LOCUS       NM_009631               2372 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus adenosine A3 receptor (Adora3), mRNA.
ACCESSION   NM_009631
VERSION     NM_009631.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   Xu,Y., Tang,L., Zhou,C., Sun,L., Hu,Y., Zhang,Z., Xia,S., Bao,X.,
            Yang,H. and Xu,Y.
  TITLE     Inhibition of ADORA3 promotes microglial phagocytosis and
            alleviates chronic ischemic white matter injury
  JOURNAL   CNS Neurosci Ther 30 (5), e14742 (2024)
   PUBMED   38715283
  REMARK    GeneRIF: Inhibition of ADORA3 promotes microglial phagocytosis and
            alleviates chronic ischemic white matter injury.
REFERENCE   2  (bases 1 to 2372)
  AUTHORS   Xiao,C., Gavrilova,O., Liu,N., Lewicki,S.A., Reitman,M.L. and
            Jacobson,K.A.
  TITLE     In vivo phenotypic validation of adenosine receptor-dependent
            activity of non-adenosine drugs
  JOURNAL   Purinergic Signal 19 (3), 551-564 (2023)
   PUBMED   36781825
REFERENCE   3  (bases 1 to 2372)
  AUTHORS   Micheli,L., Durante,M., Lucarini,E., Sgambellone,S., Lucarini,L.,
            Di Cesare Mannelli,L., Ghelardini,C. and Masini,E.
  TITLE     The Histamine H4 Receptor Participates in the Anti-Neuropathic
            Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4+ T
            Cells
  JOURNAL   Biomolecules 11 (10), 1447 (2021)
   PUBMED   34680083
  REMARK    GeneRIF: The Histamine H4 Receptor Participates in the
            Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist
            IB-MECA: Role of CD4(+) T Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2372)
  AUTHORS   Pak,E.S., Jeong,L.S., Hou,X., Tripathi,S.K., Lee,J. and Ha,H.
  TITLE     Dual Actions of A2A and A3 Adenosine Receptor Ligand Prevents
            Obstruction-Induced Kidney Fibrosis in Mice
  JOURNAL   Int J Mol Sci 22 (11), 5667 (2021)
   PUBMED   34073488
  REMARK    GeneRIF: Dual Actions of A2A and A3 Adenosine Receptor Ligand
            Prevents Obstruction-Induced Kidney Fibrosis in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2372)
  AUTHORS   Durante,M., Squillace,S., Lauro,F., Giancotti,L.A., Coppi,E.,
            Cherchi,F., Di Cesare Mannelli,L., Ghelardini,C., Kolar,G.,
            Wahlman,C., Opejin,A., Xiao,C., Reitman,M.L., Tosh,D.K.,
            Hawiger,D., Jacobson,K.A. and Salvemini,D.
  TITLE     Adenosine A3 agonists reverse neuropathic pain via T cell-mediated
            production of IL-10
  JOURNAL   J Clin Invest 131 (7) (2021)
   PUBMED   33621215
  REMARK    GeneRIF: Adenosine A3 agonists reverse neuropathic pain via T
            cell-mediated production of IL-10.
REFERENCE   6  (bases 1 to 2372)
  AUTHORS   Zhao,Z., Francis,C. and Ravid,K.
  TITLE     Characterization of the mouse A3 adenosine receptor gene:
            exon/intron organization and promoter activity
  JOURNAL   Genomics 57 (1), 152-155 (1999)
   PUBMED   10191095
REFERENCE   7  (bases 1 to 2372)
  AUTHORS   Allikmets,R., Singh,N., Sun,H., Shroyer,N.F., Hutchinson,A.,
            Chidambaram,A., Gerrard,B., Baird,L., Stauffer,D., Peiffer,A.,
            Rattner,A., Smallwood,P., Li,Y., Anderson,K.L., Lewis,R.A.,
            Nathans,J., Leppert,M., Dean,M. and Lupski,J.R.
