LOCUS       NM_007416               3222 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus adrenergic receptor, alpha 1b (Adra1b), transcript
            variant 1, mRNA.
ACCESSION   NM_007416
VERSION     NM_007416.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3222)
  AUTHORS   Musayeva A, Manicam C, Steege A, Brochhausen C, Straub BK, Bell K,
            Pfeiffer N and Gericke A.
  TITLE     Role of alpha1-adrenoceptor subtypes on corneal epithelial
            thickness and cell proliferation in mice
  JOURNAL   Am J Physiol Cell Physiol 315 (5), C757-C765 (2018)
   PUBMED   30257104
REFERENCE   2  (bases 1 to 3222)
  AUTHORS   Roewe J, Higer M, Riehl DR, Gericke A, Radsak MP and Bosmann M.
  TITLE     Neuroendocrine Modulation of IL-27 in Macrophages
  JOURNAL   J Immunol 199 (7), 2503-2514 (2017)
   PUBMED   28835457
REFERENCE   3  (bases 1 to 3222)
  AUTHORS   Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K,
            Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ and Simpson
            PC.
  TITLE     Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1
            and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation,
            and the Beta-2 and Beta-3 Are Mostly Absent
  JOURNAL   Circ Res 120 (7), 1103-1115 (2017)
   PUBMED   28219977
REFERENCE   4  (bases 1 to 3222)
  AUTHORS   Tanaka K, Hirai T, Kodama D, Kondo H, Hamamura K and Togari A.
  TITLE     alpha1B -Adrenoceptor signalling regulates bone formation through
            the up-regulation of CCAAT/enhancer-binding protein delta
            expression in osteoblasts
  JOURNAL   Br J Pharmacol 173 (6), 1058-1069 (2016)
   PUBMED   26750808
  REMARK    GeneRIF: Taken together, these results suggested that
            alpha1B-adrenoceptor signaling is required for bone formation and
            regulated cellular proliferation through a mechanism relevant to
            the up-regulation of CCAAT/enhancer-binding protein delta in
            osteoblasts and, thus, provide new evidence for the physiological
            importance of alpha1B-adrenoceptor signalling in bone homeostasis
REFERENCE   5  (bases 1 to 3222)
  AUTHORS   Wirth A, Wang S, Takefuji M, Tang C, Althoff TF, Schweda F,
            Wettschureck N and Offermanns S.
  TITLE     Age-dependent blood pressure elevation is due to increased vascular
            smooth muscle tone mediated by G-protein signalling
  JOURNAL   Cardiovasc Res 109 (1), 131-140 (2016)
   PUBMED   26531127
REFERENCE   6  (bases 1 to 3222)
  AUTHORS   Buckwalter MS, Lossie AC, Scarlett LM and Camper SA.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   7  (bases 1 to 3222)
  AUTHORS   Buckwalter MS, Katz RW and Camper SA.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
REFERENCE   8  (bases 1 to 3222)
  AUTHORS   Oakey RJ, Caron MG, Lefkowitz RJ and Seldin MF.
  TITLE     Genomic organization of adrenergic and serotonin receptors in the
            mouse: linkage mapping of sequence-related genes provides a method
            for examining mammalian chromosome evolution
  JOURNAL   Genomics 10 (2), 338-344 (1991)
   PUBMED   1676978
REFERENCE   9  (bases 1 to 3222)
  AUTHORS   Lomasney JW, Cotecchia S, Lorenz W, Leung WY, Schwinn DA, Yang-Feng
            TL, Brownstein M, Lefkowitz RJ and Caron MG.
  TITLE     Molecular cloning and expression of the cDNA for the alpha
            1A-adrenergic receptor. The gene for which is located on human
            chromosome 5
  JOURNAL   J Biol Chem 266 (10), 6365-6369 (1991)
   PUBMED   1706716
REFERENCE   10 (bases 1 to 3222)
  AUTHORS   Yang-Feng TL, Xue FY, Zhong WW, Cotecchia S, Frielle T, Caron MG,
            Lefkowitz RJ and Francke U.
  TITLE     Chromosomal organization of adrenergic receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1516-1520 (1990)
   PUBMED   2154750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139448.1, AK043877.1 and CA319459.1.
