LOCUS       NM_175028               4188 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADNP homeobox 2 (Adnp2), mRNA.
ACCESSION   NM_175028 XM_140497 XM_989242
VERSION     NM_175028.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4188)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4188)
  AUTHORS   Li,L., Ruan,X., Wen,C., Chen,P., Liu,W., Zhu,L., Xiang,P.,
            Zhang,X., Wei,Q., Hou,L., Yin,B., Yuan,J., Qiang,B., Shu,P. and
            Peng,X.
  TITLE     The COMPASS Family Protein ASH2L Mediates Corticogenesis via
            Transcriptional Regulation of Wnt Signaling
  JOURNAL   Cell Rep 28 (3), 698-711 (2019)
   PUBMED   31315048
REFERENCE   3  (bases 1 to 4188)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 4188)
  AUTHORS   Kushnir,M., Dresner,E., Mandel,S. and Gozes,I.
  TITLE     Silencing of the ADNP-family member, ADNP2, results in changes in
            cellular viability under oxidative stress
  JOURNAL   J Neurochem 105 (2), 537-545 (2008)
   PUBMED   18179478
  REMARK    GeneRIF: the adnp2 may have an important function in brain by
            playing a role in cellular survival pathways.
REFERENCE   5  (bases 1 to 4188)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   6  (bases 1 to 4188)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 4188)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB093268.1 and BC024969.1.
            
            On or before Oct 24, 2007 this sequence version replaced
            XM_989242.1, XM_140497.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB093268.1, BC047352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4185              AB093268.1         1-4185
            4186-4188           BC024969.1         1423-1425
FEATURES             Location/Qualifiers
     source          1..4188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 53.28 cM"
     gene            1..4188
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /note="ADNP homeobox 2"
                     /db_xref="GeneID:240442"
                     /db_xref="MGI:MGI:2448562"
     exon            1..117
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /inference="alignment:Splign:2.1.0"
     exon            118..238
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..3628
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /note="ADNP homeobox protein 2; zinc finger protein 508"
                     /codon_start=1
                     /product="activity-dependent neuroprotector homeobox
                     protein 2"
                     /protein_id="NP_778193.1"
                     /db_xref="CCDS:CCDS50332.1"
                     /db_xref="GeneID:240442"
                     /db_xref="MGI:MGI:2448562"
                     /translation="MFQIPVQNLDNIRKVRKRVKGILVDIGLDSCKELMKDLKSFDPG
                     EKYFYNTSWGDVSPWEPSGKKARYRTKPYCCSLCRYSTKVLTSLKNHLHRYHEDEADQ
                     ELMIPCPNCPFSSQPRVVGKHFRMFHAPARKVQSYTVNILGETKTSRSDVISFTCLKC
                     NFSNTLYYSMKKHVLVAHFNYLINSYFGLRTEETGEQPKASDPVSVDKILPFDKYYCK
                     KCSAIASSQDALMYHILTSDAHRDLENKLRSVISEHIKRTGFLKQMHIAPKPVTHLAL
                     PPNSSAPSIAAPPPCFQLALPQNSQSSGTVQSVTVTPGTSGSLTHSPPTTAQSHVALV
                     SSSLPVCQSSLSLQQSAPPPVFLSHSVALNQPVNTAVLPLTQPVGPVNKSVGTSILPV
                     NQAMCSVNQAVRPGLLPLTKPMGPMNRPVGPAVLPMGPSVNSGVLQATSPGVISVGRA
                     VPSGVLPAGQVTPAGVIPGQTATSGVLPTGQVVQSSTLPVGQTAPSRGLPPGQTVPLR
