LOCUS       NM_182928               1300 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus adrenomedullin 2 (Adm2), mRNA.
ACCESSION   NM_182928
VERSION     NM_182928.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1300)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1300)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1300)
  AUTHORS   Zhang,Y.R., Liu,S.M., Chen,Y., Zhang,L.S., Ji,D.R., Zhao,J.,
            Yu,Y.R., Jia,M.Z., Tang,C.S., Huang,W., Zhou,Y.B., Chai,S.B. and
            Qi,Y.F.
  TITLE     Intermedin alleviates diabetic vascular calcification by inhibiting
            GLUT1 through activation of the cAMP/PKA signaling pathway
  JOURNAL   Atherosclerosis 385, 117342 (2023)
   PUBMED   37879153
  REMARK    GeneRIF: Intermedin alleviates diabetic vascular calcification by
            inhibiting GLUT1 through activation of the cAMP/PKA signaling
            pathway.
REFERENCE   4  (bases 1 to 1300)
  AUTHORS   Feng,Z., Li,M., Ma,A., Wei,Y., Huang,L., Kong,L., Kang,Y., Wang,Z.,
            Xiao,F. and Zhang,W.
  TITLE     Intermedin (adrenomedullin 2) plays a protective role in sepsis by
            regulating T- and B-cell proliferation and activity
  JOURNAL   Int Immunopharmacol 121, 110488 (2023)
   PUBMED   37352568
  REMARK    GeneRIF: Intermedin (adrenomedullin 2) plays a protective role in
            sepsis by regulating T- and B-cell proliferation and activity.
REFERENCE   5  (bases 1 to 1300)
  AUTHORS   Yallampalli,C., Betancourt,A., Mishra,A., Pennington,K.A.,
            Ruano,S.H., Tacam,M. and Chauhan,M.
  TITLE     Role of adrenomedullin2/ intermedin in pregnancy induced vascular
            and metabolic adaptation in mice
  JOURNAL   Front Physiol 14, 1116042 (2023)
   PUBMED   36875025
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1300)
  AUTHORS   Fischer,M., Pereira,P.M., Holtmann,B., Simon,C.M., Hanauer,A.,
            Heisenberg,M. and Sendtner,M.
  TITLE     P90 Ribosomal s6 kinase 2 negatively regulates axon growth in
            motoneurons
  JOURNAL   Mol Cell Neurosci 42 (2), 134-141 (2009)
   PUBMED   19555761
REFERENCE   7  (bases 1 to 1300)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 1300)
  AUTHORS   Dong,F., Taylor,M.M., Samson,W.K. and Ren,J.
  TITLE     Intermedin (adrenomedullin-2) enhances cardiac contractile function
            via a protein kinase C- and protein kinase A-dependent pathway in
            murine ventricular myocytes
  JOURNAL   J Appl Physiol (1985) 101 (3), 778-784 (2006)
   PUBMED   16763098
  REMARK    GeneRIF: Our data suggest that IMD acutely augments cardiomyocyte
            contractile function through, at least in part, a protein kinase C-
            and protein kinase A-dependent mechanism.
REFERENCE   9  (bases 1 to 1300)
  AUTHORS   Roh,J., Chang,C.L., Bhalla,A., Klein,C. and Hsu,S.Y.
  TITLE     Intermedin is a calcitonin/calcitonin gene-related peptide family
            peptide acting through the calcitonin receptor-like
            receptor/receptor activity-modifying protein receptor complexes
  JOURNAL   J Biol Chem 279 (8), 7264-7274 (2004)
   PUBMED   14615490
  REMARK    GeneRIF: Intermedin is a calcitonin/calcitonin gene-related peptide
            family peptide acting through the calcitonin receptor-like
            receptor/receptor activity-modifying protein receptor complexes
REFERENCE   10 (bases 1 to 1300)
  AUTHORS   Takei,Y., Inoue,K., Ogoshi,M., Kawahara,T., Bannai,H. and Miyano,S.
  TITLE     Identification of novel adrenomedullin in mammals: a potent
            cardiovascular and renal regulator
  JOURNAL   FEBS Lett 556 (1-3), 53-58 (2004)
   PUBMED   14706825
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DV661267.1, CJ052708.1,
            DV649647.1 and BB705319.1.
            
            On Aug 4, 2015 this sequence version replaced NM_182928.4.
