LOCUS       NM_007414               1583 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ADP-ribosylarginine hydrolase (Adprh), mRNA.
ACCESSION   NM_007414
VERSION     NM_007414.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Watanabe,K., Kato,J., Zhu,J., Oda,H., Ishiwata-Endo,H. and Moss,J.
  TITLE     Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine
            hydrolase (ARH1)-deficient mice
  JOURNAL   PLoS One 13 (11), e0207693 (2018)
   PUBMED   30500844
  REMARK    GeneRIF: Intestinal loops derived from female ADP-ribosylarginine
            hydrolase knockout (ARH1-KO) mice when injected with cholera toxin
            showed increased fluid accumulation compared to male ARH1-KO mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Ishiwata-Endo,H., Kato,J., Tonouchi,A., Chung,Y.W., Sun,J.,
            Stevens,L.A., Zhu,J., Aponte,A.M., Springer,D.A., San,H.,
            Takeda,K., Yu,Z.X., Hoffmann,V., Murphy,E. and Moss,J.
  TITLE     Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and
            membrane repair
  JOURNAL   JCI Insight 3 (22), 97898 (2018)
   PUBMED   30429362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Bu,X., Kato,J., Hong,J.A., Merino,M.J., Schrump,D.S., Lund,F.E. and
            Moss,J.
  TITLE     CD38 knockout suppresses tumorigenesis in mice and clonogenic
            growth of human lung cancer cells
  JOURNAL   Carcinogenesis 39 (2), 242-251 (2018)
   PUBMED   29228209
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Kato,J., Zhu,J., Liu,C., Stylianou,M., Hoffmann,V., Lizak,M.J.,
            Glasgow,C.G. and Moss,J.
  TITLE     ADP-ribosylarginine hydrolase regulates cell proliferation and
            tumorigenesis
  JOURNAL   Cancer Res 71 (15), 5327-5335 (2011)
   PUBMED   21697277
  REMARK    GeneRIF: ARH1(-/-) and ARH1(+/-) mice spontaneously develop
            lymphomas, adenocarcinomas, & metastases more frequently than
            wild-type. Proper control of protein ADP-ribosylation levels
            affected by ARH1 is essential for cancer suppression.
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Kato,J., Zhu,J., Liu,C. and Moss,J.
  TITLE     Enhanced sensitivity to cholera toxin in ADP-ribosylarginine
            hydrolase-deficient mice
  JOURNAL   Mol Cell Biol 27 (15), 5534-5543 (2007)
   PUBMED   17526733
  REMARK    GeneRIF: Cholera toxin-catalyzed ADP-ribosylation of cell proteins
            can be counteracted by ADPRH, which could function as a modifier
            gene in disease.
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Li,H., Bishop,K.M. and O'Leary,D.D.
  TITLE     Potential target genes of EMX2 include Odz/Ten-M and other gene
            families with implications for cortical patterning
  JOURNAL   Mol Cell Neurosci 33 (2), 136-149 (2006)
   PUBMED   16919471
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Aoki,K., Kato,J., Shoemaker,M.T. and Moss,J.
  TITLE     Genomic organization and promoter analysis of the mouse
            ADP-ribosylarginine hydrolase gene
  JOURNAL   Gene 351, 83-95 (2005)
   PUBMED   15893437
  REMARK    GeneRIF: ADP-ribosylarginine hydrolase promoter activity pattern
            and involvement of Sp transcription factors are consistent with
            prior observations of widespread hydrolase expression in mammalian
            tissues.
REFERENCE   8  (bases 1 to 1583)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   9  (bases 1 to 1583)
  AUTHORS   Takada,T., Iida,K. and Moss,J.
  TITLE     Cloning and site-directed mutagenesis of human ADP-ribosylarginine
            hydrolase
  JOURNAL   J Biol Chem 268 (24), 17837-17843 (1993)
   PUBMED   8349667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ155232.1, AK153498.1 and CAAA01037235.1.
