LOCUS       NM_134079               1795 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus adenosine kinase (Adk), transcript variant 1, mRNA.
ACCESSION   NM_134079 NM_007411
VERSION     NM_134079.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1795)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1795)
  AUTHORS   Chen,T., Yu,J., Guo,X., Wang,S., Wang,Z., Chen,Y., Hu,X., Li,H.,
            Chen,L. and Zheng,J.
  TITLE     Adenosine kinase inhibits beta-cell proliferation by upregulating
            DNA methyltransferase 3A expression
  JOURNAL   Diabetes Obes Metab 26 (7), 2956-2968 (2024)
   PUBMED   38699782
  REMARK    GeneRIF: Adenosine kinase inhibits beta-cell proliferation by
            upregulating DNA methyltransferase 3A expression.
REFERENCE   3  (bases 1 to 1795)
  AUTHORS   Zocher,S., McCloskey,A., Karasinsky,A., Schulte,R., Friedrich,U.,
            Lesche,M., Rund,N., Gage,F.H., Hetzer,M.W. and Toda,T.
  TITLE     Lifelong persistence of nuclear RNAs in the mouse brain
  JOURNAL   Science 384 (6691), 53-59 (2024)
   PUBMED   38574132
REFERENCE   4  (bases 1 to 1795)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1795)
  AUTHORS   Gebril,H.M., Lai,T., Fedele,D.E. and Wahba,A.
  TITLE     Developmental and foliation changes due to dysregulation of
            adenosine kinase in the cerebellum
  JOURNAL   Sci Rep 13 (1), 19831 (2023)
   PUBMED   37963945
  REMARK    GeneRIF: Developmental and foliation changes due to dysregulation
            of adenosine kinase in the cerebellum.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1795)
  AUTHORS   Ceci,J.D., Kingsley,D.M., Silan,C.M., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific backcross linkage map of the proximal half of
            mouse chromosome 14
  JOURNAL   Genomics 6 (4), 673-678 (1990)
   PUBMED   1971251
REFERENCE   7  (bases 1 to 1795)
  AUTHORS   Snyder,F.F., Cruikshank,M.K. and Seegmiller,J.E.
  TITLE     A comparison of purine metabolism and nucleotide pools in normal
            and hypoxanthine-guanine phosphoribosyltransferase-deficient
            neuroblastoma cells
  JOURNAL   Biochim Biophys Acta 543 (4), 556-569 (1978)
   PUBMED   718989
REFERENCE   8  (bases 1 to 1795)
  AUTHORS   Chan,T.S., Creagan,R.P. and Reardon,M.P.
  TITLE     Adenosine kinase as a new selective marker in somatic cell
            genetics: isolation of adenosine kinase--deficient mouse cell lines
            and human--mouse hybrid cell lines containing adenosine kinase
  JOURNAL   Somatic Cell Genet 4 (1), 1-12 (1978)
   PUBMED   204068
REFERENCE   9  (bases 1 to 1795)
  AUTHORS   Leinwand,L., Fournier,R.E., Nichols,E.A. and Ruddle,F.H.
  TITLE     Assignment of the gene for adenosine kinase to chromosome 14 in Mus
            musculus by somatic cell hybridization
  JOURNAL   Cytogenet Cell Genet 21 (1-2), 77-85 (1978)
   PUBMED   206412
REFERENCE   10 (bases 1 to 1795)
  AUTHORS   Barankiewicz,J., Jezewska,M.M. and Chomczynski,P.
  TITLE     Purine salvage in mammary glands of mice
  JOURNAL   FEBS Lett 60 (2), 384-387 (1975)
   PUBMED   819300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163681.3, AY540996.1, AK032871.1, AK160264.1 and AI194759.1.
