LOCUS       NM_001355692            4152 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus adiponectin receptor 2 (Adipor2), transcript variant
            2, mRNA.
ACCESSION   NM_001355692 XM_006506538
VERSION     NM_001355692.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4152)
  AUTHORS   Guo,Q.W., Lin,J., Shen,Y.L., Zheng,Y.J., Chen,X., Su,M.,
            Zhang,J.C., Wang,J.H., Tang,H., Su,G.M., Li,Z.K. and Fang,D.Z.
  TITLE     Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect
            of psychosocial stress to elevate serum cholesterol
  JOURNAL   Mol Cell Endocrinol 592, 112282 (2024)
   PUBMED   38815796
  REMARK    GeneRIF: Reduced hepatic AdipoR2 by increased glucocorticoid
            mediates effect of psychosocial stress to elevate serum
            cholesterol.
REFERENCE   2  (bases 1 to 4152)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    GeneRIF: Regulation of meiotic telomere dynamics through membrane
            fluidity promoted by AdipoR2-ELOVL2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4152)
  AUTHORS   Asahara,N., Okada-Iwabu,M., Iwabu,M., Wada,K., Oka,K., Yamauchi,T.
            and Kadowaki,T.
  TITLE     A monoclonal antibody activating AdipoR for type 2 diabetes and
            nonalcoholic steatohepatitis
  JOURNAL   Sci Adv 9 (45), eadg4216 (2023)
   PUBMED   37948516
REFERENCE   5  (bases 1 to 4152)
  AUTHORS   Onodera,T., Wang,M.Y., Rutkowski,J.M., Deja,S., Chen,S.,
            Balzer,M.S., Kim,D.S., Sun,X., An,Y.A., Field,B.C., Lee,C.,
            Matsuo,E.I., Mizerska,M., Sanjana,I., Fujiwara,N., Kusminski,C.M.,
            Gordillo,R., Gautron,L., Marciano,D.K., Hu,M.C., Burgess,S.C.,
            Susztak,K., Moe,O.W. and Scherer,P.E.
  TITLE     Endogenous renal adiponectin drives gluconeogenesis through
            enhancing pyruvate and fatty acid utilization
  JOURNAL   Nat Commun 14 (1), 6531 (2023)
   PUBMED   37848446
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4152)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4152)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 4152)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 4152)
  AUTHORS   Reue,K., Xia,Y., Shi,V.W., Cohen,R.D., Welch,C. and Lusis,A.J.
  TITLE     Localization of mouse peroxisome proliferator-activated receptor
            gamma on chromosome 6
  JOURNAL   Mamm Genome 7 (5), 390-391 (1996)
   PUBMED   8661743
REFERENCE   10 (bases 1 to 4152)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126607.7 and AC115816.9.
            
            On Sep 23, 2017 this sequence version replaced XM_006506538.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148295.1, SRR7652917.648275.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AC126607.7         26168-26420         c
            254-512             AC115816.9         211123-211381       c
            513-632             AC115816.9         206234-206353       c
            633-804             AC115816.9         202801-202972       c
            805-991             AC115816.9         200324-200510       c
            992-1179            AC115816.9         199895-200082       c
            1180-1373           AC115816.9         198189-198382       c
