LOCUS       NM_007413               1844 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus adenosine A2b receptor (Adora2b), mRNA.
ACCESSION   NM_007413 XM_906536
VERSION     NM_007413.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Li,S., Han,J., Cao,J., Han,H., Lu,B., Wen,T. and Bian,W.
  TITLE     ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis
            of chondrocytes via inhibition of the PI3K/Akt pathway in mice with
            osteoarthritis
  JOURNAL   Environ Toxicol 39 (5), 2487-2501 (2024)
   PUBMED   38174997
  REMARK    GeneRIF: ADORA2B, transcriptionally suppressing by MYC, promotes
            ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway
            in mice with osteoarthritis.
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Marin-Castejon,A., Marco-Bonilla,M., Terencio,M.C., Arasa,J.,
            Carceller,M.C., Ferrandiz,M.L., Noguera,M.A., Andres-Ejarque,R. and
            Montesinos,M.C.
  TITLE     Adenosine A2B receptor agonist improves epidermal barrier integrity
            in a murine model of epidermal hyperplasia
  JOURNAL   Biomed Pharmacother 173, 116401 (2024)
   PUBMED   38460363
  REMARK    GeneRIF: Adenosine A2B receptor agonist improves epidermal barrier
            integrity in a murine model of epidermal hyperplasia.
REFERENCE   3  (bases 1 to 1844)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1844)
  AUTHORS   Pai,H.L., Wu,P.Y., Chen,D.M., Chen,Z.J., Yang,Y.S., Chang,H.H. and
            Lin,D.P.
  TITLE     Klotho Null Mutation Involvement in Adenosine A2B Receptor-Related
            Skeletal Muscle Degeneration
  JOURNAL   Am J Pathol 193 (7), 950-959 (2023)
   PUBMED   37028594
  REMARK    GeneRIF: Klotho Null Mutation Involvement in Adenosine A2B
            Receptor-Related Skeletal Muscle Degeneration.
REFERENCE   5  (bases 1 to 1844)
  AUTHORS   Ruan,W., Li,J., Choi,S., Ma,X., Liang,Y., Nair,R., Yuan,X.,
            Mills,T.W. and Eltzschig,H.K.
  TITLE     Targeting myocardial equilibrative nucleoside transporter ENT1
            provides cardioprotection by enhancing myeloid Adora2b signaling
  JOURNAL   JCI Insight 8 (11), e166011 (2023)
   PUBMED   37288658
  REMARK    GeneRIF: Targeting myocardial equilibrative nucleoside transporter
            ENT1 provides cardioprotection by enhancing myeloid Adora2b
            signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1844)
  AUTHORS   Zhong,H., Chunn,J.L., Volmer,J.B., Fozard,J.R. and Blackburn,M.R.
  TITLE     Adenosine-mediated mast cell degranulation in adenosine
            deaminase-deficient mice
  JOURNAL   J Pharmacol Exp Ther 298 (2), 433-440 (2001)
   PUBMED   11454903
REFERENCE   7  (bases 1 to 1844)
  AUTHORS   Blackburn,M.R., Wubah,J.A., Chunn,J.L., Thompson,L.F. and
            Knudsen,T.B.
  TITLE     Transitory expression of the A2b adenosine receptor during
            implantation chamber development
  JOURNAL   Dev Dyn 216 (2), 127-136 (1999)
   PUBMED   10536053
REFERENCE   8  (bases 1 to 1844)
  AUTHORS   Marquardt,D.L., Walker,L.L. and Heinemann,S.
  TITLE     Cloning of two adenosine receptor subtypes from mouse bone
            marrow-derived mast cells
  JOURNAL   J Immunol 152 (9), 4508-4515 (1994)
   PUBMED   8157966
REFERENCE   9  (bases 1 to 1844)
  AUTHORS   Brackett,L.E. and Daly,J.W.
  TITLE     Functional characterization of the A2b adenosine receptor in NIH
            3T3 fibroblasts
  JOURNAL   Biochem Pharmacol 47 (5), 801-814 (1994)
   PUBMED   8135856
REFERENCE   10 (bases 1 to 1844)
  AUTHORS   Stehle,J.H., Rivkees,S.A., Lee,J.J., Weaver,D.R., Deeds,J.D. and
            Reppert,S.M.
  TITLE     Molecular cloning and expression of the cDNA for a novel
            A2-adenosine receptor subtype
  JOURNAL   Mol Endocrinol 6 (3), 384-393 (1992)
   PUBMED   1584214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596110.15.