            
            On Jul 14, 2011 this sequence version replaced NM_134079.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189670.84526.1, AY540996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC163681.3         39049-39113         c
            66-490              AY540996.1         8-432
            491-788             AK032871.1         449-746
            789-1755            AK160264.1         786-1752
            1756-1795           AI194759.1         1-40                c
FEATURES             Location/Qualifiers
     source          1..1795
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.58 cM"
     gene            1..1795
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /note="adenosine kinase"
                     /db_xref="GeneID:11534"
                     /db_xref="MGI:MGI:87930"
     exon            1..127
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1151
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /EC_number="2.7.1.20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenosine 5'-phosphotransferase"
                     /codon_start=1
                     /product="adenosine kinase isoform 1"
                     /protein_id="NP_598840.1"
                     /db_xref="CCDS:CCDS26862.1"
                     /db_xref="GeneID:11534"
                     /db_xref="MGI:MGI:87930"
                     /translation="MAAADEPKPKKLKVEAPQALSENVLFGMGNPLLDISAVVDKDFL
                     DKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWLIQEPHKAATF
                     FGCIGIDKFGEILKRKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCY
                     KKEKHLDLERNWVLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAPFI
                     SQFFKEALMDVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKAQALPKVNSKRQR
                     TVIFTQGRDDTIVAAENDVTAFPVLDQNQEEIIDTNGAGDAFVGGFLSQLVSDKPLTE
                     CIRAGHYAASVIIRRTGCTFPEKPDFH"
     exon            128..202
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     exon            203..256
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     exon            257..335
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     exon            336..508
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     exon            509..617
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     exon            618..788
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     exon            789..824
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     exon            825..939
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1026
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1782
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1759..1764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /note="hexamer: AATAAA"
     polyA_site      1782
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /note="major polyA site"
ORIGIN      
        1 gggcggggcc accggactga ggggcgggac gcgcggcaga gccaaactac ggtgagagtg
       61 tgaagatggc agctgcggac gagcccaagc ccaaaaagct caaggtggaa gcgccacaag
      121 cgctgagtga aaatgtgcta tttggaatgg ggaatcctct tcttgacatc tctgctgtag
      181 tagacaaaga tttccttgat aagtattctc tgaaaccaaa tgaccagatc ttggctgaag
      241 acaagcacaa ggaactgttt gatgaacttg tgaaaaaatt caaagttgaa tatcatgctg
      301 gtggctctac gcagaattca atgaaagtgg ctcagtggtt gattcaggag ccacacaaag
      361 cagcaacatt ctttggatgc attgggatag ataagtttgg ggagatcctg aagcgtaagg
      421 ctgctgacgc acatgtggat gctcattact atgagcagaa cgagcagcca acaggaactt
      481 gtgctgcgtg tatcactggt ggcaacaggt ccctcgttgc taaccttgct gccgccaatt
      541 gttacaagaa agagaagcac cttgacctgg agcggaactg ggtgttggta gagaaagcca
      601 gagtttacta catagctggc ttttttctca cagtctcccc agagtcggta ttgaaagtgg
      661 ctcgctatgc tgccgagaac aacagggtct tcactttgaa cctgtctgca ccgttcatta
      721 gccagttctt caaggaagcc ttgatggacg tcatgcctta tgttgatatc ctctttggaa
      781 atgagacgga agctgccact tttgctagag agcaaggctt tgagactaaa gacattaaag
      841 aaatagccaa aaaggcgcag gctcttccaa aggtgaactc gaagaggcag aggaccgtga
      901 tcttcacaca agggcgagat gacaccatag tggctgcaga gaatgatgtc actgcttttc
      961 ctgtcttgga tcaaaaccag gaagagatca ttgacaccaa tggagctgga gatgcatttg
     1021 ttggaggctt tctgtctcaa ctggtctctg acaagcctct gactgagtgc atccgcgctg
     1081 gccactacgc agcaagcgtc atcattagac gaactggctg tacctttccc gagaagccag
     1141 acttccactg atggaagaaa gaaaactcag gctgtggagt ggagactgca gtgaccacat
     1201 cctgagcgtt cctccataag aaagaataga gttatcctct gtctttgccc accatggttc
     1261 tcattagtaa cttagagggc tcagtgctac ttctaggacc tttagtctct gaaatctggg
     1321 aaaaatgttt atttgcatag tttgttagtg cctcttaaat gtcaaacagg aatacatttc
     1381 agtagaaact ttaatttcat tttcaattgt ttgtaaattc atcagtattt agtaaattga
     1441 tctttttttt atatttctgc ttccaatgca ggtgcaattt aatataatag actttttaaa
     1501 gaaattaatg ctaacatcat tcttgagctt tttatataaa tatatttaat ttggaagcgt
     1561 gtgtgtgcac atgtcatata tatatacctg ataattgtca gataaggcac agaaatgttc
     1621 atcacaccaa ttattcctta taagctcttc catgtgcttc agacatctga tggacttggg
     1681 gcagctgcct aacccgcaac atttgcatta tgttcagact gtaacctgct tactgatggt
     1741 actctataat ttgatacaaa taaaaaaatt gccatatagg gaaaaaaaaa aaaaa
//