                     VLPAGQVVPSGLLSSNQTVPSGVVPVNQGVNSGVLQLGQPVTPGVLPVGPPVRPGVLQ
                     LSPSVSTSILPMSQPVRAGTSQNTTFFTSGSILRQLIPTGKQVNGIPTYTLAPVSVTL
                     PVPSGGGLAAVGPPPQVPVQFLPSGSGTQMGSSLPSLPSPQVLVSPAPSVFVQATPPL
                     ADANQALKQAKQWKTCPVCNELFPSNVYQVHMEVAHKQSEAQLCQVCNELFPANVYQV
                     HMEVAHKQSESKSSEKLEPEKLAACAPFLKWMREKTVRCLSCKCLVSQEELMHHLLMH
                     GLGCLFCPCTFHDVRGLVEHSRTKHLGKKRLSMDYSNRGFQLDLDANGNLLFPHLDFI
                     TILPREKLGEREVYLAILAGIHSKSLVPVYVKVRPQPEVAPKIPNKQKLTCPFCLSTF
                     MTADAYELHLKERHHVMPTVHTMLRSPAFKCIHCCGVYTGNMTLGAIAVHLLRCRSAP
                     KDSSSDLQVQPGFIESSELLMVNGDVIPESTFPVKRKLPEGHLGPEDQRDGEEPQLTL
                     DADASSGSEKGLGAVPLKRQKSEIRTEGSGPSEDSLQALALDPSKYEGRSYEEKKQFL
                     RDYFHRRPYPSRKEVELLSSLLWVWKIDVASFFGKRRYICMKAIKTHKPSVLLGFDMS
                     ELKNVKHRLNFGECESQKL"
     exon            239..328
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /inference="alignment:Splign:2.1.0"
     exon            329..4188
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3820..3825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /note="hexamer: ATTAAA"
     polyA_site      3843
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /note="major polyA site"
     regulatory      4166..4171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /note="hexamer: ATTAAA"
     polyA_site      4188
                     /gene="Adnp2"
                     /gene_synonym="8430420L05Rik; Kiaa0863; mKIAA0863; Zfp508"
                     /note="major polyA site"
ORIGIN      
        1 cttctctttc tggcgcgcgg gaggagggac gggcgcgggg cgggggtccc gccgcgtagg
       61 cggaggacgc ggcggtgttg cgacggcggc gggacgcggc gctcctcgcg ccccgcggaa
      121 aatctccaaa atgtttcaaa ttcctgtgca gaatcttgac aacatcagga aggtgcggaa
      181 gagggtgaaa ggcatccttg tggatattgg ccttgacagc tgcaaggagc tgatgaagga
      241 tcttaaaagc tttgatccag gagagaagta cttttataat acatcgtggg gagatgtttc
      301 tccttgggaa ccttctggaa agaaagcgag ataccggaca aaaccatact gctgtagtct
      361 ctgtaggtac tcaacaaagg tgctcacttc cctcaaaaat cacctgcatc gatatcatga
      421 agatgaggct gaccaggagc tgatgatccc ctgccccaac tgcccgttct cctcccagcc
      481 cagggtggtg ggcaagcact tcagaatgtt ccacgcgcct gcacgcaaag tccagagcta
      541 cacagtgaac attctgggtg agacgaagac atccaggagt gacgtgataa gcttcacgtg
      601 tctaaagtgt aacttttcca acactctgta ctacagcatg aagaagcacg tgctggtggc
      661 ccatttcaat tacttaatta actcctactt tggtttgcga actgaggaaa caggagagca
      721 accaaaagca agcgatcctg tttctgtgga taaaatcctg ccatttgaca agtactactg
      781 taaaaaatgc agtgccatcg ccagtagtca ggacgccctg atgtatcaca ttttgacatc
      841 agatgcacat agggacttgg agaataagct gaggtctgtg atctcagaac acatcaagag
      901 gactgggttt ctgaagcaga tgcatattgc tccaaaacca gtgacccact tggctttacc
      961 gcccaacagc agtgctccga gcattgcggc ccctccaccc tgcttccagc ttgctttgcc
     1021 acagaacagt caaagctctg gcactgtgca gtcagtgact gtgaccccag gcacttctgg
     1081 gagccttaca cactccccac ctaccactgc ccagtctcac gtagctttgg tctccagctc
     1141 tttgcctgtg tgccagagta gcctcagcct gcagcagtca gctcccccgc ctgtctttct
     1201 ctctcacagt gttgcactta atcagcctgt gaatactgct gtgctgcccc tgactcagcc
     1261 agttgggcct gtgaataagt ctgttggaac aagcatcctt cctgtgaacc aagccatgtg
     1321 ctccgtgaac caagctgtcc gccctggact tttacccctc actaagccca tggggcccat
     1381 gaacagacct gtggggcctg ctgtcttgcc tatgggtccc tctgttaact cgggggttct