  TITLE     A photoreceptor cell-specific ATP-binding transporter gene (ABCR)
            is mutated in recessive Stargardt macular dystrophy
  JOURNAL   Nat Genet 15 (3), 236-246 (1997)
   PUBMED   9054934
  REMARK    Erratum:[Nat Genet. 1997 Sep;17(1):122. doi: 10.1038/ng0997-122a.
            PMID: 9288113]
REFERENCE   8  (bases 1 to 2372)
  AUTHORS   Zhao,Z., Ravid,S. and Ravid,K.
  TITLE     Chromosomal mapping of the mouse A3 adenosine receptor gene, Adora3
  JOURNAL   Genomics 30 (1), 118-119 (1995)
   PUBMED   8595892
REFERENCE   9  (bases 1 to 2372)
  AUTHORS   Wilkie,T.M., Chen,Y., Gilbert,D.J., Moore,K.J., Yu,L., Simon,M.I.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Identification, chromosomal location, and genome organization of
            mammalian G-protein-coupled receptors
  JOURNAL   Genomics 18 (2), 175-184 (1993)
   PUBMED   8288218
REFERENCE   10 (bases 1 to 2372)
  AUTHORS   Ramkumar,V., Stiles,G.L., Beaven,M.A. and Ali,H.
  TITLE     The A3 adenosine receptor is the unique adenosine receptor which
            facilitates release of allergic mediators in mast cells
  JOURNAL   J Biol Chem 268 (23), 16887-16890 (1993)
   PUBMED   8349579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121847.2, AK013534.1 and BY585192.1.
            
            On Sep 24, 2013 this sequence version replaced NM_009631.3.
            
            Summary: This gene encodes a protein that belongs to the family of
            adenosine receptors, which are G-protein-coupled receptors that are
            involved in a variety of intracellular signaling pathways and
            physiological functions. The receptor encoded by this gene mediates
            a sustained cardioprotective function during cardiac ischemia, it
            is involved in the inhibition of neutrophil degranulation in
            neutrophil-mediated tissue injury, it has been implicated in both
            neuroprotective and neurodegenerative effects, and it may also
            mediate both cell proliferation and cell death. This gene shares
            its 3' terminal exon with a transcript variant from overlapping
            GeneID:69296, which encodes an immunoglobulin domain-containing
            protein. [provided by RefSeq, Nov 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154312.1, AK013534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC121847.2         28489-28498         c
            11-884              AK013534.1         10-883
            885-1082            AC121847.2         25281-25478         c
            1083-2343           AK013534.1         1083-2343
            2344-2372           BY585192.1         381-409
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.45 cM"
     gene            1..2372
                     /gene="Adora3"
                     /gene_synonym="A3AR; A3R; AA3R; ARA3; Gpcr2"
                     /note="adenosine A3 receptor"
                     /db_xref="GeneID:11542"
                     /db_xref="MGI:MGI:104847"
     exon            1..732
                     /gene="Adora3"
                     /gene_synonym="A3AR; A3R; AA3R; ARA3; Gpcr2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..2372
                     /gene="Adora3"
                     /gene_synonym="A3AR; A3R; AA3R; ARA3; Gpcr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adora3"
                     /gene_synonym="A3AR; A3R; AA3R; ARA3; Gpcr2"
                     /note="hexamer: AATAAA"
     polyA_site      1799
