LOCUS       NM_133883               1368 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ADP-ribosylserine hydrolase (Adprs), mRNA.
ACCESSION   NM_133883
VERSION     NM_133883.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1368)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1368)
  AUTHORS   Mashimo,M., Bu,X., Aoyama,K., Kato,J., Ishiwata-Endo,H.,
            Stevens,L.A., Kasamatsu,A., Wolfe,L.A., Toro,C., Adams,D.,
            Markello,T., Gahl,W.A. and Moss,J.
  TITLE     PARP1 inhibition alleviates injury in ARH3-deficient mice and human
            cells
  JOURNAL   JCI Insight 4 (4), 124519 (2019)
   PUBMED   30830864
  REMARK    GeneRIF: Arh3-deficient mouse showed vulnerability to parthanatos.
            Arh3-/- fibroblasts demonstrated the failure of normal
            poly(ADP-ribose) (PAR) degradation in the nucleus and cytoplasm
            resulted in apoptosis-inducing factor-mediated DNA fragmentation.
            Data indicate that Arh3 is a PAR-degrading enzyme responsible for
            the regulation of PAR metabolism under conditions of oxidative
            stress both in vivo and in vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1368)
  AUTHORS   Abplanalp,J., Leutert,M., Frugier,E., Nowak,K., Feurer,R., Kato,J.,
            Kistemaker,H.V.A., Filippov,D.V., Moss,J., Caflisch,A. and
            Hottiger,M.O.
  TITLE     Proteomic analyses identify ARH3 as a serine
            mono-ADP-ribosylhydrolase
  JOURNAL   Nat Commun 8 (1), 2055 (2017)
   PUBMED   29234005
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1368)
  AUTHORS   Mashimo,M., Kato,J. and Moss,J.
  TITLE     ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose)
            degradation and cell death during oxidative stress
  JOURNAL   Proc Natl Acad Sci U S A 110 (47), 18964-18969 (2013)
   PUBMED   24191052
REFERENCE   5  (bases 1 to 1368)
  AUTHORS   Niere,M., Mashimo,M., Agledal,L., Dolle,C., Kasamatsu,A., Kato,J.,
            Moss,J. and Ziegler,M.
  TITLE     ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase
            (PARG) isoforms, is responsible for degradation of mitochondrial
            matrix-associated poly(ADP-ribose)
  JOURNAL   J Biol Chem 287 (20), 16088-16102 (2012)
   PUBMED   22433848
  REMARK    GeneRIF: ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose)
            glycohydrolase (PARG) isoforms, is responsible for degradation of
            mitochondrial matrix-associated poly(ADP-ribose).
REFERENCE   6  (bases 1 to 1368)
  AUTHORS   Mueller-Dieckmann,C., Kernstock,S., Mueller-Dieckmann,J.,
            Weiss,M.S. and Koch-Nolte,F.
  TITLE     Structure of mouse ADP-ribosylhydrolase 3 (mARH3)
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 64 (Pt 3), 156-162
            (2008)
   PUBMED   18323597
  REMARK    GeneRIF: structural comparison of mouse ADP-ribosylhydrolase 3 with
            its human orthologue shows a high degree of structural similarity
REFERENCE   7  (bases 1 to 1368)
  AUTHORS   Oka,S., Kato,J. and Moss,J.
  TITLE     Identification and characterization of a mammalian 39-kDa
            poly(ADP-ribose) glycohydrolase
  JOURNAL   J Biol Chem 281 (2), 705-713 (2006)
   PUBMED   16278211
  REMARK    GeneRIF: ARH3 has poly(ADP-ribose) glycohydrolase activity but is
            structurally unrelated to poly(ADP-ribose) glycohydrolase
REFERENCE   8  (bases 1 to 1368)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL606976.25.