            1374-4152           AC115816.9         194123-196901       c
FEATURES             Location/Qualifiers
     source          1..4152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.78 cM"
     gene            1..4152
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /note="adiponectin receptor 2"
                     /db_xref="GeneID:68465"
                     /db_xref="MGI:MGI:93830"
     exon            1..253
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /inference="alignment:Splign:2.1.0"
     exon            254..512
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..632
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..804
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..991
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1179
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1373
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..4152
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4127..4132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /note="hexamer: AATAAA"
     polyA_site      4149
                     /gene="Adipor2"
                     /gene_synonym="1110001I14Rik; ADCR2; D6Ucla1e; Paqr2"
                     /note="major polyA site"
ORIGIN      
        1 ggggagacgc ggcggcggcg gcggcggcgg tcgcggcggc gcgagcacag tcccgacgcg
       61 gtaccgcggt ggcggcggcg gcggtggcgg ctccagcgag cggccccctc cctccgcgcc
      121 ccccctctcc ctccccgagg cgctgcttcc cgaggcgccc gagccgcgcg gtgagacggc
      181 cgctaactcg ggcgaagggc tgtggctcga gcgcggcttc ccgggctcag cagattgccc
      241 gggtcggaag gagggtcaac ttaccatccc ttaaaaatcc attctcccaa gaagaaggga
      301 cagaaagaaa gaccactttg taagaaaggc tttggtatcc catgaacgag ccagccaaac
      361 accgattggg gtgcaccagg actccagagc cagatatacg gctcagaaaa gggcaccaac
      421 ttgatgatac aaggggaagt aataatgaca actaccaagg agatttggag cccagcttag
      481 agacacctgt ttgttcttcc tattatgaaa atagcccgga ggagcccgag tgtcatgatg
      541 acaattccca ggaagatgaa gggtttatgg gcatgtcccc gctcctacag gcccatcatg
      601 ctatggaacg aatggaagag tttgtttgta aggtgtggga aggccgatgg cgagtgatcc
      661 ctcacgatgt gctaccggat tggcttaagg ataatgactt ccttctccat ggacaccggc
      721 ctcctatgcc ttcctttcgg gcctgtttta agagcatttt tagaatacac acagagacgg
      781 gcaacatttg gacacatctc ctaggttgtg tattcttcct gtgcctgggg atcttttata
      841 tgtttcgccc aaatatatct tttgtggccc ctctgcaaga gaaagtggtc tttggcttgt
      901 tcttcttggg agccattctc tgcctttcct tttcatggct cttccacacg gtgtactgcc
      961 actcagaagg ggtctcccga ctcttctcta aattggatta ctctggtatt gctcttctga
     1021 tcatgggaag ttttgttcct tggctttatt attctttcta ctgtaaccca caaccttgct
     1081 tcatctacct gattgtcatc tgtgtgctgg gcattgcagc cattatcgtc tctcagtggg
     1141 acatgtttgc cacccctcag tatcgggggg tcagagcagg agtgttcgtg ggcttaggcc
     1201 tgagtggaat catccctacc ttgcattatg tcatctcaga agggttcctg aaggctgcca
     1261 ccatagggca gataggctgg ctaatgctta tggctagcct ctatatcacc ggagctgccc
     1321 tctatgcggc ccgtatccct gagcgcttct ttcctggcaa atgtgacatc tggtttcact
     1381 ctcatcagct cttccacatc tttgtggttg ctggtgcctt tgttcacttc cacggagtct
     1441 caaacctgca ggaatttcgt ttcatgattg gcgggggctg cactgaagag gatgcactgt
     1501 gatactctcc aggaaccagg gactctgacc ctgagccagg cctgcaggtc ctgcaggcct
     1561 tcttactggc tgtcggtgcc agtgccagag aagccccaaa acttggacag cctcatgggc
