LOCUS       NM_001005419            4456 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus 2-aminoethanethiol dioxygenase (Ado), mRNA.
ACCESSION   NM_001005419 XM_137138
VERSION     NM_001005419.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4456)
  AUTHORS   Fernandez,R.L., Elmendorf,L.D., Smith,R.W., Bingman,C.A., Fox,B.G.
            and Brunold,T.C.
  TITLE     The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin
            of the Large Substrate Scope of This Vital Mammalian Enzyme
  JOURNAL   Biochemistry 60 (48), 3728-3737 (2021)
   PUBMED   34762398
  REMARK    GeneRIF: The Crystal Structure of Cysteamine Dioxygenase Reveals
            the Origin of the Large Substrate Scope of This Vital Mammalian
            Enzyme.
REFERENCE   2  (bases 1 to 4456)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4456)
  AUTHORS   Wang,Y., Davis,I., Chan,Y., Naik,S.G., Griffith,W.P. and Liu,A.
  TITLE     Characterization of the nonheme iron center of cysteamine
            dioxygenase and its interaction with substrates
  JOURNAL   J Biol Chem 295 (33), 11789-11802 (2020)
   PUBMED   32601061
  REMARK    GeneRIF: Characterization of the nonheme iron center of cysteamine
            dioxygenase and its interaction with substrates.
REFERENCE   4  (bases 1 to 4456)
  AUTHORS   Fernandez,R.L., Dillon,S.L., Stipanuk,M.H., Fox,B.G. and
            Brunold,T.C.
  TITLE     Spectroscopic Investigation of Cysteamine Dioxygenase
  JOURNAL   Biochemistry 59 (26), 2450-2458 (2020)
   PUBMED   32510930
  REMARK    GeneRIF: Spectroscopic Investigation of Cysteamine Dioxygenase.
REFERENCE   5  (bases 1 to 4456)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
REFERENCE   6  (bases 1 to 4456)
  AUTHORS   Dominy,J.E. Jr., Simmons,C.R., Hirschberger,L.L., Hwang,J.,
            Coloso,R.M. and Stipanuk,M.H.
  TITLE     Discovery and characterization of a second mammalian thiol
            dioxygenase, cysteamine dioxygenase
  JOURNAL   J Biol Chem 282 (35), 25189-25198 (2007)
   PUBMED   17581819
  REMARK    GeneRIF: cysteamine (2-aminoethanethiol) dioxygenase (ADO)is
            encoded by the gene Gm237 and belongs to the DUF1637 protein
            family.
REFERENCE   7  (bases 1 to 4456)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY731120.1, BC058407.1, AK047542.1 and CD775668.1.
            
            On Mar 27, 2009 this sequence version replaced NM_001005419.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY731120.1         157-169
            14-1456             BC058407.1         1-1443
            1457-1484           AK047542.1         18-45
            1485-3825           BC058407.1         1471-3811
            3826-4456           CD775668.1         1-631               c
FEATURES             Location/Qualifiers
     source          1..4456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 34.96 cM"
     gene            1..4456
                     /gene="Ado"
                     /gene_synonym="Gm237"
                     /note="2-aminoethanethiol dioxygenase"
                     /db_xref="GeneID:211488"
                     /db_xref="MGI:MGI:2685083"
     exon            1..4445
                     /gene="Ado"
                     /gene_synonym="Gm237"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..953
                     /gene="Ado"
                     /gene_synonym="Gm237"
                     /EC_number="1.13.11.19"
                     /note="cysteamine dioxygenase; 2-aminoethanethiol
                     (cysteamine) dioxygenase"
                     /codon_start=1
                     /product="2-aminoethanethiol dioxygenase"
