagctc gctgaaccct gttatctaca
     2281 ccatcttcaa ccacgacttc cgacgcgcct tcaagaagat cctctgccgt ggggacagaa
     2341 aacgcatcgt gtgagcgcat gggccttgcc ctgcgtgcag acaatggtca gacgcaggcc
     2401 ctgggcttcg agggggtgcg tctacgcatg cagcccctag cactctgaaa ccccggacct
     2461 acccagctgg gagggagctc cgtggccttt gagacctttt gttacaatgt gtaaagttct
     2521 ggctgagagg gacacatgag cccttttgct ggttgttgtg gttgttccca gcccacagcc
     2581 agtttcctgg tgggctaccc ctgatcagta tggtttcctg atgatattgt catatcccca
     2641 agtctgactc tcccaagctc ttcagagcaa gcacagtact agagagggca tggctgccaa
     2701 agggttaatg aaccaaggtt tcctctagtc ctggctaatt atctcctcca cacccccttc
     2761 cttaaataaa taaataaaga tcattcaggg cggtcctgcc tgccctccct tctccccact
     2821 gtaaatatac attatttttg atagcatact ttgggttctt cagtgtcggc cttgatgcat
     2881 attggaatca tggctgtgga gatgccctcc agtcagacag tgggctatct ggtccagacc
     2941 acgctccttt gcaatgcaag cccctttcta gtgttaagtt gctctcagtg cttttcagca
     3001 gtaactggtg actgtcccct ggacacggac ctgctttgac atttcctgac agggaaggga
     3061 tttctgctca ttttcccctg tgcctaactg cataattgcc ttttcctatg taaatattac
     3121 agcgatggac caaggcagaa ggaaatgaag cctctgcctt gcatcagccc cgtgtataaa
     3181 gccattatct gctgaggcac cgcttgcccc agtaactcac tttagaactg acttttcttc
     3241 cgttctcccc tcctctgggg cttgaagaag agcgtgtatg tttctatctt gtctgtgcgc
     3301 cgccccctcc cccagaaagt gctgactaag gggaatcttt tagctgctgt ttttagacac
     3361 ccaggagggg aaattatgtg gaagaaacca acccgataca atttgccaag gtaaacagtg
     3421 tgaggagaca aatgggctgc cacactgtat ggagccagcc ccaagagctc ttgggtatca
     3481 aagtgttacc tccccttgct gtcctggctg agatcatgtg actactgaat tgccaaagtc
     3541 agggggtagg cggagacttc gtgtttacaa cctggtttct acttatttta ggcagactgt
     3601 ggaaggcctg tgatctgatt tcacgagaga aaaactaaat gtcagcactt gttgctcgtg
     3661 acggtggatt ttttttaaat aaaagtttac agatcaaatg tgaaataaac atgaattaag
     3721 tggg
//
