LOCUS       NM_009605               1232 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus adiponectin, C1Q and collagen domain containing
            (Adipoq), mRNA.
ACCESSION   NM_009605
VERSION     NM_009605.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   McClure,J.J., McIlroy,G.D., Symons,R.A., Clark,S.M., Cunningham,I.,
            Han,W., Kania,K., Colella,F., Rochford,J.J., De Bari,C. and
            Roelofs,A.J.
  TITLE     Disentangling the detrimental effects of local from systemic
            adipose tissue dysfunction on articular cartilage in the knee
  JOURNAL   Osteoarthritis Cartilage 32 (12), 1552-1565 (2024)
   PUBMED   39103079
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Jan 27;112:105573. doi:
            10.1016/j.ebiom.2025.105573.. PMID: 39874704]
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   4  (bases 1 to 1232)
  AUTHORS   Suh,J.H., Lee,Y., Jin,S.P., Kim,E.J., Seo,E.Y., Li,N., Oh,J.H.,
            Kim,S.J., Lee,S.H., Lee,D.H., Cho,S. and Chung,J.H.
  TITLE     Adiponectin Prevents Skin Inflammation in Rosacea by Suppressing S6
            Phosphorylation in Keratinocytes
  JOURNAL   J Invest Dermatol (2024) In press
   PUBMED   39122145
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 1232)
  AUTHORS   Schill,R.L., Visser,J., Ashby,M.L., Li,Z., Lewis,K.T.,
            Morales-Hernandez,A., Hoose,K.S., Maung,J.N., Uranga,R.M.,
            Hariri,H., Hermsmeyer,I.D.K., Mori,H. and MacDougald,O.A.
  TITLE     Deficiency of glucocorticoid receptor in bone marrow adipocytes has
            mild effects on bone and hematopoiesis but does not influence
            expansion of marrow adiposity with caloric restriction
  JOURNAL   Front Endocrinol (Lausanne) 15, 1397081 (2024)
   PUBMED   38887268
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1232)
  AUTHORS   Das,K., Lin,Y., Widen,E., Zhang,Y. and Scherer,P.E.
  TITLE     Chromosomal localization, expression pattern, and promoter analysis
            of the mouse gene encoding adipocyte-specific secretory protein
            Acrp30
  JOURNAL   Biochem Biophys Res Commun 280 (4), 1120-1129 (2001)
   PUBMED   11162643
REFERENCE   7  (bases 1 to 1232)
  AUTHORS   Bogan,J.S. and Lodish,H.F.
  TITLE     Two compartments for insulin-stimulated exocytosis in 3T3-L1
            adipocytes defined by endogenous ACRP30 and GLUT4
  JOURNAL   J Cell Biol 146 (3), 609-620 (1999)
   PUBMED   10444069
REFERENCE   8  (bases 1 to 1232)
  AUTHORS   Shapiro,L. and Scherer,P.E.
  TITLE     The crystal structure of a complement-1q family protein suggests an
            evolutionary link to tumor necrosis factor
  JOURNAL   Curr Biol 8 (6), 335-338 (1998)
   PUBMED   9512423
REFERENCE   9  (bases 1 to 1232)
  AUTHORS   Hu,E., Liang,P. and Spiegelman,B.M.
  TITLE     AdipoQ is a novel adipose-specific gene dysregulated in obesity
  JOURNAL   J Biol Chem 271 (18), 10697-10703 (1996)
   PUBMED   8631877
REFERENCE   10 (bases 1 to 1232)
  AUTHORS   Scherer,P.E., Williams,S., Fogliano,M., Baldini,G. and Lodish,H.F.
  TITLE     A novel serum protein similar to C1q, produced exclusively in
            adipocytes
  JOURNAL   J Biol Chem 270 (45), 26746-26749 (1995)
   PUBMED   7592907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134112.1.
