LOCUS       NM_013460               2606 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus adrenergic receptor, alpha 1d (Adra1d), mRNA.
ACCESSION   NM_013460
VERSION     NM_013460.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2606)
  AUTHORS   Hirsch,S.J., Budig,A., Husam,S. and Birklein,F.
  TITLE     Aged females unilaterally hypersensitize, lack descending
            inhibition, and overexpress alpha1D adrenergic receptors in a
            murine posttraumatic chronic pain model
  JOURNAL   Pain 165 (9), 1966-1977 (2024)
   PUBMED   38408277
  REMARK    GeneRIF: Aged females unilaterally hypersensitize, lack descending
            inhibition, and overexpress alpha1D adrenergic receptors in a
            murine posttraumatic chronic pain model.
REFERENCE   2  (bases 1 to 2606)
  AUTHORS   Sandroni,P.B., Schroder,M.A., Hawkins,H.T., Bailon,J.D., Huang,W.,
            Hagen,J.T., Montgomery,M., Hong,S.J., Chin,A.L., Zhang,J.,
            Rodrigo,M.C., Kim,B., Simpson,P.C., Schisler,J.C., Ellis,J.M.,
            Fisher-Wellman,K.H. and Jensen,B.C.
  TITLE     The alpha-1A adrenergic receptor regulates mitochondrial oxidative
            metabolism in the mouse heart
  JOURNAL   J Mol Cell Cardiol 187, 101-117 (2024)
   PUBMED   38331556
  REMARK    GeneRIF: The alpha-1A adrenergic receptor regulates mitochondrial
            oxidative metabolism in the mouse heart.
REFERENCE   3  (bases 1 to 2606)
  AUTHORS   Konstandi,M., Kypreos,K.E., Matsubara,T., Xepapadaki,E., Shah,Y.M.,
            Krausz,K., Andriopoulou,C.E., Kofinas,A. and Gonzalez,F.J.
  TITLE     Adrenoceptor-related decrease in serum triglycerides is independent
            of PPARalpha activation
  JOURNAL   FEBS J 286 (21), 4328-4341 (2019)
   PUBMED   31230416
  REMARK    GeneRIF: the findings of the present study indicate that
            stimulation of a1 - and b1/2 -ARs markedly reduced serum TG
            steady-state levels as a result of alterations in TG synthesis,
            uptake, transport, hydrolysis, metabolism and clearance, an effect
            induced by PPARa independent mechanisms
REFERENCE   4  (bases 1 to 2606)
  AUTHORS   Musayeva,A., Manicam,C., Steege,A., Brochhausen,C., Straub,B.K.,
            Bell,K., Pfeiffer,N. and Gericke,A.
  TITLE     Role of alpha1-adrenoceptor subtypes on corneal epithelial
            thickness and cell proliferation in mice
  JOURNAL   Am J Physiol Cell Physiol 315 (5), C757-C765 (2018)
   PUBMED   30257104
  REMARK    GeneRIF: no alpha1-AR mRNA was detected in the stroma, and only
            alpha1B-AR mRNA was found in the Descemet endothelial complex.
            Remarkably, corneal epithelial thickness and mean epithelial cell
            size were reduced in alpha1A-AR(-/-) mice. Our findings suggest
            that the alpha1A-AR exerts growth effects in mouse corneal
            epithelial cells.
REFERENCE   5  (bases 1 to 2606)
  AUTHORS   Shi,T., Papay,R.S. and Perez,D.M.
  TITLE     The role of alpha1-adrenergic receptors in regulating metabolism:
            increased glucose tolerance, leptin secretion and lipid oxidation
  JOURNAL   J Recept Signal Transduct Res 37 (2), 124-132 (2017)
   PUBMED   27277698
  REMARK    GeneRIF: Our results suggest that stimulation of alpha1-ARs results
            in a favorable metabolic profile of increased glucose tolerance,
            cardiac glucose uptake, leptin secretion and increased whole body
            lipid metabolism that may contribute to its previously recognized
            cardioprotective and neuroprotective benefits.
REFERENCE   6  (bases 1 to 2606)
  AUTHORS   Alonso-Llamazares,A., Zamanillo,D., Casanova,E., Ovalle,S.,
            Calvo,P. and Chinchetru,M.A.
