LOCUS       NM_001311138            1321 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus adipose secreted signaling protein (Adissp),
            transcript variant 1, mRNA.
ACCESSION   NM_001311138 XM_011239744
VERSION     NM_001311138.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1321)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1321)
  AUTHORS   Chen,Q., Huang,L., Pan,D., Hu,K., Li,R., Friedline,R.H., Kim,J.K.,
            Zhu,L.J., Guertin,D.A. and Wang,Y.X.
  TITLE     A brown fat-enriched adipokine Adissp controls adipose
            thermogenesis and glucose homeostasis
  JOURNAL   Nat Commun 13 (1), 7633 (2022)
   PUBMED   36496438
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1321)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006622.1 and AL831736.16.
            
            On Jul 24, 2015 this sequence version replaced XM_011239744.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006622.1, BY706619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-697               AK006622.1         1-697
            698-698             AL831736.16        78560-78560         c
            699-832             AK006622.1         698-831
            833-1321            AL831736.16        77937-78425         c
FEATURES             Location/Qualifiers
     source          1..1321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.28 cM"
     gene            1..1321
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="adipose secreted signaling protein"
                     /db_xref="GeneID:67326"
                     /db_xref="MGI:MGI:1914576"
     exon            1..129
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            130..255
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..761
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0687 protein C20orf27 homolog"
                     /codon_start=1
                     /product="adipose-secreted signaling protein isoform 1"
                     /protein_id="NP_001298067.1"
                     /db_xref="CCDS:CCDS79849.1"
                     /db_xref="GeneID:67326"
                     /db_xref="MGI:MGI:1914576"
                     /translation="MAAANRGECCSKPRVRSIRFAAGHDAEGSQSHVHFDEKLHDSVV
                     MVTQESDNSFLVKVGFLKILHRYEITFTLPPVRRLSKDIRETPVHSLHLKLLSVTPTS
                     EGYSIKCEYSAHKEGVLKEEMLLACEGDIGTCVRVTVQARVMDRHHGTPMLLDGVKCV
                     GAELEYDSEQSDWLGFD"
     exon            256..398
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            399..537
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            538..660
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            661..1321
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1297..1302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1319
                     /gene="Adissp"
                     /gene_synonym="1700037H04Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggagaggg cgtggcgcga ggctgatgcg gcgcggggct cttcctcgcg ctctccagcc
       61 cgttctgctg ctgctaccgc cgcctccgcg gtcgtttctg accgcctggc cgcggggctc
      121 gcctgcaagg ttcctgctgc tgtctctgga gcatggcagg ctgctgaggt tgagtggcag
      181 tgtcaagtag gagctgcgtg tcttgcccag tggcagggag cgtgtccatg gctgcagcca
      241 acagaggtga gtgctgcagt aagcccagag tccgaagtat ccgctttgca gcaggccacg
      301 atgcagaagg ctcccagagc cacgtccact ttgatgaaaa gctgcatgac tcggtggtca
      361 tggttactca ggagagtgac aacagcttct tagtcaaggt tggcttcctg aagatcctgc
      421 acaggtatga gattaccttc actctgcctc cagtgcgcag actgagcaag gacatccgtg
      481 agacccctgt ccacagcttg cacctcaagc tgctcagcgt cacacccacc tctgaaggtt
      541 acagcatcaa gtgtgagtac tcggcacaca aagaaggtgt tctcaaagag gagatgctcc
      601 tggcctgcga gggtgacata ggcacctgtg tgcgtgtgac ggtgcaggcg cgggtcatgg
      661 accggcacca cggtacaccc atgctgctgg atggtgtcaa gtgtgtgggc gctgagctgg
      721 agtatgactc ggaacagagc gattggctcg gcttcgactg aggcctggga ccgtgcctgc
      781 ctgcctgcct gcctgcctga gcccctgagc cttaaacttc acctgctccc cgacatgctg
      841 tgtgacggtg tggcttcctc acctctcccc tggtgggcat ggcagggcta gaccttgctc
      901 atgcccccca ccccccactt ctgccttcat tccttccacc accctgcctc tccggtctcc
      961 tcccccactt cctcctctcc catgtgcctg agtctcctaa ccgaagaaaa gggttgagcc
     1021 ccaaggaggc tatctgagag gagggacctg gggtggggtt tacctcttcc accccaagcc
     1081 atagggagct ctattgggag gggacaggtg gctgtctgtg tgacattgat gccccattgc
     1141 tgctgctact gtcgtctccc cttcttcacc tctgctgccc tcatctccct tctccactgc
     1201 tggttgtgtg gtgaggaggt acagttccta gcccctaccc cctcaggtct gtggtacttg
     1261 gtttttaaat gactggttgg gatagagacc tcaataaata aaaactccgg tagatttcag
     1321 a
//
