LOCUS       NM_013461               4277 bp    mRNA    linear   ROD 25-APR-2023
DEFINITION  Mus musculus adrenergic receptor, alpha 1a (Adra1a), transcript
            variant 1, mRNA.
ACCESSION   NM_013461
VERSION     NM_013461.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4277)
  AUTHORS   Kim JD, Kwon C, Nakamura K, Muromachi N, Mori H, Muroi SI, Yamada
            Y, Saito H, Nakagawa Y and Fukamizu A.
  TITLE     Increased angiotensin II coupled with decreased Adra1a expression
            enhances cardiac hypertrophy in pregnancy-associated hypertensive
            mice
  JOURNAL   J Biol Chem 299 (3), 102964 (2023)
   PUBMED   36736425
  REMARK    GeneRIF: Increased angiotensin II coupled with decreased Adra1a
            expression enhances cardiac hypertrophy in pregnancy-associated
            hypertensive mice.
REFERENCE   2  (bases 1 to 4277)
  AUTHORS   Fu X, Teboul E, Weiss GL, Antonoudiou P, Borkar CD, Fadok JP,
            Maguire J and Tasker JG.
  TITLE     Gq neuromodulation of BLA parvalbumin interneurons induces burst
            firing and mediates fear-associated network and behavioral state
            transition in mice
  JOURNAL   Nat Commun 13 (1), 1290 (2022)
   PUBMED   35277502
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4277)
  AUTHORS   Uchiyama S, Yoshihara K, Kawanabe R, Hatada I, Koga K and Tsuda M.
  TITLE     Stress-induced antinociception to noxious heat requires
            alpha1A-adrenaline receptors of spinal inhibitory neurons in mice
  JOURNAL   Mol Brain 15 (1), 6 (2022)
   PUBMED   34980215
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4277)
  AUTHORS   Docherty JR.
  TITLE     Subtypes of functional alpha1-adrenoceptor
  JOURNAL   Cell Mol Life Sci 67 (3), 405-417 (2010)
   PUBMED   19862476
  REMARK    Review article
REFERENCE   5  (bases 1 to 4277)
  AUTHORS   Lin F, Owens WA, Chen S, Stevens ME, Kesteven S, Arthur JF,
            Woodcock EA, Feneley MP and Graham RM.
  TITLE     Targeted alpha(1A)-adrenergic receptor overexpression induces
            enhanced cardiac contractility but not hypertrophy
  JOURNAL   Circ Res 89 (4), 343-350 (2001)
   PUBMED   11509451
REFERENCE   6  (bases 1 to 4277)
  AUTHORS   O'Connell TD, Rokosh DG and Simpson PC.
  TITLE     Cloning and characterization of the mouse alpha1C/A-adrenergic
            receptor gene and analysis of an alpha1C promoter in cardiac
            myocytes: role of an MCAT element that binds transcriptional
            enhancer factor-1 (TEF-1)
  JOURNAL   Mol Pharmacol 59 (5), 1225-1234 (2001)
   PUBMED   11306707
REFERENCE   7  (bases 1 to 4277)
  AUTHORS   Kulik A, Haentzsch A, Luckermann M, Reichelt W and Ballanyi K.
  TITLE     Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+)
            release in Bergmann glial cells in situ
  JOURNAL   J Neurosci 19 (19), 8401-8408 (1999)
   PUBMED   10493741
REFERENCE   8  (bases 1 to 4277)
  AUTHORS   Xiao L, Scofield MA and Jeffries WB.
  TITLE     Molecular cloning, expression and characterization of cDNA encoding
            a mouse alpha1a-adrenoceptor
  JOURNAL   Br J Pharmacol 124 (1), 213-221 (1998)
   PUBMED   9630362
REFERENCE   9  (bases 1 to 4277)
  AUTHORS   Rockman HA, Koch WJ and Lefkowitz RJ.
  TITLE     Cardiac function in genetically engineered mice with altered
            adrenergic receptor signaling
  JOURNAL   Am J Physiol 272 (4 Pt 2), H1553-H1559 (1997)
   PUBMED   9139936
  REMARK    Review article
REFERENCE   10 (bases 1 to 4277)
  AUTHORS   Alonso-Llamazares A, Zamanillo D, Casanova E, Ovalle S, Calvo P and
            Chinchetru MA.
  TITLE     Molecular cloning of alpha 1d-adrenergic receptor and tissue
            distribution of three alpha 1-adrenergic receptor subtypes in mouse
  JOURNAL   J Neurochem 65 (6), 2387-2392 (1995)
   PUBMED   7595531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK085653.1, AK079597.1 and
            AK033490.1.
            
            [WARNING] On Jun 1, 2023 this sequence was replaced by NM_013461.5.
            
            On Nov 16, 2012 this sequence version replaced NM_013461.3.
