LOCUS       NM_009627               1394 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus adrenomedullin (Adm), mRNA.
ACCESSION   NM_009627
VERSION     NM_009627.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 1394)
  AUTHORS   Palit,S., Shrestha,A.K., Thapa,S., L Grimm,S., Coarfa,C., Theis,F.,
            Simon,L.M. and Shivanna,B.
  TITLE     Leveraging Integrated RNA Sequencing to Decipher Adrenomedullin's
            Protective Mechanisms in Experimental Bronchopulmonary Dysplasia
  JOURNAL   Genes (Basel) 15 (6), 806 (2024)
   PUBMED   38927741
  REMARK    GeneRIF: Leveraging Integrated RNA Sequencing to Decipher
            Adrenomedullin's Protective Mechanisms in Experimental
            Bronchopulmonary Dysplasia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1394)
  AUTHORS   Hu,Y., Gu,X., Zhang,Y., Ma,W., Sun,L., Wang,C. and Ren,B.
  TITLE     Adrenomedullin, transcriptionally regulated by vitamin D receptors,
            alleviates atherosclerosis in mice through suppressing
            AMPK-mediated endothelial ferroptosis
  JOURNAL   Environ Toxicol 39 (1), 199-211 (2024)
   PUBMED   37688783
  REMARK    GeneRIF: Adrenomedullin, transcriptionally regulated by vitamin D
            receptors, alleviates atherosclerosis in mice through suppressing
            AMPK-mediated endothelial ferroptosis.
REFERENCE   4  (bases 1 to 1394)
  AUTHORS   Zhang,Q., Lee,C.L., Yang,T., Li,J., Zeng,Q., Liu,X., Liu,Z.,
            Ruan,D., Li,Z., Kan,A.S.Y., Cheung,K.W., Mak,A.S.L., Ng,V.W.Y.,
            Zhao,H., Fan,X., Duan,Y.G., Zhong,L., Chen,M., Du,M., Li,R.H.W.,
            Liu,P., Ng,E.H.Y., Yeung,W.S.B., Gao,Y., Yao,Y. and Chiu,P.C.N.
  TITLE     Adrenomedullin has a pivotal role in trophoblast differentiation: A
            promising nanotechnology-based therapeutic target for early-onset
            preeclampsia
  JOURNAL   Sci Adv 9 (44), eadi4777 (2023)
   PUBMED   37922358
REFERENCE   5  (bases 1 to 1394)
  AUTHORS   Feng,W., Bais,A., He,H., Rios,C., Jiang,S., Xu,J., Chang,C.,
            Kostka,D. and Li,G.
  TITLE     Single-cell transcriptomic analysis identifies murine heart
            molecular features at embryonic and neonatal stages
  JOURNAL   Nat Commun 13 (1), 7960 (2022)
   PUBMED   36575170
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1394)
  AUTHORS   Cameron,V.A. and Fleming,A.M.
  TITLE     Novel sites of adrenomedullin gene expression in mouse and rat
            tissues
  JOURNAL   Endocrinology 139 (5), 2253-2264 (1998)
   PUBMED   9564831
REFERENCE   7  (bases 1 to 1394)
  AUTHORS   Jahnke,G.D., Miller,M.J., Martinez,A., Montuenga,L. and Cuttitta,F.
  TITLE     Adrenomedullin expression in the mouse mammary gland: evidence for
            the mature form in milk
  JOURNAL   J Mol Endocrinol 19 (3), 279-289 (1997)
   PUBMED   9460649
REFERENCE   8  (bases 1 to 1394)
  AUTHORS   Montuenga,L.M., Martinez,A., Miller,M.J., Unsworth,E.J. and
            Cuttitta,F.
  TITLE     Expression of adrenomedullin and its receptor during embryogenesis
            suggests autocrine or paracrine modes of action
  JOURNAL   Endocrinology 138 (1), 440-451 (1997)
   PUBMED   8977434
REFERENCE   9  (bases 1 to 1394)
  AUTHORS   Okazaki,T., Ogawa,Y., Tamura,N., Mori,K., Isse,N., Aoki,T.,
            Rochelle,J.M., Taketo,M.M., Seldin,M.F. and Nakao,K.
  TITLE     Genomic organization, expression, and chromosomal mapping of the
            mouse adrenomedullin gene
  JOURNAL   Genomics 37 (3), 395-399 (1996)
   PUBMED   8938454
REFERENCE   10 (bases 1 to 1394)
  AUTHORS   White,R.T., Damm,D., Hancock,N., Rosen,B.S., Lowell,B.B., Usher,P.,
            Flier,J.S. and Spiegelman,B.M.
