LOCUS       NM_009628               4953 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus activity-dependent neuroprotective protein (Adnp),
            transcript variant 2, mRNA.
ACCESSION   NM_009628 XM_001052414 XM_984587
VERSION     NM_009628.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4953)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   2  (bases 1 to 4953)
  AUTHORS   Wang,W., Gao,R., Yang,D., Ma,M., Zang,R., Wang,X., Chen,C., Kou,X.,
            Zhao,Y., Chen,J., Liu,X., Lu,J., Xu,B., Liu,J., Huang,Y., Chen,C.,
            Wang,H., Gao,S., Zhang,Y. and Gao,Y.
  TITLE     ADNP modulates SINE B2-derived CTCF-binding sites during blastocyst
            formation in mice
  JOURNAL   Genes Dev 38 (3-4), 168-188 (2024)
   PUBMED   38479840
  REMARK    GeneRIF: ADNP modulates SINE B2-derived CTCF-binding sites during
            blastocyst formation in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4953)
  AUTHORS   Cho,H., Yoo,T., Moon,H., Kang,H., Yang,Y., Kang,M., Yang,E.,
            Lee,D., Hwang,D., Kim,H., Kim,D., Kim,J.Y. and Kim,E.
  TITLE     Adnp-mutant mice with cognitive inflexibility, CaMKIIalpha
            hyperactivity, and synaptic plasticity deficits
  JOURNAL   Mol Psychiatry 28 (8), 3548-3562 (2023)
   PUBMED   37365244
  REMARK    GeneRIF: Adnp-mutant mice with cognitive inflexibility, CaMKIIalpha
            hyperactivity, and synaptic plasticity deficits.
            Erratum:[Mol Psychiatry. 2023 Aug;28(8):3563. doi:
            10.1038/s41380-023-02192-y.. PMID: 37479786]
REFERENCE   4  (bases 1 to 4953)
  AUTHORS   Ferreira,A.C.F., Szeto,A.C.H., Clark,P.A., Crisp,A., Kozik,P.,
            Jolin,H.E. and McKenzie,A.N.J.
  TITLE     Neuroprotective protein ADNP-dependent histone remodeling complex
            promotes T helper 2 immune cell differentiation
  JOURNAL   Immunity 56 (7), 1468-1484 (2023)
   PUBMED   37285842
REFERENCE   5  (bases 1 to 4953)
  AUTHORS   Conrow-Graham,M., Williams,J.B., Martin,J., Zhong,P., Cao,Q.,
            Rein,B. and Yan,Z.
  TITLE     A convergent mechanism of high risk factors ADNP and POGZ in
            neurodevelopmental disorders
  JOURNAL   Brain 145 (9), 3250-3263 (2022)
   PUBMED   35775424
  REMARK    GeneRIF: A convergent mechanism of high risk factors ADNP and POGZ
            in neurodevelopmental disorders.
REFERENCE   6  (bases 1 to 4953)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4953)
  AUTHORS   Pinhasov,A., Mandel,S., Torchinsky,A., Giladi,E., Pittel,Z.,
            Goldsweig,A.M., Servoss,S.J., Brenneman,D.E. and Gozes,I.
  TITLE     Activity-dependent neuroprotective protein: a novel gene essential
            for brain formation
  JOURNAL   Brain Res Dev Brain Res 144 (1), 83-90 (2003)
   PUBMED   12888219
  REMARK    GeneRIF: ADNP is identified as a new key gene essential for
            organogenesis in the developing embryo and may be implicated as a
            clinical target associated with proper neurodevelopment.
REFERENCE   8  (bases 1 to 4953)
  AUTHORS   Poggi,S.H., Vink,J., Goodwin,K., Hill,J.M., Brenneman,D.E.,
            Pinhasov,A., Gozes,I. and Spong,C.Y.
  TITLE     Differential expression of embryonic and maternal
            activity-dependent neuroprotective protein during mouse development
  JOURNAL   Am J Obstet Gynecol 187 (4), 973-976 (2002)
   PUBMED   12388989
REFERENCE   9  (bases 1 to 4953)
  AUTHORS   Zamostiano,R., Pinhasov,A., Gelber,E., Steingart,R.A., Seroussi,E.,
            Giladi,E., Bassan,M., Wollman,Y., Eyre,H.J., Mulley,J.C.,
            Brenneman,D.E. and Gozes,I.
  TITLE     Cloning and characterization of the human activity-dependent
            neuroprotective protein
  JOURNAL   J Biol Chem 276 (1), 708-714 (2001)
   PUBMED   11013255
REFERENCE   10 (bases 1 to 4953)
  AUTHORS   Bassan,M., Zamostiano,R., Davidson,A., Pinhasov,A., Giladi,E.,
            Perl,O., Bassan,H., Blat,C., Gibney,G., Glazner,G., Brenneman,D.E.
            and Gozes,I.
