LOCUS       NM_028121               2499 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADP-dependent glucokinase (Adpgk), transcript variant
            1, mRNA.
ACCESSION   NM_028121
VERSION     NM_028121.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2499)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2499)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2499)
  AUTHORS   Sabik,O.L., Medrano,J.F. and Farber,C.R.
  TITLE     Genetic Dissection of a QTL Affecting Bone Geometry
  JOURNAL   G3 (Bethesda) 7 (3), 865-870 (2017)
   PUBMED   28082324
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2499)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   5  (bases 1 to 2499)
  AUTHORS   Richter,J.P., Goroncy,A.K., Ronimus,R.S. and Sutherland-Smith,A.J.
  TITLE     The Structural and Functional Characterization of Mammalian
            ADP-dependent Glucokinase
  JOURNAL   J Biol Chem 291 (8), 3694-3704 (2016)
   PUBMED   26555263
  REMARK    GeneRIF: ADPGK is substrate inhibited by high glucose concentration
            and shows high specificity for glucose, with no activity for other
            sugars, as determined by NMR spectroscopy, including 2-deoxyglucose
REFERENCE   6  (bases 1 to 2499)
  AUTHORS   McDaniel,A.H., Li,X., Tordoff,M.G., Bachmanov,A.A. and Reed,D.R.
  TITLE     A locus on mouse Chromosome 9 (Adip5) affects the relative weight
            of the gonadal but not retroperitoneal adipose depot
  JOURNAL   Mamm Genome 17 (11), 1078-1092 (2006)
   PUBMED   17103052
REFERENCE   7  (bases 1 to 2499)
  AUTHORS   Gregori,C., Guillet-Deniau,I., Girard,J., Decaux,J.F. and
            Pichard,A.L.
  TITLE     Insulin regulation of glucokinase gene expression: evidence against
            a role for sterol regulatory element binding protein 1 in primary
            hepatocytes
  JOURNAL   FEBS Lett 580 (2), 410-414 (2006)
   PUBMED   16380121
  REMARK    GeneRIF: Results suggest that sterol regulatory-element binding
            protein-1c is unlikely to be the mediator of the early insulin
            effect on glucokinase gene transcription.
REFERENCE   8  (bases 1 to 2499)
  AUTHORS   Ronimus,R.S. and Morgan,H.W.
  TITLE     Cloning and biochemical characterization of a novel mouse
            ADP-dependent glucokinase
  JOURNAL   Biochem Biophys Res Commun 315 (3), 652-658 (2004)
   PUBMED   14975750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048904.1, AK011434.1 and BC094657.1.
            
            On Jul 13, 2005 this sequence version replaced NM_028121.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169590.1, AK011434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AK048904.1         1-36
            37-1888             AK011434.1         2-1853
            1889-2499           BC094657.1         4561-5171
FEATURES             Location/Qualifiers
     source          1..2499
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 32.01 cM"
     gene            1..2499
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /note="ADP-dependent glucokinase"
                     /db_xref="GeneID:72141"
                     /db_xref="MGI:MGI:1919391"
     exon            1..295
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1553
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /EC_number="2.7.1.147"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ATP-dependent glucokinase"
                     /codon_start=1
                     /product="ADP-dependent glucokinase isoform 1 precursor"
                     /protein_id="NP_082397.1"
                     /db_xref="CCDS:CCDS23248.1"
                     /db_xref="GeneID:72141"
                     /db_xref="MGI:MGI:1919391"
                     /translation="MALWRGSACAGFLALAVGCVFLLEPELPGTALRSLWSSLRLGPA
                     PVPVGPLSPESRLAAAWDALIAQPARRWRRVAVGVNACVDVVISGVKLLQALGLSPGS
                     GKDHAILHSRSDLEEAFLYFMGKGAAAERFFSDKETFHDIAQAASEFPGAQHYVGGNA
                     ALIGQRFAANTDLKVLLCGPIGPKLHELLDDNVFVPPESLQEEDEFHLILEYLAGEEW
                     GPFKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRK
                     RLLEVVTAISDIPTGIPVHLELASMTNRELMSSIVHQQVFPTVASLGLNEQELLFLSQ
                     SASGPHASLSSWDGVPDVGMVSDILFWILKEHGRSENRASDLTRIHFHTLVYHILATV