            
            On Nov 17, 2006 this sequence version replaced NM_133883.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ427296.1, AK169070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AL606976.25        38360-38621         c
            263-359             AL606976.25        35317-35413         c
            360-567             AL606976.25        34902-35109         c
            568-752             AL606976.25        34638-34822         c
            753-853             AL606976.25        34221-34321         c
            854-1368            AL606976.25        33269-33783         c
FEATURES             Location/Qualifiers
     source          1..1368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 60.36 cM"
     gene            1..1368
                     /gene="Adprs"
                     /gene_synonym="Adprhl2; Arh3"
                     /note="ADP-ribosylserine hydrolase"
                     /db_xref="GeneID:100206"
                     /db_xref="MGI:MGI:2140364"
     exon            1..262
                     /gene="Adprs"
                     /gene_synonym="Adprhl2; Arh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1146
                     /gene="Adprs"
                     /gene_synonym="Adprhl2; Arh3"
                     /EC_number="3.2.1.143"
                     /note="ADP-ribosylhydrolase 2; ecto ADP-ribosylhydrolase;
                     poly(ADP-ribose) glycohydrolase ARH3; ADP-ribosylhydrolase
                     3; [Protein ADP-ribosylarginine] hydrolase-like protein 2;
                     O-acetyl-ADP-ribose deacetylase ARH3; [Protein
                     ADP-ribosylserine] hydrolase; ADP-ribose glycohydrolase
                     ARH3; ADP-ribosylhydrolase like 2"
                     /codon_start=1
                     /product="ADP-ribosylhydrolase ARH3"
                     /protein_id="NP_598644.1"
                     /db_xref="CCDS:CCDS18650.1"
                     /db_xref="GeneID:100206"
                     /db_xref="MGI:MGI:2140364"
                     /translation="MAVAAAAAATAMSAAGGGGASAARSISRFRGCLAGALLGDCVGA
                     VYEAHDTVSLASVLSHVESLEPDPGTPGSARTETLYYTDDTAMTRALVQSLLAKEAFD
                     EVDMAHRFAQEYKKDPDRGYGAGVITVFKKLLNPKCRDVYEPARAQFNGKGSYGNGGA
                     MRVAGISLAYSSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGVSSSEHFL
                     EQLLGHMEELEGDAQSVLDAKELGMEERPYSSRLKKVGELLDQDVVSREEVVSELGNG
                     IAAFESVPTAIYCFLRCMEPHPEIPSTFNSLQRTLIYSISLGGDTDTIATMAGAIAGA
                     YYGMEQVPESWQQSCEGFEETDVLAQSLHRVFQESS"
     exon            263..359
                     /gene="Adprs"
                     /gene_synonym="Adprhl2; Arh3"
                     /inference="alignment:Splign:2.1.0"
     exon            360..567
                     /gene="Adprs"
                     /gene_synonym="Adprhl2; Arh3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..752
                     /gene="Adprs"
                     /gene_synonym="Adprhl2; Arh3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..853
                     /gene="Adprs"
                     /gene_synonym="Adprhl2; Arh3"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1368
                     /gene="Adprs"
                     /gene_synonym="Adprhl2; Arh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgatgccgga agtggcgact agtccgcgcg cggatggcgg tggctgcggc ggcagcagct
       61 acagcgatgt cggcggcggg gggcggcggg gcaagtgcgg cccgctccat ctcgcgcttc
      121 cgaggttgcc tggcgggcgc gctgctggga gattgcgtgg gcgctgtcta cgaggcacac
      181 gataccgtca gcctggcatc agtcctgagt cacgtcgaga gcctggagcc ggacccgggc
      241 acgccgggca gcgcgcggac agagacactg tactacacag atgacactgc catgaccagg
      301 gccctggtgc agtccctgct ggccaaggag gccttcgacg aggtggacat ggctcacagg
      361 tttgcccagg aatacaagaa ggaccctgac agagggtatg gggccggagt catcactgtc
      421 ttcaagaaac tcctgaatcc caagtgccgt gatgtctatg agcctgcccg ggcccagttc
      481 aacgggaagg gttcctatgg caatgggggt gccatgcggg tagcaggcat ctcgctggcc
      541 tatagcagtg tccaagatgt acagaagttt gcccggctct cggcccagct gacccacgcc
      601 tcttccctgg gctataacgg tgccatcttg caggccctgg ctgtgcacct tgctctgcag
      661 ggtgtatcat ccagtgagca cttccttgag cagcttctgg gccacatgga ggagctggaa
      721 ggtgatgccc aatcggtctt ggacgccaag gagttgggta tggaggagcg tccgtactcc
      781 agcaggctga agaaggtcgg agagctgctg gaccaggacg tggtgagccg agaggaagtg
      841 gtgtccgagc tagggaatgg cattgccgcc tttgaatctg tgcccaccgc catctactgc
      901 ttcctgcgct gcatggagcc tcaccctgag atcccctcca ccttcaacag tctccagagg
      961 actctcatct actccatctc acttggtggg gacacagaca ccatagccac catggctggg
     1021 gccattgctg gagcttacta tgggatggaa caggtgccgg agagctggca gcaaagttgt
     1081 gaaggctttg aggagacaga cgtcctggcc cagagcctgc accgagtctt ccaggagagc
     1141 tcgtaagggc cgcagcttcg gtgggcttgt cagacccatc aggaccaagg acaactcaga
     1201 ttggactcca cagttccctt aggttgccgc acctgccctc aatcctagag ggaagactga
     1261 aggtaccctt ggggctggaa tcttgagaca gcctgtggaa cagagaggag ctggtgcctt
     1321 cttggggctg cagctctggc ttgctgcagg gctgtatgac acccaggg
//