  TITLE     Human adipsin is identical to complement factor D and is expressed
            at high levels in adipose tissue
  JOURNAL   J Biol Chem 267 (13), 9210-9213 (1992)
   PUBMED   1374388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144181.1 and AC154911.4.
            
            On Mar 28, 2018 this sequence version replaced NM_009627.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144181.1, AK144649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1393              AK144181.1         4-1396
            1394-1394           AC154911.4         218663-218663
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.7 cM"
     gene            1..1394
                     /gene="Adm"
                     /gene_synonym="AM"
                     /note="adrenomedullin"
                     /db_xref="GeneID:11535"
                     /db_xref="MGI:MGI:108058"
     exon            1..165
                     /gene="Adm"
                     /gene_synonym="AM"
                     /inference="alignment:Splign:2.1.0"
     exon            166..285
                     /gene="Adm"
                     /gene_synonym="AM"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..742
                     /gene="Adm"
                     /gene_synonym="AM"
                     /note="pro-adrenomedullin"
                     /codon_start=1
                     /product="pro-adrenomedullin precursor"
                     /protein_id="NP_033757.1"
                     /db_xref="CCDS:CCDS21745.1"
                     /db_xref="GeneID:11535"
                     /db_xref="MGI:MGI:108058"
                     /translation="MKLVSITLMLLGSLAFLGADTAGPDTPSQFRKKWNKWALSRGKR
                     ELQASSSYPTGLADETTVPTQTLDPFLDEQNTTGPLQASNQSEAHIRVKRYRQSMNQG
                     SRSNGCRFGTCTFQKLAHQIYQLTDKDKDGMAPRNKISPQGYGRRRRRSLLEVLRSRT
                     VESSQEQTHTAPGPWAHISRLFRI"
     exon            286..435
                     /gene="Adm"
                     /gene_synonym="AM"
                     /inference="alignment:Splign:2.1.0"
     exon            436..1394
                     /gene="Adm"
                     /gene_synonym="AM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1374..1379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adm"
                     /gene_synonym="AM"
                     /note="hexamer: AATAAA"
     polyA_site      1394
                     /gene="Adm"
                     /gene_synonym="AM"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtggt ttcttggtga cactagacag agcaactcca gcgttaccgc tcccgctcct
       61 ggtttctcgg cttctcatcg cagtcaatct tggactttgg ggttttgcta ctgtcagaag
      121 gacttctttc tgcttcaagt gcttgacaac gcaccccttt atcagggtat cagagcatcg
      181 ccacagaatg aagctggttt ccatcaccct gatgttattg ggttcactcg ctttcctagg
      241 cgcggacact gcagggccag atactccttc gcagttccga aagaagtgga ataagtgggc
      301 gctaagtcgt gggaagaggg aactacaagc atccagcagc taccctacgg gactcgctga
      361 tgagacgaca gttcctaccc agactcttga tccattcctg gacgagcaga acacaactgg
      421 ccccctacaa gccagcaatc agagcgaagc ccacattcgt gtcaaacgct accgccagag
      481 catgaaccag ggttcccgca gcaatggatg ccgcttcggg acctgcacat ttcagaaatt
      541 ggcccaccag atctaccagc taacagacaa agacaaggac ggcatggctc ccagaaacaa
      601 gatcagccct caaggctatg gccgccggcg ccggcgttcc ctgctggagg tcctccggtc
      661 ccggactgtg gagtcctccc aggagcagac acacacagcc ccaggcccct gggcgcacat
      721 ctccagactc tttaggatat aggtgcgggt gacagcattg aacagtcggg cgagtatccc
      781 gttggcgcct gcggaatcag agaacttcgc accggggcgg actgagacaa tcctgcagag
      841 atctgcctgg ctgcccctag gggaggcaga ggaacccaag accaagccag gctcatgcca
      901 gaaaccgaga cttacaggct gatactctcc gggcaggggt ctgagccact gccttgcccg
      961 ctcataaact ggtttctcac ggggcataag cctcattact acttgaactt tccaaaacct
     1021 agcgaggaac gtgcaatgct tgttgtccag ccaaaggtaa ctatagtatt taagtttgtt
     1081 gctgtcaagg tttttttttt tgtaacttca aatatataga gatatttttg tacgttatat
     1141 attgtattaa gggcatttta aagtgattat attgtcacct tcccctattt taagacgtga
     1201 atgtctcagc aaggtgtaag gttgtttggt tccgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1261 tgtgtgtgtg tgtaaggtgg agagcgcctg attatcgcct gtggatgaag aaaaaacatt
     1321 gtgtttccta taatctattt acataaaata tgtgatctgg gaaaaagcaa accaataaac
     1381 tgtctcaatg ctga
//
