LOCUS       NM_026091               1312 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus adipose secreted signaling protein (Adissp),
            transcript variant 2, mRNA.
ACCESSION   NM_026091
VERSION     NM_026091.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1312)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1312)
  AUTHORS   Chen,Q., Huang,L., Pan,D., Hu,K., Li,R., Friedline,R.H., Kim,J.K.,
            Zhu,L.J., Guertin,D.A. and Wang,Y.X.
  TITLE     A brown fat-enriched adipokine Adissp controls adipose
            thermogenesis and glucose homeostasis
  JOURNAL   Nat Commun 13 (1), 7633 (2022)
   PUBMED   36496438
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1312)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY706619.1, AK003406.1 and AL831736.16.
            
            On Mar 19, 2018 this sequence version replaced NM_026091.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003406.1, BI652803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BY706619.1         1-61
            62-1302             AK003406.1         2-1242
            1303-1312           AL831736.16        77937-77946         c
FEATURES             Location/Qualifiers
     source          1..1312
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.28 cM"
     gene            1..1312
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="adipose secreted signaling protein"
                     /db_xref="GeneID:67326"
                     /db_xref="MGI:MGI:1914576"
     exon            1..129
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            130..246
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..752
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     UPF0687 protein C20orf27 homolog"
                     /codon_start=1
                     /product="adipose-secreted signaling protein isoform 2"
                     /protein_id="NP_080367.1"
                     /db_xref="CCDS:CCDS16756.1"
                     /db_xref="GeneID:67326"
                     /db_xref="MGI:MGI:1914576"
                     /translation="MAAANRGSKPRVRSIRFAAGHDAEGSQSHVHFDEKLHDSVVMVT
                     QESDNSFLVKVGFLKILHRYEITFTLPPVRRLSKDIRETPVHSLHLKLLSVTPTSEGY
                     SIKCEYSAHKEGVLKEEMLLACEGDIGTCVRVTVQARVMDRHHGTPMLLDGVKCVGAE
                     LEYDSEQSDWLGFD"
     exon            247..389
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            390..528
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            529..651
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1312
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1288..1293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1310
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggagaggg cgtggcgcga ggctgatgcg gcgcggggct cttcctcgcg ctctccagcc
       61 cgttctgctg ctgctaccgc cgcctccgcg gtcgtttctg accgcctggc cgcggggctc
      121 gcctgcaagg ttcctgctgc tgtctctgga gcatggcagg ctgctgaggt tgagtggcag
      181 tgtcaagtag gagctgcgtg tcttgcccag tggcagggag cgtgtccatg gctgcagcca
      241 acagaggcag taagcccaga gtccgaagta tccgctttgc agcaggccac gatgcagaag
      301 gctcccagag ccacgtccac tttgatgaaa agctgcatga ctcggtggtc atggttactc
      361 aggagagtga caacagcttc ttagtcaagg ttggcttcct gaagatcctg cacaggtatg
      421 agattacctt cactctgcct ccagtgcgca gactgagcaa ggacatccgt gagacccctg
      481 tccacagctt gcacctcaag ctgctcagcg tcacacccac ctctgaaggt tacagcatca
      541 agtgtgagta ctcggcacac aaagaaggtg ttctcaaaga ggagatgctc ctggcctgcg
      601 agggtgacat aggcacctgt gtgcgtgtga cggtgcaggc gcgggtcatg gaccggcacc
      661 acggtacacc catgctgctg gatggtgtca agtgtgtggg cgctgagctg gagtatgact
      721 cggaacagag cgattggctc ggcttcgact gaggcctggg accgtgcctg cctgcctgcc
      781 tgcctgcctg agcccctgag ccttaaactt cacctgctcc ccgacatgct gtgtgacggt
      841 gtggcttcct cacctctccc ctggtgggca tggcagggct agaccttgct catgcccccc
      901 accccccact tctgccttca ttccttccac caccctgcct ctccggtctc ctcccccact
      961 tcctcctctc ccatgtgcct gagtctccta accgaagaaa agggttgagc cccaaggagg
     1021 ctatctgaga ggagggacct ggggtggggt ttacctcttc caccccaagc catagggagc
     1081 tctattggga ggggacaggt ggctgtctgt gtgacattga tgccccattg ctgctgctac
     1141 tgtcgtctcc ccttcttcac ctctgctgcc ctcatctccc ttctccactg ctggttgtgt
     1201 ggtgaggagg tacagttcct agcccctacc ccctcaggtc tgtggtactt ggtttttaaa
     1261 tgactggttg ggatagagac ctcaataaat aaaaactccg gtagatttca ga
//