  TITLE     Molecular cloning of alpha 1d-adrenergic receptor and tissue
            distribution of three alpha 1-adrenergic receptor subtypes in mouse
  JOURNAL   J Neurochem 65 (6), 2387-2392 (1995)
   PUBMED   7595531
REFERENCE   7  (bases 1 to 2606)
  AUTHORS   Milligan,G., Svoboda,P. and Brown,C.M.
  TITLE     Why are there so many adrenoceptor subtypes?
  JOURNAL   Biochem Pharmacol 48 (6), 1059-1071 (1994)
   PUBMED   7945399
  REMARK    Review article
REFERENCE   8  (bases 1 to 2606)
  AUTHORS   Buckwalter,M.S., Katz,R.W. and Camper,S.A.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
REFERENCE   9  (bases 1 to 2606)
  AUTHORS   Oakey,R.J., Caron,M.G., Lefkowitz,R.J. and Seldin,M.F.
  TITLE     Genomic organization of adrenergic and serotonin receptors in the
            mouse: linkage mapping of sequence-related genes provides a method
            for examining mammalian chromosome evolution
  JOURNAL   Genomics 10 (2), 338-344 (1991)
   PUBMED   1676978
REFERENCE   10 (bases 1 to 2606)
  AUTHORS   Yang-Feng,T.L., Xue,F.Y., Zhong,W.W., Cotecchia,S., Frielle,T.,
            Caron,M.G., Lefkowitz,R.J. and Francke,U.
  TITLE     Chromosomal organization of adrenergic receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1516-1520 (1990)
   PUBMED   2154750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831731.6.
            
            On Feb 13, 2019 this sequence version replaced NM_013460.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.5733.1,
                                           SRR7345562.1676651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1422              AL831731.6         44657-46078         c
            1423-2606           AL831731.6         28938-30121         c
FEATURES             Location/Qualifiers
     source          1..2606
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.5 cM"
     gene            1..2606
                     /gene="Adra1d"
                     /gene_synonym="Adra-1; Adra1; Adra1a; alpha1D-AR; Gpcr8;
                     Spr8; [a]1d"
                     /note="adrenergic receptor, alpha 1d"
                     /db_xref="GeneID:11550"
                     /db_xref="MGI:MGI:106673"
     exon            1..1422
                     /gene="Adra1d"
                     /gene_synonym="Adra-1; Adra1; Adra1a; alpha1D-AR; Gpcr8;
                     Spr8; [a]1d"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..2018
                     /gene="Adra1d"
                     /gene_synonym="Adra-1; Adra1; Adra1a; alpha1D-AR; Gpcr8;
                     Spr8; [a]1d"
                     /note="alpha-1D adrenoceptor; alpha-1D adrenoreceptor;
                     alpha-1A adrenergic receptor"
                     /codon_start=1
                     /product="alpha-1D adrenergic receptor"
                     /protein_id="NP_038488.4"
                     /db_xref="CCDS:CCDS16764.1"
                     /db_xref="GeneID:11550"
                     /db_xref="MGI:MGI:106673"
                     /translation="MTFRDILSVTFEGPRASSSTGGSGAGGGAGTVGPEGPAVGGVPG
                     ATGGSAVVGTGSGEDNQSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFIL
                     TAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGR
                     TFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVA
                     LVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVAR
                     STTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGNPGTQSSKGHTLRSSLSVRLLKF
                     SREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVN
                     PLIYPCSSREFKRAFLRLLRCQCRRRRRRLWRVYGHHWRASTGDPRSDCAPSPRIAPP