                     /gene="Adora3"
                     /gene_synonym="A3AR; A3R; AA3R; ARA3; Gpcr2"
                     /note="major polyA site"
     regulatory      2348..2353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adora3"
                     /gene_synonym="A3AR; A3R; AA3R; ARA3; Gpcr2"
                     /note="hexamer: ATTAAA"
     polyA_site      2371
                     /gene="Adora3"
                     /gene_synonym="A3AR; A3R; AA3R; ARA3; Gpcr2"
ORIGIN      
        1 acactctaaa gaggagtgct tatcttgatg gagctcgaaa gttctctggg gcccagggga
       61 cagcagaagc cctgactctg tttgcctggg gaagtaagaa cggtggccct ctcggatttg
      121 gctgcagaga cctgcatcct ccaggttaat gggaaggcag ggataagcgg ctgaggttga
      181 tggtcctgta acaggccctt tctgagaaga gtctctaaga gagagtcata ccggaaggaa
      241 tgagcaagtt gtgagttctc tggactgttg tgacattcta acttctgggc agaagtctga
      301 caagagctgg gtccactggc ccatacacaa cctgctgaag agccacggaa gcttccgcct
      361 gaagcttttc tgagacagca tggaagccga caacaccacg gagacggact ggctgaacat
      421 cacctacatc accatggagg ctgccatcgg gctctgtgcc gttgtgggca acatgctggt
      481 catctgggtg gtcaagctga accccactct gaggaccacc acgttctatt tcattgtctc
      541 cctagcactg gctgacattg ccgttggggt gctggtcaca cctttggcca ttgctgtcag
      601 cctgcaagtc aagatgcact tctatgcctg ccttttcatg tcctgtgtgc tgctgatctt
      661 cacccatgct tccatcatgt ccttgctggc cattgctgta gaccgatacc tgcgggtcaa
      721 gctgacagtc agatatagaa cggttaccac tcaaagaaga atatggctat tcttgggcct
      781 ttgctggcta gtttcctttc tggtggggct gacccccatg tttggctgga atagaaaagc
      841 aaccttagcg agctctcaaa atagcagcac tcttttgtgc cacttccgtt ccgtggtcag
      901 tttggattac atggtcttct tcagcttcgt cacctggatc ctcgtccccc tggttgtcat
      961 gtgtgtcatc tacctagaca tcttctacat catccgaaat aagctcagtc aaaacctgtc
     1021 tggcttcaga gagacgcgtg cattttatgg acgggagttc aagacagcta agtccctgtt
     1081 tctggttctc ttcttgtttg cgctgtgctg gctgcctttg tccatcatca attttgtttc
     1141 ctattttgat gtaaagatac cagatgtcgc aatgtgcctg gggatcctgt tgtcccacgc
     1201 gaactccatg atgaacccta ttgtctacgc ctgcaaaata aaaaagttca aagagaccta
     1261 ctttctgatc ctcagagctc tcaggctctg tcagacctca gattctttgg actcaaacat
     1321 ggaacagact actgagtaat taccttgaca gatacagagc cagctcgtct gccttcgcat
     1381 gtggtatcag taaacactat aaggacttat cagacattct tgcttccttc actgcattgg
     1441 gatcatcggg ctggttgcca cagagttcca ctccttcccc ccaacgcccc cccccactcc
     1501 tccctccttc tgcttcagtt attttcttga gcttctctaa ttcaattctg tggaagcctg
     1561 acgtgaaggc aatgcatccc tgattaccac ggactctgcc cttccttccc agacaaagaa
     1621 gtaatggaat gtggagggag tctcgtctta tcaaaggaaa actctagtgg ggctggacgt
     1681 acagaacctg ctccgaagga tccctggaat gtggggaaca gaaggagcga attgaattta
     1741 aaaagagggc taaatccacc tgtgtgggtg catttgagca aataaaagat gatgcccaac
     1801 tgatgtgtag ctctttgcta ggattgcttg ggggttgcag gcacagttga ctgctcttgg
     1861 cattccttct gcttgcttct gggacacaat cacttctgtt ccaaggggca gcttcaccat
     1921 tgcagatggc tgtcctctgg gggtcggggg caggatgtct gttatgcaag gttctgatgt
     1981 tcttgaaatc ctaggcaact tcagcttcag gacaactgga gatttgtttg ttgttgtttg
     2041 tttggagaca gggtttctct gtgtagccct ggctgtcctg gaacttgctg tgtagaccag
     2101 gctgacctca aattcagaga tctgcctgcc tctgcctcct aagtactggg attaagggta
     2161 ggcagcacca ccatctggct acagctggag atctttagga gtgctttgta agtctggaac
     2221 aggacatttg agaacactga cactaagaca cacacatttg tggcttcagc caggatggag
     2281 gaatgaaata agttaggtat cacaagattt tatacagata ctctgtattt gttacttttc
     2341 agttgctatt aaaaaaatat ttcatgacca ag
//
