LOCUS       NM_028320               3137 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus adiponectin receptor 1 (Adipor1), transcript variant
            2, mRNA.
ACCESSION   NM_028320
VERSION     NM_028320.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3137)
  AUTHORS   Lin,F., Masterson,E. and Gilbertson,T.A.
  TITLE     Adiponectin Signaling Modulates Fat Taste Responsiveness in Mice
  JOURNAL   Nutrients 16 (21), 3704 (2024)
   PUBMED   39519538
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3137)
  AUTHORS   Liu,L., Tang,J., Liang,X., Li,Y., Zhu,P., Zhou,M., Qin,L., Deng,Y.,
            Li,J., Wang,Y., Jiang,L., Huang,D., Zhou,Y., Wang,S., Xiao,Q.,
            Luo,Y. and Tang,Y.
  TITLE     Running exercise alleviates hippocampal neuroinflammation and
            shifts the balance of microglial M1/M2 polarization through
            adiponectin/AdipoR1 pathway activation in mice exposed to chronic
            unpredictable stress
  JOURNAL   Mol Psychiatry 29 (7), 2031-2042 (2024)
   PUBMED   38361125
  REMARK    GeneRIF: Running exercise alleviates hippocampal neuroinflammation
            and shifts the balance of microglial M1/M2 polarization through
            adiponectin/AdipoR1 pathway activation in mice exposed to chronic
            unpredictable stress.
REFERENCE   3  (bases 1 to 3137)
  AUTHORS   Lewandowski,D., Gao,F., Imanishi,S., Tworak,A., Bassetto,M.,
            Dong,Z., Pinto,A.F.M., Tabaka,M., Kiser,P.D., Imanishi,Y.,
            Skowronska-Krawczyk,D. and Palczewski,K.
  TITLE     Restoring retinal polyunsaturated fatty acid balance and retina
            function by targeting ceramide in AdipoR1-deficient mice
  JOURNAL   J Biol Chem 300 (5), 107291 (2024)
   PUBMED   38636661
REFERENCE   4  (bases 1 to 3137)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3137)
  AUTHORS   Kobori,T., Iwabu,M., Okada-Iwabu,M., Ohuchi,N., Kikuchi,A.,
            Yamauchi,N., Kadowaki,T., Yamauchi,T. and Kasuga,M.
  TITLE     Decreased AdipoR1 signaling and its implications for
            obesity-induced male infertility
  JOURNAL   Sci Rep 14 (1), 5701 (2024)
   PUBMED   38459078
  REMARK    GeneRIF: Decreased AdipoR1 signaling and its implications for
            obesity-induced male infertility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3137)
  AUTHORS   Kadowaki,T., Yamauchi,T., Waki,H., Iwabu,M., Okada-Iwabu,M. and
            Nakamura,M.
  TITLE     Adiponectin, adiponectin receptors, and epigenetic regulation of
            adipogenesis
  JOURNAL   Cold Spring Harb Symp Quant Biol 76, 257-265 (2011)
   PUBMED   22492282
  REMARK    Review article
REFERENCE   7  (bases 1 to 3137)
  AUTHORS   Berner,H.S., Lyngstadaas,S.P., Spahr,A., Monjo,M., Thommesen,L.,
            Drevon,C.A., Syversen,U. and Reseland,J.E.
  TITLE     Adiponectin and its receptors are expressed in bone-forming cells
  JOURNAL   Bone 35 (4), 842-849 (2004)
   PUBMED   15454091
  REMARK    GeneRIF: a link between adiponectin and bone homeostasis by
            demonstrating transcription, translation, and secretion of
            adiponectin, as well as expression of its receptors, AdipoR1 and
            AdipoR2, in bone-forming cells
REFERENCE   8  (bases 1 to 3137)
  AUTHORS   Winzell,M.S., Nogueiras,R., Dieguez,C. and Ahren,B.
  TITLE     Dual action of adiponectin on insulin secretion in
            insulin-resistant mice
  JOURNAL   Biochem Biophys Res Commun 321 (1), 154-160 (2004)
   PUBMED   15358228
  REMARK    GeneRIF: Expressed in islets, muscle and liver; expression in mouse
            islets related to dietary fat.
REFERENCE   9  (bases 1 to 3137)
  AUTHORS   Tsuchida,A., Yamauchi,T., Ito,Y., Hada,Y., Maki,T., Takekawa,S.,
            Kamon,J., Kobayashi,M., Suzuki,R., Hara,K., Kubota,N., Terauchi,Y.,
            Froguel,P., Nakae,J., Kasuga,M., Accili,D., Tobe,K., Ueki,K.,
            Nagai,R. and Kadowaki,T.
