LOCUS       NM_009630               2604 bp    mRNA    linear   ROD 14-FEB-2024
DEFINITION  Mus musculus adenosine A2a receptor (Adora2a), transcript variant
            1, mRNA.
ACCESSION   NM_009630
VERSION     NM_009630.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2604)
  AUTHORS   Du,H., Li,C.H., Gao,R.B., Tan,Y., Wang,B., Peng,Y., Yang,N.,
            Ning,Y.L., Li,P., Zhao,Y. and Zhou,Y.G.
  TITLE     Inhibition of the interaction between microglial adenosine 2A
            receptor and NLRP3 inflammasome attenuates neuroinflammation
            posttraumatic brain injury
  JOURNAL   CNS Neurosci Ther 30 (1), e14408 (2024)
   PUBMED   37564004
  REMARK    GeneRIF: Inhibition of the interaction between microglial adenosine
            2A receptor and NLRP3 inflammasome attenuates neuroinflammation
            posttraumatic brain injury.
REFERENCE   2  (bases 1 to 2604)
  AUTHORS   Todd,K.L., Lai,J., Sek,K., Huang,Y.K., Newman,D.M., Derrick,E.B.,
            Koay,H.F., Nguyen,D., Hoang,T.X., Petley,E.V., Chan,C.W., Munoz,I.,
            House,I.G., Lee,J.N., Kim,J.S., Li,J., Tong,J., N de Menezes,M.,
            Scheffler,C.M., Yap,K.M., Chen,A.X.Y., Dunbar,P.A., Haugen,B.,
            Parish,I.A., Johnstone,R.W., Darcy,P.K. and Beavis,P.A.
  TITLE     A2AR eGFP reporter mouse enables elucidation of A2AR expression
            dynamics during anti-tumor immune responses
  JOURNAL   Nat Commun 14 (1), 6990 (2023)
   PUBMED   37914685
  REMARK    GeneRIF: A2AR eGFP reporter mouse enables elucidation of A2AR
            expression dynamics during anti-tumor immune responses.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2604)
  AUTHORS   Souza,J.R. and Machado,B.H.
  TITLE     Cardiovascular and respiratory evaluation in adenosine A2A receptor
            knockout mice submitted to short-term sustained hypoxia
  JOURNAL   Exp Physiol 108 (11), 1434-1445 (2023)
   PUBMED   37632713
  REMARK    GeneRIF: Cardiovascular and respiratory evaluation in adenosine A2A
            receptor knockout mice submitted to short-term sustained hypoxia.
REFERENCE   4  (bases 1 to 2604)
  AUTHORS   Ji,Q., Yang,Y., Xiong,Y., Zhang,Y.J., Jiang,J., Zhou,L.P., Du,X.H.,
            Wang,C.X. and Zhu,Z.R.
  TITLE     Blockade of adenosine A2A receptors reverses early spatial memory
            defects in the APP/PS1 mouse model of Alzheimer's disease by
            promoting synaptic plasticity of adult-born granule cells
  JOURNAL   Alzheimers Res Ther 15 (1), 187 (2023)
   PUBMED   37899431
  REMARK    GeneRIF: Blockade of adenosine A2A receptors reverses early spatial
            memory defects in the APP/PS1 mouse model of Alzheimer's disease by
            promoting synaptic plasticity of adult-born granule cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2604)
  AUTHORS   Lopes,C.R., Silva,A.C., Silva,H.B., Canas,P.M., Agostinho,P.,
            Cunha,R.A. and Lopes,J.P.
  TITLE     Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic
            Plasticity and of Memory in Mice Exposed to Abeta1-42 to Model
            Early Alzheimer's Disease
  JOURNAL   Biomolecules 13 (8), 1173 (2023)
   PUBMED   37627238
  REMARK    GeneRIF: Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of
            Synaptic Plasticity and of Memory in Mice Exposed to Abeta1-42 to
            Model Early Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2604)
  AUTHORS   Coppee,F., Gerard,A.C., Denef,J.F., Ledent,C., Vassart,G.,
            Dumont,J.E. and Parmentier,M.
  TITLE     Early occurrence of metastatic differentiated thyroid carcinomas in
            transgenic mice expressing the A2a adenosine receptor gene and the
            human papillomavirus type 16 E7 oncogene
  JOURNAL   Oncogene 13 (7), 1471-1482 (1996)
   PUBMED   8875985
REFERENCE   7  (bases 1 to 2604)
  AUTHORS   Noble,F. and Cox,B.M.