                     GAPLALTAHPGPGSVDTPEAQASVSGRRKPASALREWRLLGPLQRPTTQLRAKVSSLS
                     HKFRSGGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDLSNLRETDI"
     exon            1423..2606
                     /gene="Adra1d"
                     /gene_synonym="Adra-1; Adra1; Adra1a; alpha1D-AR; Gpcr8;
                     Spr8; [a]1d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgacgctc ccggaggagc caccgctcgc caggacacgc ttggagaggg gagcagggag
       61 cagggagccg gccccggccc ttgttttctt gtgactctgc agccaccgcc agagcccgtt
      121 cccgttggga ccttcacggc ctggtgacct ccgccccgct ctccctgcag caccgctccc
      181 ctgcggcccc tctgccgcgg gaacttgggc aggaccgacg ggaccggcgc gcggggctgg
      241 ctcgggcgct gcggcgatgc ccgcgggctc cctccccgcc acttgctcgc cctgtgcctg
      301 ggctcgggcc ccgacggctg cgccgtgaga tgactttccg cgacatcctg agcgtcactt
      361 tcgaaggacc ccgggcgagc agtagcactg ggggctccgg cgcgggcggc ggagctggca
      421 cggttggccc cgagggtccg gcggtgggcg gcgtgccggg tgccacaggc ggtagcgctg
      481 tggtgggaac cggcagcggc gaggacaacc agagctccac ggcagaagcg ggggccgcgg
      541 caagcggcga ggtgaatggc tcggcggccg tcggggggct agtggtgagt gctcagggcg
      601 tgggagtggg tgtcttccta gccgccttca tcctcaccgc tgtggcgggc aaccttctcg
      661 tcatcctctc cgtggcctgc aaccgccact tgcagacggt caccaactat ttcatcgtga
      721 acctagcagt ggctgacctg ctactgagtg cagctgtgtt gcccttctca gccactatgg
      781 aggttctagg cttctgggcc ttcggccgga ccttctgcga cgtatgggcc gcggtggacg
      841 tgctatgctg cactgcctcc atccttagcc tctgcaccat ctctgtggac cggtacgtgg
      901 gtgtgcgcca ctcgctcaag tatccagcca ttatgacaga acgcaaggcc gctgccattc
      961 tggctctgct ctgggcggtg gccttggtgg tatctgtggg accgctacta ggttggaagg
     1021 aaccagtgcc cccggatgag cgtttctgcg gcatcaccga ggaggtgggc tatgcgatct
     1081 tctcttccgt atgctccttc tacctcccca tggcagtgat cgtggtcatg tactgccgcg
     1141 tgtatgtggt cgcgcgcagc accacgcgca gcctcgaggc gggcatcaag agggagccgg
     1201 gcaaggcctc tgaggtggtt ctgaggatcc actgtcgcgg cgcagccact agcgccaaag
     1261 gaaatccagg gacacagagt agcaaggggc acaccttgcg cagctcgctc tccgtaaggc
     1321 tgctcaagtt ttcccgcgag aaaaaggctg ccaagaccct agccatcgtc gtgggtgtct
     1381 tcgtcctgtg ctggttcccc tttttcttcg tcctgcctct gggttctctg ttccctcagc
     1441 tgaaaccatc agagggcgtc ttcaaggtca tcttctggct gggctacttc aatagctgtg
     1501 tgaacccgct catctacccc tgctccagtc gcgagttcaa gcgcgccttc ctccgcctcc
     1561 tgcgctgcca gtgtcgccgc cgccgccgcc gcctctggcg agtctacggc caccactggc
     1621 gagcctcgac cggcgacccg cgctccgact gtgcccccag cccgcgcatc gcaccccccg
     1681 gggctcccct agccctcact gcacacccag gcccgggctc cgtagacacg ccggaggcgc
     1741 aggcttcggt ctccggccgt cgaaagccag cctccgccct ccgggagtgg aggctgcttg
     1801 ggccgctaca gagacccacg acccagctgc gtgcgaaggt gtccagcctg tcccataagt
     1861 tccgctctgg gggcgcgcgg cgcgcggaga ctgcgtgtgc cctgcgctcg gaggtagaag
     1921 cagtgtccct aaatgttccc caagacgggg cagaggctgt catctgccag gcttatgagc
     1981 cgggcgacct cagcaacctc cgggagactg acatttaagg accgaaactc aggctgagga
     2041 gggtgctggg gccagaggtg gggtgcttta taggattctg ccttcggatc caaaactctg
     2101 accagggtgg ctgctccatc tcacctcaaa gcaaccggag ctggacctgg ggtcggagca
     2161 ctcggaaggt ggtgggttat ggtgccgcct gctggacata gttgtccaga gctcttcctg
     2221 aaatggaaga gctgcgggat tcgcccttct catccagtct aaggaactgt ttagtcagct
     2281 cctgatgtct aggcagaaga cttcaagtat ggctactccc cttggggggg aagaggtaca
     2341 aattctcgtt ttgctgctcc cagggaaaag atccgtggac agttttactc cttactgcca
     2401 cctggaggaa gtcaatggac ctactgccat aggacctgcc atacagcaag ctttggtggt
     2461 atattggatg cccgccatac aaatctgttg tttttgccct gggctcactg cccccttccc
     2521 cacactccta actgtatgaa tccctcacca ttcccaccca cccccccgcc ccagggcctt
     2581 actgtttaca ctgtgtacat agttca
//