  TITLE     Insulin/Foxo1 pathway regulates expression levels of adiponectin
            receptors and adiponectin sensitivity
  JOURNAL   J Biol Chem 279 (29), 30817-30822 (2004)
   PUBMED   15123605
  REMARK    GeneRIF: adiponectin receptor expression is regulated by insulin
            and Foxo1
REFERENCE   10 (bases 1 to 3137)
  AUTHORS   Yamauchi,T., Kamon,J., Ito,Y., Tsuchida,A., Yokomizo,T., Kita,S.,
            Sugiyama,T., Miyagishi,M., Hara,K., Tsunoda,M., Murakami,K.,
            Ohteki,T., Uchida,S., Takekawa,S., Waki,H., Tsuno,N.H., Shibata,Y.,
            Terauchi,Y., Froguel,P., Tobe,K., Koyasu,S., Taira,K., Kitamura,T.,
            Shimizu,T., Nagai,R. and Kadowaki,T.
  TITLE     Cloning of adiponectin receptors that mediate antidiabetic
            metabolic effects
  JOURNAL   Nature 423 (6941), 762-769 (2003)
   PUBMED   12802337
  REMARK    GeneRIF: cloning of cDNAs encoding adiponectin receptors 1 and 2
            (AdipoR1 and AdipoR2) by expression cloning [AdipoR1 & AdipoR2]
            Erratum:[Nature. 2004 Oct 28;431(7012):1123]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131592.10, CA945374.1,
            AY424290.1, AK143680.1 and AW047193.1.
            
            On Apr 14, 2015 this sequence version replaced NM_028320.3.
            
            Summary: This gene encodes a receptor for the fat-derived hormone
            adiponectin. Binding of adiponectin to the encoded protein results
            in activation of an AMP-activated kinase signaling pathway which
            affects levels of fatty acid oxidation and insulin sensitivity.
            Homozygous knockout mice for this gene exhibit elevated plasma
            glucose and insulin levels as well as impaired glucose tolerance.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY424290.1, BC014875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC131592.10        87133-87156
            25-102              CA945374.1         1-78
            103-2109            AY424290.1         1-2007
            2110-3120           AK143680.1         2134-3144
            3121-3137           AW047193.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.22 cM"
     gene            1..3137
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /note="adiponectin receptor 1"
                     /db_xref="GeneID:72674"
                     /db_xref="MGI:MGI:1919924"
     exon            1..208
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..443
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1430
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /note="progestin and adipoQ receptor family member I;
                     progestin and adipoQ receptor family member 1"
                     /codon_start=1
                     /product="adiponectin receptor protein 1"
                     /protein_id="NP_082596.2"
                     /db_xref="CCDS:CCDS15309.1"
                     /db_xref="GeneID:72674"
                     /db_xref="MGI:MGI:1919924"
                     /translation="MSSHKGSAGAQGNGAPSGNREADTVELAELGPLLEEKGKRAASS
                     PAKAEEDQACPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPD
                     WLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPN
                     MYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMG
                     SFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGL
                     SGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWF
                     QSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDSLL"
     exon            444..560
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..732
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..919
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1107
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1301
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..3123
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1502
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /note="major polyA site"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /note="hexamer: AATAAA"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /note="hexamer: AAGAAA"
     polyA_site      2109
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /note="major polyA site"
     polyA_site      2126