  TITLE     Complete sequence of a novel protein containing a
            femtomolar-activity-dependent neuroprotective peptide
  JOURNAL   J Neurochem 72 (3), 1283-1293 (1999)
   PUBMED   10037502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005039.11, BG143403.1, BF460813.1, BC090840.1 and AK134786.1.
            
            On Jun 26, 2015 this sequence version replaced NM_009628.2.
            
            Summary: This gene encodes a member of a protein family
            characterized by nine zinc finger motifs followed by a homeobox
            domain. In vitro studies demonstrate that the encoded protein
            interacts with the brahma-related gene1-associated or hBRM factors
            (BAF) gene expression regulating complex, components of the protein
            translation machinery, and microtubule-associated proteins. This
            gene has been implicated in neuroprotection through various
            processes that include chromatin remodeling, splicing, cytoskeletal
            reorganization, and autophagy. Homozygous mutant knockout mice
            display embryonic lethality with defects in neural tube closure.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Nov 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129214.1, SRR11927937.2768066.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BX005039.11        39309-39358         c
            51-393              BG143403.1         1-343               c
            394-403             BX005039.11        38956-38965         c
            404-972             BF460813.1         1-569
            973-4921            BC090840.1         119-4067
            4922-4953           AK134786.1         4394-4425
FEATURES             Location/Qualifiers
     source          1..4953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.41 cM"
     gene            1..4953
                     /gene="Adnp"
                     /gene_synonym="mKIAA0784"
                     /note="activity-dependent neuroprotective protein"
                     /db_xref="GeneID:11538"
                     /db_xref="MGI:MGI:1338758"
     exon            1..539
                     /gene="Adnp"
                     /gene_synonym="mKIAA0784"
                     /inference="alignment:Splign:2.1.0"
     exon            540..652
                     /gene="Adnp"
                     /gene_synonym="mKIAA0784"
                     /inference="alignment:Splign:2.1.0"
     CDS             545..3871
                     /gene="Adnp"
                     /gene_synonym="mKIAA0784"
                     /note="isoform 1 is encoded by transcript variant 2;
                     activity-dependent neuroprotector homeobox protein"
                     /codon_start=1
                     /product="activity-dependent neuroprotector homeobox
                     protein isoform 1"
                     /protein_id="NP_033758.2"
                     /db_xref="CCDS:CCDS38342.1"
                     /db_xref="GeneID:11538"
                     /db_xref="MGI:MGI:1338758"
                     /translation="MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPN
                     DFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFE
                     NRILLNCPYCTFNADKKTLETHIKIFHAPNSSAPSSSLSTFKDKNKNDGLKPKQADNV
                     EQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVSLGTNAREE
                     CNIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKPLMLIAPKPQ
                     DKKGMGLPPRISSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSNVHLQQNNYGV
                     KSVGQSYGVGQSVRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSFGLGAEQRPPAAARY
                     SLQTANTSLPPGQVKSPSVSQSQASRVLGQSSSKPPPAATGPPPSNHCATQKWKICTI
                     CNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLI
                     HGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLVT
                     TYNLRDAPAESVAYHAQNNAPVPPKPQPKVQEKADVPVKSSPQAAVPYKKDVGKTLCP
                     LCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLH
                     LVHCRGVGKTQNGQDKTNAPSRLNQSPGLAPVKRTYEQMEFPLLKKRKLEEDADSPSC
                     FEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKSD
                     IASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRVN
                     ASKTVDKKHNLGKEDDSFSDSFEHLEEESNGSGSPFDPVFEVEPKIPSDNLEEPVPKV
                     IPEGALESEKLDQKEEEEEEEEEDGSKYETIHLTEEPAKLMHDASDSEVDQDDVVEWK
                     DGASPSESGPGSQQISDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATVQDDTE
                     QLKWKNSSYGKVEGFWSKDQSQWENASENAERLPNPQIEWQNSTIDSEDGEQFDSMTD
                     GVADPMHGSLTGVKLSSQQA"
     exon            653..745
                     /gene="Adnp"
                     /gene_synonym="mKIAA0784"
                     /inference="alignment:Splign:2.1.0"
     exon            746..4953
                     /gene="Adnp"
                     /gene_synonym="mKIAA0784"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4903..4908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adnp"
                     /gene_synonym="mKIAA0784"
                     /note="hexamer: AATAAA"
     polyA_site      4932
                     /gene="Adnp"
                     /gene_synonym="mKIAA0784"
                     /note="major polyA site"
ORIGIN      
        1 tttggctagg gcaggttcgg ggacttgctc tgaggcgctt gtattgtctg ctgaggggag
       61 acgcgggacc agccccctcc cccgcccgcc gccgccgccg ccacccgtcc ggtctacccg
      121 ccgccgccgg gacccatgag ctgagcgccc gcccgccgcc atcttggccc cctccccctc
      181 cagccgcgct cgctcggggg ggatttggcg tcgcctcagc cacagctccc tctctcggtc
      241 tccgccgccg aggagccgcg cggccgtcgc cgcccgcctg cccgcccgcg acggtgaagc
      301 cgcggcccca cgccctccgc cgccctccgc ccctcctttg tctgcactgc ccgcgccgcc
      361 gcccgccgct ctgctgcgcc cgccgcgccc cccggcagca gccgcggccg cggctcgagc
      421 cggagcccga gcgcgacgag gccccgggcg cgtcctcgcc gccatcgccg tgccgccgtc
      481 cacccgccgc cgtgctctag agcacgccgg ccccgcgcac gcctcgaggc cgagccaaga
      541 aactatgttc caacttcctg tcaacaatct tggcagttta agaaaagccc ggaaaactgt
      601 gaaaaaaata cttagtgaca ttgggttgga atactgtaaa gaacatatag aagattttaa
      661 acagtttgaa cctaatgact tttatttgaa aaacactaca tgggaggatg taggactgtg
      721 ggacccttct cttacgaaaa atcaggacta tcggacaaaa cctttttgct gcagtgcttg
      781 tccgttttcc tcaaaattct tctctgccta caaaagtcat ttccggaatg tccatagtga
      841 agactttgaa aataggattc tccttaactg cccttactgt accttcaatg cagataaaaa
      901 gactttggaa acacacatta aaatatttca tgctccaaac tccagcgcac caagtagcag
      961 cctcagcact ttcaaagata aaaacaaaaa cgatggcctt aaacctaagc aggctgacaa
     1021 tgtagagcaa gccgtgtatt actgcaagaa gtgcacttac cgagaccctc tctacgagat
     1081 cgtcaggaag cacatctaca gggaacattt tcaacacgtg gcagcaccct acatagcaaa
     1141 agcaggagaa aaatcactca atggtgcagt ctccctgggc acaaatgccc gagaggagtg
     1201 taacatccac tgcaagcgat gccttttcat gcccaagtcc tatgaagctt tggtacagca
     1261 tgtcattgag gaccatgaac ggataggcta tcaggtcact gccatgatcg gacacacaaa
     1321 tgttgtagtt ccccgagcca agcccttgat gctgatagct cccaaacctc aagacaaaaa
     1381 gggcatggga ctcccaccac gaatcagctc ccttgcttct ggaaatgtcc ggtcgttgcc
     1441 atcacagcag atggtaaacc gattgtcaat accaaagccc aacttaaatt caacgggagt
     1501 caacatgatg tccaatgttc acctgcagca aaacaactat ggagtcaaat ctgtgggcca
     1561 gagctatggt gttggccagt cagtgaggct gggactaggt ggcaatgctc cagtttccat
     1621 ccctcaacag tctcagtccg tgaaacagtt acttccaagt gggaatggga ggtcttttgg
     1681 gctaggtgct gagcagaggc ccccagcagc agccaggtac tccctgcaga ctgccaacac
     1741 ctctctaccc ccaggccaag tgaagtctcc ctctgtgtct cagtcacagg catctagagt
     1801 attaggtcag tccagttcta aacctccacc agccgccaca ggccctcctc caagcaacca
     1861 ctgtgccact cagaagtgga aaatctgtac aatctgtaac gagcttttcc ctgagaatgt