            
            Summary: This gene encodes a member of the calcitonin gene-related
            peptide (CGRP)/calcitonin family of hormones that play a role in
            the regulation of cardiovascular homeostasis, prolactin release,
            anti-diuresis, anti-natriuresis, and regulation of food and water
            intake. The encoded protein is proteolytically processed to
            generate one or more biologically active peptides. Intravenous
            injection of the active peptide was found to protect mouse lungs
            from ischemia/reperfusion injury. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096428.1, AB121035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               DV661267.1         1-179
            180-646             CJ052708.1         2-468
            647-1027            DV649647.1         344-724
            1028-1300           BB705319.1         226-498
FEATURES             Location/Qualifiers
     source          1..1300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.81 cM"
     gene            1..1300
                     /gene="Adm2"
                     /gene_synonym="Am2; IMD; Imdn"
                     /note="adrenomedullin 2"
                     /db_xref="GeneID:223780"
                     /db_xref="MGI:MGI:2675256"
     exon            1..414
                     /gene="Adm2"
                     /gene_synonym="Am2; IMD; Imdn"
                     /inference="alignment:Splign:2.1.0"
     exon            415..538
                     /gene="Adm2"
                     /gene_synonym="Am2; IMD; Imdn"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..878
                     /gene="Adm2"
                     /gene_synonym="Am2; IMD; Imdn"
                     /note="intermedin; protein ADM2"
                     /codon_start=1
                     /product="protein ADM2 preproprotein"
                     /protein_id="NP_891558.1"
                     /db_xref="CCDS:CCDS27744.1"
                     /db_xref="GeneID:223780"
                     /db_xref="MGI:MGI:2675256"
                     /translation="MAQLLMVTVTLGCISLLYLLPGTLSGSLGKGLRHSRPREPPAKI
                     PSSNLQPGHPSLQPVVWKSRRHAPQPQGRGNRALAMVHLPQGGGSRHPGPQRPTGSRR
                     PHAQLLRVGCVLGTCQVQNLSHRLWQLVRPAGRRDSAPVDPSSPHSYG"
     exon            539..1298
                     /gene="Adm2"
                     /gene_synonym="Am2; IMD; Imdn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1275..1280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adm2"
                     /gene_synonym="Am2; IMD; Imdn"
                     /note="hexamer: ATTAAA"
     polyA_site      1298
                     /gene="Adm2"
                     /gene_synonym="Am2; IMD; Imdn"
                     /note="major polyA site"
ORIGIN      
        1 ctttgtcgcg caccagaagg taccaggagt gagggcagta gccccacggg gtttctggtc
       61 agctgttgag catttcccag caaggatggg ccccttgaag tgacctcctg tggctctact
      121 gctttctgct gggcaggagt agccaccagg agagcgtggc taccgcagcc cacccgggtg
      181 gaggacgctc cgccccatca gcgtctgggc cacgccttta gctccaaaga ctacttagtg
      241 ctggaagtgc ttcccaaact ggttttccgc tggaccccag aaggctctct ttcctaggag
      301 accacgacct gacccacaag ttccgttgcg tgctctggga actgctagca gatcccagct
      361 ttgccagctg tctccagatc ctgagacctg tgccccgaca gacaacagac gcagcccagc
      421 ccgccatggc ccagttgctg atggtcacgg taaccctcgg ttgcatcagc ctcctctacc
      481 tgctccccgg cacgttgtct ggcagcctgg gcaagggact gaggcactcc agacccagag
      541 agcccccagc taagattcct tccagtaacc tgcagcctgg acacccttcc cttcagcctg
      601 tagtctggaa gtctcgtcgt catgcccccc agccacaggg aaggggcaac agggcccttg
      661 ctatggttca tctgcctcag ggtggtggct cacgacaccc tggtccccag cgtcccacgg
      721 gatcccgaag accccatgcc cagctcctgc gggttggctg tgtactgggt acatgccaag
      781 tccagaatct tagccatcgc ctgtggcagc ttgtccggcc agctggccgg cgggactcag
      841 ctcctgtgga tcccagcagc ccccacagtt atggctgagg tgggtcctag gtactccatc
      901 tggagtgctg tgctctgatc ccagagctgc agctgagctc cataccttgg cccgattctc
      961 tggagctcct gcttgtagcc attcctcgtg gctttggata ccctaaacct atgaggatat
     1021 gtggatctag gctgtagaat ctgcaccgac aggggcctgc gcatctcaga actgtgtaca
     1081 ctcagggtac aggtgcttgg aagaagtgct gccaatatca taggccacca agaactcgag
     1141 gaggcgtgta cctaaagaaa tgggcaaaag ctagaatctt aaatgcatct ctacctatga
     1201 ataagcagga agaaggctgg agtgacccct gtgaccccac cccaccccca accccaaccc
     1261 caaccccact gggaattaaa gtctgactgt gggcgaaaaa
//