  TITLE     Differences among mouse strains in the regulation by mu, delta 1
            and delta 2 opioid receptors of striatal adenylyl cyclases
            activated by dopamine D1 or adenosine A2a receptors
  JOURNAL   Brain Res 716 (1-2), 107-117 (1996)
   PUBMED   8738226
REFERENCE   8  (bases 1 to 2604)
  AUTHORS   Marquardt,D.L., Walker,L.L. and Heinemann,S.
  TITLE     Cloning of two adenosine receptor subtypes from mouse bone
            marrow-derived mast cells
  JOURNAL   J Immunol 152 (9), 4508-4515 (1994)
   PUBMED   8157966
REFERENCE   9  (bases 1 to 2604)
  AUTHORS   Karlsten,R., Gordh,T. and Post,C.
  TITLE     Local antinociceptive and hyperalgesic effects in the formalin test
            after peripheral administration of adenosine analogues in mice
  JOURNAL   Pharmacol Toxicol 70 (6 Pt 1), 434-438 (1992)
   PUBMED   1438021
REFERENCE   10 (bases 1 to 2604)
  AUTHORS   Stehle,J.H., Rivkees,S.A., Lee,J.J., Weaver,D.R., Deeds,J.D. and
            Reppert,S.M.
  TITLE     Molecular cloning and expression of the cDNA for a novel
            A2-adenosine receptor subtype
  JOURNAL   Mol Endocrinol 6 (3), 384-393 (1992)
   PUBMED   1584214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY349524.1, CX241487.1, AC137067.33, BC110692.1 and AK037787.1.
            
            [WARNING] On Mar 11, 2024 this sequence was replaced by
            NM_009630.4.
            
            On May 10, 2014 this sequence version replaced NM_009630.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995048.2354406.1,
                                           SRR7652917.382250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               BY349524.1         1-195
            196-279             CX241487.1         1-84
            280-664             AC137067.33        106072-106456
            665-989             CX241487.1         471-795
            990-2600            BC110692.1         490-2100
            2601-2604           AK037787.1         1823-1826
FEATURES             Location/Qualifiers
     source          1..2604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.52 cM"
     gene            1..2604
                     /gene="Adora2a"
                     /gene_synonym="A2AAR; A2aR; AA2AR; ARA2A"
                     /note="adenosine A2a receptor"
                     /db_xref="GeneID:11540"
                     /db_xref="MGI:MGI:99402"
     exon            1..271
                     /gene="Adora2a"
                     /gene_synonym="A2AAR; A2aR; AA2AR; ARA2A"
                     /inference="alignment:Splign:2.1.0"
     exon            272..838
                     /gene="Adora2a"
                     /gene_synonym="A2AAR; A2aR; AA2AR; ARA2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..1748
                     /gene="Adora2a"
                     /gene_synonym="A2AAR; A2aR; AA2AR; ARA2A"
                     /codon_start=1
                     /product="adenosine receptor A2a"
                     /protein_id="NP_033760.2"
                     /db_xref="CCDS:CCDS23924.1"
                     /db_xref="GeneID:11540"
                     /db_xref="MGI:MGI:99402"
                     /translation="MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVS
                     LAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIA
                     IRIPLRYNGLVTGMRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDENSTKTCGEGRVT
                     CLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRS
                     TLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNS
                     VVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGSSAWALAAHSTEGEQVSLRLN