            
            On Apr 27, 2007 this sequence version replaced NM_007413.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047002.1, AK077289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               AL596110.15        139054-139506       c
            454-1844            AL596110.15        122038-123428       c
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..1844
                     /gene="Adora2b"
                     /gene_synonym="A2b; A2BAR; A2BR; AA2BR; ARA2B"
                     /note="adenosine A2b receptor"
                     /db_xref="GeneID:11541"
                     /db_xref="MGI:MGI:99403"
     exon            1..453
                     /gene="Adora2b"
                     /gene_synonym="A2b; A2BAR; A2BR; AA2BR; ARA2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1117
                     /gene="Adora2b"
                     /gene_synonym="A2b; A2BAR; A2BR; AA2BR; ARA2B"
                     /note="A2b, Rs"
                     /codon_start=1
                     /product="adenosine receptor A2b"
                     /protein_id="NP_031439.2"
                     /db_xref="CCDS:CCDS24822.1"
                     /db_xref="GeneID:11541"
                     /db_xref="MGI:MGI:99403"
                     /translation="MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNY
                     FLVSLATADVAVGLFAIPFAITISLGFCTDFHGCLFLACFVLVLTQSSIFSLLAVAVD
                     RYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDSATSNCTELGDG
                     IANKSCCPVTCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFMVACKQLQRMEL
                     MDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAI
                     LLSHANSVVNPIVYAYRNRDFRYSFHKIISRYVLCQAETKGGSGQAGAQSTLSLGL"
     exon            454..1844
                     /gene="Adora2b"
                     /gene_synonym="A2b; A2BAR; A2BR; AA2BR; ARA2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adora2b"
                     /gene_synonym="A2b; A2BAR; A2BR; AA2BR; ARA2B"
                     /note="hexamer: AATAAA"
     polyA_site      1501
                     /gene="Adora2b"
                     /gene_synonym="A2b; A2BAR; A2BR; AA2BR; ARA2B"
                     /note="major polyA site"
ORIGIN      
        1 agacccagct tgggacgcgc ggtctcagcg ctgtggccat gcctggcggc accctagcag
       61 ctgtcctgag cccgacacta ccccagtaga ggactccccg ggcccggctg gcccggccat
      121 gcagctagag acgcaagacg cgctgtacgt ggcgctggag ctggttatcg ctgcgctggc
      181 ggtggcgggc aacgtgctgg tgtgcgccgc ggtgggagcc tcgagtgcat tacagacccc
      241 caccaactac tttctggtat ccctggcgac ggcagacgtg gccgtgggac tcttcgccat
      301 cccctttgcc atcaccatca gcttgggctt ctgcacggac ttccacggct gcctcttcct
      361 cgcctgcttc gtgctggtgc tcacacagag ctccatcttt agcctcttgg cggtggctgt
      421 cgaccgatat ctggccattc gcgtcccgct caggtataaa ggtttggtca ctgggacacg
      481 agcgagaggg atcattgctg tcctctgggt ccttgccttt ggcattggat tgactccgtt
      541 cctggggtgg aacagtaaag acagtgccac cagcaactgc acagaactgg gggatggcat
      601 cgcgaataaa agctgctgtc ctgtgacatg tctctttgag aatgtggtcc ccatgagcta
      661 catggtgtat ttcaacttct ttgggtgtgt ccttcctcca ctgctcataa tgctggtgat
      721 ctacatcaaa atcttcatgg tggcctgcaa gcagcttcag cgcatggaac tgatggacca
      781 ctccaggacc actctccagc gggagatcca cgcagccaag tcactggcta tgatcgtggg
      841 catttttgct ctgtgttggc tcccagtgca tgccatcaac tgtatcaccc tcttccatcc
      901 agccctggcc aaggacaagc ccaagtgggt gatgaatgtg gccatcctcc tgtcacatgc
      961 caattcagtt gtcaacccca ttgtctatgc ctacaggaac cgagacttcc gctacagttt
     1021 ccacaagatc atctccagat atgttctctg ccaggccgag accaagggtg ggagtgggca
     1081 ggctggggcg cagtctactc tcagtctggg cttatgacct aggctctggc cttttggaga
     1141 agaaggctta aaataaacaa tgggactaga cacaactggc cgatcctcac tgtgaaagac
     1201 agctgcacct cccaagcaaa tggcccgtct cccctgaatg cttgcctgga gttacacaag
     1261 tctggctgac atgcaaattg gaggctccgt ggctaacaaa tacatttatg aatctattca
     1321 gctgctctta ctgtgtggat ggtggtggca gcttgaattg attccggaaa actgtttaag
     1381 aatctgcctc attcgtggta gaaaatgact gaaacttacc ttactgtgaa acactgtgaa
     1441 ctcttataat gtaagtattt ttcacttaca ggaatagaaa aataaaagtt ggctctacta
     1501 atgaatactt gttcctgggg cagcaactca gaaaactgaa gtataaatct tcagtcaaga
     1561 tacagtagta ttaatttagg gaatgattct atcctaagct ttgaagtaga attataataa
     1621 caaaacattt aagttcaata ttttcccagt acacaaaaca ctagaggtag aaactggaga
     1681 gacgaagtcc ttcctctact ggaacctgct ttagagctag gtactgggtt ttgcttctct
     1741 tccacattaa agtttattgg gacctaaagt gtgaaaattt tactaagcaa aatcacctaa
     1801 ttgtgtattg tacccaaaga aataaacttt aaaaggtgat tccc
//