            
            On Feb 15, 2006 this sequence version replaced NM_007414.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF244347.1, AK146280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               CJ155232.1         9-146
            139-1389            AK153498.1         104-1354
            1390-1583           CAAA01037235.1     11520-11713
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.86 cM"
     gene            1..1583
                     /gene="Adprh"
                     /gene_synonym="Arh1"
                     /note="ADP-ribosylarginine hydrolase"
                     /db_xref="GeneID:11544"
                     /db_xref="MGI:MGI:1098234"
     exon            1..161
                     /gene="Adprh"
                     /gene_synonym="Arh1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..516
                     /gene="Adprh"
                     /gene_synonym="Arh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1292
                     /gene="Adprh"
                     /gene_synonym="Arh1"
                     /EC_number="3.2.2.19"
                     /note="[Protein ADP-ribosylarginine] hydrolase;
                     ADP-ribose-L-arginine cleaving enzyme"
                     /codon_start=1
                     /product="ADP-ribosylarginine hydrolase"
                     /protein_id="NP_031440.1"
                     /db_xref="CCDS:CCDS28167.1"
                     /db_xref="GeneID:11544"
                     /db_xref="MGI:MGI:1098234"
                     /translation="MGGGLIERYVAAMVLSAAGDTLGYFNGKWEFIRDGETIHQQLAQ
                     MGDLEAIDVARWRVSDDTVMHLATAEALMEAGQSPDLPRLYSLLAKHYRDCMGDMDGR
                     APGGACMQNAMLLQPNRADGYRIPFNSHEGGCGAAMRAMCIGLRFPHPSQLDLLIQVS
                     IESGRMTHHHPTGYLGSLASALFTAYAVNGKSPWQWGKGLMEVLPEAKKYITQSGYFV
                     KENLQHWSYFEKEWEKYLELRGILDGNSAPVFPQPFGVKERDQFYIDVSYSGWGGSSG
                     HDAPMIAYDALLAAGDSWKELAHRAFFHGGDSDSTAAIAGCWWGVMYGFKGVNPANYE
                     KLEYRQRLEEAGRALYSLGSKEDPVLDP"
     exon            517..877
                     /gene="Adprh"
                     /gene_synonym="Arh1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1583
                     /gene="Adprh"
                     /gene_synonym="Arh1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1578
                     /gene="Adprh"
                     /gene_synonym="Arh1"
                     /note="major polyA site"
ORIGIN      
        1 agcgacccgc ccggcccgcg gctccgcccc tgttcggctt ttggcttggg tgcccacagc
       61 aggactcctg cgcccggtac cccgcctcca gctcgggcaa tcctgccctc ggctctggac
      121 caccccgatc ccgccccacg ctctcagctc cgcctcagca ggagtctccg ttgccccata
      181 agcccgcctg tgccaagctc agcatgggtg gggggctgat tgagaggtat gtggctgcca
      241 tggtgctgag cgcggctgga gataccttgg gctacttcaa cgggaagtgg gagttcattc
      301 gggatgggga gacgatacac cagcagttgg cccagatggg tgacttggaa gccatagatg
      361 tggcacgatg gagagtcagt gatgataccg tcatgcacct ggccacagcg gaggccctca
      421 tggaagccgg ccagtccccg gatttgcctc ggctgtattc cctactagcc aaacattacc
      481 gggactgcat gggagacatg gatggccggg caccaggtgg tgcttgcatg cagaacgcca
      541 tgctgctaca gcccaacagg gccgacggct ataggattcc cttcaacagt cacgagggtg
      601 gctgcggggc tgccatgcgc gccatgtgca tcgggctgag gttcccccac cccagccaac
      661 tggatctgct gatccaagtg agcatcgaga gcggccggat gacccaccac caccccacgg
      721 gctacctcgg cagccttgcg tccgctcttt ttacggcata tgccgtgaat ggcaagtcac
      781 catggcagtg gggaaaaggg ctaatggagg tgctgcctga agccaaaaag tacatcactc
      841 agtcaggcta ctttgtgaag gagaatcttc aacactggtc ctacttcgag aaagaatggg
      901 aaaagtacct ggagcttaga ggaattttgg acggcaactc ggctcccgtc ttcccgcagc
      961 cctttggtgt gaaggaaagg gatcagttct acatcgacgt gagctactcg ggctggggtg
     1021 gcagcagcgg acacgatgcc cccatgattg cctacgatgc cctcctggcc gcgggggatt
     1081 cctggaagga gctcgcacac agagccttct tccacggtgg agacagtgat tccacggccg
     1141 ccattgctgg ctgctggtgg ggagttatgt acggctttaa aggcgtaaat cccgccaact
     1201 acgagaagct cgaataccga cagcggctag aagaggccgg aagagctttg tattctctcg
     1261 ggtcaaaaga agaccctgta ttagatccct agggagaagg tggtttgttt ctggcggttt
     1321 ctttccctgt agccctgaag ctcagtctct tcagcctttt gagagtcaag aatcctaatt
     1381 ttgtgtttga agagttctga gataacaagt cccttggatg cgtttagccc tgcctttcca
     1441 catttaccct gttctccccg agttcctctc ttgtgtatga gaatcttttt atttcagttg
     1501 atggggtcag cttttcccat tcagaaacct cataaccttg tattccagtt tttgttttta
     1561 tcacagaatt gtgcaaaatg ctt
//