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
     regulatory      3101..3106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
                     /note="hexamer: AGTAAA"
     polyA_site      3123
                     /gene="Adipor1"
                     /gene_synonym="2810031L11Rik; ACDCR1; CGI-45; Paqr1"
ORIGIN      
        1 tggcacgcgc aggaatgcct ggatcggagc gggtgaggta gcgccgggaa ggtgacgcgg
       61 ctgcggaggt gacgccgtgc ggtcgcgcgg cccttccggc gcgggcaggg cgctgaggat
      121 cgggcgcccc tcggccgcag gccgcctcca gtgccgcggg atgtagcgcc cgggcccgcg
      181 gcccccagca gaggcagcca gccaggcctg tccaccatca caggaagatc tctgccctct
      241 ggggctgaga gaccccaacc tttcttcaag ctgaagctgc caggcactga ggtaccagcc
      301 agatgtcttc ccacaaaggc tctgccgggg cacaaggcaa tggggctcct tctggtaaca
      361 gagaagctga cacagtggag ctggctgagc tggggcccct gctggaggag aagggcaagc
      421 gggcagccag cagcccagcc aaggctgagg aagatcaagc atgcccggtg cctcaggaag
      481 aggaggagga ggtgcgggtg ctgacgcttc ctctgcaagc ccaccatgcc atggagaaga
      541 tggaggagtt cgtgtataag gtctgggagg gacgttggag agtcatcccg tatgatgtgc
      601 ttcctgactg gctgaaagac aacgactacc tgctacatgg ccacagacca cctatgccct
      661 cctttcgggc ttgcttcaag agcatcttcc gcatccacac agagactggc aacatctgga
      721 cacatctgct tggttttgtg ctatttctct ttctgggaat cttgacgatg ctgagaccaa
      781 atatgtactt catggctccc ctgcaggaga aggtggtctt cgggatgttc ttcctgggcg
      841 cggtgctctg cctcagtttc tcctggctct tccacactgt ctactgtcat tcagagaagg
      901 tctctcggac tttttccaaa ctggactatt cagggattgc tctactgatt atggggagct
      961 tcgttccctg gctctattac tccttctact gctccccaca gccgcggctc atctacctct
     1021 ccatcgtctg tgtcctgggc atctctgcca tcattgtggc acagtgggac cggtttgcca
     1081 ctcccaagca ccggcagaca agagcaggag tgttcctggg acttggcttg agtggtgttg
     1141 tacccaccat gcactttact atcgctgagg gctttgtcaa ggccaccacg gtgggccaga
     1201 tgggctggtt cttcctcatg gctgtgatgt acatcaccgg cgccggcctg tatgctgctc
     1261 ggattcctga gcgcttcttc cctggaaaat ttgacatctg gttccagtct catcagattt
     1321 tccacgtcct ggtggtggca gcagctttcg tccacttcta tggtgtgtcc aaccttcagg
     1381 aattccgtta tggcctagaa ggtggctgta ccgacgactc ccttctctga gcctccccac
     1441 ctgaggggtg gaggagggac ttcccaagtg cttttaaaaa taacttcttt gctgaagtat
     1501 gaggaagagt ctgagttgtc tgtttctaga agaaatctct tagagaagtc agtaccagtg
     1561 acatgtcagc tcactgtccc agcctccgtc cgggcagtac acttcccatg tgcattcccg
     1621 gcagtcacct cggcaaggca actgctgctc cttcacagat aggacgtggg agctcatgtt
     1681 gagattttac ccattcctcc agccattttg ggaaaaaaaa aattatgaac tgggattctt
     1741 cagaaattat gttttgtttt ttcttgaaga aaatatcccc cccttacccc cgtccttact
     1801 ttgtaacctg gctgataacg ggccatccat ttttgtagca cacttttcag aaacaattat
     1861 aacctggtcc catctttcta ggacaaacaa agccacgcct tgatgtagcc cggctaatca
     1921 tggaagtacg tccaggcttc aaataacttg agtttaaatc cttttttttt tttttcttgg
     1981 cagagtaatg taaaattaaa atggggaaga tatttaatat ttaatactaa gctttaaaaa
     2041 gaaacctgct atcactgcta tgtatcttga tgcaaagact atggtgataa taaaagaaag
     2101 tatagacaac gcttggcatt caaagagtta actgtgttgt ctccactgtt tgcacacaac
     2161 tcctgaggct cgaggtttct gaggactcag cttctactga gatacaaatc ggaatcatac
     2221 cagcagtgag acgggtgtgg tcagcgaatg agcataactc agttcctaac ctctcatctc
     2281 taatacaact tagtaccata cagactcctg attagtgtcc ctcagatggt agagtgtgtg
     2341 cctagcaccc acaaagccct gggtttcgtc accattatca gataaaccag gaatggtagg
     2401 tcatgcctat aacaccaata ccaaggagat tggtatatac atgagactgt ctcagaaagg
     2461 aaaatcactg tgttaccata gtatttttgg tttttcgaga catggtctct gtgtagcatt
     2521 ggctgtctta gaactgaccc tgtagaccag gctggcctca aactctcaga gatccccctg
     2581 catccacctc ccaagtgttg ggattaaagg catgtggcac cactgcctag tatagactat
     2641 gagagtctcc agtgttgagg cataccctag aacttagttt tagtaacact accttgttgg
     2701 tgctagagaa tcattcagtt actgctcgct ggagagaaac cagggaaggc ggcatgtgat
     2761 tgtgctctca gagctgaggg ctcaggcagg tagatcactg ctccctacgc agcaaacctg
     2821 catagttgac tagtttcagg gaatcggaca gtgcttccag aacaattctt gagtgtaacc
     2881 tcccctcctc ggcctgaaat ctggctgatc aggtttgact gttagtgcta ggagagcatc
     2941 aggggtggag cctgccaccc tatcggtctg ccactcccac tgctactgcc tgccttctag
     3001 cggttccgga gccgacttga ggtcacctga aactggactc caaggatgat ttggctggaa
     3061 tgggcccctc ccccttcttc ataacccagt gtctctgaat agtaaaattg aaccttgatc
     3121 aaaaaaaaaa aaaaaaa
//