     1921 ctatagcgtt cacttcgaaa aggagcataa agctgagaaa gtcccagccg tagctaacta
     1981 cattatgaaa atacacaatt ttactagcaa atgcctctac tgtaatcgct atttgcctac
     2041 agatacccta ctcaaccata tgttaattca tggtctgtct tgtccgtatt gccgttccac
     2101 cttcaatgat gtagagaaga tggcagcaca catgcgaatg gttcatattg atgaagagat
     2161 ggggcctaaa acggattcta ctttgagctt tgatttgaca ttgcaacagg gcagtcacac
     2221 caacattcat ctcctggtga ccacatacaa cctgagggat gccccggctg aatcagttgc
     2281 ttaccatgcc caaaataatg ccccagttcc tccaaagcca caaccaaaag ttcaggaaaa
     2341 agcagatgtc ccggttaaaa gttcacctca agctgcagtg ccctataaaa aagatgttgg
     2401 gaagaccctt tgccctcttt gcttttcaat actaaaagga cccatatctg atgcacttgc
     2461 acatcattta cgagaaagac accaagttat tcagacagtt catccggttg agaaaaagct
     2521 aacttacaaa tgtatccatt gccttggtgt gtatactagc aacatgacag cctcaaccat
     2581 cactctgcat ctagtccact gcaggggtgt tggaaaaacc cagaatggcc aggacaagac
     2641 aaacgcacct tctcggctca atcagtctcc aggcctggcc cctgtgaagc gcacgtatga
     2701 gcagatggag tttccactgc taaaaaagcg gaagctggag gaggatgctg attcccctag
     2761 ctgctttgaa gagaagccag aagagcctgt tgttttagct ttagacccca agggtcatga
     2821 agatgattct tatgaggcta ggaaaagctt tctcacaaag tacttcaaca aacagcccta
     2881 tcccaccagg agagaaattg agaagttagc tgccagtcta tggctatgga agagtgacat
     2941 tgcctcccat ttcagtaaca agaggaagaa gtgtgtccgc gactgtgaaa agtacaagcc
     3001 tggtgtgctg ctaggtttta acatgaaaga attaaataaa gtcaaacacg agatggattt
     3061 tgatgctgag tggctgtttg aaaatcacga tgagaaagac tcaagagtca atgctagcaa
     3121 gactgttgac aaaaagcata accttgggaa agaagatgat agcttctcag atagttttga
     3181 acatttggaa gaagaatcca atggaagcgg gagtcctttt gaccctgtct ttgaagttga
     3241 gcctaaaatt cccagtgata atttagagga gcctgtaccg aaggttattc cggaaggtgc
     3301 tttggaatct gagaagctag accaaaaaga ggaggaggag gaggaggagg aggaggatgg
     3361 ttcaaaatat gaaactatcc atttgactga ggaaccagcc aaattaatgc atgatgcctc
     3421 tgatagtgag gtagaccaag atgatgtagt tgagtggaaa gatggtgctt caccatctga
     3481 gagtgggcct ggttcccaac aaatctcaga ctttgaggat aatacatgtg aaatgaaacc
     3541 aggaacctgg tctgatgagt cttcccagag tgaagatgca aggagcagta agccagctgc
     3601 caaaaaaaag gctacagtgc aagatgacac agagcagtta aaatggaaga atagttccta
     3661 tggaaaagtt gaagggtttt ggtccaagga ccagtcacag tgggaaaatg catctgagaa
     3721 tgcagagcgc ttaccaaacc cacagattga gtggcagaat agcacaattg acagtgagga
     3781 cggggagcag tttgacagca tgactgacgg agttgctgat cccatgcatg gcagcttaac
     3841 tggagtgaag ctgagcagcc agcaagcctg aggccctggc gtgccatagc atatgcatat
     3901 gggccgtgtt gcatcctgga cttctgctct ccttccagtc tgactgcaaa gctgtcttct
     3961 aactggcact accttgcaag gactggtcag tcagcaggct gtggggatgt gtgaccactg
     4021 tagtctcagt ggttatttcc aagtctatga tagatgactg gttgatcttt gttcagactc
     4081 ttctctggta gactcggtga tgaagtgtga aaaaccagta agctggtagc tcatgaatgc
     4141 acacagggag aagtagttcc ttacctacct gccttctcag catttcttcc cctcagatgt
     4201 ttggttggat gtcctgggaa agccttatcc tgattcacat agtagtgcag ggcgggcata
     4261 cacactacca gtcaaatgtg tctagtagac ttgggaacat ggaccgtttt ttcatgtatc
     4321 ttctgaatag ttgaaatgta tatttgtaca gtcttttaga cctaaagtga tgcttatgac
     4381 actgttactg tgtgcccgtc atagattggt ttttagtgtt gcccttgctg tgtgataaat
     4441 gctatatcta gtttacctag cagaagcttg accctgcgat agtatggacc tttggacaga
     4501 cttagttttt gcacataacc ttgtacaatc ttgcaaaaga ggccagcaac ataagatata
     4561 tatctggact ctcctgtatt atagaatttt tttcttgttc tgagtatcct tgacattaca
     4621 attgtcaaaa atggtatttc agatctcttt ctgagacctt ttaagctaaa ataacatgca
     4681 agaattgatt ttacagctac taattttgac accttttaga cctgtaagag tgttgtatca
     4741 gagcaacaag cacagttgag tgctgcgttt gggatattta gtttcctctt tagttgagca
     4801 ccactgggtg tattcattta taccatctaa tatatgacac actgttgtag tctgtatgat
     4861 tttgtggtct ttatttctct ttgtattcat tttaagcatc taaataaatt gctgtattgt
     4921 gcttaatgta aatatttgct tttattacac acg
//
