LOCUS       NM_001361375            1308 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus adipose secreted signaling protein (Adissp),
            transcript variant 5, mRNA.
ACCESSION   NM_001361375
VERSION     NM_001361375.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   Chen,Q., Huang,L., Pan,D., Hu,K., Li,R., Friedline,R.H., Kim,J.K.,
            Zhu,L.J., Guertin,D.A. and Wang,Y.X.
  TITLE     A brown fat-enriched adipokine Adissp controls adipose
            thermogenesis and glucose homeostasis
  JOURNAL   Nat Commun 13 (1), 7633 (2022)
   PUBMED   36496438
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1308)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY706619.1, CX222938.1, AK006622.1 and AL831736.16.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX222938.1, SRR7345562.942298.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               BY706619.1         1-120
            121-607             CX222938.1         48-534
            608-684             AK006622.1         621-697
            685-1308            AL831736.16        77937-78560         c
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.28 cM"
     gene            1..1308
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="adipose secreted signaling protein"
                     /db_xref="GeneID:67326"
                     /db_xref="MGI:MGI:1914576"
     exon            1..129
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            130..246
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            247..385
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..748
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="isoform 3 is encoded by transcript variant 5;
                     UPF0687 protein C20orf27 homolog"
                     /codon_start=1
                     /product="adipose-secreted signaling protein isoform 3"
                     /protein_id="NP_001348304.1"
                     /db_xref="GeneID:67326"
                     /db_xref="MGI:MGI:1914576"
                     /translation="MVTQESDNSFLVKVGFLKILHRYEITFTLPPVRRLSKDIRETPV
                     HSLHLKLLSVTPTSEGYSIKCEYSAHKEGVLKEEMLLACEGDIGTCVRVTVQARVMDR
                     HHGTPMLLDGVKCVGAELEYDSEQSDWLGFD"
     exon            386..524
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            525..647
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            648..1308
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1284..1289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1306
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggagaggg cgtggcgcga ggctgatgcg gcgcggggct cttcctcgcg ctctccagcc
       61 cgttctgctg ctgctaccgc cgcctccgcg gtcgtttctg accgcctggc cgcggggctc
      121 gcctgcaagg ttcctgctgc tgtctctgga gcatggcagg ctgctgaggt tgagtggcag
      181 tgtcaagtag gagctgcgtg tcttgcccag tggcagggag cgtgtccatg gctgcagcca
      241 acagagtaag cccagagtcc gaagtatccg ctttgcagca ggccacgatg cagaaggctc
      301 ccagagccac gtccactttg atgaaaagct gcatgactcg gtggtcatgg ttactcagga
      361 gagtgacaac agcttcttag tcaaggttgg cttcctgaag atcctgcaca ggtatgagat
      421 taccttcact ctgcctccag tgcgcagact gagcaaggac atccgtgaga cccctgtcca
      481 cagcttgcac ctcaagctgc tcagcgtcac acccacctct gaaggttaca gcatcaagtg
      541 tgagtactcg gcacacaaag aaggtgttct caaagaggag atgctcctgg cctgcgaggg
      601 tgacataggc acctgtgtgc gtgtgacggt gcaggcgcgg gtcatggacc ggcaccacgg
      661 tacacccatg ctgctggatg gtgtcaagtg tgtgggcgct gagctggagt atgactcgga
      721 acagagcgat tggctcggct tcgactgagg cctgggaccg tgcctgcctg cctgcctgcc
      781 tgcctgagcc cctgagcctt aaacttcacc tgctccccga catgctgtgt gacggtgtgg
      841 cttcctcacc tctcccctgg tgggcatggc agggctagac cttgctcatg ccccccaccc
      901 cccacttctg ccttcattcc ttccaccacc ctgcctctcc ggtctcctcc cccacttcct
      961 cctctcccat gtgcctgagt ctcctaaccg aagaaaaggg ttgagcccca aggaggctat
     1021 ctgagaggag ggacctgggg tggggtttac ctcttccacc ccaagccata gggagctcta
     1081 ttgggagggg acaggtggct gtctgtgtga cattgatgcc ccattgctgc tgctactgtc
     1141 gtctcccctt cttcacctct gctgccctca tctcccttct ccactgctgg ttgtgtggtg
     1201 aggaggtaca gttcctagcc cctaccccct caggtctgtg gtacttggtt tttaaatgac
     1261 tggttgggat agagacctca ataaataaaa actccggtag atttcaga
//