                     /protein_id="NP_001005419.2"
                     /db_xref="CCDS:CCDS48588.1"
                     /db_xref="GeneID:211488"
                     /db_xref="MGI:MGI:2685083"
                     /translation="MPRDNMASLIQRIARQACLTFRGSSTGSEGPAPGFPENLSLLKS
                     LLTQVRAEDLNIAPRKALPQPLPRNLPPVTYMHIYETEGFSLGVFLLKSGTCIPLHDH
                     PGMHGMLKVLYGTVRISCMDKLDTGAGHRRPPPEQQFEPPLQPLEREAVRPGVLRSRA
                     EYTEASGPCVLTPHRDNLHQIDAVDGPAAFLDILAPPYDPEDGRDCHYYRVVEPIRPK
                     EASGSACDLPREVWLLETPQADDFWCEGEPYPGPKVLP"
     regulatory      1302..1307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ado"
                     /gene_synonym="Gm237"
                     /note="hexamer: AATACA"
     polyA_site      1322
                     /gene="Ado"
                     /gene_synonym="Gm237"
                     /note="major polyA site"
     regulatory      3801..3806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ado"
                     /gene_synonym="Gm237"
                     /note="hexamer: AATAAA"
     polyA_site      3825
                     /gene="Ado"
                     /gene_synonym="Gm237"
                     /note="major polyA site"
     regulatory      4424..4429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ado"
                     /gene_synonym="Gm237"
                     /note="hexamer: AATAAA"
     polyA_site      4445
                     /gene="Ado"
                     /gene_synonym="Gm237"
                     /note="major polyA site"
ORIGIN      
        1 ttggcgcgct aagcgggcga ccgtgcaagg cggccccgcg cgccccgctg gccggttgtt
       61 gcggggaggt ctcccgcctg gcgcgggggt ccgcgcgggt agccgtggcg gccgccggag
      121 accgcaaggg gcggcgcaga ggcggaacgg gccggccgcg agccgcgcag gaagcgccaa
      181 gcatgccccg cgacaacatg gcctccctga tccagcgcat cgctcgccag gcgtgtctca
      241 ccttccgcgg cagctcgacg ggctccgaag ggccggcgcc gggcttcccg gagaacctga
      301 gcctgctcaa gagcctgctg acccaggtgc gcgccgagga cctcaacatc gcgccgcgca
      361 aggcgctgcc gcagccgctg ccccgcaacc tcccgccggt cacctacatg cacatctacg
      421 agacggaggg cttcagcctg ggcgtgttcc tgctcaagag cggcacgtgc atcccgctgc
      481 acgaccaccc gggcatgcac ggtatgctca aggtgctgta cggcacggtc cgcatcagct
      541 gcatggacaa gctggacacg ggggccgggc atcggcggcc gccgccagag cagcagttcg
      601 agcccccgct gcagcccttg gagcgggagg ccgtgcgacc gggcgtgctg cgttcccggg
      661 ccgagtacac cgaggccagt gggccctgcg tgctcactcc acaccgggac aacctgcacc
      721 agattgatgc cgtggacggg ccagctgcct tcctggacat cctggcccca ccctacgacc
      781 cggaggacgg ccgggactgc cactattacc gtgtagtgga gcccatcaga cccaaggagg
      841 cttccggctc tgcctgcgac cttccccgag aagtgtggct cctggagaca ccacaggccg
      901 acgacttctg gtgcgaggga gagccctatc caggccccaa ggtcctacct tgaagctcct
      961 gccgcccggg gaactgtggg ccaaagatgt accctgccct gctcaagaaa ggcctggctg
     1021 ccctctatct tccataaggg ctcttctctc cgccccctcg cctggacgat ggatttactg
     1081 gagtgaccag cgccacatct tgaggaacct tggggaacac ggcccactgg agtacagcca
     1141 ccaccgggca cggttatggg ggcgggtggg cggaaggcta ggttgattcc tggtatcctc
     1201 agtgccacca aggctttgat ttaagggaac cgggcaggga ccctaaagcg cttccatcct
     1261 aaagccataa tgaaaccatt tttgtttctc attctctaca aaatacacta agtagttttg
     1321 aatccctctt cccttcggtg actcagattt gttttctctc ctgcccacga ttgctcctta
     1381 atagtttaat ttattactga ttgtgcatga ccttgaattg ttcttgtttt cttttttttt
     1441 tttttttttt tttttttagt tattcgtttg gttaaaacac acacacaaac tactcagcat
     1501 ctaaagtgag gagttctgaa aagacatctt tctagcactg gggttcaccc tcataactgt
     1561 gcgtgttgag gacgatgtct ttcctcccct ggcttggtag ccacttctgg tgtactcagg