            
            Summary: This gene encodes one of several multipass transmembrane
            proteins that function as G protein-coupled receptors. The encoded
            protein binds to epinephrine and norepinephrine to mediate
            signaling in cells of the cardiac, nervous, and other organ
            systems. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Both variants 1 and
            3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079597.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AK085653.1         2-42
            42-3244             AK079597.1         35-3237
            3245-3846           AK033490.1         630-1231
            3847-4277           AK085653.1         3694-4124
FEATURES             Location/Qualifiers
     source          1..4277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..4277
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /note="adrenergic receptor, alpha 1a"
                     /db_xref="GeneID:11549"
                     /db_xref="MGI:MGI:104773"
     exon            1..353
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /inference="alignment:Splign:2.1.0"
     exon            354..1823
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             941..2341
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-1A adrenergic receptor; alpha-1A adrenoceptor;
                     alpha-1A adrenoreceptor; alpha-1C adrenergic receptor"
                     /codon_start=1
                     /product="alpha-1A adrenergic receptor isoform 1"
                     /protein_id="NP_038489.2"
                     /db_xref="CCDS:CCDS27223.1"
                     /db_xref="GeneID:11549"
                     /db_xref="MGI:MGI:104773"
                     /translation="MVLLSENASEGSNCTHPPAQVNISKAILLGVILGGLIIFGVLGN
                     ILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIW
                     AAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIG
                     PLFGWRQQAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGL
                     KSGLKTDKSDSEQVTLRIHRKNVPAEGSGVSSAKNKTHFSVRLLKFSREKKAAKTLGI
                     VVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFK
                     KAFQNVLRIQCLRRRQSSKHALGYTLHPPSQAVEGQHRGMVRIPVGSGETFYKISKTD
                     GVREWKFFSSMPQGSARITMPKDQSACTTARVRSKSFLQVCCCVGSSTPRPEENHQVP
                     TIKIHTISLGENGEEV"
     exon            1824..2378
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..4277
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggtactcg ctaggctaca gcctgcctgt actacgtcaa cccgagctgc aaagttccga
       61 gccgctcttt tctgtgtcca ggaactgaat atcaaactgg tgatcgtgga gttattggat
      121 cgctgtattt gtcatttctt ttctctgttt tcagtcttta ttttaaaata tccaggagaa
      181 gcaagaagcg agcccggagt ttgagggctc agcagtggtg gggtgagtca gcgggtgcta
      241 aggactgggt cttggtcttt ggagaccctg ttctcctgca gagaaccaga gggctctgcg
      301 aggactgaag gtccgcttct cctggcgcca gggcctccgc agccgcgcag cagataaacg
      361 aagctccagg gccacttcgg tctcagcaaa tattccagac ccatgttacc tagccagaac
      421 tcctagaaac tggagctagc ggtatcccat agatgggcgg ccaagttgag agtcactgcc
      481 ggtcagctgc agcgcccatt cgcccagcgt ccctgccttg agcttcgaag gctgagccac
      541 acttagctaa ccatttcagc aaagactagt cacagactcg tgaatttcta attgcgtgga
      601 tgcacaggat ggatcagagt gcacagagaa gcggattttt gtaatttctg gtggctttca
      661 cagcatgtcc ttttaaacct ttggaaggtg tccccagaag cccagagcgc gcctggccat
      721 gtctccttta atgctctgtt cctcaacgtg gccctctgag ggttcccaga gctgctccag
      781 gcggtttaca acaggtgtgt tctctccctc ccccagccca acccagcccg caggattccc
      841 ccaagcggag attttttgac ttggcttcct caggctcacg tttccgccct ccgccagagg
      901 gtggccgtcc aaagcccgac cttgccccct ccctgggacc atggtgcttc tttctgaaaa
      961 tgcttctgaa ggctccaact gcacccaccc gccagcacag gtgaacattt ctaaggccat
     1021 tctacttggg gtgatcttgg ggggcctcat cattttcggg gtcttgggga atattttagt
     1081 gatcctctcg gtggcctgtc atcggcatct gcactcggtg actcactact acattgtcaa