     1441 ccaggctaca tctcctggag tgatttctgt aggtcgagca gttccatcag gagtccttcc
     1501 tgcaggtcag gtgacccctg ctggagtgat ccctggtcag acagccactt ctggggtctt
     1561 acccactggc caggtggttc agtcatcaac tcttcctgtt ggccagacag ctccttctcg
     1621 aggtcttcct cctggccaga cagtgccctt gagggttctc cctgcaggcc aggtggtgcc
     1681 atctgggctg ctttcctcaa accagactgt cccctcggga gttgtccctg tgaatcaggg
     1741 tgtaaactct ggcgttcttc agctcggcca gccagtaaca ccaggagtgc ttcctgtggg
     1801 ccccccagtg aggcctgggg tactgcagct cagcccgtct gtcagcacca gcatcctgcc
     1861 tatgagccag ccggtgagag ctggaacgtc acaaaacact actttcttta cttcaggctc
     1921 tattctcaga cagctcattc ctactgggaa acaggtgaat ggaatcccca cgtatacact
     1981 ggcccccgtg tctgtcactc tgccggtgcc ctctggtgga ggccttgcag ctgttggacc
     2041 gccaccccag gtgccagtgc agttcttgcc ctcaggctcg ggcacacaga tgggcagctc
     2101 cttgcccagc ctgccctctc cacaggtgtt ggtgagccct gcccctagtg tgtttgtgca
     2161 ggctaccccg ccgctggcag atgcaaatca ggcactcaaa caggcgaagc agtggaaaac
     2221 atgcccggtt tgcaacgagc tcttcccttc caatgtctat caggttcaca tggaagtggc
     2281 tcacaagcag agtgaggctc agctctgcca ggtttgcaat gaactctttc ctgccaatgt
     2341 ctaccaggtt cacatggaag tggctcacaa gcagagcgag tccaagtcta gtgagaaact
     2401 tgagcctgaa aagcttgctg catgtgcccc atttctgaag tggatgcgag agaagacagt
     2461 gcgctgcctg tcttgtaagt gcctggtctc gcaggaggag ctgatgcacc atttgctcat
     2521 gcatggcctg ggctgcctgt tttgtccgtg cacttttcat gatgtccggg gccttgtgga
     2581 gcacagcagg actaagcacc tgggcaagaa gagactgtct atggattaca gtaacagagg
     2641 cttccaactg gacctggatg ctaatgggaa cctgctcttc cctcatctcg atttcatcac
     2701 catactgcca cgagagaaac ttggagagcg agaagtgtac ctggctatcc ttgctggaat
     2761 acactccaag tcgctggtac ctgtgtatgt taaggtgagg cctcagcctg aggttgcacc
     2821 aaagatacct aacaaacaga agctgacctg cccattttgt ttgagcacat ttatgaccgc
     2881 ggatgcctat gagctacact tgaaggagag gcaccatgtc atgcccacag tccatacaat
     2941 gctcaggtct ccggccttta agtgcatcca ctgttgcggg gtctacactg gaaacatgac
     3001 cttaggcgcc atcgctgtcc atttgctccg ttgtagaagt gctcccaagg acagcagctc
     3061 agacctgcaa gtccagcccg gatttattga gagcagtgaa ctgctgatgg tcaatgggga
     3121 cgtgatccct gagtccacct ttcctgtaaa gagaaagctg cctgaaggcc atttagggcc
     3181 ggaagaccag agggatgggg aggagcccca gctcacccta gatgctgatg caagttcggg
     3241 ttcagagaaa ggtctgggcg ctgtgccttt gaagagacag aagagtgaaa tcaggacgga
     3301 ggggtcgggg cccagtgaag actcactgca ggcgctagcc ttggacccca gcaagtacga
     3361 agggcgttcc tacgaggaaa agaaacagtt ccttagagat tattttcaca ggagaccata
     3421 tcctagtaga aaagaagtgg agctgctgtc ttcactcttg tgggtgtgga aaattgacgt
     3481 ggcttcattc tttgggaaga gaaggtatat ttgcatgaaa gcaataaaaa ctcacaagcc
     3541 ttctgtactt ctaggttttg atatgtctga acttaaaaat gtcaaacaca gactgaactt
     3601 tggtgagtgt gaatcacaaa agctgtagaa gagaaagtct gaagtccggc tgactttgga
     3661 catcccattc ccacctctca ctcttgttct aagtgtctga ggcccttcaa ggcgttccag
     3721 gtgctcagaa agcctgaaaa ggaagcacac acttccacag atgagctgtt ctctgcagtt
     3781 cgctttgcgg ctgtttcagt ttttccttct gtcatgtaaa ttaaatcttt ggtattccat
     3841 gcacgccttg tttccccacg agtgtcagtg tcagtagcaa cagcctgcaa tctacaaata
     3901 cttggttttt cattttaggg gatttctgct tgtttgagaa tacttgatta atagaaaatt
     3961 aaagcatcgc tccctcctag tttacagaca tcggctagtg acagtacgtg tctagagaag
     4021 ccagtgctct ggatgtgtgt ggcccctaag gacacacttg aaagcattag cttttcattc
     4081 tctgagtgct gtttgtttaa gacacagatt tgatttacac cttttcaagt gttccctgac
     4141 agctatattt ttaatatcat aattcattaa aaaaaaacaa acctcaaa
//