     1621 taacctttag taagaaggtc acatacgcga attctcttgt caggccctta aagctcgtct
     1681 ttcccttggg tctcaagatc tgtcgtttaa acaaattttt ttgttgctat tggggatttg
     1741 cctttaaagc aaagacgatt attatcctca gctgactttt tccttgacgt gcttcaaaga
     1801 tgatacaata attatgtgtt ttctaaccag acgattccga ggagcggaat ctgctatgct
     1861 tccaaataac tgaatgtaaa ggccctggcc acctgttgaa ttccatactc gtatttactt
     1921 ccagcttctt cctaggaaag aagagaaaga tactcttgac tgtttgttgt tgttgttgtt
     1981 gttgttgttg ttggttttgt tctgttttgg ttttttgttt ttgttttttt gcgttctctg
     2041 tggagggagc ctgcagagga gctgtgtggt tccagctgtg ctgccgggag atagcctccc
     2101 agcactccct taaacaagag ccagtgctgc ctactactgc cttctcttgc aggaagaggt
     2161 agagagcatg tagtaccctg ggaggggctc tggaagtagg ctgctggcta agcaggcaag
     2221 aagccctggg ctcaatcctc agtaccacat aaaccaagtg tagcacacag catttaggaa
     2281 atataggcag gaggatcaga agtcaaggtc agacttggct acatagtgaa tttgagcgga
     2341 accgtggatg cataagacac catcatataa atgtgtgtgt atacataaca tatgaatatg
     2401 tatatataca catatacata tgtatgtaca cacacacata tgaaatggat acatggaata
     2461 gatgcttgag aatttagcca tttagggcac caagattgga gactaaaccc tatgccaaca
     2521 ctgcagcaaa ccctagcgct gctgcagtat tatggctggc ggaggctcag cccctttacc
     2581 atgtttacag acgtgtctat cgattctgac catggaccac cagtttcccc tgtttactat
     2641 gtgtagggtt cctttttatc acaggccttt tcataaagac aaactgtaga aatcagatgt
     2701 gcccagctgt cttctaagct ctcttgatgg ctcatgtggc aatagaatat actaatatcg
     2761 gcaataaatg gagacttact gtcatgagtg acaaatgttt gttgacctgg cagggaaaca
     2821 aactgctttt ggctccatgt atccaggata cacatccagg ctgaaggggt gtccttcccg
     2881 gtgcagtcat taaagtggta cgagacagca aattattgct ggcttggctt gtggcttttt
     2941 gtttgtttgt ttgtttgttt cattttaata aaaatgagaa caacaggcca gtggaaacct
     3001 gctttaaacc tgacaaacca tgagcaacac ccaaacactt ccaccatggc tgctagagtt
     3061 caagttcttt ctgatcatgg tctttaaaat gcctttggag cctctcgaag cagctctttg
     3121 agccactcgt atgaacatct agataggaag tgatggtttt aaatttgact attttcatag
     3181 aatattaata atgaatatgg tttttcagcc acatacagat tttgaattgc agcaaaggtt
     3241 gattccttta caaggattgt tgagagtcat gtgtacttta cagcatactc tggaggtcct
     3301 ttcatggagc ctgtagaagt ctagcctgga attgggctag taataacaat tattatgaag
     3361 gccttcattg caaaagaagg aggagaaata ttaaaggttt gttataagca gtttggaagg
     3421 aaaaaaaccc taaggtgctt ttcaaaagag taacgaaatt gttctgagct aaaacagcaa
     3481 tactgtgttc ctcattagtt caataggaac agtgaaactg tcatttcact aataaactga
     3541 gtaaacttac ggtgaaaaca gtgtaatatg ttttaatgag ccacttgaga aagaatatgc
     3601 tcgttactaa gataaaatgt gcagaaaaat ccttgcacgt ctatgcataa actattagct
     3661 ataacttctg ccgttgtgtt tccctgtagg tctacaatat agattgtggt ctagaaatta
     3721 ggataaaagt taccttctcc ttttcttaga aaagaccaat gagcacaatg gtgttaagtc
     3781 acttaactgt tctgatgaat aataaatgca ataactagat cctgagtgag acgctgtctg
     3841 tctgtctgtc taaatacact gaaccttttc aaccttgtag ttctatcagt gaccagttat
     3901 atcgatgtaa gattttcata ccttcctact cctttgagaa ttgatgggtt tactaccaca
     3961 tgctgctgat tacattaaaa aacaacaaca acaaaaaaaa aaccctgcct tttaggtaat
     4021 gtgttttcta tgttaatagg agtgagttct cttgagtttt taacatgact gtcaaaatgt
     4081 acacctttcc ttccccactc gatccttgca ttgtcttgta ggttccttga acttgacatc
     4141 tggggagaac ctacctgctc tgatggcaaa tgagtcaact gctttagctc tcctgtcctg
     4201 cccagcagag agacagttac ccccacttcg tcactctgcc actctcctga cagcgtttgc
     4261 tcctctaccg caggcctgaa ttcagagtgt agggttatac agaacccaga ttggtccatt
     4321 gtgctgaggt ttctgctgtc aaaggagatc atttcttaac aatacccagt cttacagtgc
     4381 aggggtgttt acgtttctga gtaagatgtg tgtacttatg ggaaataaaa gcatgtttaa
     4441 aattaaaaaa aaaaaa
//