     1141 cctggctgtg gcagacctcc tcctcacctc caccgtgctg cccttctctg ccatctttga
     1201 gatcctgggc tactgggcct ttggcagggt gttctgcaac atctgggcgg cggtggacgt
     1261 cttatgctgc acagcgtcca tcatgggcct ctgcatcatc tccatcgacc gatacattgg
     1321 tgtgagctac ccgctgcgct accccaccat tgtcacccag aggaggggcg tcagggctct
     1381 gctctgcgtc tgggcgcttt ccttggtcat ctccatcgga cccctgttcg gctggaggca
     1441 gcaggctccg gaggatgaga ccatctgcca aatcaatgag gagccaggat acgtgctgtt
     1501 ctcagcgctg ggctctttct acgtgccact gaccatcatc ctggttatgt actgtcgagt
     1561 ctacgtggta gccaagagag aaagccgagg cctcaagtcc ggcctcaaga ccgacaagtc
     1621 agactcagag caagtgacgc tccgtatcca ccgtaaaaat gtccctgcag aaggcagcgg
     1681 agtaagcagt gccaagaata agactcactt ctccgtgagg ctgctcaagt tttcccgaga
     1741 gaagaaagcc gccaagacgc tgggcattgt ggtgggatgc ttcgtcctct gctggctgcc
     1801 attcttcctc gtgatgccca ttgggtcctt cttcccgaat ttcaagccac cggaaacagt
     1861 tttcaaaata gtattttggc ttgggtacct aaatagttgc atcaacccta tcatataccc
     1921 atgctccagc caggagttca agaaagcctt tcagaatgtg ctgcgaatcc agtgtcttcg
     1981 cagaaggcag tcttccaagc atgccctggg ctacactctg cacccaccca gccaggctgt
     2041 agaggggcag cacagaggca tggtgcgtat cccggtgggc tcaggagaga ctttctataa
     2101 gatctccaag acagatggag tccgtgaatg gaagtttttc tcttccatgc cccagggatc
     2161 ggccaggatt accatgccga aggaccaatc cgcctgtacc acagcccggg tgagaagtaa
     2221 aagctttttg caggtctgct gctgtgtggg gtcgtcgacc ccacgccctg aagaaaatca
     2281 ccaagttcca accattaaga tccacaccat ctccctcggt gaaaacgggg aggaagtcta
     2341 gaggatggga aaggtcacag gaaaagggat gacactaggg cttttatcca tgaaaccacc
     2401 tgtgcgacag acagacccag ttggaacact tcaccagctt tgggcctcca aactgatgct
     2461 gaggagctgg ctgaggccac atcttccaaa agccatggca acagtggcct ctggccctcc
     2521 aaggtccctg caggatgaag gagtgaactt gactgttggg ggtctgggct gggaagcaag
     2581 ctaggatttc agcatataat gttggcccct gggcaaaggt ggcattggca gggtcccctt
     2641 catgtttccc agaccctatg gcatacgagt gagctgagaa ataggcttac ttgctctctg
     2701 taggagaatg tcatggttca aaacaccact gccaaactta caaaggccgt aggagtggca
     2761 gggaccatga aaggggaaaa ttgaccaaag ctgtggctca aagcagggag tttagtcacg
     2821 atttcccgtg actggtaagc aagcaactgc cctgaaactg gaggtttatt catttcagag
     2881 ggggagataa tggccttttc tttcatatgg cttgggagtt cttgccacac tgtccctgta
     2941 gcacactcag agccatctca ctataagctg gaggtgatgg tttgttaagc catgaaaata
     3001 cagacttaag tgataaaaaa aaaatcttag tgtaacttag cattgcattt agagaaaaga
     3061 atatgatgat catcctggtc tatgaaacag gctgaataaa ataagtgtat gtgaacatca
     3121 tagggaatta agacagaaat tccaatgtga atttaattta ctgtgcctca ccacatgctt
     3181 atcaaatctt tcttggctca ttcctgtgta ggagaagaaa aggaaggagt tttgggtttt
     3241 ttttttgttt gtttgttttt tcttttttga atctactttt ggtatgtgaa gaaatagaag
     3301 ttatgagtca aggacttctt tgaacaccct catatttaat ctgtctcgga gatgcttcca
     3361 tgtcccccag tgtccgctgt gtattttgac tcactgactt tcatagtgaa ctgcttcagt
     3421 ttaactccag atctgtctgg accttctccc ctcccatcct ggccaaccac tgggaagaac
     3481 ttgttttctt ggctaacaga caggcacatg tcattttgtt ctgtcgccat agataagctg
     3541 ctacaaagcc aggggagagt cagggcaaga gttgatttgc tcaatagtgt gacatgtaag
     3601 gtcaaaacca gctgtgactg tcaccctgag gttcccaaag gaaacctgtg ggccattggg
     3661 tacactctga ccagcagccc cagatggccc ctcttcactg caccaccctg gtatgaaacc
     3721 aaagagggta atgacagtcc ccagtgtatg agctggcagg gttctgtgtt cgtctgctca
     3781 gaagtcaaga atgtgttttt ccaagaggca ttgttacaaa tgggggttgg ggggttgttc
     3841 ctaaagaagc caaaagtaaa taactaaata cctgttttat gtataccagg agttggcctg
     3901 ctatttccat gaatgagaaa cattttaggc atgataaact gtatggtctc tgttttggct
     3961 ctggcaggag gccatggaca gtcctttaaa aatatagagt catcgatagc tcaaaagaca
     4021 ggtttatcca atgggacaca atttttcatc cctgatgcaa accacttgga atggtttctg
     4081 aagaactcaa cctctcatgg tctggacatc tttcatgtgc tctctaagtc agctttgctt
     4141 ctccatcatg gtcttgtgtc tcttattttt gtcttttgtt tttgtttttt ttcatataaa
     4201 ctttccctcc taagagttcc ttaaactctt tcaaggcctt gatgaactca taaattaaac
     4261 tcagttcccc ctttacc
//