            
            On Jan 19, 2017 this sequence version replaced NM_009605.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134112.1, AK041214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1232              AK134112.1         1-1232
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.96 cM"
     gene            1..1232
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
                     /note="adiponectin, C1Q and collagen domain containing"
                     /db_xref="GeneID:11450"
                     /db_xref="MGI:MGI:106675"
     exon            1..106
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
                     /inference="alignment:Splign:2.1.0"
     exon            107..337
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..858
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
                     /note="adipocyte, C1Q and collagen domain containing;
                     adipocyte complement related protein; adipocyte-specific
                     protein AdipoQ; 30 kDa adipocyte complement-related
                     protein; adipocyte complement-related 30 kDa protein;
                     adipocyte, C1q and collagen domain-containing protein;
                     adiponectin d"
                     /codon_start=1
                     /product="adiponectin precursor"
                     /protein_id="NP_033735.3"
                     /db_xref="CCDS:CCDS28075.1"
                     /db_xref="GeneID:11450"
                     /db_xref="MGI:MGI:106675"
                     /translation="MLLLQALLFLLILPSHAEDDVTTTEELAPALVPPPKGTCAGWMA
                     GIPGHPGHNGTPGRDGRDGTPGEKGEKGDAGLLGPKGETGDVGMTGAEGPRGFPGTPG
                     RKGEPGEAAYVYRSAFSVGLETRVTVPNVPIRFTKIFYNQQNHYDGSTGKFYCNIPGL
                     YYFSYHITVYMKDVKVSLFKKDKAVLFTYDQYQEKNVDQASGSVLLHLEVGDQVWLQV
                     YGDGDHNGLYADNVNDSTFTGFLLYHDTN"
     exon            338..1232
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      992..997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
                     /note="hexamer: ATTAAA"
     polyA_site      1015
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
                     /note="hexamer: AATACA"
     polyA_site      1231
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
                     /note="major polyA site"
ORIGIN      
        1 taagctgggg tctgcctgtc cccatgagta ccagactaat gagacctggc cactttctcc
       61 tcatttctgt ctgtacgatt gtcagtggat ctgacgacac caaaagggct caggatgcta
      121 ctgttgcaag ctctcctgtt cctcttaatc ctgcccagtc atgccgaaga tgacgttact
      181 acaactgaag agctagctcc tgctttggtc cctccaccca agggaacttg tgcaggttgg
      241 atggcaggca tcccaggaca tcctggccac aatggcacac caggccgtga tggcagagat
      301 ggcactcctg gagagaaggg agagaaagga gatgcaggtc ttcttggtcc taagggtgag
      361 acaggagatg ttggaatgac aggagctgaa gggccacggg gcttccccgg aacccctggc
      421 aggaaaggag agcctggaga agccgcttat gtgtatcgct cagcgttcag tgtggggctg
      481 gagacccgcg tcactgttcc caatgtaccc attcgcttta ctaagatctt ctacaaccaa
      541 cagaatcatt atgacggcag cactggcaag ttctactgca acattccggg actctactac
      601 ttctcttacc acatcacggt gtacatgaaa gatgtgaagg tgagcctctt caagaaggac
      661 aaggccgttc tcttcaccta cgaccagtat caggaaaaga atgtggacca ggcctctggc
      721 tctgtgctcc tccatctgga ggtgggagac caagtctggc tccaggtgta tggggatggg
      781 gaccacaatg gactctatgc agataacgtc aacgactcta catttactgg ctttcttctc
      841 taccatgata ccaactgact gcaactaccc atagcccata caccaggaga atcatggaac
      901 agtcgacaca ctttcagctt agtttgagag attgatttta ttgcttagtt tgagagtcct
      961 gagtattatc cacacgtgta ctcacttgtt cattaaacga ctttataaaa aataatttgt
     1021 gttcctagtc cagaaaaaaa ggcactccct ggtctccacg actcttacat ggtagcaata
     1081 acagaatgaa aatcacattt ggtatggggg cttcacaata ttcgcatgac tgtctggaag
     1141 tagaccatgc tatttttctg ctcactgtac acaaatattg ttcacataaa ccctataatg
     1201 taaatatgaa atacagtgat tactcttctc ac
//