            
            [WARNING] On Apr 30, 2024 this sequence was replaced by
            NM_007416.5.
            
            On Oct 1, 2013 this sequence version replaced NM_007416.3.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043877.1, AK139448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AK139448.1         2-158
            158-3204            AK043877.1         3-3049
            3205-3222           CA319459.1         578-595
FEATURES             Location/Qualifiers
     source          1..3222
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.81 cM"
     gene            1..3222
                     /gene="Adra1b"
                     /gene_synonym="[a]1b"
                     /note="adrenergic receptor, alpha 1b"
                     /db_xref="GeneID:11548"
                     /db_xref="MGI:MGI:104774"
     exon            1..1350
                     /gene="Adra1b"
                     /gene_synonym="[a]1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1949
                     /gene="Adra1b"
                     /gene_synonym="[a]1b"
                     /note="alpha-1B adrenoceptor; alpha-1B adrenoreceptor;
                     alpha1B-adrenergic receptor"
                     /codon_start=1
                     /product="alpha-1B adrenergic receptor"
                     /protein_id="NP_031442.2"
                     /db_xref="CCDS:CCDS24562.1"
                     /db_xref="GeneID:11548"
                     /db_xref="MGI:MGI:104774"
                     /translation="MNPDLDTGHNTSAPAHWGELKDANFTGPNQTSSNSTLPQLDVTR
                     AISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFS
                     ATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRR
                     KAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAV
                     ILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPR
                     SSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVF
                     WLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGGCAYTYRPWTRG
                     GSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGAL
                     LSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDTTTDLANGQPGFKSNM
                     PLAPGHF"
     exon            1351..3205
                     /gene="Adra1b"
                     /gene_synonym="[a]1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3184..3189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adra1b"
                     /gene_synonym="[a]1b"
     polyA_site      3205
                     /gene="Adra1b"
                     /gene_synonym="[a]1b"
ORIGIN      
        1 attgaaagca gaccctcctc gcgatcgctg ggcggagaag gcaccgcggt ccgtagaccc
       61 gccgcgggcc gggcacagcc gggcaccccc ggcccggcgc ccgctcctcc ccgcgctccc
      121 gcgccagccc ggccaggcgc gcctgacgtg gaccattaaa cttggagctg ccgcctcgtc
      181 ccctctctcc tcctcctccc tctgacaggc gagcgagccg ctgggtgcag gcaggcgacg
      241 tgctgccggg ctaggctgcc cgggggagat gacttctcgc caggaggacg cctctggaaa
      301 gaagaccacg gagggagcaa agtttcaggg cagctgagga gctttggtcg cagcccttcc
      361 gagcccaatc tcctccctgg ctatggaggg cggactttaa aatgaatccc gatctggaca
      421 ccggccacaa cacatcagca cctgcccact ggggagagtt gaaagatgcc aacttcactg
      481 gccccaacca gacctcgagc aactccacac tgccccagct ggacgtcacc agggccatct
