LOCUS       NP_598840                361 aa            linear   ROD 18-MAR-2025
DEFINITION  adenosine kinase isoform 1 [Mus musculus].
ACCESSION   NP_598840 NP_031437
VERSION     NP_598840.1
DBSOURCE    REFSEQ: accession NM_134079.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 361)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 361)
  AUTHORS   Chen,T., Yu,J., Guo,X., Wang,S., Wang,Z., Chen,Y., Hu,X., Li,H.,
            Chen,L. and Zheng,J.
  TITLE     Adenosine kinase inhibits beta-cell proliferation by upregulating
            DNA methyltransferase 3A expression
  JOURNAL   Diabetes Obes Metab 26 (7), 2956-2968 (2024)
   PUBMED   38699782
  REMARK    GeneRIF: Adenosine kinase inhibits beta-cell proliferation by
            upregulating DNA methyltransferase 3A expression.
REFERENCE   3  (residues 1 to 361)
  AUTHORS   Zocher,S., McCloskey,A., Karasinsky,A., Schulte,R., Friedrich,U.,
            Lesche,M., Rund,N., Gage,F.H., Hetzer,M.W. and Toda,T.
  TITLE     Lifelong persistence of nuclear RNAs in the mouse brain
  JOURNAL   Science 384 (6691), 53-59 (2024)
   PUBMED   38574132
REFERENCE   4  (residues 1 to 361)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 361)
  AUTHORS   Gebril,H.M., Lai,T., Fedele,D.E. and Wahba,A.
  TITLE     Developmental and foliation changes due to dysregulation of
            adenosine kinase in the cerebellum
  JOURNAL   Sci Rep 13 (1), 19831 (2023)
   PUBMED   37963945
  REMARK    GeneRIF: Developmental and foliation changes due to dysregulation
            of adenosine kinase in the cerebellum.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 361)
  AUTHORS   Ceci,J.D., Kingsley,D.M., Silan,C.M., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific backcross linkage map of the proximal half of
            mouse chromosome 14
  JOURNAL   Genomics 6 (4), 673-678 (1990)
   PUBMED   1971251
REFERENCE   7  (residues 1 to 361)
  AUTHORS   Snyder,F.F., Cruikshank,M.K. and Seegmiller,J.E.
  TITLE     A comparison of purine metabolism and nucleotide pools in normal
            and hypoxanthine-guanine phosphoribosyltransferase-deficient
            neuroblastoma cells
  JOURNAL   Biochim Biophys Acta 543 (4), 556-569 (1978)
   PUBMED   718989
REFERENCE   8  (residues 1 to 361)
  AUTHORS   Chan,T.S., Creagan,R.P. and Reardon,M.P.
  TITLE     Adenosine kinase as a new selective marker in somatic cell
            genetics: isolation of adenosine kinase--deficient mouse cell lines
            and human--mouse hybrid cell lines containing adenosine kinase
  JOURNAL   Somatic Cell Genet 4 (1), 1-12 (1978)
   PUBMED   204068
REFERENCE   9  (residues 1 to 361)
  AUTHORS   Leinwand,L., Fournier,R.E., Nichols,E.A. and Ruddle,F.H.
  TITLE     Assignment of the gene for adenosine kinase to chromosome 14 in Mus
            musculus by somatic cell hybridization
  JOURNAL   Cytogenet Cell Genet 21 (1-2), 77-85 (1978)
   PUBMED   206412
REFERENCE   10 (residues 1 to 361)
  AUTHORS   Barankiewicz,J., Jezewska,M.M. and Chomczynski,P.
  TITLE     Purine salvage in mammary glands of mice
  JOURNAL   FEBS Lett 60 (2), 384-387 (1975)
   PUBMED   819300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163681.3, AY540996.1, AK032871.1, AK160264.1 and AI194759.1.
            
            On May 29, 2003 this sequence version replaced NP_031437.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189670.84526.1, AY540996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.58 cM"
     Protein         1..361
                     /product="adenosine kinase isoform 1"
                     /EC_number="2.7.1.20"
                     /note="adenosine 5'-phosphotransferase"
                     /calculated_mol_wt=40018
     Region          7..15
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P55263"
                     /note="propagated from UniProtKB/Swiss-Prot (P55264.2)"
     Region          28..360
                     /region_name="ribokinase_pfkB_like"
                     /note="ribokinase/pfkB superfamily: Kinases that accept a
                     wide variety of substrates, including carbohydrates and
                     aromatic small molecules, all are phosphorylated at a
                     hydroxyl group. The superfamily includes ribokinase,
                     fructokinase, ketohexokinase; cl00192"
                     /db_xref="CDD:469648"
     Site            order(30,32,34,54,79..81,84,139,150,152,154,186,217,
                     312..313,316)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238573"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P55263; propagated from
                     UniProtKB/Swiss-Prot (P55264.2)"
     Site            order(281,283..284,287,300,302,308,311,314..315,318,343,
                     347)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:238573"
     CDS             1..361
                     /gene="Adk"
                     /gene_synonym="2310026J05Rik; 5033405D03Rik; Ak"
                     /coded_by="NM_134079.4:66..1151"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS26862.1"
                     /db_xref="GeneID:11534"
                     /db_xref="MGI:MGI:87930"
ORIGIN      
        1 maaadepkpk klkveapqal senvlfgmgn plldisavvd kdfldkyslk pndqilaedk
       61 hkelfdelvk kfkveyhagg stqnsmkvaq wliqephkaa tffgcigidk fgeilkrkaa
      121 dahvdahyye qneqptgtca acitggnrsl vanlaaancy kkekhldler nwvlvekarv
      181 yyiagffltv spesvlkvar yaaennrvft lnlsapfisq ffkealmdvm pyvdilfgne
      241 teaatfareq gfetkdikei akkaqalpkv nskrqrtvif tqgrddtiva aendvtafpv
      301 ldqnqeeiid tngagdafvg gflsqlvsdk plteciragh yaasviirrt gctfpekpdf
      361 h
//
