LOCUS       NM_134052               1676 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus acireductone dioxygenase 1 (Adi1), mRNA.
ACCESSION   NM_134052 XM_912836
VERSION     NM_134052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Xu,Q., Schwarzenbacher,R., Krishna,S.S., McMullan,D., Agarwalla,S.,
            Quijano,K., Abdubek,P., Ambing,E., Axelrod,H., Biorac,T.,
            Canaves,J.M., Chiu,H.J., Elsliger,M.A., Grittini,C.,
            Grzechnik,S.K., DiDonato,M., Hale,J., Hampton,E., Han,G.W.,
            Haugen,J., Hornsby,M., Jaroszewski,L., Klock,H.E., Knuth,M.W.,
            Koesema,E., Kreusch,A., Kuhn,P., Miller,M.D., Moy,K.,
            Nigoghossian,E., Paulsen,J., Reyes,R., Rife,C., Spraggon,G.,
            Stevens,R.C., van den Bedem,H., Velasquez,J., White,A., Wolf,G.,
            Hodgson,K.O., Wooley,J., Deacon,A.M., Godzik,A., Lesley,S.A. and
            Wilson,I.A.
  TITLE     Crystal structure of acireductone dioxygenase (ARD) from Mus
            musculus at 2.06 angstrom resolution
  JOURNAL   Proteins 64 (3), 808-813 (2006)
   PUBMED   16783794
  REMARK    GeneRIF: Crystal structure of acireductone dioxygenase (ARD) was
            determined to 2.06 A resolution using the multi-wavelength
            anomalous diffraction (MAD) method and the structure show nine
            beta-strands, five helices, and a metal-binding site inside the
            -barrel.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC136986.6.
            
            On Nov 17, 2006 this sequence version replaced NM_134052.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005695.1, AK145831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC136986.6         61012-61177
            167-286             AC136986.6         63583-63702
            287-466             AC136986.6         65195-65374
            467-1676            AC136986.6         66771-67980
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 11.05 cM"
     gene            1..1676
                     /gene="Adi1"
                     /gene_synonym="ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /note="acireductone dioxygenase 1"
                     /db_xref="GeneID:104923"
                     /db_xref="MGI:MGI:2144929"
     exon            1..166
                     /gene="Adi1"
                     /gene_synonym="ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..586
                     /gene="Adi1"
                     /gene_synonym="ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /EC_number="1.13.11.54"
                     /EC_number="1.13.11.53"
                     /note="1,2-dihydroxy-3-keto-5-methylthiopentene
                     dioxygenase; ARD; aci-reductone dioxygenase; acireductone
                     dioxygenase (Ni(2+)-requiring); acireductone dioxygenase
                     (Fe(2+)-requiring); membrane-type 1 matrix
                     metalloproteinase cytoplasmic tail-binding protein 1;
                     fe-ARD"
                     /codon_start=1
                     /product="acireductone dioxygenase"
                     /protein_id="NP_598813.1"
                     /db_xref="CCDS:CCDS25853.1"
                     /db_xref="GeneID:104923"
                     /db_xref="MGI:MGI:2144929"
                     /translation="MVQAWYMDESTADPRKPHRAQPDRPVSLEQLRTLGVLYWKLDAD
                     KYENDPELEKIRKMRNYSWMDIITICKDTLPNYEEKIKMFFEEHLHLDEEIRYILEGS
                     GYFDVRDKEDKWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFVGEPVWTPYNR
                     PADHFDARVQYMSFLEGTA"
     exon            167..286
                     /gene="Adi1"
                     /gene_synonym="ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /inference="alignment:Splign:2.1.0"
     exon            287..466
                     /gene="Adi1"
                     /gene_synonym="ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1676
                     /gene="Adi1"
                     /gene_synonym="ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1649..1654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adi1"
                     /gene_synonym="ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /note="hexamer: AATAAA"
     polyA_site      1676
                     /gene="Adi1"
                     /gene_synonym="ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /note="major polyA site"
ORIGIN      
        1 aagcaacgcc ccttccagcc agttagtgga agccgccgcc gccaccatgg tgcaggcctg
       61 gtatatggac gagtccaccg ccgacccgcg gaagccccac cgcgcacagc ccgaccgccc
      121 cgtgagcctg gagcagctgc gcacgctcgg agtgctctat tggaagctag atgctgacaa
      181 gtatgagaac gatccagaac tggaaaagat ccggaaaatg agaaactact cctggatgga
      241 catcatcacc atatgcaaag atacacttcc caattacgag gagaagatca agatgttctt
      301 tgaggaacat ctgcatctgg atgaggagat ccgctacatc ctggagggta gtgggtactt
      361 cgatgtcagg gacaaggagg acaagtggat ccggatttcc atggagaagg gggacatgat
      421 tactcttcct gccggcatct atcaccgctt cacactggac gagaagaatt acgtgaaggc
      481 catgcggctg tttgttggag aacctgtgtg gacaccatac aaccggccag ctgaccattt
      541 tgatgcccgt gtacagtaca tgagtttttt ggaaggaaca gcatagcagt gctcctcaaa
      601 gagaaaactg cactgtgtga atctcctgct gtggtaaccg aatggaaagt tgctcacttt
      661 tctgcttttg tatttgaact tgaggctaga ctagctctct ttgctaggat tgtgagatca
      721 gtgtctttta aatgaaagcc tctctaaaag tgagttttac atggaagcca caaaaatgtg
      781 aaaaagtgac cttaattttc cctaactgtc aagacttaga ggtataggag ccctggattg
      841 gtatgtgcat tcatgcatgg ccaatcttca tctcccagat ctttaggtgt ctgttggtgt
      901 gaagctatgc ctcctgcaag agggcagtta taaccagcac aactaaccag atgacgtttt
      961 tctcctttgc tgattgttga gtggggaagt ggggttgttg ttctttctta aaactaagtt
     1021 tccttaattg tatgctcaca gctaagctgt atgtacattc atgtgtacct acagtatttt
     1081 acttggttca ttaaaacctc ccatttagat tccttatgtg atttttatat gtacatagtt
     1141 aatttctata tcagggtgaa agatcctgac agaatgtaaa aggtcacaga agccctgaaa
     1201 ttggcaaaat agatttcatt gttaacagaa ctagcttcac tgatttagaa aaatagaggt
     1261 gcataatgct ctggccgctc cttgaacccg tgtgtctgcc aatgttttga ccgttccttg
     1321 acccatgtgt gtgcccactg ctaaagtcca ctgccaggtg tttgtgatat tggttgctgg
     1381 ggaagagtca gaaaatctcc ccagcaacca cagccgggtc aatccggagt tgctacacct
     1441 gcaccagact ctttccttgt acccctccca aacccatttc ttgagaaatc attttagaat
     1501 agatattgtt tagattggga aatcccctac tccttccttc tcctttcccc cctgagggcc
     1561 tataaaaact gggacccctt tctcctcggg gtcaactcct ctacccctgc gtgggatatg
     1621 agtcattccc agagctctgg ctttccccaa taaagcctcg tgtggtttgc atcaaa
//