      541 ctgtgggcct ggtgctgggc gccttcatcc tctttgccat cgtgggcaac atcttggtca
      601 tcctgtcggt ggcctgcaac cggcacctgc ggacgcccac caactacttc attgtcaacc
      661 tggccattgc tgacctgctg ttgagcttca cagtcctgcc cttctccgct accctggaag
      721 tgctcggcta ctgggtgctg gggcgcatct tctgtgacat ctgggcagcg gttgatgtcc
      781 tgtgttgcac ggcctccatc ctgagcctat gtgccatctc cattgaccgc tacattgggg
      841 tgcgatactc tctgcagtac cccacgctgg tcacccgcag gaaggccatc ttggcgctcc
      901 tcagtgtgtg ggtcttgtcc acggtcatct ccatcgggcc tctccttgga tggaaagaac
      961 ctgcgcccaa tgacgacaaa gaatgtgggg tcacagaaga acccttctac gccctctttt
     1021 cctccctggg ctccttctac atcccactgg cggtcatcct ggtcatgtac tgccgagtct
     1081 acatcgtggc caagaggacc accaagaatc tggaggcggg agtcatgaag gaaatgtcca
     1141 actccaaaga gctgaccctg agaatccact ctaagaactt tcatgaggac accctcagca
     1201 gtaccaaggc caagggccac aaccccagga gttccatagc tgtcaaactt tttaagttct
     1261 ccagggaaaa gaaagcagcc aaaaccttgg gcattgtagt cggaatgttc atcttatgtt
     1321 ggctcccctt cttcatcgct ctcccacttg gctccctgtt ctccacccta aagcccccgg
     1381 acgccgtatt caaggtagtg ttctggctgg gctacttcaa cagctgcctc aaccccatca
     1441 tctacccgtg ctccagcaag gagttcaaac gcgccttcat gcgtatcctg gggtgccagt
     1501 gccgcggtgg ccgtcgccgc cgccgccgtc gccgtctagg aggctgcgct tacacctacc
     1561 ggccgtggac ccgcggcggc tcgctggaga ggtcgcagtc gcggaaggac tctctggatg
     1621 acagtggcag ctgcatgagc ggcagccagc ggaccctgcc ctcggcgtca cccagcccgg
     1681 gatacctggg tcgtggaacg cagccacccg tggagctgtg cgccttcccc gagtggaaac
     1741 ccggagcgct gctcagcctg ccagagcctc ctggccgccg cggccgcctc gactccgggc
     1801 cactcttcac tttcaagctc ctgggcgagc ctgagagccc ggggaccgaa ggcgacgcca
     1861 gcaatggggg ctgcgacacc acaactgacc tggccaacgg gcagccgggc ttcaagagca
     1921 acatgcccct ggcgcccggg cacttttagg gtctctcttc atccacccgc ccccgaacac
     1981 acacacatcg ggggttgggg gaagaacacc atcatgggag gtgggagggc gcgtgggggg
     2041 agtgtgtcag tcctgagtag acacaaggtc tcaaggggac aaaggggagg gggtggggag
     2101 aggggcagct gcttttctgg cagaggcatg ggtgccaggt acagcgaaga gctgggctga
     2161 gcatgctgag agcctggggg ccccccctac gccggccggg acttaagtct ctctctcttc
     2221 tctctctgta tatacataaa atgagttcct ctatatgtat ttatctgtgg gtacacgtgc
     2281 gtgtgtctgt ttggtgtacg tgtgggctgc gtgggtgcgt gtgtgaggcc tgcccgcaag
     2341 catgtgctgg ggcagagtga gtgtgacccc tggtgatgtc taggtgtgtt gtttgtttct
     2401 tgactttgta cctctcaaac ccctccctgc tctccagtca atgctggccc tttgataggg
     2461 tcggaaaaca agtcaaatat taaagatcat ttctcctgtg cgcctttgag tgatttgtga
     2521 aggagagcct tgtgtttcct cttccttcag gtctgatcaa atcctaggac ttttcttttg
     2581 gggcaggcca ggaggagtta gactattatt attagtgaca ttgttatgat tatcgtattt
     2641 atgattacat ttttatttat tattttatgt atttaaaaga ggtattcagg tgccacaaca
     2701 gatgtggaaa ccagaggact ccttggagga gtcaatacca caaaaactat agacaaggcc
     2761 attccaaaaa gtacacacac acacacacac acacacacac acacacacac acacacatat
     2821 ttgcagacaa ttagggtccc ttatcttgga tctcctgggt taatcacaac ttccaaggta
     2881 cacaagtatc ctacactgaa ccagaattat ctcagccaag tcctggtttt tatagatggg
     2941 tgactgaggt taagattttg gcatgggcca gcaagacact gagcaggtaa aggtgttcgc
     3001 tgccaagcct gaggacctga gttcgatctc tgggacacac aaggtaaagc agagtctgga
     3061 ctctggcaag ttatgctctg acctcctccc atgcattata ccactgggct tgtacacaca
     3121 cacaagcaca cacacaatgt aatagcaatg ttttttcttt tttaaagaac ttgacaaagt
     3181 gttattaaag ttacacttcc tttgcaaaaa aaaaaaaaaa aa
//