     1621 cttgtgttgg cccaagggct ccatggggta caagactaag aagagaaaaa caaaaataaa
     1681 tcatacctca aaggatggaa tgcatcgatt aggagagaag gagaaatggc tcatcccctg
     1741 gcttcctctt gggatctacc gattgaaagc aactctgcaa gaccctcgcc tgacaggctg
     1801 gcttctgatg tgatcgtatt tatttgtaga agatggggaa acagtttagt tggtggtctt
     1861 tcttctccct tccttgctcc ttgcagcagt aacatgtatg agtaccatgc accaactgat
     1921 cgtgccattg gagctcctta aacagtaatc acaaccaagt taggggaaca tttgtatcca
     1981 ataaaggggt gggagtgcgg ttttaggcac tcctttggga gaacaaagaa attaatgtaa
     2041 ataagatttc taatttactg tttaaataag aatttatata aacatttaag acataggggc
     2101 agggagggag ggagactttt tttaaaaaga atgaaacatg caagtaccac acactgtttc
     2161 aattttgcac aagtgatggg aggaggatgg agtggtagcc ccagaatgca cgatgtcttg
     2221 gtgcaccaag gtgccttccc taggccgata acacttggac cctgctgggg cagagtggac
     2281 agccccagcc caggaacttc ctggccactc tcaagactga gagcctttgg gcattcagag
     2341 ggggagggat gtggaagtcg tgtgtgcttt tcaatggaag cagcacaggt tgtcatagtg
     2401 gctctagaga aagtgtcatt tgggagactg ttatgtaggc tagtgatgac ccttttgaag
     2461 agtgaagcca cctggttcta ctgtagatgt agtagagact tgatgaaggg gaggaggacc
     2521 tgggggcatc agcataggaa tggtctgctt ctccctggtg tctcgtttga ccaggtggta
     2581 gttcttatct gaatagaggt atggccattt tccagaccct ctctgtggag ctctgagcca
     2641 ttctgcaaat tttgctctat tgagaatcac tgccctaact gtccttcctc ctggaaatca
     2701 aaaactgccc cccccccccc ccccccagca tcaaagctcc ttcgtggagc cggccactag
     2761 tgagattctg atgagcatgg gtcccacctg aagtcatgca ggcaggtgtg gaggaccatc
     2821 ccttggacta ggaatggtgg cgcttttctc tggtgcaggc ttggcaggct tggcatgaca
     2881 acagattctt ctcccgttga acaagaaagt cagtaatacc tactgtggag ttgttagcac
     2941 gcactgaatg ccatttgcaa gacctgtgct acagagttga aaaggaagtg gactgttatt
     3001 accaggtagt cggatagaat taaacccaca attttgaatt gctgctagaa gttacaaata
     3061 atttctttgt cctagggcct tcttgttatg ggttttagag agtggcagtg agttgggtct
     3121 tggctcctaa gtgagaaacc aagcacttga gtctcttaga ctctaggcct cactccttgg
     3181 ggctggtggg tattgcagtg taacatgggc ctcgggcatc ccaaaagggg tgctgggcag
     3241 tatgaggagg tcctgttttt acagtagtgt tttcttggtc gtcgttgtcc ttcctctacc
     3301 ttcagatcgc cacccagctg cagctgggac ccaggaagga gtccattgaa aacctgggaa
     3361 gaacttcaga gtattgggtt gtggataagg tcactgccct aggtaggccc aacaggaagc
     3421 tctgggtgaa cagcattgtg ccagacaact aagaacagtg ttaattcctc aagaagcagt
     3481 tcatcaagac agtgtccatc cggaaggaag ctcacctagg cttgtggtag caacagcaca
     3541 tatcagcagc cagacgcact ctctggtcgt gcactttggg acatgagttt gagacgcttc
     3601 ctcatgacac ctacaggagt agaggtcttt gggactggtc atccctcttc ccaaagcagg
     3661 gagactctgg ttcaacatag cacaaactct tagggaaccg aatcaccacc accactgtag
     3721 tccagtaact tcccttcggt gtgtgtgtgt gggcatgtgt gtgccctgta tgtctgcgca
     3781 gctcactacc aacagcctcc atgtgcactt gaccttgtgg tgcctccggg aactttccag
     3841 gttggcacct gaatgcctta ctctcagcag tctgaggctc gcttgctctg cgcacacgtt
     3901 tcagtctcct tttttggccc taggctggtt aggaacctgt acaccttcac tctctcatca
     3961 ttaaatagtg gcctttttca gtatttcctc tctcccctct ataagttgct gaaatcacaa
     4021 agcacacttt tggggatcat agaaggttgg ggttccagaa aggcatctct gtgatggttc
     4081 cattcactat ggggatttcc ctacttgctg tcttcttgat ttctctaata aaaagagcca
     4141 aatggaaaat ga
//