                     DGHWANQLAAVAAGARVAGTQACATETIDTNRVSLRAPQEFTTSHLESGSRIVLNPDK
                     PVVEWHREGITFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEARPD"
     exon            296..521
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /inference="alignment:Splign:2.1.0"
     exon            522..584
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /inference="alignment:Splign:2.1.0"
     exon            585..705
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /inference="alignment:Splign:2.1.0"
     exon            706..902
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1001
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..2471
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2447..2452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /note="hexamer: ATTAAA"
     polyA_site      2471
                     /gene="Adpgk"
                     /gene_synonym="2610017G09Rik; Adp-gk"
                     /note="major polyA site"
ORIGIN      
        1 agctgggagg aggcgcgagc cgagaaagga tcctgtagcc accggtgcgg cggtgtgtgc
       61 acatggcgct gtggcgcggc tctgcgtgcg ccggcttcct ggcgctggcc gtgggctgcg
      121 tgttcctgct ggagccggag ctgccgggca cggcgctgcg ctcgctctgg agctccctga
      181 ggctgggacc cgcgccagtg cccgtgggac ctctgtcccc ggagagccgg ctggcagccg
      241 cttgggacgc cctcatcgcg cagcccgccc ggcgctggcg ccgcgtggct gtgggagtca
      301 acgcctgtgt ggatgtggta atctctggcg tgaaactcct gcaggccctc ggcctcagtc
      361 ctgggagtgg aaaagatcat gctattctac actcgagaag tgatctggaa gaagccttcc
      421 tctacttcat ggggaaggga gccgctgctg agcgcttctt cagtgataaa gagacctttc
      481 atgacattgc ccaggctgca tctgagtttc caggagctca gcattatgta ggaggaaatg
      541 ctgctttaat tggacagagg tttgctgcca acacagactt aaaggttctt ctttgtggtc
      601 caattggccc aaaactgcat gaacttcttg atgacaatgt gtttgttcca ccagagtcac
      661 tgcaggaaga ggatgagttc caccttattt tagagtacct ggcaggggag gagtggggcc
      721 cgtttaaagc tccccatgcc aaccgcttca tcttctctca cgacctctcc aacggggcca
      781 tgaatatgct ggaggtgttt gtgtctagcc tggaggagtt ccagcctgac ctggtggtcc
      841 tttctggatt gcacatgatg gagggacaaa gcaaggagct ccagaggaag aggctcttgg
      901 aggttgtgac cgccatttct gacatcccca ctggtattcc agttcaccta gagctggcca
      961 gtatgaccaa cagggagctc atgagcagta ttgtgcatca gcaggtcttt cccacggtgg
     1021 cttctcttgg gctgaatgaa caggagctgc tgtttctcag ccagtcggca tctggacccc
     1081 atgcttctct ctcctcctgg gatggtgttc ctgatgtggg catggtcagt gacatcctct
     1141 tctggatctt gaaagaacat ggaaggagtg aaaacagagc ctcggatctc accaggatcc
     1201 atttccacac gctggtctac cacattctgg caactgtgga cggacactgg gccaaccagc
     1261 tcgcagccgt agctgcggga gctcgtgtag ctgggacaca agcctgtgcc acagaaacca
     1321 tagacaccaa ccgagtgtct ctaagagcac ctcaggagtt tacgacatcc catttggaat
     1381 ccggttccag gattgtattg aacccagata agccagtggt ggagtggcac agggagggaa
     1441 taactttcca cttcacacct gtgttggtgt gtaaagaccc cgttcgaact gtaggccttg
     1501 gtgatgccat ttccgctgaa ggcctcttct attcagaagc acgccctgat tagacacgtt
     1561 gtgtgaggaa tgaaagtcac ccatcttaag aattccagca agaacatagc ttgggaacta
     1621 ggcttgtgag tgtcagaaca gttcctagat caaattggaa tagagccaaa gaaatcacag
     1681 cagattaaac tgtacagata cattccagcc tgttggcaac ataaaaacac ttcaggtata
     1741 attgaaactc agctgtctac taatgagact ggatttttgt tttttatgtt gtgctacaaa
     1801 ggttaaaacc tctttctgaa tccccagttg atgtaccatg actctggaga gctcatccag
     1861 ccacagaaag tactcccccc ccccccccca agcctggtca ctcatgaaac ctggccaagg
     1921 cagtcatgac agcttatgct cctggcagaa tcaacttgtc cattcagtgt tacagtgaca
     1981 atatttgctg tgtgtacctt ctcagcctcc tgctctcaga cataggtcag agccacagga
     2041 gagaacaaaa cagtcttgtg ctttatggtc tcagactgga aacccctggg agagctatga
     2101 gccacctgac cattctgcac ttgcttggaa gcaccatgcc ttcctgcccc ggcgtcatgg
     2161 actggggctg gctgagaaaa ggccccacag cttgttctca gcctcagcgc tgagctccgg
     2221 cagtgctttc tgcagcacaa gactgctact cgttcctttt gagccttgaa gagatgtgtt
     2281 ttataactgg aaagtgcttc tatatagaac acatcatgta ttttgtgttt ttgttttgac
     2341 acatccatta aagagtttga cctcttaaaa gccccaggat catgaataaa tgcgtcatgt
     2401 atatttattt tttaataaat caagatttct gtgtgctttt aaaaatatta aaataattta
     2461 catttccagg aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