                     GHPLGVWANGSAPHSGRRPNGYTLGPGGGGSTQGSPGDVELLTQEHQEGQEHPGLGDH
                     LAQGRVGTASWSSEFAPS"
     exon            839..2604
                     /gene="Adora2a"
                     /gene_synonym="A2AAR; A2aR; AA2AR; ARA2A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtggcgct ggaggaggcg gtcaggacgc gtggacctga agcgcccacg ttggggcgaa
       61 gggtgctttg ctgccggacc catcaccacc tcgcccttcc agagacagtt tcccctggtt
      121 cccgcctcga ggcctcggtt tcccccagca gcggggcggg gcgggagcag cgctggtttc
      181 gaagtcgcct gcagggtgcg cccatgagcg gcgcggccgg agctggagcc cgagcggtcg
      241 ctgagacggt gggagccaga gcaagaggca ggtatctcag aaccctgaag ctgagtggag
      301 ccaggcccgg accccctgta gaagtcatgg tttcgggaga tgcagaatta tccgtgagaa
      361 agcctttggg aagctctccc tgggaacgct cgcggctctt gtgaggaaag ggctgcgggg
      421 tttgagtggg tacacggctg ggctgcagct atggaccgag agctggccca ggcccgcatc
      481 cttgctgagc ctgcccaagt gtggcttctc ccgccatggg ctcctcggtg tacatcatgg
      541 tggagctggc cattgctgtg ctggccatcc tgggtaacgt gcttgtgtgc tgggccgtgt
      601 ggatcaacag caacctgcag aacgtcacca acttcttcgt ggtatctctg gcggcggctg
      661 acatcgcggt gggcgtgctc gccatcccat tcgccatcac catcagcact ggcttctgcg
      721 ctgcctgcca tggctgcctc ttcttcgcct gctttgtcct ggtcctcacg cagagttcca
      781 tcttcagcct cttggctatt gccatcgaca gatacatcgc catccgaatt ccactccggt
      841 acaatggctt ggtgacgggt atgagggcga agggcatcat tgcgatttgc tgggtgctgt
      901 cattcgccat cggcctgacc cccatgctgg gctggaacaa ctgcagtcag aaagatgaga
      961 actccacaaa gacctgcggc gagggccggg tgacctgtct gtttgaggac gtggtaccca
     1021 tgaattacat ggtttactac aacttcttcg cttttgtgtt gctccccctc ctgctcatgc
     1081 tggccatcta cctaaggatt tttttggcag cccggagaca gctgaagcag atggagagcc
     1141 aacccctacc aggggagcgg actcgctcca cactgcagaa ggaagtccac gccgccaagt
     1201 ccctggccat catcgtgggg ctctttgccc tctgctggtt gcccctgcac atcatcaact
     1261 gcttcacctt cttctgctcc acgtgccagc acgcccctcc ttggctcatg tacctggcca
     1321 tcatcctctc ccacagcaat tccgttgtca accccttcat ctacgcctac aggatccggg
     1381 agttccgcca gaccttccgg aagatcatcc gaacccacgt cctgaggcgg caggaaccct
     1441 tcagggcagg gggttccagt gcctgggcct tggcggctca cagcactgag ggcgagcagg
     1501 tcagcctccg cctcaatggc caccccctgg gagtatgggc caatgggagt gctccccact
     1561 ctggacggcg gcccaatggc tacaccctgg ggccgggagg tggagggagc acccaagggt
     1621 ctcctgggga tgtagagctt cttacccagg agcaccagga agggcaagag caccctggcc
     1681 taggggatca tctggcccag ggtagggtag gaacagcctc atggtcttca gagtttgccc
     1741 cttcctgagg gaaagacatt ttaatatttt tgggttggct ggaccaatct cattaagaga
     1801 agagaagaaa cgcccacgcc aggaaaccca ctgggtgccc ggctcccact ctgcgggagc
     1861 atcaagctgg agcagcatga agcccagtaa gaaaggcctg gggcggagga ggcgatgctt
     1921 cggtctatag ggccccgagt taggtcaggg ctacagcagc atcttcgaag gcagggccca
     1981 gttcccctgc tccagaagcg tccacaagag ctgccttgcc ttgtagagca gctgtggctt
     2041 agaggcctgg cctgatgctg gggtatggct gcctcaggcc tcctgctaat acactactct
     2101 ccccagaccg ccgaggcctc agggagctgc tgacctagaa gtggcacttg gctatttttt
     2161 ttttccaaga agataacaat gtgaggaaac cctttctatt ttattgactt cccctccctg
     2221 gctgctgggt ctgtggtcga tcctgctgtg actctcccct ccacacccca cccaccaagg
     2281 aattgcagac ggtcctctcg ggttagccca agctgccatg cactcagtca cagggctatc
     2341 tcccgctaat aaagctgggc tggaagacag aaactatgaa aggcagggtg ccagagtgtg
     2401 ggctcacgtc tcaggattga gtttagagac atcaagtcat ggacccgagc tggatagttc
     2461 agagctgccc tgtggggagg ccctgcctac tgcctttcct tcgggggtgg ggtggggtgg
     2521 gggtggggct tgtttgtttg tttgtgtttt attttccccc tgagataaaa taaaatgagc
     2581 cacactgtgt tttaaatttg cctg
//
