LOCUS       NM_145635                665 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus adipogenin (Adig), mRNA.
ACCESSION   NM_145635
VERSION     NM_145635.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 665)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 665)
  AUTHORS   Givony,T., Leshkowitz,D., Del Castillo,D., Nevo,S., Kadouri,N.,
            Dassa,B., Gruper,Y., Khalaila,R., Ben-Nun,O., Gome,T., Dobes,J.,
            Ben-Dor,S., Kedmi,M., Keren-Shaul,H., Heffner-Krausz,R., Porat,Z.,
            Golani,O., Addadi,Y., Brenner,O., Lo,D.D., Goldfarb,Y. and
            Abramson,J.
  TITLE     Thymic mimetic cells function beyond self-tolerance
  JOURNAL   Nature 622 (7981), 164-172 (2023)
   PUBMED   37674082
  REMARK    Erratum:[Nature. 2023 Dec;624(7991):E4. doi:
            10.1038/s41586-023-06881-0.. PMID: 38036683]
REFERENCE   3  (bases 1 to 665)
  AUTHORS   Aibara,D., Sakaguchi,A. and Matsusue,K.
  TITLE     Transcriptional regulation of adipogenin expression in liver
            steatosis by hepatic peroxisome proliferator-activated receptor
            gamma
  JOURNAL   Genes Cells 28 (8), 585-594 (2023)
   PUBMED   37249025
  REMARK    GeneRIF: Transcriptional regulation of adipogenin expression in
            liver steatosis by hepatic peroxisome proliferator-activated
            receptor gamma.
REFERENCE   4  (bases 1 to 665)
  AUTHORS   Alvarez-Guaita,A., Patel,S., Lim,K., Haider,A., Dong,L.,
            Conway,O.J., Ma,M.K.L., Chiarugi,D., Saudek,V., O'Rahilly,S. and
            Savage,D.B.
  TITLE     Phenotypic characterization of Adig null mice suggests roles for
            adipogenin in the regulation of fat mass accrual and leptin
            secretion
  JOURNAL   Cell Rep 34 (10), 108810 (2021)
   PUBMED   33691105
  REMARK    GeneRIF: Phenotypic characterization of Adig null mice suggests
            roles for adipogenin in the regulation of fat mass accrual and
            leptin secretion.
REFERENCE   5  (bases 1 to 665)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 665)
  AUTHORS   Ren,G., Eskandari,P., Wang,S. and Smas,C.M.
  TITLE     Expression, regulation and functional assessment of the 80 amino
            acid Small Adipocyte Factor 1 (Smaf1) protein in adipocytes
  JOURNAL   Arch Biochem Biophys 590, 27-36 (2016)
   PUBMED   26427354
  REMARK    GeneRIF: Together our findings show that Smaf1 is a novel small
            protein endogenous to adipocytes and that Smaf1 expression is
            closely tied to PPARgamma-mediated signals and the adipocyte
            phenotype.
REFERENCE   7  (bases 1 to 665)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 665)
  AUTHORS   Hong,Y.H., Hishikawa,D., Miyahara,H., Tsuzuki,H., Nishimura,Y.,
            Gotoh,C., Choi,K.C., Hokari,Y., Takagi,Y., Lee,H.G., Cho,K.K.,
            Roh,S.G. and Sasaki,S.
  TITLE     Up-regulation of adipogenin, an adipocyte plasma transmembrane
            protein, during adipogenesis
  JOURNAL   Mol Cell Biochem 276 (1-2), 133-141 (2005)
   PUBMED   16132694
  REMARK    GeneRIF: Adipocyte-specific membrane protein adipogenin may be
            involved with adipogenesis as one of the regulators of adipose
            tissue development.
REFERENCE   9  (bases 1 to 665)
  AUTHORS   Kim,J.Y., Tillison,K. and Smas,C.M.
  TITLE     Cloning, expression, and differentiation-dependent regulation of
            SMAF1 in adipogenesis
  JOURNAL   Biochem Biophys Res Commun 326 (1), 36-44 (2005)
   PUBMED   15567149
REFERENCE   10 (bases 1 to 665)
  AUTHORS   Pang,A.L., Taylor,H.C., Johnson,W., Alexander,S., Chen,Y., Su,Y.A.,
            Li,X., Ravindranath,N., Dym,M., Rennert,O.M. and Chan,W.Y.
  TITLE     Identification of differentially expressed genes in mouse
            spermatogenesis
  JOURNAL   J Androl 24 (6), 899-911 (2003)
   PUBMED   14581517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE624674.1, AK131610.1 and AY092026.1.
            
            On Nov 4, 2005 this sequence version replaced NM_145635.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY092026.1, BC054059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BE624674.1         1-52
            53-625              AK131610.1         3-575
            626-665             AY092026.1         633-672
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.72 cM"
     gene            1..665
                     /gene="Adig"
                     /gene_synonym="SMAF-1; Smaf1"
                     /note="adipogenin"
                     /db_xref="GeneID:246747"
                     /db_xref="MGI:MGI:2675492"
     exon            1..258
                     /gene="Adig"
                     /gene_synonym="SMAF-1; Smaf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..374
                     /gene="Adig"
                     /gene_synonym="SMAF-1; Smaf1"
                     /note="small adipocyte factor 1"
                     /codon_start=1
                     /product="adipogenin"
                     /protein_id="NP_663610.1"
                     /db_xref="CCDS:CCDS16990.1"
                     /db_xref="GeneID:246747"
                     /db_xref="MGI:MGI:2675492"
                     /translation="MKYPLVPLVSDLTLSFLVFWLCLPVALLLFLTIVWLHFLLSQES
                     KEDDSDLCFNWEPWSKRPSECGCEETFPGEEDGLHW"
     exon            259..388
                     /gene="Adig"
                     /gene_synonym="SMAF-1; Smaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..632
                     /gene="Adig"
                     /gene_synonym="SMAF-1; Smaf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      597..602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adig"
                     /gene_synonym="SMAF-1; Smaf1"
                     /note="hexamer: AAGAAA"
     polyA_site      628
                     /gene="Adig"
                     /gene_synonym="SMAF-1; Smaf1"
                     /note="major polyA site"
ORIGIN      
        1 cttccttgtt acatcacact ctccgtaact aagtcacaat tggactcaaa gtagatcctg
       61 ccaagctgac aggtcttcag gagcagccct cccgctgaat ccaggtggcc ccgcagggcc
      121 ccaggtatgc gatgaagtac cctctggtgc ctctggtgag cgacctcaca ctctctttcc
      181 tggttttctg gctctgcctg cccgtggctt tgctgctgtt cttgacgatc gtctggttgc
      241 atttcttact tagtcaagag tcaaaggaag atgattcaga tttgtgcttc aactgggagc
      301 cctggagcaa aagaccatct gagtgtggct gtgaggagac atttcctggt gaggaggacg
      361 gactccactg gtgatcctgc tctaccaggt accatctggg cctaagtgga tggagggaga
      421 acactggtga ccgatggcct tccctgggat ctcccgttgt cagacctgcc aagcctcttg
      481 ccaaaccatc ccttctccat caccacagat gacccggaac ctggaagagc caggcccaag
      541 cggcttatgg gggccagttg gccagtcaac tcacagggtg tgttggatac ctattaaaga
      601 aatgggggtg ctcttgtgcc cctacagagc ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      661 aaaaa
//
